Cited by 1,876Neuroscience and Neuropharmacology ResearchAdvanced Fluorescence Microscopy TechniquesNeurogenesis and neuroplasticity mechanisms

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system

Livet, Jean, Weissman, Tamily A., Kang, Hyuno, Draft, Ryan W., Lu, Ju, Bennis, Robyn A., Sanes, Joshua R., Lichtman, Jeff W.·2007·Nature

DOI 10.1038/nature06293

Open this paper in CoChat — free account

Abstract

Detailed analysis of neuronal network architecture requires the development of new methods. Here we present strategies to visualize synaptic circuits by genetically labelling neurons with multiple, distinct colours. In Brainbow transgenes, Cre/lox recombination is used to create a stochastic choice of expression between three or more fluorescent proteins (XFPs). Integration of tandem Brainbow copies in transgenic mice yielded combinatorial XFP expression, and thus many colours, thereby providing a way to distinguish adjacent neurons and visualize other cellular interactions. As a demonstration, we reconstructed hundreds of neighbouring axons and multiple synaptic contacts in one small volume of a cerebellar lobe exhibiting approximately 90 colours. The expression in some lines also allowed us to map glial territories and follow glial cells and neurons over time in vivo. The ability of the Brainbow system to label uniquely many individual cells within a population may facilitate the analysis of neuronal circuitry on a large scale.

Integrity signals

Registry

Crossref · 10.1038/nature06293

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Genome-wide atlas of gene expression in the adult mouse brain
Lein, E. S., Hawrylycz, M. J., Ao, N., Ayres, M., Bensinger, A., Bernard, A., Boe, A. F., Boguski, M. S., Brockway, K. S., Byrnes, E. J., et al. (2007) · Nature · doi:10.1038/nature05453 · Cited by 5,572
Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein
Shaner, N. C., Campbell, R. E., Steinbach, P. A., Giepmans, B. N. G., Palmer, A. E., & Tsien, R. Y. (2004) · Nature Biotechnology · doi:10.1038/nbt1037 · Cited by 4,619
The Cerebellum as a Neuronal Machine
Eccles, J. C., Ito, M., & Szentágothai, J. (1967) · Springer eBooks · doi:10.1007/978-3-662-13147-3 · Cited by 3,229
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121
Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP
Feng, G., Mellor, R. H., Bernstein, M., Keller-Peck, C., Nguyen, Q. T., Wallace, M., Nerbonne, J. M., Lichtman, J. W., & Sanes, J. R. (2000) · Neuron · doi:10.1016/s0896-6273(00)00084-2 · Cited by 3,042
A guide to choosing fluorescent proteins
Shaner, N. C., Steinbach, P. A., & Tsien, R. Y. (2005) · Nature Methods · doi:10.1038/nmeth819 · Cited by 2,823
Cerebellar Cortex
Palay, S. L., & Chan‐Palay, V. (1974) · Springer eBooks · doi:10.1007/978-3-642-65581-4 · Cited by 2,468
A monomeric red fluorescent protein
Campbell, R. E., Tour, O., Palmer, A. E., Steinbach, P. A., Baird, G. S., Zacharias, D. A., & Tsien, R. Y. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.082243699 · Cited by 2,346
Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells
Zacharias, D. A., Violin, J. D., Newton, A. C., & Tsien, R. Y. (2002) · Science · doi:10.1126/science.1068539 · Cited by 2,270
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108

Flagged first, then by citations

Show all 42 references

Sorted by citations

Items 501–600 of 1,000

Algorithms for automated DNA assembly
Densmore, D. M., Hsiau, T. H.-C., Kittleson, J. T., DeLoache, W., Batten, C., & Anderson, J. C. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq165 · Cited by 53
Raeppli: a whole-tissue labeling tool for live imaging of Drosophila development
Kanca, O., Caussinus, E., Denes, A. S., Percival‐Smith, A., & Affolter, M. (2013) · Development · doi:10.1242/dev.102913 · Cited by 53
Astrocyte structural reactivity and plasticity in models of retinal detachment
Luna, G., Keeley, P. W., Reese, B. E., Linberg, K. A., Lewis, G. P., & Fisher, S. K. (2016) · Experimental Eye Research · doi:10.1016/j.exer.2016.03.027 · Cited by 53
Xenopus Resources: Transgenic, Inbred and Mutant Animals, Training Opportunities, and Web-Based Support
Horb, M. E., Wlizla, M., Abu‐Daya, A., McNamara, S., Gajdasik, D., Igawa, T., Suzuki, A., Ogino, H., & Noble, A. M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00387 · Cited by 52
Mapping Transgene Insertion Sites Reveals Complex Interactions Between Mouse Transgenes and Neighboring Endogenous Genes
Laboulaye, M. A., Duan, X., Qiao, M., Whitney, I. E., & Sanes, J. R. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00385 · Cited by 48
Activity Correlation Imaging: Visualizing Function and Structure of Neuronal Populations
Junek, S., Chen, T., Alevra, M., & Schild, D. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2008.12.3962 · Cited by 52
Quantitative Analysis of Embryogenesis: A Perspective for Light Sheet Microscopy
Höckendorf, B., Thumberger, T., & Wittbrodt, J. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.10.008 · Cited by 52
Viral strategies for studying the brain, including a replication‐restricted self‐amplifying delta‐G vesicular stomatis virus that rapidly expresses transgenes in brain and can generate a multicolor golgi‐like expression
van den Pol, A. N., Özduman, K., Wollmann, G., Ho, W. S., Simon, I. D., Yao, Y., Rose, J. K., & Ghosh, P. K. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22131 · Cited by 54
Whole-body gene expression pattern registration in Platynereis larvae
Asadulina, A., Panzera, A., Verasztó, C., Liebig, C., & Jékely, G. (2012) · EvoDevo · doi:10.1186/2041-9139-3-27 · Cited by 52
Multicolor lineage tracing reveals clonal architecture and dynamics in colon cancer
Lamprecht, S., Schmidt, E. M., Blaj, C., Hermeking, H., Jung, A., Kirchner, T., & Horst, D. A. (2017) · Nature Communications · doi:10.1038/s41467-017-00976-9 · Cited by 52
Stem cell safe harbor: the hematopoietic stem cell niche in zebrafish
Wattrus, S. J., & Zon, L. I. (2018) · Blood Advances · doi:10.1182/bloodadvances.2018021725 · Cited by 55
Fluorescent Protein Tracking and Detection: Applications Using Fluorescent Proteins in Living CellsPreprint
Rizzo, M. A., Davidson, M. W., & Piston, D. W. (2009) · Cold Spring Harbor Protocols · doi:10.1101/pdb.top64 · Cited by 52
The Development of Fluorescence Microscopy
Masters, B. R. (2010) · Wiley eBooks · doi:10.1002/9780470015902.a0022093 · Cited by 61
Human connectomics — What will the future demand?
Johansen‐Berg, H. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.05.082 · Cited by 53
Second Near‐Infrared (NIR‐II) Window for Imaging‐Navigated Modulation of Brain Structure and Function
Zhang, K., Chen, F., Wang, L., & Hu, J. (2023) · Small · doi:10.1002/smll.202206044 · Cited by 52
Microcavity- and Microlaser-Based Optical Barcoding: A Review of Encoding Techniques and Applications
Anwar, A., Mur, M., & Humar, M. (2023) · ACS Photonics · doi:10.1021/acsphotonics.2c01611 · Cited by 50
In Vivo Development of Outer Retinal Synapses in the Absence of Glial Contact
Williams, P. R., Suzuki, S. C., Yoshimatsu, T., Lawrence, O. T., Waldron, S., Parsons, M. J., Nonet, M. L., & Wong, R. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3391-10.2010 · Cited by 50
Dendritic Translocation Establishes the Winner in Cerebellar Climbing Fiber Synapse Elimination
Carrillo, J., Nishiyama, N., & Nishiyama, H. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4561-12.2013 · Cited by 50
Subset of early radial glial progenitors that contribute to the development of callosal neurons is absent from avian brain
García‐Moreno, F., & Molnár, Z. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1506377112 · Cited by 48
Barcoding cells using cell-surface programmable DNA-binding domains
Mali, P., Aach, J., Lee, J., Levner, D., Nip, L., & Church, G. M. (2013) · Nature Methods · doi:10.1038/nmeth.2407 · Cited by 50
Bimodal behaviour of interfollicular epidermal progenitors regulated by hair follicle position and cycling
Roy, E., Neufeld, Z., Cerone, L., Wong, H. Y., Hodgson, S., Livet, J., & Khosrotehrani, K. (2016) · The EMBO Journal · doi:10.15252/embj.201693806 · Cited by 50
An ancestral apical brain region contributes to the central complex under the control of foxQ2 in the beetle Tribolium
He, B., Buescher, M., Farnworth, M. S., Strobl, F., Stelzer, E. H. K., Koniszewski, N. D. B., Mühlen, D., & Bucher, G. (2019) · eLife · doi:10.7554/elife.49065 · Cited by 52
Activation of Meiotic Genes Mediates Ploidy Reduction during Cryptococcal Infection
Zhao, Y., Wang, Y., Upadhyay, S., Xue, C., & Lin, X. (2020) · Current Biology · doi:10.1016/j.cub.2020.01.081 · Cited by 52
Detection of the optimal neuron traces in confocal microscopy images
Vasilkoski, Z., & Stepanyants, A. (2008) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2008.11.008 · Cited by 53
A dual genetic tracing system identifies diverse and dynamic origins of cardiac valve mesenchyme
Liu, K., Yu, W., Tang, M., Tang, J., Liu, X., Liu, Q., Li, Y., He, L., Zhang, L., Evans, S. M., et al. (2018) · Development · doi:10.1242/dev.167775 · Cited by 51
Mesenchymal stem cells lineage and their role in disease development
Xu, Q., Hou, W., Zhao, B., Fan, P., Sheng, W., Wang, L., & Gao, J. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00967-9 · Cited by 49
Advanced Zebrafish Transgenesis with Tol2 and Application for Cre/lox Recombination Experiments
Mosimann, C., & Zon, L. I. (2011) · Methods in cell biology · doi:10.1016/b978-0-12-374814-0.00010-0 · Cited by 49
Modelling melanoma in mice
Walker, G. J., Soyer, H. P., Terzian, T., & Box, N. F. (2011) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2011.00923.x · Cited by 49
Zebrafish approaches enhance the translational research tackle box
Pickart, M. A., & Klee, E. W. (2013) · Translational research · doi:10.1016/j.trsl.2013.10.007 · Cited by 52
3D resolved mapping of optical aberrations in thick tissues
Zeng, J., Mahou, P., Schanne‐Klein, M., Beaurepaire, E., & Débarre, D. (2012) · Biomedical Optics Express · doi:10.1364/boe.3.001898 · Cited by 49
Developmental origins and lineage descendants of endogenous adult cardiac progenitor cells
Chong, J. J. H., Forte, E., & Harvey, R. P. (2014) · Stem Cell Research · doi:10.1016/j.scr.2014.09.008 · Cited by 52
Photodetachment Spectra of Deprotonated Fluorescent Protein Chromophore Anions
Mooney, C. R. S., Sanz, M. E., McKay, A. R., Fitzmaurice, R. J., Aliev, A. E., Caddick, S., & Fielding, H. H. (2012) · The Journal of Physical Chemistry A · doi:10.1021/jp3058349 · Cited by 49
UbC-StarTrack, a clonal method to target the entire progeny of individual progenitors
Figueres‐Oñate, M., García‐Marqués, J., & López‐Mascaraque, L. (2016) · Scientific Reports · doi:10.1038/srep33896 · Cited by 48
Optical Barcoding for Single-Clone Tracking to Study Tumor Heterogeneity
Mohme, M., Maire, C. L., Riecken, K., Zapf, S., Aranyossy, T., Westphal, M., Lamszus, K., & Fehse, B. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2016.12.014 · Cited by 49
Morphologic evidence for spatially clustered spines in apical dendrites of monkey neocortical pyramidal cells
Yadav, A., Gao, Y. Z., Rodriguez, A., Dickstein, D. L., Wearne, S. L., Luebke, J. I., Hof, P. R., & Weaver, C. M. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23070 · Cited by 49
Molecular anatomy of the gut-brain axis revealed with transgenic technologies: implications in metabolic research
Udit, S., & Gautron, L. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00134 · Cited by 53
Defining Lineage Potential and Fate Behavior of Precursors during Pancreas Development
Sznurkowska, M. K., Hannezo, É., Azzarelli, R., Rulands, S., Nestorowa, S., Hindley, C. J., Nichols, J., Göttgens, B., Huch, M., Philpott, A., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.06.028 · Cited by 46
Orderly compartmental mapping of premotor inhibition in the developing zebrafish spinal cord
Kishore, S., Cadoff, E. B., Agha, M. A., & McLean, D. L. (2020) · Science · doi:10.1126/science.abb4608 · Cited by 48
Spatial constraints dictate glial territories at murine neuromuscular junctions
Brill, M. S., Lichtman, J. W., Thompson, W. J., Zuo, Y., & Misgeld, T. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201108005 · Cited by 47
Ascidians as excellent chordate models for studying the development of the nervous system during embryogenesis and metamorphosis
Sasakura, Y., Mita, K., Ogura, Y., & Horie, T. (2012) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2012.01343.x · Cited by 46
In-vivo RGB marking and multicolour single-cell tracking in the adult brain
Gómez‐Nicola, D., Riecken, K., Fehse, B., & Perry, V. H. (2014) · Scientific Reports · doi:10.1038/srep07520 · Cited by 47
A Cleared View on Retinal Organoids
Cora, V., Haderspeck, J., Antkowiak, L., Mattheus, U., Neckel, P. H., Mack, A. F., Bolz, S., Ueffing, M., Pashkovskaia, N., Achberger, K., et al. (2019) · Cells · doi:10.3390/cells8050391 · Cited by 48
Principles for the design of multicellular engineered living systems
Aydin, O., Passaro, A. P., Raman, R., Spellicy, S. E., Weinberg, R. P., Kamm, R. D., Sample, M., Truskey, G. A., Zartman, J. J., Dar, R. D., et al. (2022) · APL Bioengineering · doi:10.1063/5.0076635 · Cited by 46
Slide preparation for single-cell–resolution imaging of fluorescent proteins in their three-dimensional near-native environment
Snippert, H. J. G., Schepers, A. G., Delconte, G., Siersema, P. D., & Clevers, H. C. (2011) · Nature Protocols · doi:10.1038/nprot.2011.365 · Cited by 47
Cell autonomy of DSCAM function in retinal development
Fuerst, P. G., Bruce, F., Rounds, R. P., Erskine, L., & Burgess, R. W. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.10.028 · Cited by 46
The epilepsies: Complex challenges needing complex solutions
Tejada, J., Costa, K. M., Bertti, P., & Garcia‐Cairasco, N. (2012) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2012.09.029 · Cited by 47
Projection Neuron Circuits Resolved Using Correlative Array Tomography
Oberti, D., Kirschmann, M., & Hahnloser, R. H. R. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00050 · Cited by 48
Defining hierarchies of stemness in the intestine: evidence from biomarkers and regulatory pathways
Gracz, A. D., & Magness, S. T. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00066.2014 · Cited by 48
Zebrafish as a model to assess cancer heterogeneity, progression and relapse
Blackburn, J. S., & Langenau, D. M. (2014) · Disease Models & Mechanisms · doi:10.1242/dmm.015842 · Cited by 52
Neuronal Tracing for Connectomic Studies
Lu, J. (2011) · Neuroinformatics · doi:10.1007/s12021-011-9101-6 · Cited by 48
Roles of Wnt pathway genes wls, wnt9a, wnt5b, frzb and gpc4 in regulating convergent-extension during palate morphogenesis
Rochard, L. J., Monica, S. D., Ling, I. T. C., Kong, Y., Roberson, S., Harland, R. M., Halpern, M. E., & Liao, E. C.-W. (2016) · Development · doi:10.1242/dev.137000 · Cited by 46
Extracting structural and functional features of widely distributed biological circuits with single cell resolution via tissue clearing and delivery vectors
Treweek, J. B., & Gradinaru, V. (2016) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2016.03.012 · Cited by 46
The Ratio of 2-AG to Its Isomer 1-AG as an Intrinsic Fine Tuning Mechanism of CB1 Receptor Activation
Dócs, K., Mészár, Z., Gonda, S., Kiss‐Szikszai, A., Holló, K., Antal, M., & Hegyi, Z. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00039 · Cited by 49
Postnatal Migration of Cerebellar Interneurons
Galas, L., Bénard, M., Lebon, A., Komuro, Y., Schapman, D., Vaudry, H., Vaudry, D., & Komuro, H. (2017) · Brain Sciences · doi:10.3390/brainsci7060062 · Cited by 48
Neural lineage tracing in the mammalian brain
Ma, J., Shen, Z., Yu, Y., & Shi, S. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.10.013 · Cited by 46
Neuronal hypothalamic regulation of body metabolism and bone density is galanin dependent
Idelevich, A., Sato, K., Nagano, K., Rowe, G. C., Gori, F., & Baron, R. (2018) · Journal of Clinical Investigation · doi:10.1172/jci99350 · Cited by 45
A method using electroporation for the protein delivery of Cre recombinase into cultured Arabidopsis cells with an intact cell wall
Furuhata, Y., Sakai, A., Murakami, T., Morikawa, M., Nakamura, C., Yoshizumi, T., Fujikura, U., Nishida, K., & Kato, Y. (2019) · Scientific Reports · doi:10.1038/s41598-018-38119-9 · Cited by 47
Lineage Tracing: Computational Reconstruction Goes Beyond the Limit of Imaging.
Wu, S.-H. S., Lee, J., & Koo, B. (2019) · Europe PMC (PubMed Central) · doi:10.14348/molcells.2019.0006 · Cited by 46
Skin cells undergo asynthetic fission to expand body surfaces in zebrafish
Chan, K. Y., Yan, C. S., Roan, H.-Y., Hsu, S., Tseng, T.-L., Hsiao, C., Hsu, C., & Chen, C. (2022) · Nature · doi:10.1038/s41586-022-04641-0 · Cited by 46
An integrated pipeline for the multidimensional analysis of branching morphogenesis
Combes, A. N., Short, K. M., Lefevre, J., Hamilton, N., Little, M. H., & Smyth, I. (2014) · Nature Protocols · doi:10.1038/nprot.2014.193 · Cited by 45
Neutral lineage tracing of proliferative embryonic and adult mammary stem/progenitor cells
Lloyd‐Lewis, B., Davis, F. M., Harris, O. B., Hitchcock, J. R., & Watson, C. J. (2018) · Development · doi:10.1242/dev.164079 · Cited by 45
Photoacoustic Neuroimaging - Perspectives on a Maturing Imaging Technique and its Applications in Neuroscience
Bodea, S., & Westmeyer, G. G. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.655247 · Cited by 45
Reversible Inhibition of Murine Cytomegalovirus Replication by Gamma Interferon (IFN-γ) in Primary Macrophages Involves a Primed Type I IFN-Signaling Subnetwork for Full Establishment of an Immediate-Early Antiviral State
Kropp, K. A., Robertson, K. A., Sing, G. K., Rodriguez-Martin, S., Blanc, M., Lacaze, P. A., Hassim, M. F. N., Khondoker, M. R., Busche, A., Dickinson, P., et al. (2011) · Journal of Virology · doi:10.1128/jvi.00373-11 · Cited by 44
Generating and Imaging Multicolor Brainbow MicePreprint
Weissman, T. A., Sanes, J. R., Lichtman, J. W., & Livet, J. (2011) · Cold Spring Harbor Protocols · doi:10.1101/pdb.top114 · Cited by 50
The Human Connectome
Sporns, O. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374709-9.00014-6 · Cited by 46
Endothelial Heterogeneity in the Response to Autophagy Drives Small Vessel Muscularization in Pulmonary Hypertension
Zhang, Q., Yaoita, N., Tabuchi, A., Liu, S., Chen, S.-H., Li, Q., Hegemann, N., Li, C., Rodor, J., Timm, S., et al. (2024) · Circulation · doi:10.1161/circulationaha.124.068726 · Cited by 47
Spatial multiplexing and omics
Carstens, J. L., Krishnan, S., Rao, A. U. K., Sorace, A. G., Seeley, E. H., Borgogno, S. F., & Burks, J. K. (2024) · Nature Reviews Methods Primers · doi:10.1038/s43586-024-00330-6 · Cited by 50
Gut stem cells in tissue renewal and disease: methods, markers, and myths
Rizk, P., & Barker, N. (2012) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1176 · Cited by 44
Mutants of Cre recombinase with improved accuracy
Eroshenko, N., & Church, G. (2013) · Nature Communications · doi:10.1038/ncomms3509 · Cited by 41
Mutationally Activated PIK3CAH1047R Cooperates with BRAFV600E to Promote Lung Cancer Progression
Trejo, C. L., Green, S., Marsh, V. L., Collisson, E. A., Iezza, G., Phillips, W. A., & McMahon, M. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0681 · Cited by 42
Getting the whole picture: combining throughput with content in microscopy
Rimon, N., & Schuldiner, M. (2011) · Journal of Cell Science · doi:10.1242/jcs.087486 · Cited by 40
Clonal Analysis of Cells with Cellular Barcoding: When Numbers and Sizes Matter
Bystrykh, L. V., & Belderbos, M. E. (2016) · Methods in molecular biology · doi:10.1007/7651_2016_343 · Cited by 43
Context-dependent intravital imaging of therapeutic response using intramolecular FRET biosensors
Conway, J. R. W., Warren, S. C., & Timpson, P. (2017) · Methods · doi:10.1016/j.ymeth.2017.04.014 · Cited by 41
SynCAM1, a Synaptic Adhesion Molecule, Is Expressed in Astrocytes and Contributes to erbB4 Receptor-Mediated Control of Female Sexual Development
Sandau, U. S., Mungenast, A. E., Alderman, Z., Sardi, S. P., Fogel, A. I., Taylor, B., Parent, A., Biederer, T., Corfas, G., & Ojeda, S. R. (2011) · Endocrinology · doi:10.1210/en.2010-1435 · Cited by 44
Survival and Immunogenicity of Mesenchymal Stem Cells From the Green Fluorescent Protein Transgenic Rat in the Adult Rat Brain
Moloney, T. C., Dockery, P., Windebank, A. J., Barry, F., Howard, L., & Dowd, E. (2010) · Neurorehabilitation and neural repair · doi:10.1177/1545968309357745 · Cited by 43
Rodent Facial Nerve Recovery after Selected Lesions and Repair Techniques
Hadlock, T. A., Kowaleski, J. M., Lo, D., Mackinnon, S. E., & Heaton, J. T. (2009) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0b013e3181c2a5ea · Cited by 43
Functional Assessments of the Rodent Facial Nerve: A Synkinesis Model
Hadlock, T. A., Kowaleski, J. M., Lo, D., Bermejo, R., Zeigler, H. P., Mackinnon, S. E., & Heaton, J. T. (2008) · The Laryngoscope · doi:10.1097/mlg.0b013e31817f5255 · Cited by 43
Massively parallel clonal analysis using CRISPR/Cas9 induced genetic scarsPreprint
Junker, J. P., Spanjaard, B., Peterson-Maduro, J., Alemany, A., Hu, B., Florescu, M., & van Oudenaarden, A. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/056499 · Cited by 45
Imaging and optogenetic modulation of vascular mural cells in the live brain
Тонг, Л., Hill, R., Damisah, E. C., Murray, K. N., Yuan, P., Bordey, A., & Grutzendler, J. (2020) · Nature Protocols · doi:10.1038/s41596-020-00425-w · Cited by 45
The lives of cells, recorded
Askary, A., Chen, W., Choi, J., Du, L. Y., Elowitz, M. B., Gagnon, J. A., Schier, A. F., Seidel, S., Shendure, J., Stadler, T., et al. (2024) · Nature Reviews Genetics · doi:10.1038/s41576-024-00788-w · Cited by 40
MorphoNeuroNet: An automated method for dense neurite network analysis
Pani, G., Vos, W. H. D., Samari, N., de Saint‐Georges, L., Baatout, S., Oostveldt, P. V., & Benotmane, M. A. (2013) · Cytometry Part A · doi:10.1002/cyto.a.22408 · Cited by 43
Fate specification in the adult brain – lessons for eliciting neurogenesis from glial cells
Ninkovic, J., & Götz, M. (2013) · BioEssays · doi:10.1002/bies.201200108 · Cited by 44
Mechanisms driving neural crest induction and migration in the zebrafish and Xenopus laevis
Klymkowsky, M. W., Rossi, C. C., & Artinger, K. (2010) · Cell Adhesion & Migration · doi:10.4161/cam.4.4.12962 · Cited by 41
Single Collateral Reconstructions Reveal Distinct Phases of Corticospinal Remodeling after Spinal Cord Injury
Lang, C. C. V., Guo, X., Kerschensteiner, M., & Bareyre, F. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030461 · Cited by 42
A decade of chemical biology
Bucci, M., Goodman, C. M., & Sheppard, T. L. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.489 · Cited by 44
Microtomographic Analysis of Neuronal Circuits of Human Brain
Mizutani, R., Takeuchi, A., Uesugi, K., Takekoshi, S., OSAMURA, R. Y., & Suzuki, Y. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp237 · Cited by 43
Untwisting the Caenorhabditis elegans embryo
Christensen, R. P., Bokinsky, A., Santella, A., Wu, Y., Marquina-Solis, J., Guo, M. Y., Kovacevic, I., Kumar, A., Winter, P. W., Tashakkori, N., et al. (2015) · eLife · doi:10.7554/elife.10070 · Cited by 42
Contemporary zebrafish transgenesis with Tol2 and application for Cre/lox recombination experiments
Felker, A., & Mosimann, C. (2016) · Methods in cell biology · doi:10.1016/bs.mcb.2016.01.009 · Cited by 37
Intravital Insights into Heterogeneity, Metastasis, and Therapy Responses
Scheele, C. L. G. J., Maynard, C., & van Rheenen, J. (2016) · Trends in cancer · doi:10.1016/j.trecan.2016.03.001 · Cited by 40
A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion
Boone, P. G., Rochelle, L. K., Ginzel, J. D., Lubkov, V., Roberts, W. L., NICHOLLS, P. J., Bock, C. B., Flowers, M. L., von Furstenberg, R. J., Stripp, B. R., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13330-y · Cited by 42
Endocytosis and Signaling during DevelopmentPreprint
Bökel, C., & Brand, M. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a017020 · Cited by 42
High-resolution spatial mapping of cell state and lineage dynamics in vivo with PEtracer
Koblan, L. W., Yost, K. E., Zheng, P., Colgan, W. N., Jones, M. G., Yang, D., Kumar, A., Sandhu, J., Schnell, A., Sun, D., et al. (2025) · Science · doi:10.1126/science.adx3800 · Cited by 53
Simultaneous visualization of multiple neuronal properties with single-cell resolution in the living rodent brain
Ako, R., Wakimoto, M., Ebisu, H., Tanno, K., Hira, R., Kasai, H., Matsuzaki, M., & Kawasaki, H. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.08.005 · Cited by 41
Microbial rhodopsins in the spotlight
Bamann, C., Nagel, G., & Bamberg, E. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.07.003 · Cited by 42
A Population Dynamics Model for Clonal Diversity in a Germinal Center
Amitai, A., Mesin, L., Victora, G. D., Mehran Kardar, A., & Chakraborty, A. K. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01693 · Cited by 39
Methods for lineage tracing on the organism-wide level
Spanjaard, B., & Junker, J. P. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.11.004 · Cited by 41
Features of hippocampal astrocytic domains and their spatial relation to excitatory and inhibitory neurons
Refaeli, R., Doron, A., Benmelech-Chovav, A., Groysman, M., Kreisel, T., Loewenstein, Y., & Goshen, I. (2021) · Glia · doi:10.1002/glia.24044 · Cited by 41
Chapter 10 In Vivo Measurements of Blood Flow and Glial Cell Function with Two‐Photon Laser‐Scanning Microscopy
Helmchen, F., & Kleinfeld, D. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)02810-3 · Cited by 40
GAP43 phosphorylation is critical for growth and branching of retinotectal arbors in zebrafish
Leu, B., Koch, E., & Schmidt, J. T. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20829 · Cited by 41
Mouse liver assembloids model periportal architecture and biliary fibrosis
Dowbaj, A. M., Sljukic, A., Niksic, A., Landerer, C., Delpierre, J., Yang, H., Lahree, A., Kühn, A. C., Beers, D., Byrne, H. M., et al. (2025) · Nature · doi:10.1038/s41586-025-09183-9 · Cited by 40

Authors: Livet, J., Weissman, T. A., Kang, H., Draft, R. W., Lu, J., Bennis, R. A., Sanes, J. R., & Lichtman, J. W.
Affiliations: Harvard University (US)
Corresponding author: Lichtman, Jeff W.
ORCID: Livet, Jean
Weissman, Tamily A.
Kang, Hyuno
Draft, Ryan W.
Lu, Ju
Sanes, Joshua R.
Lichtman, Jeff W.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2007-11
Volume: 450
Issue: 7166
Pages: 56-62
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature06293
OpenAlex: W2110232607
Cited by: 1,876
References: 42
Citations by year: 2026: 52 · 2025: 76 · 2024: 68 · 2023: 90 · 2022: 88 · 2021: 88 · 2020: 115 · 2019: 104 · 2018: 124 · 2017: 101 · 2016: 117 · 2015: 101 · 2014: 124 · 2013: 161 · 2012: 110
FWCI: 30.01
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Advanced Fluorescence Microscopy Techniques
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: Brainbow, transgenic mice, fluorescent proteins, Cre-loxP recombination, stochastic gene expression, neuronal circuit mapping, axon reconstruction, synaptic circuits, cerebellum, hippocampus
MeSH terms: Animals, Attachment Sites, Microbiological, Axons, Cell Communication, Cell Line, Cerebellum, Color, Genetic Engineering, Humans, Luminescent Proteins, Mice, Transgenic, Nervous System, Neural Pathways, Neuroglia, Recombination, Genetic, Stochastic Processes, Synapses, Time Factors, Gene Expression, Transgenes, Integrases, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks