Replication and protection of telomeres

The serial cultivation of human diploid cell strains

Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508

Telomeres shorten during ageing of human fibroblasts

Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975

Shelterin: the protein complex that shapes and safeguards human telomeres

de Lange, T. (2005) · Genes & Development · doi:10.1101/gad.1346005 · Cited by 3,056

A DNA damage checkpoint response in telomere-initiated senescence

Fagagna, F. D. D., Reaper, P. M., Clay-Farrace, L., Fiegler, H., Carr, P., von Zglinicki, T., Saretzki, G., Carter, N. P., & Jackson, S. P. (2003) · Nature · doi:10.1038/nature02118 · Cited by 2,917

Mammalian Telomeres End in a Large Duplex Loop

Griffith, J. D., Comeau, L., Rosenfield, S., Stansel, R. M., Bianchi, A., Moss, H., & de Lange, T. (1999) · Cell · doi:10.1016/s0092-8674(00)80760-6 · Cited by 2,447

Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

Blasco, M. A., Lee, H.-W., Hande, M. P., Samper, E., Lansdorp, P. M., DePinho, R. A., & Greider, C. W. (1997) · Cell · doi:10.1016/s0092-8674(01)80006-4 · Cited by 2,108

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B., & Bacchetti, S. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05245.x · Cited by 2,096

Untitled work

Olovnikov (1973) · doi:10.1016/0022-5193(73)90198-7 · Cited by 1,847

TRF2 Protects Human Telomeres from End-to-End Fusions

van Steensel, B., Smogorzewska, A., & de Lange, T. (1998) · Cell · doi:10.1016/s0092-8674(00)80932-0 · Cited by 1,709

Replicative Senescence as an Intrinsic Tumor-Suppressor Mechanism

Chang, S. S. (2009) · Springer eBooks · doi:10.1007/978-1-4419-1075-2_8

Functional competence of CD8+ T cell responses specific to human cytomegalovirus in common variable immunodeficiency

Marashi, S. M. (2011) · UCL Discovery (University College London)

Differential Effects of the G-Quadruplex Ligand 360A in Human Normal and Cancer Cells

Granotier-Beckers, C., & Francois, D. (2011) · InTech eBooks · doi:10.5772/24130 · Cited by 1

Discovery and Identification of New DNA Photoproducts and Investigation of the Redox Mechanism of Human Apurinic/Apyrimidinic Endonuclease 1 (hApe1) Protein

Su, D. G. T. (2010) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k798852s

Telomere Structure in Telomerase Regulation

Vodenicharov, M. D., & Wellinger, R. J. (2012) · Wiley eBooks · doi:10.1002/9781118268667.ch7

Presença da Caspase-3 ativa e das proteínas de reparo de lesões do DNA em embriões suínos ativados partenogeneticamente com alta ou baixa capacidade de desenvolvimento

Coutinho, A. R. S. (2007) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.10.2007.tde-12122007-100619

The role of immune inhibitory receptors in age-associatedimmune decline

Macaulay, R. (2011) · UCL Discovery (University College London)

Polymerase alpha components associate with telomeres to mediate overhang processing

Diotti, R. (2014) · CUNY Academic Works (City University of New York)

Wnt-5a signaling in breast cancer metastasis

Säfholm, A. (2007) · Lund University Publications (Lund University)

Linking Human RecQ Helicases to DNA Damage Response and Aging

Cheng, W., Ahn, B., & Bohr, V. A. (2009) · Springer eBooks · doi:10.1007/978-90-481-2561-6_15

Telomere Dysfunction and the DNA Damage Response

Diehl, M. C., Elmore, L. W., & Holt, S. E. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-879-9_4

RAD51C IS A TUMOR SUPPRESSOR IN MAMMARY AND SEBACEOUS GLANDS

Tumiati, M. (2015) · Työväentutkimus Vuosikirja

Telomeres and Telomerase in Aging, Longevity, and Health

Janssens, G. E. (2009) · Utrecht University Repository (Utrecht University)

Identification of a Conserved Sequence Motif of an RNA Aptamer Binding to a G-rich Sequence RNA with Structural Probes

Choi, S.-Y., & Cho, B. (2013) · Bulletin of the Korean Chemical Society · doi:10.5012/bkcs.2013.34.11.3471

Telomere dynamics in chronic myeloid leukaemia

Gil, M. E. (2013) · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)

Âge et cancer

Morin, F., Spano, J., & Morère, J. (2010) · Springer eBooks · doi:10.1007/978-2-8178-0000-4_2

Acute coronary syndrome: Role of the telomere dynamic

Behjati, M. (2010) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.5897/ajb2010.000-3076

Telomerase in hematological and other malignancies : therapeutic implications

Li, B. (2015) · Figshare

Regulation of the initiation of DNA replication: Interplay between DNA topology and chromatin structure

Rampakakis, E. (2009) · doi:10.82308/4729

The Biology and Plasticity of Stem Cells: Progress and Promise

Çetin, A., & Ural, A. U. (2010)

Dynamics of Telomeres and MicroRNAs During Oocyte Maturation and Embryo Development in the Cow

Gilchrist, G. (2015) · The Atrium (University of Guelph)

Phosphorylation events surrounding the DNA damage response in "Saccharomyces cerevisiae"

Schleker, T. (2007) · edoc (University of Basel) · doi:10.5451/unibas-004360832

Telomere-associated proteins in Arabidopsis thaliana

Surovtseva, Y. V. (2008) · OakTrust (Texas A&M University Libraries)

Molecular dissection of telomere dysfunction and analysis of G-overhangs in Arabidopsis thaliana

Heacock, M. L. (2009) · OakTrust (Texas A&M University Libraries)

Exploring biological risk factors of chronic obstructive pulmonary disease : old age and female sex

Mui, T. (2010) · cIRcle (University of British Columbia) · doi:10.14288/1.0070956

Covalent and Non-covalent Conjugates of Oligonucleotides as Artificial Restriction DNA Cutters

Komiyama, M., Xu, Y., & Sumaoka, J. (2012) · Royal Society of Chemistry eBooks · doi:10.1039/9781849734936-00278

Telomeres and the End Replication Problem

Bryan, T. M. (2009) · Royal Society of Chemistry eBooks · doi:10.1039/9781847559852-00217

Aging of Mammalian Intestinal Stem Cells

Sperka, T., & Rudolph, K. L. (2015) · Springer eBooks · doi:10.1007/978-3-7091-1232-8_9

Single-molecule analysis of DNA cross-links using nanopore technology

Wolna, A. H. (2015) · doi:10.26053/0h-s10f-9fg0

Measuring Telomerase Activity in Senescent Human T Cells Upon Genetic Modification

Lanna, A. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6548-9_10

Telomeres in Liver Transplantation Allografts

Tsuruyama, T., & Aini, W. (2016) · InTech eBooks · doi:10.5772/62196

Regulation of Telomere Maintenance by the Shelterin Complex in Fission Yeast Schizosaccharomyces pombe

Chang, Y.-T. (2014) · Figshare

The identification and characterization of EWS as a telomerase-associated protein

Kwan, R. (2014) · eScholarship@McGill (McGill) · doi:10.82308/48686

MUTAGENIC POTENTIAL OF TELOMERIC REPEATS AND THE ROLE OF WERNER SYNDROME HELICASE PROTEIN IN FACILITATING TELOMERIC DNA REPLICATION

Damerla, R. R. (2011) · D-Scholarship@Pitt (University of Pittsburgh)

Functions of SUMO in the Maintenance of Genome Stability

Zilio, N., & Ulrich, H. D. (2009) · Springer eBooks · doi:10.1007/978-90-481-2649-1_5

Telomere

Martin, C. L., & Ledbetter, D. H. (2008) · Wiley eBooks · doi:10.1002/9780470015902.a0005787.pub2

Telomere

Raffa, G. D., & Cenci, G. (2015) · Wiley eBooks · doi:10.1002/9780470015902.a0005787.pub3

Estudio de algunos factores relacionados con la senescencia del epitelio superficial del ovario

Chuaire Noack, L. (2020) · doi:10.11144/javeriana.10554.835

Avaliação da biologia telomérica na tumorigênese dos craniofaringiomas

Mota, J. Í. S. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2022.tde-03022023-103701

Impact of shelterin complex on telomere accessibility

Shiekh, S. A., Jack, A., Mustafa, G., Kodikara, S. G., Gyawali, P., Hoque, M. E., Yıldız, A., & Balci, H. (2023) · Biophysical Journal · doi:10.1016/j.bpj.2022.11.601

The Immunologic Complications and Genetic Origins of Telomere Biology Disorders

de Tocqueville, S., Touzot, F., & Revy, P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-128-24465-4.00040-5

Three-Dimensional Organization of Telomeres: An Emerging Prognostic Biomarker in Multiple Myeloma

Shifrin, Y., & Mai, S. (2025) · Cells · doi:10.3390/cells14231890

Novel approaches for the isolation and expansion of cytomegalovirus-specific T cells for adoptive immunotherapy

Samuel, E. R. (2013) · UCL Discovery (University College London)

Expression of TRF2 and GAPDH in the aging of the in vitro ovarian surface epithelial cells

Chuaire, L., Monterrey, P. A., & Payán‐Gómez, C. (2011) · Desafíos (Universidad del Rosario)

Additional file 1 of Telomere length dynamics over 10-years and related outcomes in patients with COPD

Córdoba-Lanús, E., Cazorla-Rivero, S., García-Bello, M. A., Mayato, D., Gonzalvo, F. R., Ayra-Plasencia, J., Celli, B. R., & Casanova, C. (2021) · Figshare · doi:10.6084/m9.figshare.14068059

Additional file 1 of Atlas of telomeric repeat diversity in Arabidopsis thaliana

Tao, Y., Xian, W., Bao, Z., Rabanal, F. A., Movilli, A., Lanz, C., Shirsekar, G. S., & Weigel, D. (2024) · Figshare · doi:10.6084/m9.figshare.27042419

Additional file 2 of Atlas of telomeric repeat diversity in Arabidopsis thaliana

Tao, Y., Xian, W., Bao, Z., Rabanal, F. A., Movilli, A., Lanz, C., Shirsekar, G. S., & Weigel, D. (2024) · Figshare · doi:10.6084/m9.figshare.27042425

Additional file 3 of Atlas of telomeric repeat diversity in Arabidopsis thaliana

Tao, Y., Xian, W., Bao, Z., Rabanal, F. A., Movilli, A., Lanz, C., Shirsekar, G. S., & Weigel, D. (2024) · Figshare · doi:10.6084/m9.figshare.27042431

Déprotection et raccourcissement télomériques dans le carcinome hépatocellulaire

Idrissi, L. M. E. (2013) · theses.fr (ABES) · doi:10.70675/50e7c10bzdd88z48e5zb5c2z8168406fadd4

野外条件下におけるウミネコのテロメア動態に関する研究

水谷, 友., & Mizutani, Y. (2015) · Institutional Repositories DataBase (IRDB)

Réplication et maintenance des télomères chez Schizosaccharomyces pombe : Rôle du complexe RPA dans la prévention ou la résolution de structures secondaires de type G-quadruplexes

Audry, J. (2015) · theses.fr (ABES) · doi:10.70675/65abfb6az2efdz4f2czb8aez4682cfc31a1d

"Rôle du complexe Stn1-Ten1 et de la télomérase dans le contrôle du stress réplicatif aux télomères chez la levure Schizosaccharomyces pombe"

Matmati, S. (2019) · theses.fr (ABES) · doi:10.70675/fadbf506z1c0fz43aeza97bz78a486b3638b

Maintenance télomérique : intérêt dans le diagnostic des gliomes en lien avec le métabolisme mitochondrial

Billard, P. (2021) · theses.fr (ABES) · doi:10.70675/7d145f6az2700z4c8bzad56z3286d493fb31

L'épigénétique comme modulateur de l'expression de hTERT dans les lymphomes T cutanés

Chebly, A. (2020) · theses.fr (ABES) · doi:10.70675/9464cf37z20b3z4d7cz9053z3a974daff409

Étude des mécanismes moléculaires impliqués dans la maintenance des séquences télomériques dans les cellules quiescentes et cyclantes de la levure Schizosaccharomyces pombe

Vaurs, M. (2021) · theses.fr (ABES) · doi:10.70675/9f201d13z3a7bz4df7z8559z76f8d0cbb0c0

Genome-Scale CRISPR Screens Reveal DNA Repair Dependencies That Sensitize Hepatocellular Carcinoma to Oxaliplatin

Ouyang, H., Huang, D., Wen, D., Huang, L., Wu, Z. Z., Lai, Z., He, M., Wu, W., & Shi, M. (2026) · Cancers · doi:10.3390/cancers18091360

Branched DNA Nanoplatform-Based Multivalent PROTACs for Tumor Microenvironment-Responsive Degradation of Telomere-Binding Proteins in Tumor Therapy

Zhu, H., Li, X., Wang, H., Liu, H., Li, D., Yang, C., Ding, B., & Liu, J. (2026) · Nano Letters · doi:10.1021/acs.nanolett.6c02181

The polycentric aging framework: epigenetic regulation as a dominant lifespan-limiting center in human aging

Bartoszewicz, M., & Niemczyk, M. (2026) · Aging · doi:10.18632/aging.206426

Acquired Cytogenetic Changes in Adult Twins Discordant for a History of Childhood Sexual Abuse

Brumelle, J. (2011) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/pqck-z230

Investigation of telomere maintenance in BRCA2 defective mammalian cell lines

Chianea, Y. G. (2014) · Brunel University Research Archive (BURA) (Brunel University London)

Telomeres, Epigenetics, and Aging

Londoño‐Vallejo, A. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0639-7_12 · Cited by 1

Telomeric armor: the layers of end protection

Oganesian, L., & Karlseder, J. (2009) · Journal of Cell Science · doi:10.1242/jcs.050567 · Cited by 61

Defending the end zone: Studying the players involved in protecting chromosome ends

Chan, S., & Chang, S. S. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.06.016 · Cited by 26

Telomeres: Protection and Maintenance

de Lange, T. (2005) · Encyclopedia of Life Sciences · doi:10.1038/npg.els.0005281

In the End, its all Structure

Crabbé, L., & Karlseder, J. (2005) · Current Molecular Medicine · doi:10.2174/1566524053586527 · Cited by 16

Telomeres: protecting chromosomes against genome instability

O’Sullivan, R. J., & Karlseder, J. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2848 · Cited by 1,043