Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells

T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases

Mempel, T. R., Henrickson, S. E., & von Andrian, U. H. (2004) · Nature · doi:10.1038/nature02238 · Cited by 1,720

MACROPHAGE RECEPTORS AND IMMUNE RECOGNITION

Taylor, P. R., Martínez‐Pomares, L., Stacey, M. A., Lin, H.-H., Brown, G. D., & Gordon, S. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115816 · Cited by 1,366

Homing and cellular traffic in lymph nodes

von Andrian, U. H., & Mempel, T. R. (2003) · Nature reviews. Immunology · doi:10.1038/nri1222 · Cited by 1,271

CD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organs

Shiow, L. R., Rosen, D. B., Brdičková, N., Xu, Y., An, J., Lanier, L. L., Cyster, J. G., & Matloubian, M. (2006) · Nature · doi:10.1038/nature04606 · Cited by 1,189

Control of Early Viral and Bacterial Distribution and Disease by Natural Antibodies

Ochsenbein, A. F., Fehr, T. H., Lutz, C., Suter, M., Brombacher, F., Hengartner, H., & Zinkernagel, R. M. (1999) · Science · doi:10.1126/science.286.5447.2156 · Cited by 911

Antigen-Engaged B Cells Undergo Chemotaxis toward the T Zone and Form Motile Conjugates with Helper T Cells

Okada, T., Miller, M. J., Parker, I., Krummel, M. F., Neighbors, M., Hartley, S. B., O’Garra, A., Cahalan, M. D., & Cyster, J. G. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030150 · Cited by 586

Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position

Reif, K., Ekland, E. H., Ohl, L., Nakano, H., Lipp, M., Förster, R., & Cyster, J. G. (2002) · Nature · doi:10.1038/416094a · Cited by 572

B cell receptor signal strength determines B cell fate

Casola, S. S., Otipoby, K. L., Alimzhanov, M. B., Humme, S., Uyttersprot, N., Kutok, J. L., Carroll, M. C., & Rajewsky, K. (2004) · Nature Immunology · doi:10.1038/ni1036 · Cited by 561

Extrafollicular Activation of Lymph Node B Cells by Antigen-Bearing Dendritic Cells

Qi, H., Egen, J. G., Huang, A. Y.-C., & Germain, R. N. (2006) · Science · doi:10.1126/science.1125703 · Cited by 521

Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity.

Wessels, M. R., Butko, P., Ma, M., Warren, H. B., Lage, A. L., & Carroll, M. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11490 · Cited by 503

Imaging reveals novel innate immune responses in lung, liver, and beyond*

Neupane, A. S., & Kubes, P. (2021) · Immunological Reviews · doi:10.1111/imr.13040 · Cited by 21

3D and 4D imaging of immune cells in vitro and in vivo

Nitschke, C., Garin, A., Kosco‐Vilbois, M. H., & Gunzer, M. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0520-x · Cited by 20

Cellular choreography in the germinal center: new visions from in vivo imaging

Hauser, A. E., Kerfoot, S. M., & Haberman, A. M. (2010) · Seminars in Immunopathology · doi:10.1007/s00281-010-0214-z · Cited by 20

Cytokine/Stromal Cell Networks and Lymphoid Tissue Environments

Fritz, J. H., & Gommerman, J. L. (2010) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2010.0121 · Cited by 19

B cell mechanosensing: A mechanistic overview

Shaheen, S., Wan, Z., Haneef, K., Zeng, Y., Wang, J., & Liu, W. (2019) · Advances in immunology · doi:10.1016/bs.ai.2019.08.003 · Cited by 19

CD4+ T Cells Provide Intermolecular Help To Generate Robust Antibody Responses in Vaccinia Virus–Vaccinated Humans

Yin, L., Calvo‐Calle, J. M., Cruz, J., Newman, F. K., Frey, S. E., Ennis, F. A., & Stern, L. J. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202523 · Cited by 19

Anterograde or Retrograde Transsynaptic Circuit Tracing in Vertebrates with Vesicular Stomatitis Virus Vectors

Beier, K. T., Mundell, N. A., Pan, Y. A., & Cepko, C. L. (2016) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0126s74 · Cited by 19

Stromal cell control of conventional and ectopic germinal centre reactions

Silva-Cayetano, A., & Linterman, M. A. (2020) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.03.007 · Cited by 21

Geography and plumbing control the T cell response to infection

Khanna, K. M., & Lefrançois, L. (2008) · Immunology and Cell Biology · doi:10.1038/icb.2008.22 · Cited by 20

Splenic macrophages are required for protective innate immunity against West Nile virus

Bryan, M. A., Giordano, D., Draves, K. E., Green, R. R., Gale, M., & Clark, E. A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191690 · Cited by 20

Crosstalk Between the Spleen and Other Organs/Systems: Downstream Signaling Events

Tarantino, G., & Citro, V. (2024) · Immuno · doi:10.3390/immuno4040030 · Cited by 18

Modulation of B cell activation by extracellular vesicles and potential alteration of this pathway in patients with rheumatoid arthritis

Rincón-Arévalo, H., Burbano, C., Atehortúa, L., Rojas, M., Vanegas-García, A. L., Vásquez, G. M., & Castaño, D. (2022) · Arthritis Research & Therapy · doi:10.1186/s13075-022-02837-3 · Cited by 20

Engineered Ferritin Nanoparticle Vaccines Enable Rapid Screening of Antibody Functionalization to Boost Immune Responses

Vu, M. N., Pilkington, E. H., Lee, W. S., Tan, H., Davis, T. P., Truong, N. P., Kent, S. J., & Wheatley, A. K. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202202595 · Cited by 18

Entry receptor LDLRAD3 is required for Venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in mice

Kafai, N. M., Jáňová, H., Cain, M. D., Alippe, Y., Muraro, S. P., Sariol, A., Elam-Noll, M., Klein, R. S., & Diamond, M. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112946 · Cited by 18

Cell-targeted vaccines: implications for adaptive immunity

Ung, T. W.-M., Rutledge, N. S., Weiss, A. M., Esser-Kahn, A. P., & Deak, P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1221008 · Cited by 19

Reshaping Intratumoral Mononuclear Phagocytes with Antibody‐Opsonized Immunometabolic Nanoparticles

Liu, C., Zhou, Y., Guo, D., Huang, Y., Ji, X., Li, Q., Chen, N., Fan, C., & Song, H. (2023) · Advanced Science · doi:10.1002/advs.202303298 · Cited by 18

FcγRIIb inhibits immune complex-induced VEGF-A production and intranodal lymphangiogenesis

Clatworthy, M. R., Harford, S. K., Mathews, R. J., & Smith, K. G. C. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1413915111 · Cited by 18

Macrophages enhance tumor-derived autophagosomes (DRibbles)-induced B cells activation by TLR4/MyD88 and CD40/CD40L

Zhou, M., Li, W., Wen, Z., Sheng, Y., Ren, H., Dong, H., Cao, M., Hu, H., & Wang, L. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.10.015 · Cited by 18

Sevoflurane Promotes Bactericidal Properties of Macrophages through Enhanced Inducible Nitric Oxide Synthase Expression in Male Mice

Gerber, T. J., Fehr, V. C. O., Oliveira, S. D., Hu, G., Dull, R. O., Bonini, M. G., Beck‐Schimmer, B., & Minshall, R. D. (2019) · Anesthesiology · doi:10.1097/aln.0000000000002992 · Cited by 18

The Immune-Modulatory Properties of iPSC-Derived Antigen-Presenting Cells

Ackermann, M., Dragon, A. C., & Lachmann, N. (2020) · Transfusion Medicine and Hemotherapy · doi:10.1159/000512721 · Cited by 18

Understanding immunity in a tissue‐centric context: Combining novel imaging methods and mathematics to extract new insights into function and dysfunction*

Germain, R. N., Radtke, A. J., Thakur, N., Schrom, E. C., Hor, J. L., Ichise, H., Arroyo-Mejías, A., Chu, C. J., & Grant, S. M. (2021) · Immunological Reviews · doi:10.1111/imr.13052 · Cited by 19

Modulating Antigen Availability in Lymphoid Organs to Shape the Humoral Immune Response to Vaccines

Aung, A., & Irvine, D. J. (2024) · The Journal of Immunology · doi:10.4049/jimmunol.2300500 · Cited by 17

Sialoglycans on lymphatic endothelial cells augment interactions with Siglec‐1 (CD169) of lymph node macrophages

D’Addio, M., Frey, J., Tacconi, C., Commerford, C. D., Halin, C., Detmar, M. J., Cummings, R. D., & Otto, V. I. (2021) · The FASEB Journal · doi:10.1096/fj.202100300r · Cited by 19

Spatial determinates of effector and memory CD8+ T cell fates*

Duckworth, B. C., Qin, R. Z., & Groom, J. R. (2021) · Immunological Reviews · doi:10.1111/imr.13044 · Cited by 18

Defining the niche for stem-like CD8+ T cell formation and function

Broomfield, B. J., & Groom, J. R. (2024) · Current Opinion in Immunology · doi:10.1016/j.coi.2024.102454 · Cited by 17

Interactions of Immune Cells and Lymphatic Vessels

Kataru, R. P., Lee, Y. G., & Koh, G. Y. (2013) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-7091-1646-3_9 · Cited by 17

B cells do not take up bacterial DNA: an essential role for antigen in exposure of DNA to toll‐like receptor‐9

Roberts, T. L., Turner, M. L., Dunn, J. A., Lenert, P. S., Ross, I. L., Sweet, M. J., & Stacey, K. J. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2010.112 · Cited by 17

TLR7 Controls VSV Replication in CD169+ SCS Macrophages and Associated Viral Neuroinvasion

Solmaz, G., Puttur, F. K., Francozo, M., Lindenberg, M., Guderian, M., Swallow, M., Duhan, V., Khairnar, V., Kalinke, U., Ludewig, B., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00466 · Cited by 17

Indispensable Role of CX3CR1+ Dendritic Cells in Regulation of Virus-Induced Neuroinflammation Through Rapid Development of Antiviral Immunity in Peripheral Lymphoid Tissues

Choi, J., Kim, J. H., Hossain, F. M. A., Uyangaa, E., Park, S. O., Kim, B., Kim, K., & Eo, S. K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01467 · Cited by 17

Development of Sentinel LN Imaging with a Combination of HAase Based on a Comprehensive Analysis of the Intra-lymphatic Kinetics of LPs

Gomi, M., Sakurai, Y., Okada, T., Miura, N., Tanaka, H., & Akita, H. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.09.014 · Cited by 17

Auditing Protein Therapeutics Management by Professional APCs: Toward Prevention of Immune Responses against Therapeutic Proteins

Dasgupta, S., Bayry, J., André, S., Dimitrov, J. D., Kaveri, S. V., & Lacroix‐Desmazes, S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.3.1609 · Cited by 17

Microbial pathogenesis revealed by intravital microscopy: pros, cons and cautions

Stolp, B., & Melican, K. (2016) · FEBS Letters · doi:10.1002/1873-3468.12122 · Cited by 18

The Janus Face of Follicular T Helper Cells in Chronic Viral Infections

Greczmiel, U., & Oxenius, A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01162 · Cited by 17

HIV-Captured DCs Regulate T Cell Migration and Cell-Cell Contact Dynamics to Enhance Viral Spread

Koh, W. H., Lopez, P., Ajibola, O., Parvarchian, R., Mohammad, U., Hnatiuk, R., Kindrachuk, J., & Murooka, T. T. (2020) · iScience · doi:10.1016/j.isci.2020.101427 · Cited by 17

Secondary Lymphoid Organs in Mesenchymal Stromal Cell Therapy: More Than Just a Filter

Zheng, D., Bhuvan, T., Payne, N. L., & Heng, T. S. P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.892443 · Cited by 18

Nonclinical pharmacokinetics and biodistribution of VSV-GP using methods to decouple input drug disposition and viral replication

Dambra, R., Matter, A. M., Graca, K., Akhand, S. S., Mehta, S., Bell-Cohn, A. J., Swenson, J. M., Abid, S., Xin, D., Lewis, C., et al. (2022) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2022.12.013 · Cited by 16

Phenotypic and functional heterogeneity of CD169+ and CD163+ macrophages from porcine lymph nodes and spleen

Álvarez, B., Martínez, P., Yuste, M. T., Poderoso, T., Alonso, F., Domı́nguez, J., Ezquerra, Á., & Revilla, C. (2013) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2013.11.010 · Cited by 16

Macrophages Induce Long-Term Trapping of γδ T Cells with Innate-like Properties within Secondary Lymphoid Organs in the Steady State

Audemard‐Verger, A., Rivière, M., Durand, A., Peranzoni, E., Guichard, V., Hamon, P., Bonilla, N., Guilbert, T., Boissonnas, A., Auffray, C., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700430 · Cited by 17

Infection of non-cancer cells: A barrier or support for oncolytic virotherapy?

Naumenko, V., Stepanenko, A. A., Lipatova, A. V., Vishnevskiy, D. A., & Chekhonin, V. P. (2022) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2022.02.004 · Cited by 16

The Role of Innate Immunity in B Cell Acquisition of Antigen Within LNs

González, S., Kuligowski, M., Pitcher, L. A., Roozendaal, R., & Carroll, M. C. (2010) · Advances in immunology · doi:10.1016/s0065-2776(10)06001-3 · Cited by 16

Overexpression of Bovine FcRn in Mice Enhances T-Dependent Immune Responses by Amplifying T Helper Cell Frequency and Germinal Center Enlargement in the Spleen

Schneider, Z., Jani, P. K., Szikora, B., Végh, A. G., Kövesdi, D., Iliás, A., Cervenak, J., Balogh, P., Kurucz, I., & Kacskovıcs, I. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00357 · Cited by 16

Accelerating antibody discovery using transgenic animals overexpressing the neonatal Fc receptor as a result of augmented humoral immunity

Cervenak, J., Kurrle, R., & Kacskovıcs, I. (2015) · Immunological Reviews · doi:10.1111/imr.12364 · Cited by 16

Advances in Imaging The Innate and Adaptive Immune Response to Toxoplasma Gondii

John, B., Weninger, W., & Hunter, C. A. (2010) · Future Microbiology · doi:10.2217/fmb.10.97 · Cited by 16

Active Tuning of Synaptic Patterns Enhances Immune Discrimination

Knežević, M., Jiang, H., & Wang, S. (2018) · Physical Review Letters · doi:10.1103/physrevlett.121.238101 · Cited by 16

In Vivo Imaging-Driven Approaches to Study Virus Dissemination and Pathogenesis

Uchil, P. D., Haugh, K. A., Pi, R., & Mothes, W. (2019) · Annual Review of Virology · doi:10.1146/annurev-virology-101416-041429 · Cited by 16

Stromal structure remodeling by B lymphocytes limits T cell activation in lymph nodes of Mycobacterium tuberculosis–infected mice

Daniel, L., Bhattacharyya, N. D., Counoupas, C., Cai, Y., Chen, X., Triccas, J. A., Britton, W. J., & Feng, C. G. (2022) · Journal of Clinical Investigation · doi:10.1172/jci157873 · Cited by 16

Identifying physiological tissue niches that support the HIV reservoir in T cells

Ikeogu, N. M., Ajibola, O., Zayats, R., & Murooka, T. T. (2023) · mBio · doi:10.1128/mbio.02053-23 · Cited by 16

In vivo imaging of retrovirus infection reveals a role for Siglec-1/CD169 in multiple routes of transmission

Haugh, K. A., Ladinsky, M. S., Ullah, I., Stone, H. M., Pi, R., Gilardet, A., Grunst, M. W., Kumar, P., Björkman, P. J., Mothes, W., et al. (2021) · eLife · doi:10.7554/elife.64179 · Cited by 18

The Wdr1-LIMK-Cofilin Axis Controls B Cell Antigen Receptor-Induced Actin Remodeling and Signaling at the Immune Synapse

Bolger-Munro, M., Choi, K., Cheung, F., Liu, J., Dang-Lawson, M., Deretic, N., Keane, C., & Gold, M. R. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.649433 · Cited by 16

Macrophages and their interactions with oncolytic viruses

Jakeman, P. G., Hills, T. E., Fisher, K. D., & Seymour, L. W. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.06.007 · Cited by 18

Micro- and Macro-Anatomical Frameworks of Lymph Nodes Indispensable for the Lymphatic System Filtering Function

Ozawa, M., Nakajima, S., Kobayashi, D., Tomii, K., Li, N.-J., Watarai, T., Suzuki, R., Watanabe, S., Kanda, Y., Takeuchi, A., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.902601 · Cited by 14

Multiple Sclerosis: Immune Cells, Histopathology, and Therapeutics

Patil, M. S., Lin, L. Y., Marsh‐Wakefield, F., James, E. J., Palendira, M., Hawke, S. H., & Grau, G. E. (2024) · Sclerosis · doi:10.3390/sclerosis2030009 · Cited by 15

The cellular factors that impair the germinal center in advanced age

Foster, W. S., Marcial‐Juárez, E., & Linterman, M. A. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkae039 · Cited by 14

Fibroblastic reticular cells form reactive myeloid cell niches in human lymph nodes

Lütge, M., Kurz, L., Stanossek, Y., Meili, S., Cheng, H., Martin, A. D., Brandstadter, J. D., Maillard, I. P., Robinson, M. D., Stoeckli, S. J., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.ads6820 · Cited by 14

Formation of BCR oligomers provides a mechanism for B cell affinity discrimination

Tsourkas, P. K., Das Somkanya, C., Yu-Yang, P., Liu, W., Pierce, S. K., & Raychaudhuri, S. (2012) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2012.05.008 · Cited by 14

The Role of Dendritic Cells in S. pneumoniae Transport to Follicular Dendritic Cells

Heesters, B. A., & Carroll, M. C. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.049 · Cited by 14

Characterization of Antigen-Presenting Cell Subsets in Human Liver-Draining Lymph Nodes

Boor, P. P. C., Bosma, B. M., Tran, K. T. C., van der Laan, L. J. W., Hagenaars, H., IJzermans, J. N. M., Metselaar, H. J., & Kwekkeboom, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00441 · Cited by 14

Destruction of Lymphoid Organ Architecture and Hepatitis Caused by CD4+ T Cells

Matter, M. S., Hilmenyuk, T., Claus, C., Marone, R., Schürch, C. M., Tinguely, M., Terracciano, L., Luther, S. A., & Ochsenbein, A. F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024772 · Cited by 14

Exploring CD169+ Macrophages as Key Targets for Vaccination and Therapeutic Interventions

Bouma, R. G., Wang, A. Z., & den Haan, J. M. M. (2025) · Vaccines · doi:10.3390/vaccines13030330 · Cited by 13

Splenic Dendritic Cells and Macrophages Drive B Cells to Adopt a Plasmablast Cell Fate

McNamara, H. A., Lahoud, M. H., Cai, Y., Durrant-Whyte, J., O’Connor, J. H., Caminschi, I., & Cockburn, I. A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.825207 · Cited by 13

Development and organization of omental milky spots

Okabe, Y. (2024) · Immunological Reviews · doi:10.1111/imr.13337 · Cited by 14

Determining the role of mononuclear phagocytes in prion neuroinvasion from the skin

Wathne, G. J., Kissenpfennig, A., MALISSEN, B., Zurzolo, C., & Mabbott, N. A. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.1211633 · Cited by 13

The Antidepressant Mirtazapine Activates Hepatic Macrophages, Facilitating Pathogen Clearance While Limiting Tissue Damage in Mice

Davis, R. P., Almishri, W., Jenne, C. N., & Swain, M. G. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.578654 · Cited by 13

Lymph Node but Not Intradermal Injection Site Macrophages Are Critical for Germinal Center Formation and Antibody Responses to Rabies Vaccination

Lytle, A. G., Shen, S., & McGettigan, J. P. (2014) · Journal of Virology · doi:10.1128/jvi.03409-14 · Cited by 13

Potential of mannan or dextrin nanogels as vaccine carrier/adjuvant systems

Gonçalves, C., Ferreira, S. A., Correia, A., Lopes, C. C. C., Fleming, C. E., Rocha, E., Vilanova, M., & Gama, M. (2016) · Journal of Bioactive and Compatible Polymers · doi:10.1177/0883911516631354 · Cited by 13

Extracellular matrix rigidity modulates physical properties of subcapsular sinus macrophage-B cell immune synapses

Iliopoulou, M., Bajur, A. T., McArthur, H. C. W., Gabai, M., Coyle, C., Ajao, F., Köchl, R., Cope, A. P., & Spillane, K. M. (2023) · Biophysical Journal · doi:10.1016/j.bpj.2023.10.010 · Cited by 12

Differential kinetics of splenic CD169+ macrophage death is one underlying cause of virus infection fate regulation

Casella, V., Domenjo‐Vila, E., Esteve‐Codina, A., Pedragosa, M., Rica, P. C., Vidal, E., de la Rubia, I., López‐Rodríguez, C., Bocharov, G. A., Argilaguet, J. M., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06374-y · Cited by 12

Chikungunya virus infection disrupts lymph node lymphatic endothelial cell composition and function via MARCO

Lucas, C. J., Sheridan, R. M., Reynoso, G. V., Davenport, B., McCarthy, M. K., Uecker-Martin, A., Hesselberth, J. R., Hickman, H. D., Tamburini, B. A. J., & Morrison, T. E. (2024) · JCI Insight · doi:10.1172/jci.insight.176537 · Cited by 12

Stepwise Ultra-pH-Sensitive Micelles Overcome a p K a Barrier for Systemic Lymph Node Delivery

Bennett, Z. T., Huang, G., Dellinger, M. T., Sumer, B. D., & Gao, J. (2024) · ACS Nano · doi:10.1021/acsnano.4c00876 · Cited by 12

Early Activation of MAP Kinases by Influenza A Virus X-31 in Murine Macrophage Cell Lines

Cannon, G., Callahan, M. A., Gronemus, J. Q., & Lowy, R. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105385 · Cited by 12

Mechanisms of lymphatic system-specific viral replication and its potential role in autoimmune disease

Friedrich, S.-K., Lang, P. A., Friebus‐Kardash, J., Duhan, V., Bezgovsek, J., & Lang, K. S. (2018) · Clinical & Experimental Immunology · doi:10.1111/cei.13241 · Cited by 12

Understanding the Initiation of B Cell Signaling Through Live Cell Imaging

Davey, A. M., Liu, W., Sohn, H. W., Brzostowski, J. A., & Pierce, S. K. (2012) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-391856-7.00038-x · Cited by 12

Multi-enveloping of particulated antigens with biopolymers and immunostimulant polynucleotides

Correia‐Pinto, J. F., Peleteiro, M., Csaba, N., González‐Fernández, Á., & Alonso, M. J. (2015) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2015.08.010 · Cited by 12

CD169+ macrophages take the bullet

Ludewig, B., & Cervantes‐Barragán, L. (2011) · Nature Immunology · doi:10.1038/ni.2189 · Cited by 12

Lymphotoxin-sensitive microenvironments in homeostasis and inflammation

Boulianne, B., Porfilio, E. A., Pikor, N. B., & Gommerman, J. L. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00243 · Cited by 12

An integrin/MFG-E8 shuttle loads HIV-1 viral-like particles onto follicular dendritic cells in mouse lymph node

Park, C., & Kehrl, J. H. (2019) · eLife · doi:10.7554/elife.47776 · Cited by 12

Breast cancer remodels lymphatics in sentinel lymph nodes

Eichin, D., Lehotina, D., Kauko, A., Uenaka, M., Leppänen, M., Elima, K., Piipponen, M., Lönnberg, T., Boström, P., Koskivuo, I., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-64981-z · Cited by 11

The Problem of Antigen Affinity Discrimination in B-Cell Immunology

Raychaudhuri, S. (2013) · ISRN Biomathematics · doi:10.1155/2013/845918 · Cited by 11

Monocyte-Plasmablast Crosstalk during Dengue

Green, A. M., & Harris, E. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.06.011 · Cited by 11

Rodent Plasmodium-infected red blood cells: Imaging their fates and interactions within their hosts

Claser, C., Malleret, B., Peng, K., Bakočević, N., Gun, S. Y., Russell, B., Ng, L. G., & Rénia, L. (2013) · Parasitology International · doi:10.1016/j.parint.2013.07.012 · Cited by 11

Corrected Super-Resolution Microscopy Enables Nanoscale Imaging of Autofluorescent Lung Macrophages

Ambrose, A. R., Dechantsreiter, S., Shah, R. D., Montero, Á., Quinn, A. M., Hessel, E. M., Beinke, S., Tannahill, G. M., & Davis, D. M. (2020) · Biophysical Journal · doi:10.1016/j.bpj.2020.10.041 · Cited by 11

In vivo imaging of the T cell response to infection

Mueller, S. N., & Hickman, H. D. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.12.009 · Cited by 11

Multiphoton imaging of host‐pathogen interactions

Melican, K., & Richter‐Dahlfors, A. (2009) · Biotechnology Journal · doi:10.1002/biot.200800347 · Cited by 11

Plasma Membrane Sheets for Studies of B Cell Antigen Internalization from Immune Synapses

Nowosad, C. R., & Tolar, P. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-6881-7_6 · Cited by 11

In vivo imaging of adaptive immune responses to viruses

Giovanni, M. D., & Iannacone, M. (2017) · Current Opinion in Virology · doi:10.1016/j.coviro.2017.12.002 · Cited by 11

Elastin Shapes Small Molecule Distribution in Lymph Node Conduits

Lin, Y., Louie, D., Ganguly, A., Wu, D., Huang, P., & Liao, S. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800074 · Cited by 12

A Single Amino Acid Substitution in the Matrix Protein (M51R) of Vesicular Stomatitis New Jersey Virus Impairs Replication in Cultured Porcine Macrophages and Results in Significant Attenuation in Pigs

Velázquez-Salinas, L., Pauszek, S. J., Holinka, L. G., Gladue, D. P., Rekant, S. I., Bishop, E. A., Stenfeldt, C., Verdugo-Rodríguez, A., Borca, M. V., Arzt, J., et al. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01123 · Cited by 11

Studying MHC class II Presentation of Immobilized Antigen by B Lymphocytes

Yuseff, M.-I., & Lennon‐Duménil, A. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-218-6_39 · Cited by 11

Lymph-derived chemokines direct early neutrophil infiltration in the lymph nodes upon Staphylococcus aureus skin infection

Xue, J., Lin, Y., Oo, D., Zhang, J., Zardynezhad, A., de Jesus, F. N., Stephens, M., de Almeida, L. G. N., Young, D. W., Dufour, A., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2111726119 · Cited by 10

Repeated dosing improves oncolytic rhabdovirus therapy in mice via interactions with intravascular monocytes

Naumenko, V., Rajwani, J., Turk, M., Zhang, C., Tse, M., Davis, R. P., Kim, D., Rakic, A., Dastidar, H., Van, S., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-04254-3 · Cited by 10

Subcapsular sinus macrophages maximize germinal center development in non-draining lymph nodes during blood-borne viral infection

Aguilar, C. C., Kalia, A., Brisse, M. E., Dowd, K. A., Wise-Dent, O., Burgomaster, K. E., Droppo, J. M., Pierson, T. C., & Hickman, H. D. (2024) · Science Immunology · doi:10.1126/sciimmunol.adi4926 · Cited by 10

Microenvironment Matters

Pásztói, M., Pezoldt, J., & Huehn, J. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.07.012 · Cited by 10

The synaptic recruitment of lipid rafts is dependent on CD19-PI3K module and cytoskeleton remodeling molecules

Xu, L., Auzins, A., Sun, X., Xu, Y., Harnischfeger, F., Lu, Y., Li, Z., Chen, Y., Zheng, W., & Liu, W. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.2a0614-287rr · Cited by 10

Application of Modeling Approaches to Explore Vaccine Adjuvant Mode-of-Action

Buckley, P. R., Alden, K., Coccia, M., Chalon, A., Collignon, C., Temmerman, S. T., Didierlaurent, A. M., der Most, R. G. V., Timmis, J., Andersen, C. A. F., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02150 · Cited by 11

Map3k14 as a Regulator of Innate and Adaptive Immune Response during Acute Viral Infection

Hamdan, T. A., Bhat, H., Cham, L. B., Adomati, T., Lang, J., Li, F., Ali, M., Hardt, C., Lang, P. A., Duhan, V., et al. (2020) · Pathogens · doi:10.3390/pathogens9020096 · Cited by 10

Usp18 Expression in CD169+ Macrophages is Important for Strong Immune Response after Vaccination with VSV-EBOV

Friedrich, S.-K., Schmitz, R., Bergerhausen, M., Lang, J., Cham, L. B., Duhan, V., Häussinger, D., Hardt, C., Addo, M. M., Prinz, M., et al. (2020) · Vaccines · doi:10.3390/vaccines8010142 · Cited by 10

Gene Expression Profiling of Lymph Node Sub-Capsular Sinus Macrophages in Cancer

Pellin, D., Claudio, N., Guo, Z., Ziglari, T., & Pucci, F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.672123 · Cited by 10

The diverse roles of mononuclear phagocytes in prion disease pathogenesis

Wathne, G. J., & Mabbott, N. A. (2012) · Prion · doi:10.4161/pri.18853 · Cited by 10

Illuminating the covert mission of mononuclear phagocytes in their regional niches

Chong, S. Z., Evrard, M., Goh, C. C., & Ng, L. G. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.12.004 · Cited by 10

Viral Infection and Dissemination Through the Lymphatic System

Brisse, M. E., & Hickman, H. D. (2025) · Microorganisms · doi:10.3390/microorganisms13020443 · Cited by 11

Subcapsular sinus macrophages prevent lethal vesicular stomatitis virus (VSV) infection (43.11)

Iannacone, M., Moseman, E. A., Tonti, E., van Rooijen, N., & von Andrian, U. H. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.supp.43.11

Lymph Node Subcapsular Sinus Macrophages Confer Resistance to CNS Invasion upon Peripheral Infection with a Neurotropic Virus

Iannacone, M., Moseman, E. A., Tonti, E., Bosurgi, L., & von Andrian, U. H. (2010) · Clinical Immunology · doi:10.1016/j.clim.2010.03.101 · Cited by 1

Subcapsular Sinus Macrophages: The Seat of Innate and Adaptive Memory in Murine Lymph Nodes

Moran, I., Grootveld, A. K., Nguyen, A., & Phan, T. G. (2018) · Trends in Immunology · doi:10.1016/j.it.2018.11.004 · Cited by 92

The role of lymph node sinus macrophages in host defense

Kuka, M., & Iannacone, M. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12387 · Cited by 80

Subcapsular sinus macrophages maximize germinal center development in non-draining lymph nodes during blood-borne viral infection

Aguilar, C. C., Kalia, A., Brisse, M. E., Dowd, K. A., Wise-Dent, O., Burgomaster, K. E., Droppo, J. M., Pierson, T. C., & Hickman, H. D. (2024) · Science Immunology · doi:10.1126/sciimmunol.adi4926 · Cited by 10