Puzzles, promises and a cure for ageing

Vijg, Jan, Campisi, Judith·2008·Nature

DOI 10.1038/nature07216

Cited by (406)

Items 201–300 of 406

Accumulation of annexin A5 at the nuclear envelope is a biomarker of cellular aging
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Jean‐Yves Le Gall, Raymond Ardaillou · 2009 · PubMed
Human mortality at extreme age
Léo R. Belzile, Anthony C. Davison, Holger Rootzén, Dmitrii Zholud · 2021 · Royal Society Open Science
Horizons in Human Aging Neuroscience: From Normal Neural Aging to Mental (Fr)Agility
K. Richard Ridderinkhof, Harm J. Krugers · 2022 · Frontiers in Human Neuroscience
Human genetic variations: Beacons on the pathways to successful ageing
Christie Cluett, David R. Melzer · 2009 · Mechanisms of Ageing and Development
Control of aging by the renin–angiotensin system: a review of C. elegans, Drosophila, and mammals
Brian M. Egan, Andrea Scharf, Franziska Pohl, Kerry Kornfeld · 2022 · Frontiers in Pharmacology
Dietary amelioration of locomotor, neurotransmitter and mitochondrial aging
Vadim Aksenov, Jiangang Long, Sonali Lokuge, Jane Allyson Foster, Jiankang Liu, C. David Rollo · 2010 · Experimental Biology and Medicine
Aging on a different scale – chronological versus pathology-related aging
Joost P.M. Melis, Martijs J. Jonker, Jan Vijg, Jan H.J. Hoeijmakers, Timo M. Breit, Harry VAN STEEG · 2013 · Aging
Expression Profiling of Cytokine, Cholinergic Markers, and Amyloid-β Deposition in the APP SWE /PS1dE9 Mouse Model of Alzheimer’s Disease Pathology
Marcella Reale, Chiara D’Angelo, Erica Costantini, Marta Di Nicola, Nagendra Sastry Yarla, Mohammad Amjad Kamal, Nieves Salvador, George L. Perry · 2018 · Journal of Alzheimer s Disease
Decline in oxygen consumption correlates with lifespan in long-lived and short-lived mutants of Caenorhabditis elegans
Tetsuji Shoyama, Yuka Shimizu, Hitoshi Suda · 2009 · Experimental Gerontology
Postprandial Activation of P53-Dependent DNA Repair Is Modified by Mediterranean Diet Supplemented With Coenzyme Q10 in Elderly Subjects
Francisco Miguel Gutierrez-Mariscal, Elena M. Yubero‐Serrano, Oriol Alberto Rangel-Zúñiga, Carmen Marı́n, Antonio García‐Ríos, Pablo Pérez‐Martínez, Javier Delgado‐Lista, Marı́a M. Malagón, Francisco José Tinahones, Francisco Pérez‐Jiménez et al. · 2013 · The Journals of Gerontology Series A
Genome instability: Linking ageing and brain degeneration
Ari Barzilai, Björn Schumacher, Yosef Shiloh · 2016 · Mechanisms of Ageing and Development
Aging Biomarkers and Novel Targets for Anti-Aging Interventions
Kang Xu, Yannan Guo, Zhongchi Li, Zhao Wang · 2019 · Advances in experimental medicine and biology
2,6-Dimethoxy-1,4-benzoquinone increases skeletal muscle mass and performance by regulating AKT/mTOR signaling and mitochondrial function
Ahyoung Yoo, Young Jin Jang, Jiyun Ahn, Chang Hwa Jung, Tae Youl Ha · 2021 · Phytomedicine
Protein acetylation and aging
Jin‐Ying Lu, Yu-Yi Lin, Heng Zhu, Lee‐Ming Chuang, Jef D. Boeke · 2011 · Aging
Imaging biomarkers of ageing: a review of artificial intelligence-based approaches for age estimation
Fridolin Haugg, Grace Clara Lee, John He, Justin Johnson, Anna Zapaishchykova, Danielle S. Bitterman, Benjamin Harris Kann, Hugo J.W.L. Aerts, Raymond H. Mak · 2025 · The Lancet Healthy Longevity
The telomere-mitochondrial axis of aging in newborns
Charlotte Van Der Stukken, Tim S. Nawrot, Rossella Alfano, Congrong Wang, Sabine A. S. Langie, Michelle Plusquin, Bram G. Janssen, Dries S. Martens · 2022 · Aging
Ageing world: Health care challenges
Vinay K. Mahishale · 2015 · Journal of the Scientific Society
Speeding up the clock: The past, present and future of progeria
Vijay Swahari, Ayumi Nakamura · 2015 · Development Growth & Differentiation
Motor performance is preserved in healthy aged adults following severe whole-body hyperthermia
Marius Brazaitis, Henrikas Paulauskas, Nerijus Eimantas, Laura Daniusevičiūtė, Gintautas Volungevičius, Albertas Skurvydas · 2018 · International Journal of Hyperthermia
Hypothalamic lipophagy and energetic balance
Rajat Singh · 2011 · Aging
Aging Promotes Chronic Stress-Induced Depressive-Like Behavior by Activating NLRP1 Inflammasome-Driven Inflammatory Signaling in Mice
Yajing Zhu, Jun-Juan Fan, Fangyi Wu, Ming Zhang, Aoqi Song, Yong Li, Yan-Kun Li, Wen‐Ning Wu · 2022 · Inflammation
Sarcoplasmic reticulum Ca2+ decreases with age and correlates with the decline in muscle function in Drosophila
Alba Delrio-Lorenzo, Jonathan Rojo‐Ruiz, Marı́a Teresa Alonso, Javier Garcı́a-Sancho · 2020 · Journal of Cell Science
The DNA Methylome As A Biomarker for Epigenetic Instability and Human Aging
Andrew R. Mendelsohn, James W. Larrick · 2013 · Rejuvenation Research
MTBP and MYC: A Dynamic Duo in Proliferation, Cancer, and Aging
Brian C. Grieb, Christine M. Eischen · 2022 · Biology
Copy Number Variations in Alternative Splicing Gene Networks Impact Lifespan
Joseph Glessner, Albert V. Smith, Saarene Panossian, Cecilia Kim, Nagahide Takahashi, Kelly Thomas, Fengxiang Wang, Kallyn Seidler, Tamara B. Harris, Lenore J. Launer et al. · 2013 · PLoS ONE
Functional relevance of miRNAs in premature ageing
Xurde M. Caravia, David Roiz‐Valle, Alba Morán-Álvarez, Carlos López-Otín · 2017 · Mechanisms of Ageing and Development
The human ΔNp53 isoform triggers metabolic and gene expression changes that activate mTOR and alter mitochondrial function
Shih‐Chieh Lin, Edward D. Karoly, Dylan J. Taatjes · 2013 · Aging Cell
Health- and Disease-Related Biomarkers in Aging Research
Hilaire J. Thompson, Joachim G. Voss · 2009 · Research in Gerontological Nursing
Rejuvenating somatotropic signaling: a therapeutical opportunity for premature aging?
Alejandro Pineiro Ugalde, Guillermo Mariño, Carlos López-Otı́n · 2010 · Aging
APOEϵ4, rated life experiences, and affect among centenarians
Peter Martin, S. Michal Jazwinski, Adam Davey, Robert C. Green, Maurice M. MacDonald, Jennifer A. Margrett, Ilene C. Siegler, Jonathan Arnold, John L. Woodard, Mary Ann Johnson et al. · 2013 · Aging & Mental Health
Does Taurine Prolong Lifespan by Improving Heart Function?
Stephen W. Schaffer, K. C. Ramila, Chian Ju Jong, Aza Shetewy, Kayoko Shimada, Takashi Ito, Junichi Azuma, Eugene A. Cioffi · 2015 · Advances in experimental medicine and biology
Correction: RNA Editing Genes Associated with Extreme Old Age in Humans and with Lifespan in C. elegans
Paola Sebastiani B, Monty A Montano, Annibale Alessandro Puca, Nadia Solovieff, Toshio Kojima, Meng Carla Wang, Efthymia Melista, Micah Meltzer, Sylvia E. J. Fischer, Stacy L. Andersen et al. · 2009 · PLoS ONE
Myc-Interacting Zinc Finger Protein 1 (Miz-1) Is Essential to Maintain Homeostasis and Immunocompetence of the B Cell Lineage
Eva-Maria Piskor, Julie Ross, Tarik Möröy, Christian Kosan · 2022 · Biology
Facilitation of Ovarian Response by Mechanical Force—Latest Insight on Fertility Improvement in Women with Poor Ovarian Response or Primary Ovarian Insufficiency
Chia Lin Chang · 2023 · International Journal of Molecular Sciences
Amelioration of cognitive ability in senescence-accelerated mouse prone 8 (SAMP8) by intra-bone marrow-bone marrow transplantation
Ming Li, Muneo Inaba, Kequan Guo, Nader G. Abraham, Susumu Ikehara · 2009 · Neuroscience Letters
Age-associated molecular changes are deleterious and may modulate life span through diet
Sang‐Goo Lee, Alaattin Kaya, Andrei S. Avanesov, Dmitriy I. Podolskiy, Eun Ju Song, Du‐Min Go, Gwi-Deuk Jin, Jae Yeon Hwang, Eun Bae Kim, Dae-Yong Kim et al. · 2017 · Science Advances
Impact of aging on gene expression response to x-ray irradiation using mouse blood
Constantinos G. Broustas, Axel J. Duval, Sally A. Amundson · 2021 · Scientific Reports
Shining a light on defective autophagy by proteomics approaches: implications for neurodegenerative illnesses
Fabio Di Domenico, Ilaria Zuliani, Antonella Tramutola · 2019 · Expert Review of Proteomics
Aging — Lost in Translation?
Pankaj Kapahi, Jan Vijg · 2009 · New England Journal of Medicine
The Biological Mechanisms of Aging: A Historical and Critical Overview
Sataro Goto · 2015 · Springer eBooks
Transplanting Microglia for Treating CNS Injuries and Neurological Diseases and Disorders, and Prospects for Generating Exogenic Microglia
Susanna R. Var, Phoebe Strell, Sether T. Johnson, Alex Roman, Zoey Vasilakos, Walter C. Low · 2023 · Cell Transplantation
Extending the Human Life Span: An Exploratory Study of Pro- and Anti-Longevity Attitudes
Nathan Kogan, Jennifer Tucker, Matthew Porter · 2011 · The International Journal of Aging and Human Development
Amino Acid Homeostasis and Chronological Longevity in Saccharomyces cerevisiae
John P. Aris, Laura K. Fishwick, Michelle L. Marraffini, Arnold Young Seo, Christiaan Leeuwenburgh, William A. Dunn · 2011 · Sub-cellular biochemistry/Subcellular biochemistry
“Boomerang Neuropathology” of Late-Onset Alzheimer’s Disease is Shrouded in Harmful “BDDS”: Breathing, Diet, Drinking, and Sleep During Aging
Daulatzai, Mak Adam · 2015 · Neurotoxicity Research
Cell proliferation arrest and redox state status as part of different stages during senescence establishment in mouse fibroblasts
Francisco Triana-Martínez, Norma Edith López‐Díazguerrero, Luis Ángel Maciel-Barón, Sandra Lizbeth Morales-Rosales, Sonia Galván‐Arzate, Francisco José Fernández, Alejandro Zentella‐Dehesa, Viviana Pérez, Luis Enrique Gómez-Quiroz, Mina Königsberg · 2013 · Biogerontology
dbAARD & AGP: A computational pipeline for the prediction of genes associated with age related disorders
Isha Srivastava, Lokesh Kumar Gahlot, Pooja Khurana, Yasha Hasija · 2016 · Journal of Biomedical Informatics
Genes Related to Fatty Acid β-Oxidation Play a Role in the Functional Decline of the Drosophila Brain with Age
António Laranjeira, Joachim Schulz, Carlos G. Dotti · 2016 · PLoS ONE
Functional analyses of human DNA repair proteins important for aging and genomic stability using yeast genetics
Monika Aggarwal, Robert M. Brosh · 2012 · DNA repair
Warfarin Accelerates Aortic Calcification by Upregulating Senescence-Associated Secretory Phenotype Maker Expression
Wei, Ningle, Lu, Liuyi, Zhang, Huanji, Gao, Ming, Ghosh, Sounak, Liu, Zhaoyu, Qi, Junhua, Wang, Jingfeng, Chen, Jie, Huang, Hui · 2020 · Oxidative Medicine and Cellular Longevity
Transgenic mice overexpressing glia maturation factor-β, an oxidative stress inducible gene, show premature aging due to Zmpste24 down-regulation
Rika Imai, Kanae Asai, Jun‐ichi Hanai, Masaru Takenaka · 2015 · Aging
Association between WNT-1-inducible signaling pathway protein-1 (WISP1) genetic polymorphisms and the risk of gastric cancer in Guangxi Chinese
Yanqiong Liu, Weijuan Qin, Fuyong Zhang, Jian Wang, Xi Li, Shan Li, Xue Ying Qin, Yuefeng Lu · 2021 · Cancer Cell International
Changes in the frequencies of human hematopoietic stem and progenitor cells with age and site
Tracy L. Farrell, Timothy R. McGuire, Laura D. Bilek, Susan K. Brusnahan, John D. Jackson, Judy T. Lane, Kevin L. Garvin, Barbara Jean O'Kane, Ann M. Berger, Sonal R. Tuljapurkar et al. · 2013 · Experimental Hematology
Telomerase regulation and the intimate relationship with aging
Garrett Morgan · 2013 · Research and Reports in Biochemistry
Strategies for future histocompatible stem cell therapy
Jan Olof Nehlin, Torben Barington · 2009 · Biogerontology
Chronological and Functional Ageing
Jack M. Guralnik, David R. Melzer · 2002 · Wiley eBooks
Using Functional Proteome Microarrays to Study Protein Lysine Acetylation
Jin‐Ying Lu, Yu-Yi Lin, Jef D. Boeke, Heng Zhu · 2012 · Methods in molecular biology
Integration of Metabolism
Gerhard Meisenberg, William H. Simmons · 2012 · Elsevier eBooks
Biologie du vieillissement
Jean‐Yves Le Gall, Raymond Ardaillou · 2009 · Bulletin de l Académie Nationale de Médecine
Ageing, clinical complexity, and exercise therapy: a multidimensional approach
Salvatore Corrao, Dario Cerasola, Daniela Lucini, Christiano Argano · 2025 · Frontiers in Sports and Active Living
Biomarker Validation for Aging: Lessons from mtDNA Heteroplasmy Analyses in Early Cancer Detection
Peter E. Barker, Mahadev Murthy · 2009 · Biomarker Insights
Studying health histories of cancer: A new model connecting cancer incidence and survival
Anatoli I. Yashin, Igor V. Akushevich, Konstantin G. Arbeev, Lucy Akushevich, Alexander M. Kulminski, Svetlana V. Ukraintseva · 2009 · Mathematical Biosciences
Redefining medicine from an anticipatory perspective
Mihai Nadin · 2018 · Progress in Biophysics and Molecular Biology
Biological Restraints on Indefinite Survival
Jan Vijg, Steven N. Austad · 2022 · Cold Spring Harbor Perspectives in Medicine
Identifying gender independent biomarkers responsible for human muscle aging using microarray data
Emmanouil G. Sifakis, Ioannis K. Valavanis, Olga Papadodima, Aristotelis A. Chatziioannou · 2013 · IEEE International Conference on Bioinformatics and Bioengineering (BIBE)
Can Biogerontologists and Geriatricians Unite to Apply Aging Science to Health Care in the Decade Ahead?
David Hamerman · 2010 · The Journals of Gerontology Series A
Ageing impacts phenotypic flexibility in an air-acclimated amphibious fish
Giulia S. Rossi, Paige V. Cochrane, Louise Tunnah, Patricia A. Wright · 2019 · Journal of Comparative Physiology B
Burn Fat, Live Longer
Ting Xie · 2008 · Science
A physicochemical perspective on cellular ageing
Sara N. Mouton, Arnold J. Boersma, Liesbeth M. Veenhoff · 2023 · Trends in Biochemical Sciences
Artificial Hsp104-mediated systems for re-localizing protein aggregates
Arthur Fischbach, Angela Johns, Kara L. Schneider, Xinxin Hao, Peter Tessarz, Thomas Nyström · 2023 · Nature Communications
Aging and Obesity Induce Distinct Gene Expression Adaptation in the Liver of C57BL/6J Mice
Frédéric Capel, Marie-Hélène Delmotte, M. Brun, Michel Lonchampt, Brant A. De Fanti, Laura Xuereb, Louise Baschet, G. Rolland, Jean‐Pierre Galizzi, Brian Paul Lockhart et al. · 2011 · Lifestyle Genomics
The rosetta stone of successful ageing: does oral health have a role?
Maximilian Poser, Katie E. A. Sing, Thomas Ebert, Dirk Ziebolz, Gerhard Schmalz · 2023 · Biogerontology
Constitutive, Muscle-Specific Orai1 Knockout Results in the Incomplete Assembly of Ca2+ Entry Units and a Reduction in the Age-Dependent Formation of Tubular Aggregates
Alessia Di Fonso, Matteo Serano, Miao He, Jennifer Leigh, Giorgia Rastelli, Robert T. Dirksen, Feliciano Protasi, Laura Pietrangelo · 2024 · Biomedicines
High Preservation of CpG Cytosine Methylation Patterns at Imprinted Gene Loci in Liver and Brain of Aged Mice
Silvia Gravina, Martijn E.T. Dollé, Tao Wang, Harry VAN STEEG, Paul Hasty, Jan H.J. Hoeijmakers, Jan Vijg · 2013 · PLoS ONE
Biomarkers of chondriome topology and function: implications for the extension of healthy aging
David Hollar · 2016 · Biogerontology
Aging of Podospora anserina Leads to Alterations of OXPHOS and the Induction of Non-Mitochondrial Salvage Pathways
Verena Warnsmann, Jana Meisterknecht, Ilka Wittig, Heinz Dieter Osiewacz · 2021 · Cells
MORE for multiple organ dysfunction syndrome: Multiple Organ REanimation, REgeneration, and REprogramming*
J. Perren Cobb · 2010 · Critical Care Medicine
mTOR signaling controls protein aggregation during heat stress and cellular aging in a translation- and Hsf1-independent manner
Arthur Fischbach, Per O. Widlund, Xinxin Hao, Thomas Nyström · 2025 · Journal of Biological Chemistry
Aging and Altered Gravity: A Cellular Perspective
Sharon van Rijthoven, Jack J. W. A. van Loon · 2025 · The FASEB Journal
Natural polymorphism in protein kinase G modulates functional senescence in D. melanogaster
Stephanie P. Kelly, Ken D. Dawson-Scully · 2019 · Journal of Experimental Biology
EFFECTS AND MECHANISMS OF A NEW MULTIVITAMIN ON CHRONIC METABOLIC SYNDROMES AND AGING
Suxi Wu, Xuewei Jiang, Yuying Liu, Lin‐Feng Chen, Jun Tao · 2016 · African Journal of Traditional Complementary and Alternative Medicines
Aging: rewiring the circadian clock
Rika Ohkubo, Danica Chen · 2017 · Nature Structural & Molecular Biology
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Byung Mook Weon, Jung Ho Je · 2010 · Natural Science
Calorie Restriction Mimetics and Aging
Brian J. Morris · 2010 · Springer eBooks
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Arti Hurria, Hyman Bernard Muss, Harvey Jay Cohen · 2017 · Wiley eBooks
Nectandrin B significantly increases the lifespan of Drosophila - Nectandrin B for longevity
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Yinghao Xia, Jili Li, Linlin Wang, Yuqi Xie, Lili Zhang, Xiaoyan Han, Weihong Tan, Yanlan Liu · 2022 · Angewandte Chemie
Aging and bone
Maria Almeida, Stavros C. Manolagas · 2019 · Elsevier eBooks
Old Age Is an Incurable Disease—or Is It?
Maartje Schermer · 2012 · Ethics and health policy
The Emergence of GeroMIRs: A Group of MicroRNAs Implicated in Aging
Alejandro Pineiro Ugalde, Agnieszka Kwarciak, Xurde M. Caravia, Carlos López-Otı́n, Andrew J. Ramsay · 2013 · Wiley eBooks
Editorial - Progress and Vision for ‘Current Aging Science’
Debomoy K. Lahiri · 2009 · Current Aging Science
Effects of molecular interactions between the exposome and oxylipin metabolism on healthspan
Jennifer Hinman, Jamie K. Alan, Kin Sing Stephen Lee · 2025 · Frontiers in Physiology
The Hallmarks of aging: Paradigms and scientific progress
Pablo García‐Barranquero, Víctor J. Luque · 2026 · Ageing Research Reviews
Integrating Aging into Geriatric Practice: An Emerging Orientation for Health Care
David Hamerman · 2010 · Journal of the American Geriatrics Society
Noncoding RNAs evolutionarily extend animal lifespan
Anyou Wang · 2025 · Global Medical Genetics
Gerontology versus Geriatrics: Different Ways of Understanding Ageing and Old Age
Chris J. Gilleard, PAUL F. D. HIGGS · 2016 · Palgrave Macmillan UK eBooks
Loss of immune regulation in aged T-cells: A metabolic review to show lack of ability to control responses within the self
Bharat Singh, Ambak Kumar Rai · 2022 · Human Immunology