The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system
Abstract
Detailed analysis of neuronal network architecture requires the development of new methods. Here we present strategies to visualize synaptic circuits by genetically labelling neurons with multiple, distinct colours. In Brainbow transgenes, Cre/lox recombination is used to create a stochastic choice of expression between three or more fluorescent proteins (XFPs). Integration of tandem Brainbow copies in transgenic mice yielded combinatorial XFP expression, and thus many colours, thereby providing a way to distinguish adjacent neurons and visualize other cellular interactions. As a demonstration, we reconstructed hundreds of neighbouring axons and multiple synaptic contacts in one small volume of a cerebellar lobe exhibiting approximately 90 colours. The expression in some lines also allowed us to map glial territories and follow glial cells and neurons over time in vivo. The ability of the Brainbow system to label uniquely many individual cells within a population may facilitate the analysis of neuronal circuitry on a large scale.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“We confirmed our hypothesis of a common progenitor pool by lineage tracing the progeny of Wnt1+ progenitors (by crossing Wnt1-CRE2 (Lewis et al., 2013) with R26R-Confetti mice (Livet et al., 2007; Snippert et al., 2010), Figure 2H,I.”
From A cellular and spatial map of the choroid plexus across brain ventricles and ages (2021) · cites this paper as Livet et al., 2007
Citations
Cites
Genome-wide atlas of gene expression in the adult mouse brain
Lein, E. S., Hawrylycz, M. J., Ao, N., Ayres, M., Bensinger, A., Bernard, A., Boe, A. F., Boguski, M. S., Brockway, K. S., Byrnes, E. J., et al. (2007) · Nature · doi:10.1038/nature05453 · Cited by 5,572
Shaner, N. C., Campbell, R. E., Steinbach, P. A., Giepmans, B. N. G., Palmer, A. E., & Tsien, R. Y. (2004) · Nature Biotechnology · doi:10.1038/nbt1037 · Cited by 4,619
The Cerebellum as a Neuronal Machine
Eccles, J. C., Ito, M., & Szentágothai, J. (1967) · Springer eBooks · doi:10.1007/978-3-662-13147-3 · Cited by 3,229
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121
Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP
Feng, G., Mellor, R. H., Bernstein, M., Keller-Peck, C., Nguyen, Q. T., Wallace, M., Nerbonne, J. M., Lichtman, J. W., & Sanes, J. R. (2000) · Neuron · doi:10.1016/s0896-6273(00)00084-2 · Cited by 3,042
A guide to choosing fluorescent proteins
Shaner, N. C., Steinbach, P. A., & Tsien, R. Y. (2005) · Nature Methods · doi:10.1038/nmeth819 · Cited by 2,823
Palay, S. L., & Chan‐Palay, V. (1974) · Springer eBooks · doi:10.1007/978-3-642-65581-4 · Cited by 2,468
A monomeric red fluorescent protein
Campbell, R. E., Tour, O., Palmer, A. E., Steinbach, P. A., Baird, G. S., Zacharias, D. A., & Tsien, R. Y. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.082243699 · Cited by 2,346
Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells
Zacharias, D. A., Violin, J. D., Newton, A. C., & Tsien, R. Y. (2002) · Science · doi:10.1126/science.1068539 · Cited by 2,270
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–300 of 1,000
Wong, H. S., Park, K., Gola, A., Baptista, A. P., Miller, C. H., Deep, D., Lou, M., Boyd, L. F., Rudensky, A. Y., Savage, P. A., et al. (2021) · Cell · doi:10.1016/j.cell.2021.05.028 · Cited by 152
Brown, K. M., Barrionuevo, G., Canty, A. J., Paola, V. D., Hirsch, J. A., Jefferis, G. S. X. E., Lu, J., Snippe, M., Sugihara, I., & Ascoli, G. A. (2011) · Neuroinformatics · doi:10.1007/s12021-010-9095-5 · Cited by 144
D’Amelio, M., & Rossini, P. M. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.07.001 · Cited by 147
Alexander, S., Weigelin, B., Winkler, F., & Friedl, P. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2013.07.001 · Cited by 149
Liu, W., Luo, Z., Wang, Y., Pham, N. T., Tuck, L., Pérez‐Pi, I., Liu, L., Shen, Y., French, C. E., Auer, M., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04254-0 · Cited by 142
Davis, F. M., Lloyd‐Lewis, B., Harris, O. B., Kozar, S., Winton, D. J., Mureşan, L., & Watson, C. J. (2016) · Nature Communications · doi:10.1038/ncomms13053 · Cited by 138
Next-Generation Lineage Tracing and Fate Mapping to Interrogate Development
VanHorn, S., & Morris, S. A. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.10.021 · Cited by 139
Serine Integrases: Advancing Synthetic Biology
Merrick, C., Zhao, J., & Rosser, S. J. (2018) · ACS Synthetic Biology · doi:10.1021/acssynbio.7b00308 · Cited by 138
Mm, C., & Sulik, K. K. (1992) · PubMed · Cited by 138
Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis
Xie, T., Liang, J., Liu, N., Huan, C., Zhang, Y., Liu, W., Kumar, M. E., Xiao, R., D'Armiento, J. M., METZGER, D., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci85328 · Cited by 139
Pervasive Synaptic Branch Removal in the Mammalian Neuromuscular System at Birth
Tapia, J. C., Wylie, J. D., Kasthuri, N., Hayworth, K. J., Schalek, R. L., Berger, D. R., Guatimosim, C., Seung, H. S., & Lichtman, J. W. (2012) · Neuron · doi:10.1016/j.neuron.2012.04.017 · Cited by 135
Blind Source Separation Techniques for the Decomposition of Multiply Labeled Fluorescence Images
Neher, R. A., Mitkovski, M., Kirchhoff, F., Neher, E., Theis, F. J., & Zeug, A. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2008.10.068 · Cited by 136
Murray, L. M., Talbot, K., & Gillingwater, T. H. (2010) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2009.01061.x · Cited by 140
Endothelial cell clonal expansion in the development of cerebral cavernous malformations
Malinverno, M., Maderna, C., Taha, A. A., Corada, M., Orsenigo, F., Valentino, M., Pisati, F., Fusco, C., Graziano, P., Giannotta, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10707-x · Cited by 133
Network Structure within the Cerebellar Input Layer Enables Lossless Sparse Encoding
Billings, G. O., Piasini, E., Lőrincz, A., Nusser, Z., & Silver, R. A. (2014) · Neuron · doi:10.1016/j.neuron.2014.07.020 · Cited by 135
Genetically encoded fluorescent tags
Thorn, K. S. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-07-0504 · Cited by 135
Chuapoco, M. R., Flytzanis, N. C., Goeden, N., Octeau, J. C., Roxas, K. M., Chan, K. Y., Scherrer, J., Winchester, J., Blackburn, R. J., Campos, L., et al. (2023) · Nature Nanotechnology · doi:10.1038/s41565-023-01419-x · Cited by 141
Transneuronal Circuit Analysis With Pseudorabies Viruses
Card, J. P., & Enquist, L. W. (1999) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0105s09 · Cited by 135
Early stem cell aging in the mature brain
Ibrayeva, A., Bay, M., Pu, E., Jörg, D. J., Peng, L., Jun, H., Zhang, N., Aaron, D., Lin, C., Resler, G., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.03.018 · Cited by 137
Grand challenges in organismal biology
Schwenk, K., Padilla, D. K., Bakken, G. S., & Full, R. J. (2009) · Integrative and Comparative Biology · doi:10.1093/icb/icp034 · Cited by 133
Lineage Tracing of Stem and Progenitor Cells of the Murine Corneal Epithelium
Amitai-Lange, A., Altshuler, A., Bubley, J. A., Dbayat, N., Tiosano, B., & Shalom‐Feuerstein, R. (2014) · Stem Cells · doi:10.1002/stem.1840 · Cited by 131
Lgr5 and Lgr6 as markers to study adult stem cell roles in self-renewal and cancer
Leushacke, M., & Barker, N. (2011) · Oncogene · doi:10.1038/onc.2011.479 · Cited by 130
Mechanisms of radial glia progenitor cell lineage progression
Beattie, R., & Hippenmeyer, S. (2017) · FEBS Letters · doi:10.1002/1873-3468.12906 · Cited by 136
Fluorescent Polymer Nanoparticles for Cell Barcoding In Vitro and In Vivo
Andreiuk, B., Reisch, A., Lindecker, M., Follain, G., Peyriéras, N., Goetz, J. G., & Klymchenko, A. S. (2017) · Small · doi:10.1002/smll.201701582 · Cited by 129
Stierli, S., Napoli, I., White, I. J., Cattin, A.-L., Cabrejos, A. M., Calavia, N. G., Malong, L., Ribeiro, S., Sigurðardottir, J. N., Williams, R. L., et al. (2018) · Development · doi:10.1242/dev.170316 · Cited by 131
Clonal Expansion of Endothelial Cells Contributes to Ischemia-Induced Neovascularization
Manavski, Y., Lucas, T., Glaser, S.-F., Dorsheimer, L., Günther, S., Braun, T. W., Rieger, M. A., Zeiher, A. M., Boon, R. A., & Dimmeler, S. (2018) · Circulation Research · doi:10.1161/circresaha.117.312310 · Cited by 122
A transgenic embryonic sexing system for Anastrepha suspensa (Diptera: Tephritidae)
Schetelig, M. F., & Handler, A. M. (2012) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2012.07.007 · Cited by 126
Intravital microscopy: a novel tool to study cell biology in living animals
Weigert, R., Šrámková, M., Parente, L., Amornphimoltham, P., & Masedunskas, A. (2010) · Histochemistry and Cell Biology · doi:10.1007/s00418-010-0692-z · Cited by 127
Cabeza-Cabrerizo, M., van Blijswijk, J., Wienert, S., Heim, D., Jenkins, R. P., Chakravarty, P., Rogers, N. C., Frederico, B., Acton, S. E., Beerling, E., et al. (2019) · Science Immunology · doi:10.1126/sciimmunol.aaw1941 · Cited by 125
Advances in the speed and resolution of light microscopy
Ji, N., Shroff, H., Zhong, H., & Betzig, E. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.03.009 · Cited by 131
Diversity of astroglial responses across human neurodegenerative disorders and brain aging
Ferrer, I. (2017) · Brain Pathology · doi:10.1111/bpa.12538 · Cited by 135
Feeding signals and brain circuitry
Dietrich, M. O., & Horváth, T. L. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06963.x · Cited by 130
Cell migration promotes dynamic cellular interactions to control cerebral cortex morphogenesis
Silva, C. G., Peyre, E., & Nguyen, L. (2019) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0148-y · Cited by 125
Imaging cell biology in live animals: Ready for prime time
Weigert, R., Porat‐Shliom, N., & Amornphimoltham, P. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201212130 · Cited by 124
Life-Long Genetic and Functional Access to Neural Circuits Using Self-Inactivating Rabies Virus
Ciabatti, E., González-Rueda, A., Mariotti, L., Morgese, F., & Tripodi, M. (2017) · Cell · doi:10.1016/j.cell.2017.06.014 · Cited by 121
Quantum dot/antibody conjugates for in vivo cytometric imaging in mice
Han, H., Niemeyer, E., Huang, Y., Kamoun, W. S., Martin, J. D., Bhaumik, J., Chen, Y., Roberge, S., Cui, J., Martin, M. R., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421632111 · Cited by 127
Whole-body cellular mapping in mouse using standard IgG antibodies
Mai, H., Luo, J., Hoeher, L., Al-Maskari, R., Horvath, I., Chen, Y., Kofler, F., Piraud, M., Paetzold, J. C., Modamio, J., et al. (2023) · Nature Biotechnology · doi:10.1038/s41587-023-01846-0 · Cited by 119
The Genomic and Genetic Toolbox of the Teleost Medaka ( Oryzias latipes )
Kirchmaier, S., Naruse, K., Wittbrodt, J., & Loosli, F. (2015) · Genetics · doi:10.1534/genetics.114.173849 · Cited by 120
Building a functional connectome of the Drosophila central complex
Franconville, R., Beron, C. C., & Jayaraman, V. (2018) · eLife · doi:10.7554/elife.37017 · Cited by 129
Axon-Carrying Dendrites Convey Privileged Synaptic Input in Hippocampal Neurons
Thome, C., Kelly, T., Yanez, A., Schultz, C., Engelhardt, M., Cambridge, S. B., Both, M., Draguhn, A., Beck, H., & Egorov, A. V. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.013 · Cited by 123
Li, L., Newton, P. T., Bouderlique, T., Šejnohová, M., Zikmund, T., Kozhemyakina, E. A., Xie, M., Křivánek, J., Kaiser, J., Qian, H., et al. (2016) · The FASEB Journal · doi:10.1096/fj.201600918r · Cited by 116
Single-Cell Analysis Uncovers Clonal Acinar Cell Heterogeneity in the Adult Pancreas
Wollny, D., Zhao, S., Everlien, I., Lun, X., Brunken, J., Brüne, D., Ziebell, F., Tabansky, I., Weichert, W., Marciniak-Czochra, A. K., et al. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.10.002 · Cited by 116
Quantitative Single-Cell Approaches to Stem Cell Research
Etzrodt, M., Endele, M., & Schroeder, T. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.10.015 · Cited by 119
Programmable disorder in random DNA tilings
Tikhomirov, G. A., Petersen, P., & Qian, L. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.256 · Cited by 117
Kochhan, E., Lenard, A., Ellertsdóttir, E., Herwig, L., Affolter, M., Belting, H., & Siekmann, A. F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075060 · Cited by 116
Branching Morphogenesis: From Cells to Organs and BackPreprint
Ochoa‐Espinosa, A., & Affolter, M. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008243 · Cited by 118
Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?
Lin, L., & Sibille, E. L. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00110 · Cited by 122
Electroluminescent synaptic devices with logic functions
Zhao, S., Ni, Z., Tan, H., Wang, Y., Jin, H., Nie, T., Xu, M., Pi, X., & Yang, D. (2018) · Nano Energy · doi:10.1016/j.nanoen.2018.10.018 · Cited by 118
Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate
Wu, F., Kaczynski, T. J., Sethuramanujam, S., Li, R., Jain, V., Slaughter, M. M., & Mu, X. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421535112 · Cited by 115
Reporter Mouse Lines for Fluorescence Imaging
Abe, T., & Fujimori, T. (2013) · Development Growth & Differentiation · doi:10.1111/dgd.12062 · Cited by 115
Leone, M., Magadum, A., & Engel, F. B. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00559.2015 · Cited by 115
Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development
Henninger, J. E., Santoso, B., Hans, S., Durand, E. M., Moore, J. L., Mosimann, C., Brand, M., Traver, D. J., & Zon, L. I. (2016) · Nature Cell Biology · doi:10.1038/ncb3444 · Cited by 116
High mitogenic stimulation arrests angiogenesis
Pontes-Quero, S., Fernández-Chacón, M., Luo, W., Lunella, F. F., Casquero-García, V., García-Gónzalez, I., Hermoso, A., Rocha, S. F., Bansal, M., & Benedito, R. (2019) · Nature Communications · doi:10.1038/s41467-019-09875-7 · Cited by 118
The Interscutularis Muscle Connectome
Lu, J., Tapia, J. C., White, O. L., & Lichtman, J. W. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000032 · Cited by 120
Liu, G., Moake, M. M., Har‐el, Y., Long, C. M., Chan, K. W. Y., Cardona, A., Jamil, M., Walczak, P., Gilad, A. A., Sgouros, G., et al. (2011) · Magnetic Resonance in Medicine · doi:10.1002/mrm.23100 · Cited by 113
Cerebral Cavernous Malformations Develop Through Clonal Expansion of Mutant Endothelial Cells
Detter, M. R., Snellings, D. A., & Marchuk, D. A. (2018) · Circulation Research · doi:10.1161/circresaha.118.313970 · Cited by 114
Epidermal γδ T cells originate from yolk sac hematopoiesis and clonally self-renew in the adult
Gentek, R., Ghigo, C., Hoeffel, G., Jorquera, A., Msallam, R., Wienert, S., Klauschen, F., Ginhoux, F., & Bajénoff, M. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20181206 · Cited by 112
Tunable dynamics of B cell selection in gut germinal centres
Nowosad, C. R., Mesin, L., Castro, T. B. R., Wichmann, C., Donaldson, G. P., Araki, T., Schiepers, A., Lockhart, A. A. K., Bilate, A. M. B., Mucida, D., et al. (2020) · Nature · doi:10.1038/s41586-020-2865-9 · Cited by 112
Super-resolving Microscopy in Neuroscience
Werner, C. D., Sauer, M., & Geis, C. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01174 · Cited by 113
Gilad, A. A., Ziv, K., McMahon, M. T., van Zijl, P. C. M., Neeman, M., & Bulte, J. W. M. (2008) · Journal of Nuclear Medicine · doi:10.2967/jnumed.108.053520 · Cited by 111
Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp
Cheng, H., Onder, L., Novković, M., Soneson, C., Lütge, M., Pikor, N. B., Scandella, E., Robinson, M. D., Miyazaki, J., Tersteegen, A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09728-3 · Cited by 111
Genetic dissection of GABAergic neural circuits in mouse neocortex
Taniguchi, H. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00008 · Cited by 106
Lineage Plasticity in Cancer Progression and Treatment
Magnen, C. L., Shen, M. M., & Abate-Shen, C. T. (2017) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030617-050224 · Cited by 105
Molecular Spies in Action: Genetically Encoded Fluorescent Biosensors Light up Cellular Signals
Gest, A. M. M., Sahan, A. Z., Zhong, Y., Lin, W., Mehta, S., & Zhang, J. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.4c00293 · Cited by 112
Genetic and optical targeting of neural circuits and behavior — zebrafish in the spotlight
Baier, H., & Scott, E. K. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.08.001 · Cited by 110
Advances in whole-embryo imaging: a quantitative transition is underway
Pantazis, P., & Supatto, W. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3786 · Cited by 106
Pooled‐matrix protein interaction screens using Barcode Fusion Genetics
Yachie, N., Petsalaki, E., Mellor, J. C., Weile, J., Jacob, Y., Verby, M., Ozturk, S. B., Li, S., Coté, A. G., Mosca, R., et al. (2016) · Molecular Systems Biology · doi:10.15252/msb.20156660 · Cited by 106
Lysosomal Activity Associated with Developmental Axon Pruning
Song, J. W., Misgeld, T., Kang, H., Knecht, S., Lu, J., Cao, Y., Cotman, S. L., Bishop, D. L., & Lichtman, J. W. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0720-08.2008 · Cited by 113
Multiple Retinal Axons Converge onto Relay Cells in the Adult Mouse Thalamus
Hammer, S., Monavarfeshani, A., Lemon, T., Su, J., & Fox, M. A. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.08.003 · Cited by 107
Fighting Fat with Fat: The Expanding Field of Adipose Stem Cells
Zeve, D., Tang, W., & Graff, J. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.10.014 · Cited by 109
Site-specific recombinases: molecular machines for the Genetic Revolution
Olorunniji, F. J., Rosser, S. J., & Stark, W. M. (2016) · Biochemical Journal · doi:10.1042/bj20151112 · Cited by 107
Precise Lamination of Retinal Axons Generates Multiple Parallel Input Pathways in the Tectum
Robles, E., Filosa, A., & Baier, H. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4990-12.2013 · Cited by 107
Kobiler, O., Lipman, Y., Therkelsen, K. E., Daubechies, I. C., & Enquist, L. W. (2010) · Nature Communications · doi:10.1038/ncomms1145 · Cited by 107
Shining light on wakefulness and arousal
de Lecea, L., Carter, M. E., & Adamantidis, A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.032 · Cited by 103
Pagán, A. J., Yang, C.-T., Cameron, J. R., Swaim, L. E., Ellett, F. E., Lieschke, G. J., & Ramakrishnan, L. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.06.008 · Cited by 107
Highly efficient baculovirus-mediated multigene delivery in primary cells
Mansouri, M., Bellón-Echeverría, I., Rizk, A., Ehsaei, Z., Cosentino, C., Silva, C. S., Xie, Y., Boyce, F. M., Davis, M. W., Neuhauss, S. C. F., et al. (2016) · Nature Communications · doi:10.1038/ncomms11529 · Cited by 105
Patterned cell and matrix dynamics in branching morphogenesis
Wang, S., Sekiguchi, R., Daley, W. P., & Yamada, K. M. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201610048 · Cited by 103
The issue of the multipotency of the neural crest cells
Dupin, É., Calloni, G. W., Coelho‐Aguiar, J. M., & Douarin, N. M. L. (2018) · Developmental Biology · doi:10.1016/j.ydbio.2018.03.024 · Cited by 105
Rubin, J. D., Nguyen, T. V., Allen, K. L., Ayasoufi, K., & Barry, M. A. (2019) · Human Gene Therapy · doi:10.1089/hum.2019.127 · Cited by 106
Basic principles of hydrogel-based tissue transformation technologies and their applications
Choi, S. W., Guan, W., & Chung, K. (2021) · Cell · doi:10.1016/j.cell.2021.07.009 · Cited by 106
Single-cell technologies sharpen up mammalian stem cell research
Hoppe, P. S., Coutu, D. L., & Schroeder, T. (2014) · Nature Cell Biology · doi:10.1038/ncb3042 · Cited by 107
Anatomy and spatial organization of Müller glia in mouse retina
Wang, J., O’Sullivan, M. L., Mukherjee, D., Puñal, V. M., Farsiu, S., & Kay, J. N. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.24153 · Cited by 106
MACS: Rapid Aqueous Clearing System for 3D Mapping of Intact Organs
Zhu, J., Yu, T., Li, Y., Xu, J., Qi, Y., Yao, Y., Ma, Y., Wan, P., Chen, Z., Li, X., et al. (2020) · Advanced Science · doi:10.1002/advs.201903185 · Cited by 105
A Bayesian approach for inferring neuronal connectivity from calcium fluorescent imaging data
Mishchenko, Y., Vogelstein, J. T., & Paninski, L. (2011) · The Annals of Applied Statistics · doi:10.1214/09-aoas303 · Cited by 104
Zador, A. M., Dubnau, J., Oyibo, H. K., Zhan, H., Cao, G., & Peikon, I. D. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001411 · Cited by 105
Sensory Experience and Cortical Rewiring
Barnes, S. J., & Finnerty, G. T. (2009) · The Neuroscientist · doi:10.1177/1073858409343961 · Cited by 104
Tutorial: practical considerations for tissue clearing and imaging
Weiss, K. R., Voigt, F. F., Shepherd, D. P., & Huisken, J. (2021) · Nature Protocols · doi:10.1038/s41596-021-00502-8 · Cited by 108
RGB marking with lentiviral vectors for multicolor clonal cell tracking
Riecken, K., Thomaschewski, M., Benten, D., & Fehse, B. (2012) · Nature Protocols · doi:10.1038/nprot.2012.026 · Cited by 103
Emerging applications for DNA writers and molecular recorders
Farzadfard, F., & Lu, T. K. (2018) · Science · doi:10.1126/science.aat9249 · Cited by 102
Chapter 3 Mapping and Manipulating Neural Circuits in the Fly Brain
Simpson, J. H. (2009) · Advances in genetics · doi:10.1016/s0065-2660(09)65003-3 · Cited by 105
Perfluorocarbon‐Based 19F MRI Nanoprobes for In Vivo Multicolor Imaging
Akazawa, K., Sugihara, F., Nakamura, T., Matsushita, H., Mukai, H., Akimoto, R., Minoshima, M., Mizukami, S., & Kikuchi, K. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201810363 · Cited by 102
Principles of Genetic Engineering
Lanigan, T. M., Kopera, H. C., & Saunders, T. L. (2020) · Genes · doi:10.3390/genes11030291 · Cited by 114
Binary recombinase systems for high-resolution conditional mutagenesis
Hermann, M., Stillhard, P., Wildner, H., Seruggia, D., Kapp, V., Sánchez-Iranzo, H., Mercader, N., Montoliu, L., Zeilhofer, H. U., & Pelczar, P. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1361 · Cited by 99
Brain/MINDS: brain-mapping project in Japan
Okano, H., Miyawaki, A., & Kasai, K. (2015) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2014.0310 · Cited by 106
Laser Scanning Confocal Microscopy: History, Applications, and Related Optical Sectioning Techniques
Paddock, S. W., & Eliceiri, K. W. (2013) · Methods in molecular biology · doi:10.1007/978-1-60761-847-8_2 · Cited by 101
Improving Axial Resolution in Confocal Microscopy with New High Refractive Index Mounting Media
Fouquet, C., Gilles, J.-F., Heck, N., Santos, M. D., Schwartzmann, R., Cannaya, V., Morel, M., Davidson, R. S., Trembleau, A., & Bolte, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121096 · Cited by 101
Blundell, J. R., & Levy, S. F. (2014) · Genomics · doi:10.1016/j.ygeno.2014.09.005 · Cited by 98
Transneuronal Circuit Analysis with Pseudorabies Viruses
Card, J. P., & Enquist, L. W. (2014) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0105s68 · Cited by 100
Zhang, L., Zhao, X., Zhang, G., Zhang, J., Wang, X., Zhang, S., Wang, W., & Wei, D. (2016) · Scientific Reports · doi:10.1038/srep20761 · Cited by 99
Thymic Crosstalk Coordinates Medulla Organization and T-Cell Tolerance Induction
Lopes, N., Sergé, A., Ferrier, P., & Irla, M. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00365 · Cited by 113
Metadata
- Authors
- Livet, J., Weissman, T. A., Kang, H., Draft, R. W., Lu, J., Bennis, R. A., Sanes, J. R., & Lichtman, J. W.
- Affiliations
- Harvard University (US)
- Corresponding author
- Lichtman, Jeff W.
- Venue
- Nature
- Published
- 2007-11
- Volume
- 450
- Issue
- 7166
- Pages
- 56-62
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2110232607
- Cited by
- 1,876
- References
- 42
- Citations by year
- 2026: 52 · 2025: 76 · 2024: 68 · 2023: 90 · 2022: 88 · 2021: 88 · 2020: 115 · 2019: 104 · 2018: 124 · 2017: 101 · 2016: 117 · 2015: 101 · 2014: 124 · 2013: 161 · 2012: 110
- FWCI
- 30.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Advanced Fluorescence Microscopy Techniques
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- Brainbow, transgenic mice, fluorescent proteins, Cre-loxP recombination, stochastic gene expression, neuronal circuit mapping, axon reconstruction, synaptic circuits, cerebellum, hippocampus
- MeSH terms
- Animals, Attachment Sites, Microbiological, Axons, Cell Communication, Cell Line, Cerebellum, Color, Genetic Engineering, Humans, Luminescent Proteins, Mice, Transgenic, Nervous System, Neural Pathways, Neuroglia, Recombination, Genetic, Stochastic Processes, Synapses, Time Factors, Gene Expression, Transgenes, Integrases, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
