Cited by 132Sleep and Wakefulness ResearchNeurobiology and Insect Physiology ResearchCircadian rhythm and melatonin

Call it worm sleep

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Trojanowski, Nicholas F., Raizen, David M.·2016·Trends in Neurosciences

Abstract

The nematode Caenorhabditis elegans stops feeding and moving during a larval transition stage called lethargus and following exposure to cellular stressors. These behaviors have been termed 'sleep-like states'. We argue that these behaviors should instead be called sleep. Sleep during lethargus is similar to sleep regulated by circadian timers in insects and mammals, and sleep in response to cellular stress is similar to sleep induced by sickness in other animals. Sleep in mammals and Drosophila shows molecular and functional conservation with C. elegans sleep. The simple neuroanatomy and powerful genetic tools of C. elegans have yielded insights into sleep regulation and hold great promise for future research into sleep regulation and function.

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  1. [92]Lenz O 2015 Brain, Behavior, and Immunity Brain, Behaviour, and Immunity 47 141 148 PMC4467992 25668617

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Authors
Trojanowski, N. F., & Raizen, D. M.
Affiliations
University of Pennsylvania (US)
Corresponding author
Raizen, David M.
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2016-02
Volume
39
Issue
2
Pages
54-62
ISSN
0166-2236 (ISSN-L)
OpenAlex
W2204439106
Cited by
132
References
101
Citations by year
2026: 16 · 2025: 6 · 2024: 14 · 2023: 10 · 2022: 7 · 2021: 9 · 2020: 16 · 2019: 12 · 2018: 13 · 2017: 18 · 2016: 11
FWCI
1.38
Type
journal article
Language
en
Open access
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Heart, Lung, and Blood Institute (T32HL007953)
  • National Institute of Neurological Disorders and Stroke (R21NS091500, R01NS088432)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
Caenorhabditis elegans, sleep, sleep-like state, cellular stress, circadian rhythm, sleep regulation, larval development
MeSH terms
Animals, Humans, Locomotion, Nerve Net, Sleep, Species Specificity, Caenorhabditis elegans, Caenorhabditis elegans Proteins

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