Cited by 1,634Psoriasis: Treatment and PathogenesisT-cell and B-cell ImmunologyImmunotoxicology and immune responses

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

Open access

Veldhoen, Marc, Hirota, Keiji, Westendorf, Astrid M., Buer, Jan, Dumoutier, Laure, Renauld, Jean-Christophe, Stockinger, Brigitta·2008·Nature

DOI 10.1038/nature06881

Open this paper in CoChat — free account Open PDF

Abstract

The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor best known for mediating the toxicity of dioxin. Environmental factors are believed to contribute to the increased prevalence of autoimmune diseases, many of which are due to the activity of T(H)17 T cells, a new helper T-cell subset characterized by the production of the cytokine IL-17. Here we show that in the CD4+ T-cell lineage of mice AHR expression is restricted to the T(H)17 cell subset and its ligation results in the production of the T(H)17 cytokine interleukin (IL)-22. AHR is also expressed in human T(H)17 cells. Activation of AHR by a high-affinity ligand during T(H)17 cell development markedly increases the proportion of T(H)17 T cells and their production of cytokines. CD4+ T cells from AHR-deficient mice can develop T(H)17 cell responses, but when confronted with AHR ligand fail to produce IL-22 and do not show enhanced T(H)17 cell development. AHR activation during induction of experimental autoimmune encephalomyelitis causes accelerated onset and increased pathology in wild-type mice, but not AHR-deficient mice. AHR ligands may therefore represent co-factors in the development of autoimmune diseases.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nature06881

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099
Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
Liang, S. C., Tan, X.-Y., Luxenberg, D. P., Karim, R., Dunussi-Joannopoulos, K., Collins, M., & Fouser, L. A. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061308 · Cited by 2,330
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Zheng, Y., Danilenko, D. M., Valdez, P. A., Kasman, I. M., Eastham‐Anderson, J., Wu, J., & Ouyang, W. (2006) · Nature · doi:10.1038/nature05505 · Cited by 1,888
Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells
Acosta-Rodriguez, E. V., Rivino, L., Geginat, J., Jarrossay, D., Gattorno, M., Lanzavecchia, A., Sallusto, F., & Napolitani, G. (2007) · Nature Immunology · doi:10.1038/ni1467 · Cited by 1,828
Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation
Kebir, H., Kreymborg, K., Ifergan, I., Dodelet-Devillers, A., Cayrol, R., Bernard, M., Giuliani, F., Arbour, N., Becher, B., & Prat, A. (2007) · Nature Medicine · doi:10.1038/nm1651 · Cited by 1,759
Immune System Impairment and Hepatic Fibrosis in Mice Lacking the Dioxin-Binding Ah Receptor
Fernandez-Salguero, P., Pineau, T., Hilbert, D. M., McPhail, T., Lee, S. S. T., Kimura, S., Nebert, D. W., Rudikoff, S., Ward, J. M., & Gonzalez, F. J. (1995) · Science · doi:10.1126/science.7732381 · Cited by 1,075
Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model
Hirota, K., Yoshitomi, H., Hashimoto, M., Maeda, S., Teradaira, S., Sugimoto, N., Yamaguchi, T., Nomura, T., Ito, H., Nakamura, T., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071397 · Cited by 937
Self-citation
Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development.
Schmidt, J. V., Su, G. H., Reddy, J. K., Simon, M. C., & Bradfield, C. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6731 · Cited by 902
AH RECEPTOR SIGNALING PATHWAYS
Schmidt, J. V., & Bradfield, C. A. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.55 · Cited by 899

Flagged first, then by citations

Show all 31 references

Sorted by citations

Items 301–400 of 1,001

Current Concepts of Hyperinflammation in Chronic Granulomatous Disease
Rieber, N. P., Hector, A., Kuijpers, T. W., Roos, D., & Hartl, D. (2011) · Clinical and Developmental Immunology · doi:10.1155/2012/252460 · Cited by 144
Balancing Inflammation: The Link between Th17 and Regulatory T Cells
Diller, M. L., Kudchadkar, R. R., Delman, K. A., Lawson, D. H., & Ford, M. L. (2016) · Mediators of Inflammation · doi:10.1155/2016/6309219 · Cited by 141
Cancer cells induce interleukin-22 production from memory CD4 + T cells via interleukin-1 to promote tumor growth
Voigt, C., May, P., Gottschlich, A., Markota, A., Wenk, D., Gerlach, I., Voigt, S., Stathopoulos, G. T., Arendt, K. A. M., Heise, C., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705165114 · Cited by 141
Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease
Basson, A. R., Trotter, A., Rodriguez‐Palacios, A., & Cominelli, F. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00290 · Cited by 140
Tumour microenvironment factors shaping the cancer metabolism landscape
Anastasiou, D. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.412 · Cited by 138
Aryl Hydrocarbon Receptor (AHR) Ligands as Selective AHR Modulators (SAhRMs)
Safe, S. H., Jin, U.-H., Park, H., Chapkin, R. S., & Jayaraman, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186654 · Cited by 143
The role of transcription factors in shaping regulatory T cell identity
Trujillo-Ochoa, J. L., Kazemian, M., & Afzali, B. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00893-7 · Cited by 142
Role of AHR Ligands in Skin Homeostasis and Cutaneous Inflammation
Fernández‐Gallego, N., Sánchez‐Madrid, F., & Cibrián, D. (2021) · Cells · doi:10.3390/cells10113176 · Cited by 138
The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation
Smith, B. W., Rozelle, S. S., Leung, A., Ubellacker, J. M., Parks, A. J., Nah, S., French, D. L., Gadue, P. J., Monti, S., Chui, D. H. K., et al. (2013) · Blood · doi:10.1182/blood-2012-11-466722 · Cited by 140
AHR Function in Lymphocytes: Emerging Concepts
Zhou, L. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.11.007 · Cited by 145
Aryl hydrocarbon receptor inhibition downregulates the TGF-β/Smad pathway in human glioblastoma cells
Gramatzki, D., Pantazis, G., Schittenhelm, J., Tabatabai, G., Köhle, C., Wick, W., Schwarz, M., Weller, M., & Tritschler, I. (2009) · Oncogene · doi:10.1038/onc.2009.104 · Cited by 139
Hypoxia and Mucosal Inflammation
Colgan, S. P., Campbell, E. L., & Kominsky, D. J. (2016) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012615-044231 · Cited by 137
Deletion or activation of the aryl hydrocarbon receptor alters adult hippocampal neurogenesis and contextual fear memory
Latchney, S. E., Hein, A. M., O’Banion, M. K., DiCicco-Bloom, E. M., & Opanashuk, L. A. (2012) · Journal of Neurochemistry · doi:10.1111/jnc.12130 · Cited by 139
Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis
Nakahama, T., Kimura, A., Nguyen, N. T., Chinen, I., Hanieh, H., Nohara, K., Fujii‐Kuriyama, Y., & Kishimoto, T. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111786108 · Cited by 136
Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense
Luan, H. H., & Medzhitov, R. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.08.013 · Cited by 130
Identification of Cinnabarinic Acid as a Novel Endogenous Aryl Hydrocarbon Receptor Ligand That Drives IL-22 Production
Lowe, M. M., Mold, J. E., Kanwar, B., Huang, Y., Louie, A., Pollastri, M. P., Wang, C., Patel, G., Franks, D. G., Schlezinger, J. J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087877 · Cited by 136
The aryl hydrocarbon receptor: a multifunctional chemical sensor for host defense and homeostatic maintenance
Kawajiri, K., & Fujii‐Kuriyama, Y. (2016) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.16-0092 · Cited by 137
Microbial Metabolites and Gut Immunology
Takeuchi, T., Nakanishi, Y., & Ohno, H. (2024) · Annual Review of Immunology · doi:10.1146/annurev-immunol-090222-102035 · Cited by 143
Healing of intestinal inflammation by IL-22
Mizoguchi, A. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.22929 · Cited by 137
IL-22 Fate Reporter Reveals Origin and Control of IL-22 Production in Homeostasis and Infection
Ahlfors, H., Morrison, P. J., Duarte, J. H., Li, Y., Bíró, J., Tolaini, M., Meglio, P. D., Potocnik, A. J., & Stockinger, B. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401244 · Cited by 131
Self-citation
How functional foods play critical roles in human health
Pang, G., Xie, J., Chen, Q., & Zhi-he, H. (2012) · Food Science and Human Wellness · doi:10.1016/j.fshw.2012.10.001 · Cited by 134
Genome-wide Analysis Identifies Bcl6-Controlled Regulatory Networks during T Follicular Helper Cell Differentiation
Liu, X., Li, J., Chen, T., Nallaparaju, K. C., Yan, X. S., Tanaka, S., Ichiyama, K., Zhang, X., Zhang, L., Wen, X., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.01.038 · Cited by 133
The aryl hydrocarbon receptor ligand omeprazole inhibits breast cancer cell invasion and metastasis
Jin, U.-H., Lee, S., Pfent, C. M., & Safe, S. H. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-498 · Cited by 133
Molecular mechanisms of the physiological functions of the aryl hydrocarbon (dioxin) receptor, a multifunctional regulator that senses and responds to environmental stimuli
Fujii‐Kuriyama, Y., & Kawajiri, K. (2010) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.86.40 · Cited by 135
USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1–TAB1 complex
Liu, X., Li, H., Zhong, B., Blonska, M., Gorjestani, S., Yan, M., Tian, Q., Zhang, D., Lin, X., & Dong, C. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20122327 · Cited by 130
Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORγt induction as downstream targets of Stat3
Tanaka, S., Suto, A., Iwamoto, T., Kashiwakuma, D., Kagami, S., Suzuki, K., Takatori, H., Tamachi, T., Hirose, K., Onodera, A., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20130791 · Cited by 133
Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex
Seok, S., Lee, W., Jiang, L., Molugu, K., Zheng, A., Li, Y., Park, S., Bradfield, C. A., & Xing, Y. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617035114 · Cited by 135
Functional and phenotypic effects of AhR activation in inflammatory dendritic cells
Bankoti, J., Rase, B., Simones, T., & Shepherd, D. M. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.03.013 · Cited by 136
COVID-19, an opportunity to reevaluate the correlation between long-term effects of anthropogenic pollutants on viral epidemic/pandemic events and prevalence
Tsatsakis, A. M., Petrakis, D., Νikolouzakis, Τ. Κ., Docea, A. O., Călina, D. C., Vinceti, M., Γούμενου, Μ., Kostoff, R. N., Mamoulakis, C., Aschner, M., et al. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111418 · Cited by 130
Influence of nutrient-derived metabolites on lymphocyte immunity
Veldhoen, M., & Ferreira, C. (2015) · Nature Medicine · doi:10.1038/nm.3894 · Cited by 125
Self-citation
IL-17–producing ST2+ group 2 innate lymphoid cells play a pathogenic role in lung inflammation
Cai, T., Qiu, J., Ji, Y., Li, W., Ding, Z., Suo, C., Wang, J., Wang, J., He, R., Qian, Y., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.03.007 · Cited by 128
The Anti-Inflammatory Drug Leflunomide Is an Agonist of the Aryl Hydrocarbon Receptor
O'Donnell, E. F., Saili, K. S., Koch, D. C., Kopparapu, P. R., Farrer, D., Bisson, W. H., Mathew, L. K., Sengupta, S., Kerkvliet, N. I., Tanguay, R. L., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013128 · Cited by 124
Th17 Cells in Immunopathogenesis and treatment of rheumatoid arthritis
Azizi, G., Jadidi‐Niaragh, F., & Mirshafiey, A. (2013) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.12132 · Cited by 127
Differential Influences of the Aryl Hydrocarbon Receptor on Th17 Mediated Responses in vitro and in vivo
Duarte, J. H., Meglio, P. D., Hirota, K., Ahlfors, H., & Stockinger, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079819 · Cited by 128
Self-citation
Flavonoids and Asthma
Tanaka, T., & Takahashi, R. (2013) · Nutrients · doi:10.3390/nu5062128 · Cited by 128
Regulation and pro‐inflammatory function of interleukin‐17 family cytokines
Dong, C. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00709.x · Cited by 127
The role of sodium in modulating immune cell function
Wilck, N., Balogh, A., Markó, L., Bartolomaeus, H., & Müller, D. N. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0167-y · Cited by 129
Immunity to Commensal Fungi: Detente and Disease
Wheeler, M. L., Limon, J. J., & Underhill, D. M. (2017) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-052016-100342 · Cited by 124
The pathogenesis of thyroid autoimmune diseases: New T lymphocytes – Cytokines circuits beyond the Th1−Th2 paradigm
Li, Q., Wang, B., Mu, K., & Zhang, J. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27180 · Cited by 126
Role of AHR and HIF-1α in Glioblastoma Metabolism
Gabriely, G., Wheeler, M. A., Takenaka, M. C., & Quintana, F. J. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.02.009 · Cited by 124
CD8+CD161+ T-Cells: Cytotoxic Memory Cells With High Therapeutic Potential
Konduri, V., Oyewole-Said, D., Vazquez‐Perez, J., Weldon, S. A., Halpert, M. M., Levitt, J. M., & Decker, W. K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.613204 · Cited by 121
Cardiovascular endothelial inflammation by chronic coexposure to lead (Pb) and polycyclic aromatic hydrocarbons from preschool children in an e-waste recycling area
Zheng, X., Huo, X., Zhang, Y., Wang, Q., Zhang, Y., & Xu, X. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.12.055 · Cited by 120
Regulation of common neurological disorders by gut microbial metabolites
Park, J., & Kim, C. H. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00703-x · Cited by 126
Oral epithelial IL-22/STAT3 signaling licenses IL-17-mediated immunity to oral mucosal candidiasis
Aggor, F. E. Y., Break, T. J., Trevejo-Nuñez, G., Whibley, N., Coleman, B. M., Bailey, R. D., Kaplan, D. H., Naglik, J. R., Shan, W., Shetty, A. C., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.aba0570 · Cited by 119
Aryl hydrocarbon receptor: Linking environment to immunity
Cella, M., & Colonna, M. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.10.002 · Cited by 119
The Aryl Hydrocarbon Receptor: A Key Bridging Molecule of External and Internal Chemical Signals
Tian, J., Yu, F., Fu, H., Xie, H. Q., Jiang, J. X., & Zhao, B. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b00385 · Cited by 124
The tryptophan derivative 6-formylindolo[3,2- b ]carbazole, FICZ, a dynamic mediator of endogenous aryl hydrocarbon receptor signaling, balances cell growth and differentiation
Rannug, A., & Rannug, U. (2018) · Critical Reviews in Toxicology · doi:10.1080/10408444.2018.1493086 · Cited by 126
Cellular and Molecular Dynamics of Th17 Differentiation and its Developmental Plasticity in the Intestinal Immune Response
Bhaumik, S., & Basu, R. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00254 · Cited by 119
Emerging role of interleukin-22 in autoimmune diseases
Pan, H., Li, X.-P., Zheng, S. G., & Ye, D. (2012) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2012.07.002 · Cited by 123
Regulation of type 17 helper T-cell function by nitric oxide during inflammation
Niedbala, W., Alves-Filho, J. C., Fukada, S. Y., Vieira, S. M., Mitani, A., Sonego, F., Mirchandani, A., Nascimento, D. C., Cunha, F. Q., & Liew, F. Y. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100667108 · Cited by 117
Prostaglandin E2 Suppresses Antifungal Immunity by Inhibiting Interferon Regulatory Factor 4 Function and Interleukin-17 Expression in T Cells
Valdez, P. A., Vithayathil, P. J., Janelsins, B., Shaffer, A. L., Williamson, P. R., & Datta, S. K. (2012) · Immunity · doi:10.1016/j.immuni.2012.02.013 · Cited by 118
Development of Small Molecule Chimeras That Recruit AhR E3 Ligase to Target Proteins
Ohoka, N., Tsuji, G., Shoda, T., Fujisato, T., Kurihara, M., Demizu, Y., & Naito, M. (2019) · ACS Chemical Biology · doi:10.1021/acschembio.9b00704 · Cited by 119
The Biology and Functions of Th22 Cells
Jia, L., & Wu, C. Y. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-94-017-9487-9_8 · Cited by 125
Th22 in inflammatory and autoimmune disease: prospects for therapeutic intervention
Zhang, N., Pan, H., & Ye, D. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-0772-y · Cited by 119
Exposure to Polycyclic Aromatic Hydrocarbons: Bulky DNA Adducts and Cellular Responses
Henkler, F., Stolpmann, K., & Luch, A. (2012) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-7643-8340-4_5 · Cited by 119
Dihydroartemisinin Ameliorates Inflammatory Disease by Its Reciprocal Effects on Th and Regulatory T Cell Function via Modulating the Mammalian Target of Rapamycin Pathway
Zhao, Y. G., Wang, Y., Guo, Z., Gu, A.-D., Dan, H. C., Baldwin, A. S., Hao, W., & Wan, Y. Y. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200919 · Cited by 116
The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation
Liu, Z., Cao, W., Xu, L., Chen, X., Zhan, Y., Yang, Q., Liu, S., Chen, P., Jiang, Y., Sun, X., et al. (2015) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjv022 · Cited by 121
The Aryl Hydrocarbon Receptor Meets Immunology: Friend or Foe? A Little of Both
Julliard, W. A., Fechner, J. H., & Mezrich, J. D. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00458 · Cited by 118
Cancer cell metabolic reprogramming: a keystone for the response to immunotherapy
Cerezo, M., & Rocchi, S. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03175-5 · Cited by 118
Dioxin toxicity, aryl hydrocarbon receptor signaling, and apoptosis—Persistent pollutants affect programmed cell death
Chopra, M., & Schrenk, D. (2011) · Critical Reviews in Toxicology · doi:10.3109/10408444.2010.524635 · Cited by 114
Interleukin-22: A likely target for treatment of autoimmune diseases
Yang, X., & Zheng, S. G. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2013.11.008 · Cited by 116
A catch‐22: Interleukin‐22 and cancer
Hernández, P. P., Gronke, K., & Diefenbach, A. (2017) · European Journal of Immunology · doi:10.1002/eji.201747183 · Cited by 117
Amino Acid Trp: The Far Out Impacts of Host and Commensal Tryptophan Metabolism
Grifka‐Walk, H. M., Jenkins, B. R., & Kominsky, D. J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.653208 · Cited by 115
The aryl hydrocarbon receptor: a molecular pathway for the environmental control of the immune response
Quintana, F. J. (2012) · Immunology · doi:10.1111/imm.12046 · Cited by 117
The IDO–AhR Axis Controls Th17/Treg Immunity in a Pulmonary Model of Fungal Infection
de Araújo, E. F., Feriotti, C., Galdino, N. A. D. L., Preite, N. W., Calich, V. L. G., & Loures, F. V. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00880 · Cited by 113
Indoles mitigate the development of experimental autoimmune encephalomyelitis by induction of reciprocal differentiation of regulatory T cells and Th17 cells
Rouse, M. D., Singh, N. P., Nagarkatti, P. S., & Nagarkatti, M. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12205 · Cited by 113
Regulation of TH17 cell differentiation by innate immune signals
Huang, G., Wang, Y., & Chi, H. (2012) · Cellular and Molecular Immunology · doi:10.1038/cmi.2012.10 · Cited by 114
1α,25-Dihydroxyvitamin D3 and all-trans retinoic acid synergistically inhibit the differentiation and expansion of Th17 cells
Ikeda, U., Wakita, D., Ohkuri, T., Chamoto, K., Kitamura, H., Iwakura, Y., & Nishimura, T. (2010) · Immunology Letters · doi:10.1016/j.imlet.2010.07.002 · Cited by 114
T Helper Cell Differentiation
Zygmunt, B. M., & Veldhoen, M. (2011) · Advances in immunology · doi:10.1016/b978-0-12-387664-5.00005-4 · Cited by 116
Self-citation
Expert Panel Workshop Consensus Statement on the Role of the Environment in the Development of Autoimmune Disease
Parks, C. G., Miller, F. W., Pollard, K. M., Selmi, C. F., Germolec, D. R., Joyce, K. A., Rose, N., & Humble, M. C. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150814269 · Cited by 112
A mouse model links asthma susceptibility to prenatal exposure to diesel exhaust
Manners, S., Alam, R., Schwartz, D. A., & Gorska, M. M. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.10.047 · Cited by 110
Th17 cells and Tregs: unlikely allies
Chen, X., & Oppenheim, J. J. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.1213633 · Cited by 111
Mechanisms controlling Th17 cytokine expression and host defense
McAleer, J. P., & Kolls, J. K. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0211099 · Cited by 116
Aryl Hydrocarbon Receptor and Its Diverse Ligands and Functions: An Exposome Receptor
Larigot, L., Benoit, L., Koual, M., Tomkiewicz, C., Barouki, R., & Coumoul, X. (2021) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-052220-115707 · Cited by 117
Identification of a High-Affinity Ligand That Exhibits Complete Aryl Hydrocarbon Receptor Antagonism
Smith, K. J., Murray, I. A., Tanos, R., Tellew, J. E., Boitano, A. E., Bisson, W. H., Kolluri, S. K., Cooke, M. P., & Perdew, G. H. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.178392 · Cited by 113
Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation
Aden, K., Rehman, A., Falk‐Paulsen, M., Sécher, T., Kuiper, J. W., Tran, F., Pfeuffer, S., Sheibani‐Tezerji, R., Breuer, A., Luzius, A., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.054 · Cited by 107
The role of gut microbiome and associated metabolome in the regulation of neuroinflammation in multiple sclerosis and its implications in attenuating chronic inflammation in other inflammatory and autoimmune disorders
Dopkins, N., Nagarkatti, P. S., & Nagarkatti, M. (2018) · Immunology · doi:10.1111/imm.12903 · Cited by 110
The effects of trastuzumab on the CD4+CD25+FoxP3+ and CD4+IL17A+ T-cell axis in patients with breast cancer
Horlock, C., Stott, B., Dyson, P. J., Morishita, M., Coombes, R. C., Savage, P. M., & Stebbing, J. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6604963 · Cited by 107
Regulatory mechanisms of immune responses to intestinal bacteria
Honda, K., & Takeda, K. (2009) · Mucosal Immunology · doi:10.1038/mi.2009.8 · Cited by 107
The Autoimmune Ecology
Anaya, J., Ramírez-Santana, C., Alzate-Vinasco, M. A., Molano‐González, N., & Rojas‐Villarraga, A. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00139 · Cited by 113
IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation
Takahashi, K., Hirose, K., Kawashima, S., Niwa, Y., Wakashin, H., Iwata, A., Tokoyoda, K., Renauld, J., Iwamoto, I., Nakayama, T., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.06.018 · Cited by 113
Self-citation
Aryl hydrocarbon receptor signaling regulates NF‐κB RelB activation during dendritic‐cell differentiation
Vogel, C. F. A., Wu, D., Goth, S. R., Baek, J., Lollies, A., Domhardt, R., Grindel, A., & Pessah, I. N. (2013) · Immunology and Cell Biology · doi:10.1038/icb.2013.43 · Cited by 111
The Natural Cytotoxicity Receptor NKp46 Is Dispensable for IL-22-Mediated Innate Intestinal Immune Defense against Citrobacter rodentium
Satoh‐Takayama, N., Dumoutier, L., Lesjean‐Pottier, S., Ribeiro, V. S. G., Mandelboim, O., Renauld, J., Vosshenrich, C. A. J., & Santo, J. P. D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901935 · Cited by 114
Self-citation
The Aryl Hydrocarbon Receptor Promotes IL-10 Production by NK Cells
Wagage, S., John, B., Krock, B. L., Hall, A. O., Randall, L. M., Karp, C. L., Simon, M. C., & Hunter, C. A. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1300497 · Cited by 112
mTOR Mediates IL-23 Induction of Neutrophil IL-17 and IL-22 Production
Chen, F., Cao, A., Yao, S., Evans‐Marin, H., Liu, H., Wu, W. H., Carlsen, E. D., Dann, S. M., Soong, L., Sun, J., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501541 · Cited by 107
MHC class I‐related molecule, MR 1, and mucosal‐associated invariant T cells
Franciszkiewicz, K., Salou, M., Legoux, F. P., Zhou, Q., Cui, Y., Bessoles, S., & Lantz, O. J. (2016) · Immunological Reviews · doi:10.1111/imr.12423 · Cited by 113
Effects of cigarette smoke on immunity, neuroinflammation and multiple sclerosis
Alrouji, M., Manouchehrinia, A., Gran, B., & Constantinescu, C. S. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.10.004 · Cited by 110
The IL-23/IL-17 pathway in inflammatory bowel disease
Geremia, A., & Jewell, D. P. (2012) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.11.107 · Cited by 112
Autoimmune effector memory T cells: the bad and the good
Devarajan, P., & Chen, Z. (2013) · Immunologic Research · doi:10.1007/s12026-013-8448-1 · Cited by 110
Th17 cells: positive or negative role in tumor?
Ji, Y., & Zhang, W. (2010) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-010-0849-6 · Cited by 108
Adaptive capabilities and fitness consequences associated with pollution exposure in fish
Hamilton, P. B., Rolshausen, G., Webster, T. M. U., & Tyler, C. R. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0042 · Cited by 113
The Th17 Lineage: From Barrier Surfaces Homeostasis to Autoimmunity, Cancer, and HIV-1 Pathogenesis
Wacleche, V. S., LANDAY, A. L., Routy, J., & Ancuța, P. (2017) · Viruses · doi:10.3390/v9100303 · Cited by 109
Dysregulation of immune homeostasis in autoimmune diseases
Kuchroo, V. K., Ohashi, P. S., Sartor, R. B., & Vinuesa, C. G. (2012) · Nature Medicine · doi:10.1038/nm.2621 · Cited by 105
Autoimmunity and infection in Sjögren's syndrome
Igoe, A., & Scofield, R. H. (2013) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e32836200d2 · Cited by 109
The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells
Khor, B., Gagnon, J. D., Goel, G., Roche, M. I., Conway, K. L., Tran, K. A., Aldrich, L. N., Sundberg, T. B., Paterson, A. M., Mordecai, S., et al. (2015) · eLife · doi:10.7554/elife.05920 · Cited by 108
Control of epithelial cell function by interleukin-22-producing RORγt+ innate lymphoid cells
Sanos, S. L., Vonarbourg, C., Mortha, A., & Diefenbach, A. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03410.x · Cited by 108
IL-22: There Is a Gap in Our Knowledge
Zenewicz, L. A. (2018) · ImmunoHorizons · doi:10.4049/immunohorizons.1800006 · Cited by 106
Indole Propionic Acid, an Unusual Antibiotic Produced by the Gut Microbiota, With Anti-inflammatory and Antioxidant Properties
Negatu, D. A., Gengenbacher, M., Dartois, V. A., & Dick, T. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.575586 · Cited by 108
Review: Transcriptional Regulation of CD 4+ T Cell Differentiation in Experimentally Induced Arthritis and Rheumatoid Arthritis
Kondo, Y., Yokosawa, M., Kaneko, S., Furuyama, K., Segawa, S., Tsuboi, H., Matsumoto, I., & Sumida, T. (2017) · Arthritis & Rheumatology · doi:10.1002/art.40398 · Cited by 104
Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology
Sonner, J. K., Keil, M., Falk‐Paulsen, M., Mishra, N., Rehman, A., Kramer, M., Deumelandt, K., Röwe, J., Sanghvi, K., Wolf, L., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12776-4 · Cited by 105

Authors: Veldhoen, M., Hirota, K., Westendorf, A. M., Buer, J., Dumoutier, L., Renauld, J.-C., & Stockinger, B.
Affiliations: National Institute for Medical Research (GB)
Essen University Hospital (DE)
Ludwig Cancer Research (BE)
Corresponding author: Stockinger, Brigitta
ORCID: Veldhoen, Marc
Hirota, Keiji
Westendorf, Astrid M.
Buer, Jan
Dumoutier, Laure
Renauld, Jean-Christophe
Stockinger, Brigitta
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2008-03-23
Volume: 453
Issue: 7191
Pages: 106-109
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature06881
OpenAlex: W1993003564
Cited by: 1,634
References: 31
Citations by year: 2026: 33 · 2025: 44 · 2024: 49 · 2023: 54 · 2022: 87 · 2021: 94 · 2020: 96 · 2019: 90 · 2018: 96 · 2017: 93 · 2016: 96 · 2015: 82 · 2014: 114 · 2013: 107 · 2012: 118
FWCI: 52.43
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
HZI (Helmholtz Centre for Infection Research) (submittedVersion)
RePEc: Research Papers in Economics (submittedVersion)
DIAL (Catholic University of Leuven) (submittedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: University of Leicester
Topics: Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords: aryl hydrocarbon receptor, Th17 cells, autoimmunity, environmental toxins, IL-22, experimental autoimmune encephalitis, multiple sclerosis, regulatory T cells, CD4+ T cells, immunomodulation, AhR ligands, dioxins, IL-17
MeSH terms: Interleukin-22, Animals, Cell Differentiation, Cells, Cultured, Encephalomyelitis, Autoimmune, Experimental, Environmental Exposure, Environmental Pollutants, T-Lymphocytes, Helper-Inducer, Humans, Interleukins, Ligands, Mice, Inbred C57BL, Transduction, Genetic, Hazardous Substances, Autoimmunity, Receptors, Aryl Hydrocarbon, Interleukin-17, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks