Puzzles, promises and a cure for ageing

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

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Cellular senescence: when bad things happen to good cells

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Resveratrol improves health and survival of mice on a high-calorie diet

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Epigenetic differences arise during the lifetime of monozygotic twins

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Nothing in Biology Makes Sense except in the Light of Evolution

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Evolution of ageing

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Understanding the odd science of aging

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AN UNSOLVED PROBLEM OF BIOLOGY

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Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging

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Mitochondrial Respiratory-Chain Diseases

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Molecular determinants of life span

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27 Biodemography

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Is Alzheimer’s a Disorder of Ageing and Why Don’t Mice get it? The Centrality of Insulin Signalling to Alzheimer’s Disease Pathology

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Iron Depletion Reduces Abce1 Transcripts While Inducing the Mitophagy Factors Pink1 and ParkinPreprint

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A Multidisciplinary Approach to Explain Biological Aging and LongevityPreprint

Augsburger, B. N. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/045633 · Cited by 3

Why Do We Wish to be Enhanced?

Menuz, V. (2015) · Palgrave Macmillan UK eBooks · doi:10.1057/9781137530073_4 · Cited by 2

Phosphorus – A luminous (enlightening) element

Hahn, K. M., & Winterberg, B. (2020) · Trace Elements and Electrolytes · doi:10.5414/tex01632 · Cited by 2

An Unsolved Problem in Gerontology Yet: Molecular Mechanisms of Biological Aging—A Historical and Critical Overview

Goto, S. (2022) · Springer eBooks · doi:10.1007/978-981-16-7977-3_1 · Cited by 2

Is there a need for consensus in aging biology?

Guillermain, C. (2022) · Biology & Philosophy · doi:10.1007/s10539-022-09882-x · Cited by 3

Leukocyte Telomere Dynamics, Human Aging, and Life Span

Aviv, A. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-378638-8.00007-5 · Cited by 3

Fear of Death as the Foundation of Modern Political Philosophy and Its Overcoming by Transhumanism

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An Intensive Mind and Body Therapeutic Program Leads to Alteration in Gene Expression Critical to Aging Process in Peripheral Blood Stem Cells

Rao, K. S., Chakrabarti, S. K., Dongare, V. S., Sharath, B. S., Vikas, H. M., Chetana, K., & Deb, K. D. (2015) · Advances in Aging Research · doi:10.4236/aar.2015.43011 · Cited by 2

From space medicine to preventive and personalized health care on earth

Ongaro, F. (2014) · Acta Astronautica · doi:10.1016/j.actaastro.2014.05.007 · Cited by 2

Systems Biology and Bioinformatics in Aging Research: A Workshop Report

Fuellen, G., Dengjel, J., Hoeflich, A., Hoeijemakers, J., Kestler, H. A., Kowald, A., Priebe, S., Rebholz‐Schuhmann, D., Schmeck, B., Schmitz, U., et al. (2012) · Rejuvenation Research · doi:10.1089/rej.2012.1360 · Cited by 2

Infección por el virus de la inmunodeficiencia humana como modelo de envejecimiento prematuro: perspectivas e implicaciones

Joven, J., & Menéndez, J. A. (2012) · Medicina Clínica · doi:10.1016/j.medcli.2012.01.015 · Cited by 2

A Web-Based Environment for Explanatory Biological Modeling

Pat Langley, B., & Hunt, G. (2012) · ResearchSpace (University of Auckland) · Cited by 2

The Stem Cell Hypothesis of Aging

Meiliana, A., & Wijaya, A. (2010) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v2i1.108 · Cited by 2

The Role of Senescence in Hepatic Diseases

Pacheco-Rivera, R., Arellanes‐Robledo, J., de León, M. C. G., Shibayama, M., & Serrano‐Luna, J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804274-8.00023-0 · Cited by 3

Supraphysiological protection from replication stress does not extend mammalian lifespan

Albers, E., Avram, A., Sbroggió, M., Fernández-Capetillo, Ó., & Lopez-Contreras, A. J. (2020) · Aging · doi:10.18632/aging.103039 · Cited by 2

Senescent Liver

Timchenko, N. A. (2010) · Molecular pathology library · doi:10.1007/978-1-4419-7107-4_19 · Cited by 2

Impact of Curcumin on Aging: Its Manifestations and Limitations

Banji, D., & Banji, O. J. F. (2023) · Springer eBooks · doi:10.1007/978-981-99-7731-4_13 · Cited by 2

Three different motor task strategies to assess neuromuscular adjustments during fatiguing muscle contractions in young and older men

Kyguolienė, L., Skurvydas, A., Eimantas, N., Baranauskienė, N., Steponavičiūtė, R., Daniusevičiūtė, L., Paulauskas, H., Černych, M., & Brazaitis, M. (2018) · Experimental Brain Research · doi:10.1007/s00221-018-5285-4 · Cited by 2

The Age of Obsolescence: Senescence and Scientific Rejuvenation in Twentieth Century America

Lamb, E. G. (2008) · DukeSpace (Duke University) · Cited by 2

Chronological and Functional Ageing

Melzer, D. R., & Lang, I. (2010) · Wiley eBooks · doi:10.1002/9780470669600.ch12 · Cited by 2

Redox homeostasis in ferroptosis and aging: a causal role for fard-1 and dhs-25 in Caenorhabditis elegans

Pensotti, R., Sciandrone, B., Bovio, F., Schröter, L., Maglioni, S., Thewes, L., Forcella, M. E., Rossi, A., Fusi, P. A., Berndt, C., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103912 · Cited by 2

Face aging rate quantifies change in biological age to predict cancer outcomes

Haugg, F., Lee, G.-S. M., He, J., Warrington, A., Bontempi, D., Bitterman, D. S., Catalano, P. J., Prudente, V., Pai, S., Guthier, C., et al. (2026) · Nature Communications · doi:10.1038/s41467-025-66758-w · Cited by 1

Biomarkers of Cardiovascular Aging

Neki, N. S., Tappia, P. S., & Dhalla, N. S. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0268-2_20 · Cited by 1

Assessment of Aging in Saccharomyces Cerevisiae Yeast Mutants Using Microscopy Techniques

Krzepiłko, A. (2009) · Polish Journal of Environmental Studies · Cited by 1

An interactive environment for explanatory biological modeling

Langley, P. (2010) · eScholarship (California Digital Library) · Cited by 1

Establishing the microcrustacean Daphnia as a model system for research on aging

Schumpert, C. A. (2015) · Scholar Commons (University of South Carolina) · Cited by 1

Comparison of Lazy and Eager Hierarchical Feature Selection Methods and Biological Interpretation on Frequently Selected Gene Ontology Terms Relevant to the Biology of Ageing

Wan, C. (2018) · Advanced information and knowledge processing · doi:10.1007/978-3-319-97919-9_7 · Cited by 1

Background on Biology of Ageing and Bioinformatics

Wan, C. (2018) · Advanced information and knowledge processing · doi:10.1007/978-3-319-97919-9_4 · Cited by 1

Hepatocyte Growth, Proliferation and Experimental Carcinogenesis

Ledda‐Columbano, G. M., & Columbano, A. (2010) · Molecular pathology library · doi:10.1007/978-1-4419-7107-4_54 · Cited by 1

A constraints-based theory of the primary cause of senescence: imbalance of epigenetic and non-epigenetic information in histone crosstalkPreprint

Veloso, F. A. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/310300 · Cited by 1

Dietary shift improves the survival of stressed nematodesPreprint

Liu, T., Yu, F., Zhou, M., Xu, J., Hu, F., Li, H., & Whalen, J. K. (2024) · doi:10.22541/au.170664948.89171069/v1 · Cited by 1

Regulation of the Promyelocytic Leukemia Protein and Its Role in Premature Senescence

Lau, A. W., Tron, A. E., & Wei, W. (2014) · Springer eBooks · doi:10.1007/978-94-017-9325-4_9

On the Search for Reliable Human Aging Models: Understanding Aging by Nuclear Reprogramming

Sancho-Martinez, I., Nivet, E., & Belmonte, J. C. I. (2013) · Research and perspectives in neurosciences · doi:10.1007/978-3-642-36648-2_11

Worming to Complete the Insulin/IGF-1 Signaling Cascade: A Dissertation

Padmanabhan, S. (2009) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/40am-yf26

Molecular studies of Hutchinson-Gilford progeria syndrome

Sagelius, H. (2009) · Figshare

Biological role and disease impact of copy number variation in complex disease

Glessner, J. (2014) · ScholarlyCommons (University of Pennsylvania)

Genomics and bioinformatics strategies in the study of aging and Alzheimer disease

Hong, M. (2011) · Figshare

Molecular and Endocrine Mechanisms Underlying the Stem Cell Theory of Aging

Coutu, D. L., & Galipeau, J. (2013) · Stem cell biology and regenerative medicine · doi:10.1007/978-1-4614-9569-7_17

An Entropy-based Statistical Workflow Provides Noise-Minimizing Biological Annotation for

Aging, M., Koutsandreas, T., Valavanis, I. K., Pilalis, E. D., & Chatziioannou, A. A. (2014) · IEEE International Conference on Systems Biology · doi:10.1109/isb.2014.6990749

Influences du concept de mort dans les efforts visant à ralentir le vieillissement et augmenter la longévité

Menuz, V. (2014) · Psychologie clinique · doi:10.1051/psyc/201438140

A strategy for successful late life based on biomedical findings in gerontology

Goto, S. (2010) · Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics · doi:10.3143/geriatrics.47.107

Human lifespan: what determines the intrinsic length of human lives?

Crosse, D. J. (2011) · Reviews in Clinical Gerontology · doi:10.1017/s0959259811000062

Brief View on Future and Current Ageing Science and beyond: Going Simple is the New Exciting

Li, Y. Z. Y. (2013) · Journal of Aging Science · doi:10.4172/2329-8847.1000e101

Methods for Identifying Pathway Epistasis and the Effects of Aging on the Human Methylome

Hannum, G. (2012) · eScholarship (California Digital Library)

Calibrating Notch/TGF-β Signaling for Youthful, Healthy Tissue Maintenance and Repair

Carlson, M. E., & Conboy, I. M. (2010) · Springer eBooks · doi:10.1007/978-90-481-3999-6_13

Increasing Genetic Contribution to Exceptional Longevity with Increasing Age

Perls, T. T., & Sebastiani, P. (2012)

A data mining-based approach for investigating the relationship between DNA repair genes and ageing

Freitas, A. A. (2011) · University of Liverpool · doi:10.17638/00001475

The Biology of Immortality

Stratmann, H. G. (2015) · Science and fiction · doi:10.1007/978-3-319-16015-3_9

The effect of radiation on cellular ageing

Sabin, R. J. (2012) · Brunel University Research Archive (BURA) (Brunel University London)

An Entropy-based Statistical Workflow Provides Noise-Minimizing Biological Annotation for Muscular Aging

Koutsandreas, T., Valavanis, I. K., Pilalis, E. D., & Chatziioannou, A. A. (2014) · doi:10.13140/2.1.1415.2644

Padrão de metilação de DNA para fins forenses: análise de células de sangue, sêmen e saliva; e estudo de sensibilidade e especificidade

Silva, D. S. B. S. (2015) · Americanae (AECID Library)

Oncogène RAS et Cancer Colorectal : Étude de la Réponse au Stress Oncogénique et de l'Échappement à la Sénescence

Trécesson, S. D. C. (2010) · OpenGrey (Institut de l'Information Scientifique et Technique)

Vorzeitiges Sterben in molekularbiologischer Perspektive

Boege, F. (2009) · Social Science Open Access Repository (GESIS – Leibniz Institute for the Social Sciences) · doi:10.12759/hsr.34.2009.4.61-65

The influence of ageing and culture conditions on limbal epithelial cells

Hallam, D. (2015)

An Interactive Environment for Qualitative Biological Modeling

Pat Langley, B., & Kim, S. (2011)

Physiological Role of Autophagy and Implications in Disease

Karanasios, E., & Ktistakis, N. T. (2016) · Springer eBooks · doi:10.1007/978-3-319-33145-4_5

The Role of p38 MAPK in Protein Homeostasis and Aging

Ryan, S. M. (2016) · Digital Commons - DU (University of Denver)

Der Alterungsprozess und potentielle Interventionen zur Verlängerung der Lebenszeit

Schaetzlein, S. (2017) · Interdisziplinäre Anthropologie · doi:10.1007/978-3-658-19556-4_9

Chemoprevention of Gastric Cancer: Metformin

Kim, Y., & Cho, S. (2017) · The Korean Journal of Helicobacter and Upper Gastrointestinal Research · doi:10.7704/kjhugr.2017.17.4.179

Immunomodulation by raw bovine milk and its ingredients: effects in nutritional intervention, oral vaccination and trained immunity

van Splunter, M. (2018) · doi:10.18174/453828

Case history-taking

Conway, P. (2010) · Elsevier eBooks · doi:10.1016/b978-0-443-07492-9.00011-4

Investigating the role of cua-1 in maintaining copper homeostasis within a long-lived, insulin-signalling, C. elegans mutants

Ganio, K. (2017) · Minerva Access (University of Melbourne)

Predicting human lifespan limits

Weon, B. M. (2010) · Natural Science · doi:10.4236/ns.2009.29120

The Origins of Ageing

Swynghedauw, B. (2019) · Practical issues in geriatrics · doi:10.1007/978-3-030-15111-9_3

The Molecular Physiology of Ageing: New Targets for Regenerative Medicine

Macip, S., & Althubiti, M. (2019) · Springer eBooks · doi:10.1007/978-3-030-15458-5_3

THE ASSOCIATION OF HABITUAL MILK INTAKE WITH THE RATE OF COGNITIVE DECLINE, AND RISK OF MILD COGNITIVE IMPAIRMENT AND DEMENTIA.

Petruski‐Ivleva, N. (2017) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/j7sy-9s93

Senėjimo molekuliniai mechanizmai ir įtaka kvėpavimo takų ligoms

Januškevičius, A., & Lavinskienė, S. (2015) · Pulmonology and allergology · doi:10.37499/pia.311

Sarcoplasmic reticulum Ca2+ dynamics in aging Drosophila and correlation with sarcopenia

Delrio-Lorenzo, A. (2020) · UVaDOC UVaDOC University of Valladolid Documentary Repository (University of Valladolid) · doi:10.35376/10324/43643

Strategies for Engineered Negligible Senescence

de Grey, A. D. N. J., & Rae, M. J. (2021) · Springer eBooks · doi:10.1007/978-3-030-22009-9_387

Faculty Opinions recommendation of The thyroid hormone receptor β induces DNA damage and premature senescence.

Santisteban, P. (2014) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718229787.793493009

Faculty Opinions recommendation of The hallmarks of aging.

Hickson, I. D., & Mankouri, H. W. (2013) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718061760.793481794

Faculty Opinions recommendation of Genome-wide methylation profiles reveal quantitative views of human aging rates.

Promislow, D. (2013) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.717970933.793472305

Strategies for Engineered Negligible Senescence

de Grey, A. D. N. J., & Rae, M. J. (2021) · Springer eBooks · doi:10.1007/978-3-319-69892-2_387-2

Strategies for Engineered Negligible Senescence

de Grey, A. D. N. J., & Rae, M. J. (2019) · Springer eBooks · doi:10.1007/978-3-319-69892-2_387-1

Introduction

Swynghedauw, B. (2019) · Practical issues in geriatrics · doi:10.1007/978-3-030-15111-9_1

Faculty Opinions recommendation of Fisetin is a senotherapeutic that extends health and lifespan.

Schumacher, B. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734139615.793563345

Aging

Rommy von Bernhardi, M., Flores, B., & Nakanishi, H. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1429-6_13

Risk Factors and Non-Pharmacological Prevention of Dementia

D’Hooge, R., der Jeugd, A. V., Engelborghs, S., Waldorff, F. B., & Vandenbulcke, M. (2022) · Cambridge University Press eBooks · doi:10.1017/9781108918954.009

Elimination of damaged cells-dependent antiaging strategy

Naik, R. A., Dubey, V., Rajpoot, R., Dash, D., Gupta, N., & Koiri, R. K. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90235-9.00013-6

Aging

Zeliger, H. I. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91890-9.00025-8

Resolving Geroplasticity to the Balance of Rejuvenins and Geriatrins

TABIBZADEH, S. S. (2022) · Aging and Disease · doi:10.14336/ad.2022.0414

A Peek Behind the Curtain of Anti-aging Science

Lupton, M. (2023) · Springer eBooks · doi:10.1007/978-981-99-2439-4_7

Aging: Generation of oxidative stress

Rehman, R., Zulkipli, I. N., & Khan, H. N. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18807-7.00007-7

Hypomethylation of the p53 and p16 suppressor genes in cellular aging

Kadirova, D. A., Mirkhamidova, P., Shakhmurova, G. A., & Alimova, R. (2024) · BIO Web of Conferences · doi:10.1051/bioconf/202414901050

Gene Therapy Against Age-Related Diseases

Rai, R. R., Barage, S. H., & Singh, R. (2025) · IGI Global eBooks · doi:10.4018/979-8-3693-9730-5.ch005

Musculoskeletal biomarkers in health and disease: implications for the aging spine—a review for spinal surgeons by the SRS adult spinal deformity task force on senescence

Azad, T. D., Li, M., Chiu, P.-Y., Jones, K. E., Lord, E. L., Molina, C. A., Walker, C. T., Osorio, J. A., Pizones, J., Theologis, A. A., et al. (2025) · Spine Deformity · doi:10.1007/s43390-025-01124-w · Cited by 1

Mechanisms of Biological Aging with Special Reference to the Skeletal Muscle

Goto, S., & Radak, Z. O. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-88361-3_13

Neurological aging and neurodegenerative disease in humans and great apes

Edler, M. K., Hearn, C. J., Guevara, E. E., Mhatre‐Winters, I., Varghese, M., Freire‐Cobo, C., Sherwood, C. C., Richardson, J. R., Raghanti, M. A., & Hof, P. R. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27380-3.00074-9

Additional file 4 of Association between WNT-1-inducible signaling pathway protein-1 (WISP1) genetic polymorphisms and the risk of gastric cancer in Guangxi Chinese

Liu, Y., Qin, W., Zhang, F., Wang, J., Li, X., Li, S., Qin, X., & Lu, Y. (2021) · Figshare · doi:10.6084/m9.figshare.15086144

Additional file 2 of Association between WNT-1-inducible signaling pathway protein-1 (WISP1) genetic polymorphisms and the risk of gastric cancer in Guangxi Chinese

Liu, Y., Qin, W., Zhang, F., Wang, J., Li, X., Li, S., Qin, X., & Lu, Y. (2021) · Figshare · doi:10.6084/m9.figshare.15086138

Additional file 1 of Association between WNT-1-inducible signaling pathway protein-1 (WISP1) genetic polymorphisms and the risk of gastric cancer in Guangxi Chinese

Liu, Y., Qin, W., Zhang, F., Wang, J., Li, X., Li, S., Qin, X., & Lu, Y. (2021) · Figshare · doi:10.6084/m9.figshare.15086135

Additional file 3 of Association between WNT-1-inducible signaling pathway protein-1 (WISP1) genetic polymorphisms and the risk of gastric cancer in Guangxi Chinese

Liu, Y., Qin, W., Zhang, F., Wang, J., Li, X., Li, S., Qin, X., & Lu, Y. (2021) · Figshare · doi:10.6084/m9.figshare.15086141

Intra- and inter-organ communications in aging and cancer: Local and global spatial perspectives

Mulay, O., Benedicto, A., Murata, Y., Ng, M. S. Y., Cruz, J. L. G., & Nguyen, Q. H. (2026) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2026.103672

Caractérisation des neutrophiles circulants et associés aux tumeurs aux stades précoces et tardifs de la tumorigenèse

Lecot, P. (2020) · theses.fr (ABES) · doi:10.70675/9b11dabdz736ez42d1zb6d1z4ff564c39ce6

Mechanisms of precocious ageing in a human progeroid syndrome

Molina, C. F. (2021) · theses.fr (ABES) · doi:10.70675/f78c9fa2z621cz48b6zbf00z1133c36b723a

Investigations génétiques et physiopathologiques des dysplasies corticales focales de type 2

Ribierre, T. (2020) · theses.fr (ABES) · doi:10.70675/7ac267e2z8712z4e0fza9a1z424bc9445787

REVIEWS Prospects for postponing human aging

Rose, M. R., Theodore, & Nusbaum, J. (2013)

Prospects for postponing human aging

Rose, M. R., & Nusbaum, T. J. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.12.8088458 · Cited by 13

Genes, aging, and prospects for extended life span.

Curtsinger, J. W. (2007) · PubMed

Aging interventions get human

Kennedy, B. K., & Pennypacker, J. K. (2015) · Oncotarget · doi:10.18632/oncotarget.3173 · Cited by 14

Lessons on longevity from budding yeast

Kaeberlein, M. R. (2010) · Nature · doi:10.1038/nature08981 · Cited by 427