Cited by 1,634Psoriasis: Treatment and PathogenesisT-cell and B-cell ImmunologyImmunotoxicology and immune responses

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The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

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Veldhoen, Marc, Hirota, Keiji, Westendorf, Astrid M., Buer, Jan, Dumoutier, Laure, Renauld, Jean-Christophe, Stockinger, Brigitta·2008·Nature

DOI 10.1038/nature06881

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Abstract

The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor best known for mediating the toxicity of dioxin. Environmental factors are believed to contribute to the increased prevalence of autoimmune diseases, many of which are due to the activity of T(H)17 T cells, a new helper T-cell subset characterized by the production of the cytokine IL-17. Here we show that in the CD4+ T-cell lineage of mice AHR expression is restricted to the T(H)17 cell subset and its ligation results in the production of the T(H)17 cytokine interleukin (IL)-22. AHR is also expressed in human T(H)17 cells. Activation of AHR by a high-affinity ligand during T(H)17 cell development markedly increases the proportion of T(H)17 T cells and their production of cytokines. CD4+ T cells from AHR-deficient mice can develop T(H)17 cell responses, but when confronted with AHR ligand fail to produce IL-22 and do not show enhanced T(H)17 cell development. AHR activation during induction of experimental autoimmune encephalomyelitis causes accelerated onset and increased pathology in wild-type mice, but not AHR-deficient mice. AHR ligands may therefore represent co-factors in the development of autoimmune diseases.

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Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099
Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
Liang, S. C., Tan, X.-Y., Luxenberg, D. P., Karim, R., Dunussi-Joannopoulos, K., Collins, M., & Fouser, L. A. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061308 · Cited by 2,330
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Zheng, Y., Danilenko, D. M., Valdez, P. A., Kasman, I. M., Eastham‐Anderson, J., Wu, J., & Ouyang, W. (2006) · Nature · doi:10.1038/nature05505 · Cited by 1,888
Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells
Acosta-Rodriguez, E. V., Rivino, L., Geginat, J., Jarrossay, D., Gattorno, M., Lanzavecchia, A., Sallusto, F., & Napolitani, G. (2007) · Nature Immunology · doi:10.1038/ni1467 · Cited by 1,828
Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation
Kebir, H., Kreymborg, K., Ifergan, I., Dodelet-Devillers, A., Cayrol, R., Bernard, M., Giuliani, F., Arbour, N., Becher, B., & Prat, A. (2007) · Nature Medicine · doi:10.1038/nm1651 · Cited by 1,759
Immune System Impairment and Hepatic Fibrosis in Mice Lacking the Dioxin-Binding Ah Receptor
Fernandez-Salguero, P., Pineau, T., Hilbert, D. M., McPhail, T., Lee, S. S. T., Kimura, S., Nebert, D. W., Rudikoff, S., Ward, J. M., & Gonzalez, F. J. (1995) · Science · doi:10.1126/science.7732381 · Cited by 1,075
Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model
Hirota, K., Yoshitomi, H., Hashimoto, M., Maeda, S., Teradaira, S., Sugimoto, N., Yamaguchi, T., Nomura, T., Ito, H., Nakamura, T., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071397 · Cited by 937
Self-citation
Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development.
Schmidt, J. V., Su, G. H., Reddy, J. K., Simon, M. C., & Bradfield, C. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6731 · Cited by 902
AH RECEPTOR SIGNALING PATHWAYS
Schmidt, J. V., & Bradfield, C. A. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.55 · Cited by 899

Show all 31 references

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Cella, M., Otero, K., & Colonna, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005641107 · Cited by 348
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Sun, M., Ma, N., He, T., Johnston, L. J., & Ma, X. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1598334 · Cited by 345
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Rook, G. A. W. (2010) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2010.04133.x · Cited by 332
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Bernard, J. J., Gallo, R. L., & Krutmann, J. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0185-9 · Cited by 329
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Emerging role of air pollution in autoimmune diseases
Zhao, C., Xu, Z., Wu, G., Mao, Y., Liu, L., Qian-Wu, Dan, Y., Tao, S., Zhang, Q., Sam, N. B., et al. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2018.12.010 · Cited by 321
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Morris, G., Berk, M., Carvalho, A. F., Caso, J. R., Sanz, Y., Walder, K. R., & Maes, M. H. J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0004-2 · Cited by 318
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Vogel, C. F. A., Goth, S. R., Dong, B., Pessah, I. N., & Matsumura, F. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.07.156 · Cited by 309
An introduction to the molecular basics of aryl hydrocarbon receptor biology
Abel, J., & Haarmann‐Stemmann, T. (2010) · Biological Chemistry · doi:10.1515/bc.2010.128 · Cited by 309
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O'Shea, J. J., Lahesmaa, R., Vahedi, G., Laurence, A., & Kanno, Y. (2011) · Nature Reviews Immunology · doi:10.1038/nri2958 · Cited by 295
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Reynolds, J. M., Pappu, B. P., Peng, J., Martínez, G., Zhang, Y., Chung, Y., Ma, L., Yang, X. O., Nurieva, R., Tian, Q., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.04.010 · Cited by 304
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Mehler, M. F. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.10.001 · Cited by 300
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Stadhouders, R., Lubberts, E., & Hendriks, R. W. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.12.007 · Cited by 298
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Singh, N. P., Singh, U. P., Singh, B., Price, R. L., Nagarkatti, M., & Nagarkatti, P. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023522 · Cited by 296
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Bluestone, J. A., Mackay, C. R., O’Shea, J. J., & Stockinger, B. (2009) · Nature reviews. Immunology · doi:10.1038/nri2654 · Cited by 286
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Self-citation
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Zhu, S., & Qian, Y. (2012) · Clinical Science · doi:10.1042/cs20110496 · Cited by 291
Effector and Regulatory T-cell Subsets in Autoimmunity and Tissue Inflammation
Jäger, A., & Kuchroo, V. K. (2010) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2010.02432.x · Cited by 296
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Wincent, E., Amini, N., Luecke-Johansson, S., Glatt, H. R., Bergman, J., Crescenzi, C., Rannug, A., & Rannug, U. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m808321200 · Cited by 288
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Bedoya, S. K., Lam, B. K., Lau, K., & Larkin, J. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/986789 · Cited by 293
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Ma, N., & Ma, X. (2018) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12401 · Cited by 285
Translational Mini-Review Series on Th17 Cells: Function and regulation of human T helper 17 cells in health and disease
Crome, S. Q., Wang, A. Y., & Levings, M. K. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2009.04037.x · Cited by 283
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Vogel, C. F. A., Khan, E. M., Leung, P. S. C., Gershwin, M. E., Chang, W. L. W., Wu, D., Haarmann‐Stemmann, T., Hoffmann, A., & Denison, M. S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.505578 · Cited by 290
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Cui, G., Qin, X., Wu, L., Zhang, Y., Sheng, X., Yu, Q., Sheng, H., Xi, B., Zhang, J. Z., & Zang, Y. Q. (2011) · Journal of Clinical Investigation · doi:10.1172/jci42974 · Cited by 276
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Danneskiold‐Samsøe, N. B., Barros, H. D. D. F. Q., dos Santos, R., Bicas, J. L., Cazarin, C. B. B., Madsen, L., Kristiansen, K., Pastore, G. M., Brix, S., & Maróstica, M. R. (2018) · Food Research International · doi:10.1016/j.foodres.2018.07.043 · Cited by 278
Epigenetic Instability of Cytokine and Transcription Factor Gene Loci Underlies Plasticity of the T Helper 17 Cell Lineage
Mukasa, R., Balasubramani, A., Lee, Y. K., Whitley, S. K., Weaver, B. T., Shibata, Y., Crawford, G. E., Hatton, R. D., & Weaver, C. T. (2010) · Immunity · doi:10.1016/j.immuni.2010.04.016 · Cited by 284
IκBζ regulates TH17 development by cooperating with ROR nuclear receptors
Okamoto, K., Iwai, Y., Oh‐hora, M., Yamamoto, M., Morio, T., Aoki, K., Ohya, K., Jetten, A. M., Akira, S., Muta, T., et al. (2010) · Nature · doi:10.1038/nature08922 · Cited by 275
Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens
Geiger, T. L., Abt, M. C., Gasteiger, G., Firth, M. A., O'Connor, M. H., Geary, C. D., O’Sullivan, T. E., van den Brink, M. R. M., Pamer, E. G., Hanash, A. M., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20140212 · Cited by 268
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Self-citation
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Kawajiri, K., Kobayashi, Y., Ohtake, F., Ikuta, T., Matsushima, Y., Mimura, J., Pettersson, S., Pollenz, R. S., Sakaki, T., Hirokawa, T., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902132106 · Cited by 270
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Therapeutic targeting of the interleukin-6 receptor.
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Th17 plasticity and its relevance to inflammatory bowel disease
Ueno, A., Jeffery, L. E., Kobayashi, T., Hibi∥, T., Ghosh, S. K., & Jijon, H. B. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.12.004 · Cited by 273
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Paulos, C. M., Carpenito, C., Plesa, G., Suhoski, M. M., Varela‐Rohena, A., Golovina, T. N., Carroll, R. G., Riley, J. L., & June, C. H. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3000448 · Cited by 266
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Yamada, T., Horimoto, H., Kameyama, T., Hayakawa, S., Yamato, H., Dazai, M., Takada, A., Kida, H., Bott, D., Zhou, A. C., et al. (2016) · Nature Immunology · doi:10.1038/ni.3422 · Cited by 251
Interleukin-17 in chronic inflammatory neurological diseases
Milovanovic, J., Arsenijevic, A., Stojanovic, B., Kanjevac, T., Arsenijevic, D., Radosavljevic, G., Milovanovic, M., & Arsenijevic, N. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00947 · Cited by 250
Aiolos promotes TH17 differentiation by directly silencing Il2 expression
Quintana, F. J., Jin, H., Burns, E. J., Nadeau, M., Yeste, A., Kumar, D., Rangachari, M., Zhu, C. Y., Xiao, S., Seavitt, J., et al. (2012) · Nature Immunology · doi:10.1038/ni.2363 · Cited by 259
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Th17 cytokines and their emerging roles in inflammation and autoimmunity
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Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition
Cui, W., Guo, M., Liu, D., Xiao, P., Yang, C., Huang, H., Liang, C., Yang, Y., Fu, X., Zhang, Y., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-023-01314-6 · Cited by 251
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Lineage-specific Effects of 1,25-Dihydroxyvitamin D3 on the Development of Effector CD4 T Cells
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Impacts of microbiome metabolites on immune regulation and autoimmunity
Haase, S., Haghikia, A., Wilck, N., Müller, D. N., & Linker, R. A. (2018) · Immunology · doi:10.1111/imm.12933 · Cited by 239
γδ T cells protect against lung fibrosis via IL-22
Simonian, P. L., Wehrmann, F., Roark, C. L., Born, W. K., O’Brien, R. L., & Fontenot, A. P. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100061 · Cited by 251
IL-17 and IL-22: siblings, not twins
Eyerich, S., Eyerich, K., Cavani, A., & Schmidt‐Weber, C. B. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.06.004 · Cited by 242
IL-17 family member cytokines: Regulation and function in innate immunity
Reynolds, J. M., Angkasekwinai, P., & Dong, C. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.10.002 · Cited by 244
CD1a-autoreactive T cells are a normal component of the human αβ T cell repertoire
de Jong, A., Peña‐Cruz, V., Cheng, T., Clark, R. A., Rhijn, I. V., & Moody, D. B. (2010) · Nature Immunology · doi:10.1038/ni.1956 · Cited by 243
Smoking in inflammatory bowel disease: Impact on disease course and insights into the aetiology of its effect
Parkes, G. C., Whelan, K., & Lindsay, J. O. (2014) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2014.02.002 · Cited by 235
The Treg/Th17 Cell Balance: A New Paradigm for Autoimmunity
Eisenstein, E. M., & Williams, C. B. (2009) · Pediatric Research · doi:10.1203/pdr.0b013e31819e76c7 · Cited by 235
Interleukin-22: A cytokine produced by T, NK and NKT cell subsets, with importance in the innate immune defense and tissue protection
Witte, E., Witte, K., Warszawska, K., Sabat, R., & Wolk, K. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.08.002 · Cited by 243
Nutrition Facts in Multiple Sclerosis
Riccio, P., & Rossano, R. (2015) · ASN NEURO · doi:10.1177/1759091414568185 · Cited by 247
BET bromodomain inhibition suppresses TH17-mediated pathology
Mele, D. A., Salmerón, A., Ghosh, S., Huang, H.-R., Bryant, B. M., & Lora, J. M. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20130376 · Cited by 234
Tr1 Cells and the Counter-Regulation of Immunity: Natural Mechanisms and Therapeutic Applications
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NFAT pulls the strings during CD4+ T helper cell effector functions
Hermann-Kleiter, N., & Baier, G. (2010) · Blood · doi:10.1182/blood-2009-10-233585 · Cited by 218
The emerging roles of AhR in physiology and immunity
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Microbiota-derived tryptophan catabolites mediate the chemopreventive effects of statins on colorectal cancer
Han, J., Tao, Z., Wang, J., Zhang, L., Yu, C., Kang, Z., Xie, Y., Li, J., Lu, S., Cui, Y., et al. (2023) · Nature Microbiology · doi:10.1038/s41564-023-01363-5 · Cited by 223
Signal transduction pathways and transcriptional regulation in Th17 cell differentiation
Hirahara, K., Ghoreschi, K., Laurence, A. D. J., Yang, X., Kanno, Y., & O’Shea, J. J. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.10.006 · Cited by 231
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Furue, M., Hashimoto-Hachiya, A., & Tsuji, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215424 · Cited by 215
Inhibition of cytochrome P4501-dependent clearance of the endogenous agonist FICZ as a mechanism for activation of the aryl hydrocarbon receptor
Wincent, E., Bengtsson, J., Mohammadi‐Bardbori, A., Alsberg, T. E., Luecke-Johansson, S., Rannug, U., & Rannug, A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118467109 · Cited by 221
Differential Expression of Interleukin-17A and -17F Is Coupled to T Cell Receptor Signaling via Inducible T Cell Kinase
Gómez‐Rodríguez, J., Sahu, N., Handon, R., Davidson, T. S., Anderson, S. M., Kirby, M., August, A., & Schwartzberg, P. L. (2009) · Immunity · doi:10.1016/j.immuni.2009.07.009 · Cited by 217
Aryl hydrocarbon receptor negatively regulates NLRP3 inflammasome activity by inhibiting NLRP3 transcription
Huai, W., Zhao, R., Song, H., Zhao, J., Zhang, L., Zhang, L., Gao, C., Han, L., & Zhao, W. (2014) · Nature Communications · doi:10.1038/ncomms5738 · Cited by 211
Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function
Li, S., Bostick, J. W., Ye, J., Qiu, J., Zhang, B., Urban, J. F., Avram, D., & Zhou, L. (2018) · Immunity · doi:10.1016/j.immuni.2018.09.015 · Cited by 215
IL-10 and IL-22 in Mucosal Immunity: Driving Protection and Pathology
Wei, H.-X., Wang, B., & Li, B. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01315 · Cited by 218
Interleukin-1β Selectively Expands and Sustains Interleukin-22+ Immature Human Natural Killer Cells in Secondary Lymphoid Tissue
Hughes, T. L., Becknell, B., Freud, A. G., McClory, S., Briercheck, E. L., Yu, J., Mao, C., Giovenzana, C., Nuovo, G. J., Wei, L., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.06.007 · Cited by 222
Intestinal Effector T Cells in Health and Disease
Maynard, C. L., & Weaver, C. T. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.012 · Cited by 215
The HSP60 immune system network
Quintana, F. J., & Cohen, I. R. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.11.001 · Cited by 210

Authors: Veldhoen, M., Hirota, K., Westendorf, A. M., Buer, J., Dumoutier, L., Renauld, J.-C., & Stockinger, B.
Affiliations: National Institute for Medical Research (GB)
Essen University Hospital (DE)
Ludwig Cancer Research (BE)
Corresponding author: Stockinger, Brigitta
ORCID: Veldhoen, Marc
Hirota, Keiji
Westendorf, Astrid M.
Buer, Jan
Dumoutier, Laure
Renauld, Jean-Christophe
Stockinger, Brigitta
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2008-03-23
Volume: 453
Issue: 7191
Pages: 106-109
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature06881
OpenAlex: W1993003564
Cited by: 1,634
References: 31
Citations by year: 2026: 33 · 2025: 44 · 2024: 49 · 2023: 54 · 2022: 87 · 2021: 94 · 2020: 96 · 2019: 90 · 2018: 96 · 2017: 93 · 2016: 96 · 2015: 82 · 2014: 114 · 2013: 107 · 2012: 118
FWCI: 52.43
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
HZI (Helmholtz Centre for Infection Research) (submittedVersion)
RePEc: Research Papers in Economics (submittedVersion)
DIAL (Catholic University of Leuven) (submittedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: University of Leicester
Topics: Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords: aryl hydrocarbon receptor, Th17 cells, autoimmunity, environmental toxins, IL-22, experimental autoimmune encephalitis, multiple sclerosis, regulatory T cells, CD4+ T cells, immunomodulation, AhR ligands, dioxins, IL-17
MeSH terms: Interleukin-22, Animals, Cell Differentiation, Cells, Cultured, Encephalomyelitis, Autoimmune, Experimental, Environmental Exposure, Environmental Pollutants, T-Lymphocytes, Helper-Inducer, Humans, Interleukins, Ligands, Mice, Inbred C57BL, Transduction, Genetic, Hazardous Substances, Autoimmunity, Receptors, Aryl Hydrocarbon, Interleukin-17, Mice

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The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

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