Cited by 1,634Psoriasis: Treatment and PathogenesisT-cell and B-cell ImmunologyImmunotoxicology and immune responses

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The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

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Veldhoen, Marc, Hirota, Keiji, Westendorf, Astrid M., Buer, Jan, Dumoutier, Laure, Renauld, Jean-Christophe, Stockinger, Brigitta·2008·Nature

DOI 10.1038/nature06881

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Abstract

The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor best known for mediating the toxicity of dioxin. Environmental factors are believed to contribute to the increased prevalence of autoimmune diseases, many of which are due to the activity of T(H)17 T cells, a new helper T-cell subset characterized by the production of the cytokine IL-17. Here we show that in the CD4+ T-cell lineage of mice AHR expression is restricted to the T(H)17 cell subset and its ligation results in the production of the T(H)17 cytokine interleukin (IL)-22. AHR is also expressed in human T(H)17 cells. Activation of AHR by a high-affinity ligand during T(H)17 cell development markedly increases the proportion of T(H)17 T cells and their production of cytokines. CD4+ T cells from AHR-deficient mice can develop T(H)17 cell responses, but when confronted with AHR ligand fail to produce IL-22 and do not show enhanced T(H)17 cell development. AHR activation during induction of experimental autoimmune encephalomyelitis causes accelerated onset and increased pathology in wild-type mice, but not AHR-deficient mice. AHR ligands may therefore represent co-factors in the development of autoimmune diseases.

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Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
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Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099
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Liang, S. C., Tan, X.-Y., Luxenberg, D. P., Karim, R., Dunussi-Joannopoulos, K., Collins, M., & Fouser, L. A. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061308 · Cited by 2,330
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Zheng, Y., Danilenko, D. M., Valdez, P. A., Kasman, I. M., Eastham‐Anderson, J., Wu, J., & Ouyang, W. (2006) · Nature · doi:10.1038/nature05505 · Cited by 1,888
Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells
Acosta-Rodriguez, E. V., Rivino, L., Geginat, J., Jarrossay, D., Gattorno, M., Lanzavecchia, A., Sallusto, F., & Napolitani, G. (2007) · Nature Immunology · doi:10.1038/ni1467 · Cited by 1,828
Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation
Kebir, H., Kreymborg, K., Ifergan, I., Dodelet-Devillers, A., Cayrol, R., Bernard, M., Giuliani, F., Arbour, N., Becher, B., & Prat, A. (2007) · Nature Medicine · doi:10.1038/nm1651 · Cited by 1,759
Immune System Impairment and Hepatic Fibrosis in Mice Lacking the Dioxin-Binding Ah Receptor
Fernandez-Salguero, P., Pineau, T., Hilbert, D. M., McPhail, T., Lee, S. S. T., Kimura, S., Nebert, D. W., Rudikoff, S., Ward, J. M., & Gonzalez, F. J. (1995) · Science · doi:10.1126/science.7732381 · Cited by 1,075
Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model
Hirota, K., Yoshitomi, H., Hashimoto, M., Maeda, S., Teradaira, S., Sugimoto, N., Yamaguchi, T., Nomura, T., Ito, H., Nakamura, T., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071397 · Cited by 937
Self-citation
Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development.
Schmidt, J. V., Su, G. H., Reddy, J. K., Simon, M. C., & Bradfield, C. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6731 · Cited by 902
AH RECEPTOR SIGNALING PATHWAYS
Schmidt, J. V., & Bradfield, C. A. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.55 · Cited by 899

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Self-citation
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Self-citation
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Haase, S., Grohme, D. A., Erzler, M., Binsfeld, M., Haghikia, A., Müller, D. N., Linker, R. A., & Kleinewietfeld, M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2311-1 · Cited by 156
Metabolism Controls the Balance of Th17/T-Regulatory Cells
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Progress in our understanding of the pathogenesis of ankylosing spondylitis
Simone, D., Al‐Mossawi, H., & Bowness, P. (2018) · Rheumatology · doi:10.1093/rheumatology/key001 · Cited by 151
TH17 cells in human recurrent pregnancy loss and pre-eclampsia
Fu, B., Tian, Z., & Wei, H. (2014) · Cellular and Molecular Immunology · doi:10.1038/cmi.2014.54 · Cited by 155
TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer
Pérez, L. G., Kempski, J., McGee, H. M., Pelczar, P., Agalioti, T., Giannou, A. D., Konczalla, L., Brockmann, L., Wahib, R., Xu, H. Y., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16363-w · Cited by 157
Modeling of the Aryl Hydrocarbon Receptor (AhR) Ligand Binding Domain and Its Utility in Virtual Ligand Screening to Predict New AhR Ligands
Bisson, W. H., Koch, D. C., O’Donnell, E. F., Khalil, S. M., Kerkvliet, N. I., Tanguay, R. L., Abagyan, R., & Kolluri, S. K. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm900199u · Cited by 149
Modulation of natural killer cell antitumor activity by the aryl hydrocarbon receptor
Shin, J. H., Zhang, L. H., Murillo, O., Kim, J., Kohrt, H. E. K., Bui, J. D., & Sunwoo, J. B. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1302856110 · Cited by 155
Influence of microbial environment on autoimmunity
Chervonsky, A. V. (2009) · Nature Immunology · doi:10.1038/ni.1801 · Cited by 168
Aryl Hydrocarbon Receptor Ligands in Cigarette Smoke Induce Production of Interleukin-22 to Promote Pancreatic Fibrosis in Models of Chronic Pancreatitis
Xue, J., Zhao, Q., Sharma, V., Nguyen, L. P., Lee, Y. N., Pham, K. L., Edderkaoui, M., Pandol, S. J., Park, W., & Habtezion, A. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.09.064 · Cited by 146
AhR and ARNT modulate ER signaling
Swedenborg, E., & Pongratz, I. (2009) · Toxicology · doi:10.1016/j.tox.2009.09.007 · Cited by 153
Exposure to Atmospheric Particulate Matter Enhances Th17 Polarization through the Aryl Hydrocarbon Receptor
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Structural Basis for Aryl Hydrocarbon Receptor-Mediated Gene Activation
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Neuroimmune regulation during intestinal development and homeostasis
Veiga‐Fernandes, H., & Pachnis, V. (2017) · Nature Immunology · doi:10.1038/ni.3634 · Cited by 146
The role of Th17 cells in psoriasis
Li, B., Huang, L., Lv, P., Li, X., Liu, G., Chen, Y., Wang, Z., Qian, X., Shen, Y., Li, Y., et al. (2020) · Immunologic Research · doi:10.1007/s12026-020-09149-1 · Cited by 152
Aryl hydrocarbon receptor-mediated induction of the microRNA-132/212 cluster promotes interleukin-17–producing T-helper cell differentiation
Nakahama, T., Hanieh, H., Nguyen, N. T., Chinen, I., Ripley, B., Millrine, D., Lee, S.-Y., Nyati, K. K., Dubey, P. K., Chowdhury, K., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311087110 · Cited by 144
The AhR twist: ligand-dependent AhR signaling and pharmaco-toxicological implications
Guyot, E., Chevallier, A., Barouki, R., & Coumoul, X. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.11.014 · Cited by 160
IL-17A–Producing γδ T and Th17 Lymphocytes Mediate Lung Inflammation but Not Fibrosis in Experimental Silicosis
Re, S. L., Dumoutier, L., Couillin, I., Vyve, C. V., Yakoub, Y., Uwambayinema, F., Marien, B., van den Brûle, S., Snick, J. V., Uyttenhove, C., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0900459 · Cited by 144
Self-citation
Regulation of TH17 Cells and Associated Cytokines in Wound Healing, Tissue Regeneration, and Carcinogenesis
Brockmann, L., Giannou, A. D., Gagliani, N., & Huber, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18051033 · Cited by 152
Gut-Brain Connection: Microbiome, Gut Barrier, and Environmental Sensors
Gwak, M.-G., & Chang, S. (2021) · Immune Network · doi:10.4110/in.2021.21.e20 · Cited by 151
Structural Basis of Digoxin That Antagonizes RORγt Receptor Activity and Suppresses Th17 Cell Differentiation and Interleukin (IL)-17 Production
Fujita-Sato, S., Ito, S., Isobe, T., Ohyama, T., Wakabayashi, K., Morishita, K., Ando, O., & Isono, F. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.254003 · Cited by 142
Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases
Abraham, C., Dulai, P. S., Vermeire, S., & Sandborn, W. J. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.10.018 · Cited by 142
Mechanistic impact of outdoor air pollution on asthma and allergic diseases.
Huang, S.-K., Zhang, Q., Qiu, Z., & Chung, K. F. (2015) · PubMed · doi:10.3978/j.issn.2072-1439.2014.12.13 · Cited by 142

Authors: Veldhoen, M., Hirota, K., Westendorf, A. M., Buer, J., Dumoutier, L., Renauld, J.-C., & Stockinger, B.
Affiliations: National Institute for Medical Research (GB)
Essen University Hospital (DE)
Ludwig Cancer Research (BE)
Corresponding author: Stockinger, Brigitta
ORCID: Veldhoen, Marc
Hirota, Keiji
Westendorf, Astrid M.
Buer, Jan
Dumoutier, Laure
Renauld, Jean-Christophe
Stockinger, Brigitta
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2008-03-23
Volume: 453
Issue: 7191
Pages: 106-109
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature06881
OpenAlex: W1993003564
Cited by: 1,634
References: 31
Citations by year: 2026: 33 · 2025: 44 · 2024: 49 · 2023: 54 · 2022: 87 · 2021: 94 · 2020: 96 · 2019: 90 · 2018: 96 · 2017: 93 · 2016: 96 · 2015: 82 · 2014: 114 · 2013: 107 · 2012: 118
FWCI: 52.43
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
HZI (Helmholtz Centre for Infection Research) (submittedVersion)
RePEc: Research Papers in Economics (submittedVersion)
DIAL (Catholic University of Leuven) (submittedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: University of Leicester
Topics: Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords: aryl hydrocarbon receptor, Th17 cells, autoimmunity, environmental toxins, IL-22, experimental autoimmune encephalitis, multiple sclerosis, regulatory T cells, CD4+ T cells, immunomodulation, AhR ligands, dioxins, IL-17
MeSH terms: Interleukin-22, Animals, Cell Differentiation, Cells, Cultured, Encephalomyelitis, Autoimmune, Experimental, Environmental Exposure, Environmental Pollutants, T-Lymphocytes, Helper-Inducer, Humans, Interleukins, Ligands, Mice, Inbred C57BL, Transduction, Genetic, Hazardous Substances, Autoimmunity, Receptors, Aryl Hydrocarbon, Interleukin-17, Mice

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The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

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