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Cited by 536Sleep and Wakefulness ResearchNeurobiology and Insect Physiology ResearchCircadian rhythm and melatonin

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Lethargus is a Caenorhabditis elegans sleep-like state

Raizen, David M., Zimmerman, John E., Maycock, Matthew H., Ta, Uyen D., You, Young-jai, Sundaram, Meera V., Pack, Allan I.·2008·Nature
DOI 10.1038/nature06535
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Abstract

There are fundamental similarities between sleep in mammals and quiescence in the arthropod Drosophila melanogaster, suggesting that sleep-like states are evolutionarily ancient. The nematode Caenorhabditis elegans also has a quiescent behavioural state during a period called lethargus, which occurs before each of the four moults. Like sleep, lethargus maintains a constant temporal relationship with the expression of the C. elegans Period homologue LIN-42 (ref. 5). Here we show that quiescence associated with lethargus has the additional sleep-like properties of reversibility, reduced responsiveness and homeostasis. We identify the cGMP-dependent protein kinase (PKG) gene egl-4 as a regulator of sleep-like behaviour, and show that egl-4 functions in sensory neurons to promote the C. elegans sleep-like state. Conserved effects on sleep-like behaviour of homologous genes in C. elegans and Drosophila suggest a common genetic regulation of sleep-like states in arthropods and nematodes. Our results indicate that C. elegans is a suitable model system for the study of sleep regulation. The association of this C. elegans sleep-like state with developmental changes that occur with larval moults suggests that sleep may have evolved to allow for developmental changes.

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Crossref · 10.1038/nature06535

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Metadata

Authors
Raizen, D. M., Zimmerman, J. E., Maycock, M. H., Ta, U. D., You, Y.-J., Sundaram, M. V., & Pack, A. I.
Affiliations
  • University of Pennsylvania (US)
  • The University of Texas Southwestern Medical Center (US)
Corresponding author
Raizen, David M.
ORCID
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2008-01-09
Volume
451
Issue
7178
Pages
569-572
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/nature06535
OpenAlex
W2072681733
Cited by
536
References
31
Citations by year
2026: 19 · 2025: 26 · 2024: 36 · 2023: 37 · 2022: 32 · 2021: 33 · 2020: 39 · 2019: 35 · 2018: 36 · 2017: 36 · 2016: 26 · 2015: 28 · 2014: 26 · 2013: 34 · 2012: 18
FWCI
12.75
Type
journal article
Language
en
Update notices
erratum (2008-06-12)
Open access
closed
Licence
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
sleep-like state, Caenorhabditis elegans, cGMP signaling, egl-4, cGMP-dependent protein kinase, sensory neurons, sleep homeostasis, sleep evolution, quiescence
MeSH terms
Animals, Arousal, Drosophila melanogaster, Biological Evolution, Homeostasis, Larva, Sleep, Conserved Sequence, Caenorhabditis elegans, Cyclic GMP-Dependent Protein Kinases, Molting, Caenorhabditis elegans Proteins, Lethargy

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