Cited by 1,050Sleep and Wakefulness ResearchNeurobiology and Insect Physiology ResearchCircadian rhythm and melatonin

Rest in Drosophila is a sleep-like state

Open access
Hendricks, Joan C, Finn, Stefanie M, Panckeri, Karen A, Chavkin, Jessica, Williams, Julie A, Sehgal, Amita, Pack, Allan I·2000·Neuron

Abstract

To facilitate the genetic study of sleep, we documented that rest behavior in Drosophila melanogaster is a sleep-like state. The animals choose a preferred location, become immobile for periods of up to 157 min at a particular time in the circadian day, and are relatively unresponsive to sensory stimuli. Rest is affected by both homeostatic and circadian influences: when rest is prevented, the flies increasingly tend to rest despite stimulation and then exhibit a rest rebound. Drugs acting on a mammalian adenosine receptor alter rest as they do sleep, suggesting conserved neural mechanisms. Finally, normal homeostatic regulation depends on the timeless but not the period central clock gene. Understanding the molecular features of Drosophila rest should shed new light on the mechanisms and function of sleep.

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Crossref · 10.1016/s0896-6273(00)80877-6

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36 of 36 references verified0 citation errors · 0 not checkable

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  • Sleep has been identified in every animal that has been carefully studied.

    “Sleep has been recognized in each animal carefully scrutinized.”

    From The Biology of General Anesthesia from Paramecium to Primate (2019) · cites this paper as [27]

  • Behaviorally quiescent or sleep-like states may be as globally widespread as susceptibility to volatile anesthetics.

    “behaviorally quiescent or sleep-like states may be as globally penetrant as susceptibility to volatile anesthetics [22–29].”

    From The Biology of General Anesthesia from Paramecium to Primate (2019) · cites this paper as [27]

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Authors
Hendricks, J. C., Finn, S. M., Panckeri, K. A., Chavkin, J., Williams, J. A., Sehgal, A., & Pack, A. I.
Affiliations
University of Pennsylvania (US)
Corresponding author
Hendricks, Joan C
Venue
Neuron
Publisher
Elsevier BV
Published
2000-01
Volume
25
Issue
1
Pages
129-138
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2119706891
Cited by
1,050
References
36
Citations by year
2026: 50 · 2025: 69 · 2024: 67 · 2023: 66 · 2022: 64 · 2021: 62 · 2020: 49 · 2019: 56 · 2018: 44 · 2017: 52 · 2016: 31 · 2015: 48 · 2014: 43 · 2013: 41 · 2012: 43
FWCI
11.08
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (P50HL060287, HL60287, R01HL59496)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
resting behavior, sleep-like state, Drosophila melanogaster, sleep homeostasis, circadian rhythm, adenosine receptors, timeless gene, period gene, immobility
MeSH terms
Animals, Circadian Rhythm, Drosophila melanogaster, Male, Nervous System, Neurons, Afferent, Nuclear Proteins, Rest, Sleep, Sleep Deprivation, Gene Expression, Mutagenesis, Insect Proteins, Drosophila Proteins, Animals, Genetically Modified, Period Circadian Proteins

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