Bowels control brain: gut hormones and obesity
Open accessAbstract
Peptide hormones are released from the gastrointestinal tract in response to nutrients and communicate information regarding the current state of energy balance to the brain. These hormones regulate appetite, energy expenditure and glucose homeostasis. They can act either via the circulation at target peripheral tissues, by activation of the vagus nerve or by acting on key brain regions implicated in energy homeostasis such as the hypothalamus and brainstem. This review gives an overview of the main gut hormones implicated in the regulation of food intake and how some of these are being targeted to develop anti obesity treatments.
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These receptors are targets of gut hormones and regulatory peptides released from enteroendocrine cells in response to nutrients, by distension of the stomach, and by neuronal signals.
“These receptors are targets of gut hormones and regulatory peptides that are released from enteroendocrine cells of the gastrointestinal system in response to nutrients, by distension of the stomach and by neuronal signals (38).”
From Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders (2018) · cites this paper as [38]
Visceral afferent endings of the vagus nerve in the intestine express a diverse array of chemical and mechanosensitive receptors.
“Histological and electrophysiological evidence indicates that visceral afferent endings of the vagus nerve in the intestine express a diverse array of chemical and mechanosensitive receptors.”
From Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders (2018) · cites this paper as [38]
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POVEZANOST DEBLJINE I GASTROINTESTINALNIH HORMONA
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- Authors
- Bewick, G. A.
- Affiliations
- Imperial College London (GB)
- Corresponding author
- Bewick, Gavin A.
- ORCID
- Bewick, Gavin A.
- Venue
- Biochemia Medica
- Published
- 2012
- Volume
- 22
- Issue
- 3
- Pages
- 283-297
- ISSN
- 1330-0962 (ISSN-L)
- 1846-7482
- PMC
- PMC3900054
- OpenAlex
- W2126442652
- Cited by
- 36
- References
- 179
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 4 · 2015: 1 · 2014: 4 · 2013: 4
- FWCI
- 0.33
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Biochemia Medica (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Hrčak Portal of scientific journals of Croatia (University Computing Centre) (submittedVersion, other-oa)
- Research Portal (King's College London) (submittedVersion, other-oa)
- Funders
- National Institute for Health and Care Research (FP7-HEALTH-2009-241592, CDF-2011-04-006)
- Medical Research Council (FP7-HEALTH-2009-241592)
- Biotechnology and Biological Sciences Research Council
- NIHR Imperial Biomedical Research Centre
- FP7 Health (2009-241592 EuroCHIP)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Keywords
- gastrointestinal hormones, obesity, peptide hormones, gut-brain axis, vagus nerve, appetite regulation, energy homeostasis, hypothalamus, brainstem, food intake regulation, anti-obesity drugs, glucose homeostasis, energy expenditure
- MeSH terms
- Animals, Appetite, Eating, Gastrointestinal Hormones, Humans, Obesity, Peptide Hormones
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