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Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells
Abstract
Lymph nodes prevent the systemic dissemination of pathogens such as viruses that infect peripheral tissues after penetrating the body's surface barriers. They are also the staging ground of adaptive immune responses to pathogen-derived antigens. It is unclear how virus particles are cleared from afferent lymph and presented to cognate B cells to induce antibody responses. Here we identify a population of CD11b+CD169+MHCII+ macrophages on the floor of the subcapsular sinus (SCS) and in the medulla of lymph nodes that capture viral particles within minutes after subcutaneous injection. Macrophages in the SCS translocated surface-bound viral particles across the SCS floor and presented them to migrating B cells in the underlying follicles. Selective depletion of these macrophages compromised local viral retention, exacerbated viraemia of the host, and impaired local B-cell activation. These findings indicate that CD169+ macrophages have a dual physiological function. They act as innate 'flypaper' by preventing the systemic spread of lymph-borne pathogens and as critical gatekeepers at the lymph-tissue interface that facilitate the recognition of particulate antigens by B cells and initiate humoral immune responses.
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“These macrophages can capture larger molecules, viruses, and bacteria (89, 90) and are capable of mounting a protective immune response even in the absence of antigen-presenting DCs (91).”
From Transport and Immune Functions of the Lymphatic System. (2025) · cites this paper as [90]
Citations
Cites
T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
Mempel, T. R., Henrickson, S. E., & von Andrian, U. H. (2004) · Nature · doi:10.1038/nature02238 · Cited by 1,720
Self-citationMACROPHAGE RECEPTORS AND IMMUNE RECOGNITION
Taylor, P. R., Martínez‐Pomares, L., Stacey, M. A., Lin, H.-H., Brown, G. D., & Gordon, S. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115816 · Cited by 1,366
Homing and cellular traffic in lymph nodes
von Andrian, U. H., & Mempel, T. R. (2003) · Nature reviews. Immunology · doi:10.1038/nri1222 · Cited by 1,271
Self-citationCD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organs
Shiow, L. R., Rosen, D. B., Brdičková, N., Xu, Y., An, J., Lanier, L. L., Cyster, J. G., & Matloubian, M. (2006) · Nature · doi:10.1038/nature04606 · Cited by 1,189
Control of Early Viral and Bacterial Distribution and Disease by Natural Antibodies
Ochsenbein, A. F., Fehr, T. H., Lutz, C., Suter, M., Brombacher, F., Hengartner, H., & Zinkernagel, R. M. (1999) · Science · doi:10.1126/science.286.5447.2156 · Cited by 911
Okada, T., Miller, M. J., Parker, I., Krummel, M. F., Neighbors, M., Hartley, S. B., O’Garra, A., Cahalan, M. D., & Cyster, J. G. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030150 · Cited by 586
Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position
Reif, K., Ekland, E. H., Ohl, L., Nakano, H., Lipp, M., Förster, R., & Cyster, J. G. (2002) · Nature · doi:10.1038/416094a · Cited by 572
B cell receptor signal strength determines B cell fate
Casola, S. S., Otipoby, K. L., Alimzhanov, M. B., Humme, S., Uyttersprot, N., Kutok, J. L., Carroll, M. C., & Rajewsky, K. (2004) · Nature Immunology · doi:10.1038/ni1036 · Cited by 561
Extrafollicular Activation of Lymph Node B Cells by Antigen-Bearing Dendritic Cells
Qi, H., Egen, J. G., Huang, A. Y.-C., & Germain, R. N. (2006) · Science · doi:10.1126/science.1125703 · Cited by 521
Wessels, M. R., Butko, P., Ma, M., Warren, H. B., Lage, A. L., & Carroll, M. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11490 · Cited by 503
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Ugur, M., & Mueller, S. N. (2019) · Immunological Reviews · doi:10.1111/imr.12753 · Cited by 32
Motley, M. P., Bennett‐Guerrero, E., Fries, B. C., & Spitzer, E. D. (2020) · Critical Care Explorations · doi:10.1097/cce.0000000000000154 · Cited by 32
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Coughlan, L., Mullarkey, C. E., & Gilbert, S. C. (2015) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12350 · Cited by 29
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Ketchum, C. M., Sun, X., Suberi, A., Fourkas, J. T., Song, W., & Upadhyaya, A. (2018) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-06-0422 · Cited by 31
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Yoo, E., Salyer, A. C. D., Brush, M. J. H., Li, Y., Trautman, K. L., Shukla, N. M., Beuckelaer, A. D., Lienenklaus, S., Deswarte, K., Lambrecht, B. N., et al. (2018) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.8b00386 · Cited by 29
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Grosman‐Rimon, L., Ajrawat, P., Lioe, J., Tumiati, L. C., Rao, V. A., Billia, F., & Chruscinski, A. J. (2019) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2019.01.002 · Cited by 29
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Pineau, J., Pinon, L., Mesdjian, O., Fattaccioli, J., Lennon‐Duménil, A., & Pierobon, P. (2022) · eLife · doi:10.7554/elife.78330 · Cited by 29
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den Haan, J. M. M., & Martínez‐Pomares, L. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0378-4 · Cited by 28
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Hofman, L., Lawler, S. E., & Lamfers, M. L. M. (2021) · Viruses · doi:10.3390/v13081570 · Cited by 33
Clark, M. R., Tanaka, A., Powers, S. E., & Veselits, M. (2010) · Molecular Immunology · doi:10.1016/j.molimm.2010.10.024 · Cited by 32
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Arcangeli, M.-L., Frontera, V., & Aurrand‐Lions, M. (2012) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-012-0199-5 · Cited by 30
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Simon, I. D., van Rooijen, N., & Rose, J. K. (2009) · Journal of Virology · doi:10.1128/jvi.02052-09 · Cited by 28
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Pecetta, S., Tontini, M., Faenzi, E., Cioncada, R., Proietti, D., Seubert, A., Nuti, S., Berti, F., & Romano, M. R. (2016) · Vaccine · doi:10.1016/j.vaccine.2016.03.055 · Cited by 27
Zimmermann, M., Rose, N., Lindner, J. M., Kim, H.-I., Gonçalves, A. R., Callegari, I., Syedbasha, M., Kaufmann, L., Egli, A., Lindberg, R. L. P., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00829 · Cited by 28
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Bordet, É., Frétaud, M., Crisci, E., Bouguyon, E., Rault, S., Pezant, J., Pléau, A., Renson, P., Giuffra, E., Larcher, T., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00953 · Cited by 26
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Kochappan, R., Cao, E., Han, S., Hu, L., Quach, T., Senyschyn, D., Ferreira, V. D. M., Lee, G., Leong, N. J., Sharma, G., et al. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.02.008 · Cited by 28
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Pierce, S. K. (2008) · Immunologic Research · doi:10.1007/s12026-008-8052-y · Cited by 24
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Spanier, J., Lienenklaus, S., Paijo, J., Keßler, A., Borst, K., Heindorf, S., Baker, D. P., Kröger, A., Weiß, S., Detje, C. N., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400959 · Cited by 24
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Tsourkas, P. K., Liu, W., Das, S. C., Pierce, S. K., & Raychaudhuri, S. (2011) · Cellular and Molecular Immunology · doi:10.1038/cmi.2011.29 · Cited by 23
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Parekh, N. J., Krouse, T. E., Reider, I. E., Hobbs, R. P., Ward, B. M., & Norbury, C. C. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007778 · Cited by 23
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Turner, J. S., Benet, Z. L., & Grigorova, I. (2020) · Immunological Reviews · doi:10.1111/imr.12865 · Cited by 22
Ulloa, R., Corrales, O., Cabrera-Reyes, F., de la Jara, J. J., Sáez, J. J., Rivas, C., Lagos, J., Härtel, S., Quiroga, C., Gomes, E. R., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.801164 · Cited by 22
Chen, X., Liu, H., Zhang, T., Liu, Y., Xie, X.-X., Wang, Z., & Xu, X. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095448 · Cited by 22
Fujiwara, Y., Saito, Y., Shiota, T., Pan, C., Ikeda, T., Ohnishi, K., Takeya, M., & Komohara, Y. (2018) · Journal of the Japan Society of the Reticuloendothelial System · doi:10.3960/jslrt.17032 · Cited by 22
Urata, S., Kenyon, E., Nayak, D., Cubitt, B., Kurosaki, Y., Yasuda, J., de la Torre, J. C., & McGavern, D. B. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007172 · Cited by 22
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Yewdell, J. W., Pierson, T. C., & Bennink, J. R. (2009) · Wiley eBooks · doi:10.1128/9781555815981.ch14 · Cited by 22
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Matheu, M. P., Cahalan, M. D., & Parker, I. (2011) · Cold Spring Harbor Protocols · doi:10.1101/pdb.top99 · Cited by 22
Sapoznikov, A., Kozlovski, S., Levi, N., Feigelson, S. W., Regev, O., Davidzohn, N., Ben‐Dor, S., Haffner‐Krausz, R., Feldmesser, E., Wigoda, N., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112864 · Cited by 21
Mauvais, F., Hamel, Y., Silvin, A., Mulder, K., Hildner, K., Akyol, R., Dalod, M., Koumantou, D., Saveanu, L., Garfa‐Traoré, M., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.02.027 · Cited by 21
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Bala, N., McGurk, A. I., Zilch, T. J., Rup, A. N., Carter, E. M., Leddon, S. A., & Fowell, D. J. (2021) · Immunological Reviews · doi:10.1111/imr.13047 · Cited by 21
Beek, M. V., Nussenzweig, M. C., & Chakraborty, A. K. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2205598119 · Cited by 21
Fibroblastic reticular cells provide a supportive niche for lymph node–resident macrophages
D’Rozario, J., Knoblich, K., Lütge, M., Perez‐Shibayama, C., Cheng, H., Alexandre, Y. O., Roberts, D., Campos, J., Astarita, J., Dutton, E., et al. (2023) · European Journal of Immunology · doi:10.1002/eji.202250355 · Cited by 21
A Macrophage-Specific Fluorescent Probe for Intraoperative Lymph Node Staging
Yoo, J. S., Lee, S.-C., Jow, Z. Y., Koh, P. Y. X., & Chang, Y. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-2129 · Cited by 21
The Role of Lymphatic Niches in T Cell Differentiation
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Metadata
- Authors
- Junt, T., Moseman, E. A., Iannacone, M., Massberg, S., Lang, P. A., Boes, M., Fink, K., Henrickson, S. E., Shayakhmetov, D. M., Di Paolo, N. C., van Rooijen, N., Mempel, T. R., Whelan, S. P., & von Andrian, U. H.
- Affiliations
- Harvard University (US)
- University Hospital Zurich (CH)
- Brigham and Women's Hospital (US)
- Novartis Institute For Tropical Diseases (SG)
- University of Washington (US)
- Vrije Universiteit Amsterdam (NL)
- Corresponding author
- von Andrian, Ulrich H.
- ORCID
- Venue
- Nature
- Published
- 2007-10-14
- Volume
- 450
- Issue
- 7166
- Pages
- 110-114
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2019206924
- Cited by
- 846
- References
- 29
- Citations by year
- 2026: 21 · 2025: 38 · 2024: 37 · 2023: 34 · 2022: 35 · 2021: 55 · 2020: 46 · 2019: 49 · 2018: 53 · 2017: 53 · 2016: 46 · 2015: 53 · 2014: 46 · 2013: 38 · 2012: 66
- FWCI
- 17.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM007753)
- National Institute of Allergy and Infectious Diseases (R01AI059371)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- subcapsular sinus macrophages, lymph node macrophages, CD169+ macrophages, viral clearance, B cell activation, antigen presentation, afferent lymph, humoral immune response, viremia, macrophage depletion
- MeSH terms
- Animals, Antibody Formation, B-Lymphocytes, Cell Line, Lymph, Lymph Nodes, Macrophages, Membrane Glycoproteins, Mice, Inbred C57BL, Receptors, Immunologic, Vesiculovirus, CD11b Antigen, Mice, Sialic Acid Binding Ig-like Lectin 1
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