Cited by 407Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and SenescenceSirtuins and Resveratrol in Medicine

The DOI matches its Crossref record; 75 of the 76 references it cites were found in a registry or an index.

Puzzles, promises and a cure for ageing

Open access

Vijg, Jan, Campisi, Judith·2008·Nature

DOI 10.1038/nature07216PMC PMC2774752

Open this paper in CoChat — free account

Abstract

Recent discoveries in the science of ageing indicate that lifespan in model organisms such as yeast, nematodes, flies and mice is plastic and can be manipulated by genetic, nutritional or pharmacological intervention. A better understanding of the targets of such interventions, as well as the proximate causes of ageing-related degeneration and disease, is essential before we can evaluate if abrogation of human senescence is a realistic prospect.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nature07216

Cites

75 of 75 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
The ENCODE Project Consortium (2007) · Nature · doi:10.1038/nature05874 · Cited by 5,223
Cellular senescence: when bad things happen to good cells
Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441
Self-citation
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
Epigenetic differences arise during the lifetime of monozygotic twins
Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500398102 · Cited by 3,602
Nothing in Biology Makes Sense except in the Light of Evolution
Dobzhansky, T. (1973) · The American Biology Teacher · doi:10.2307/4444260 · Cited by 3,219
Evolution of ageing
Kirkwood, T. B. L. (1977) · Nature · doi:10.1038/270301a0 · Cited by 2,007
Understanding the odd science of aging
Kirkwood, T. B. L. (2005) · Cell · doi:10.1016/j.cell.2005.01.027 · Cited by 1,984
AN UNSOLVED PROBLEM OF BIOLOGY
(1953) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1953.tb84985.x · Cited by 1,806
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
Krtolica, A., Parrinello, S., Lockett, S., Desprez, P.-Y., & Campisi, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211053698 · Cited by 1,730
Self-citation
Mitochondrial Respiratory-Chain Diseases
DiMauro, S., & Schon, E. A. (2003) · New England Journal of Medicine · doi:10.1056/nejmra022567 · Cited by 1,672

Show all 76 references

Sorted by citations

Items 101–200 of 406

Extending healthy ageing: nutrient sensitive pathway and centenarian population
Davinelli, S., Willcox, D. C., & Scapagnini, G. (2012) · Immunity & Ageing · doi:10.1186/1742-4933-9-9 · Cited by 85
Rapamycin preserves gut homeostasis during Drosophila aging
Fan, X., Liang, Q. D., Lian, T., Wu, Q., Gaur, U., Li, D., Yang, D., Mao, X., Jin, Z., Li, Y., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5895 · Cited by 82
Emerging roles of frailty and inflammaging in risk assessment of age-related chronic diseases in older adults: the intersection between aging biology and personalized medicine
Wu, I., Lin, C., & Hsiung, C. A. (2015) · Biomedicine · doi:10.7603/s40681-015-0001-1 · Cited by 83
Manipulation of Behavioral Decline in Caenorhabditis elegans with the Rag GTPase raga-1
Schreiber, M. A., Pierce-Shimomura, J. T., Chan, S., Parry, D., & McIntire, S. L. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000972 · Cited by 77
Fission Yeast and Other Yeasts as Emergent Models to Unravel Cellular Aging in Eukaryotes
Roux, A. E., Chartrand, P., Ferbeyre, G., & Rokeach, L. A. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp152 · Cited by 84
Recent advances and possibilities for the use of plant phenolic compounds to manage ageing-related diseases
Arruda, H. S., Neri-Numa, I. A., Kido, L. A., Maróstica, M. R., & Pastore, G. M. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104203 · Cited by 85
Ablation of the p16INK4a tumour suppressor reverses ageing phenotypes of klotho mice
Sato, S., Kawamata, Y., Takahashi, A., Imai, Y., Hanyu, A., Okuma, A., Takasugi, M., Yamakoshi, K., Sorimachi, H., Kanda, H., et al. (2015) · Nature Communications · doi:10.1038/ncomms8035 · Cited by 77
Drastic increase of myosin light chain MLC-2 in senescent skeletal muscle indicates fast-to-slow fibre transition in sarcopenia of old age
Gannon, J., Doran, P., Kirwan, A., & Ohlendieck, K. (2009) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2009.06.004 · Cited by 74
Cellular Senescence and Lung Function during Aging. Yin and Yang
Campisi, J. (2016) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201609-703aw · Cited by 75
Self-citation
Relationships between cancer and aging: a multilevel approach
Anisimov, V. N., Sikora, E., & Pawelec, G. (2009) · Biogerontology · doi:10.1007/s10522-008-9209-8 · Cited by 73
Mammalian models of extended healthy lifespan
Selman, C., & Withers, D. J. (2010) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0243 · Cited by 75
Biochemical Markers of Aging for Longitudinal Studies in Humans
Engelfriet, P. M., Jansen, E. H. J. M., Picavet, H. S. J., & Dollé, M. E. T. (2013) · Epidemiologic Reviews · doi:10.1093/epirev/mxs011 · Cited by 75
The Aging Thyroid: A Reappraisal Within the Geroscience Integrated Perspective
Franceschi, C., Ostan, R., Mariotti, S., Monti, D., & Vitale, G. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00170 · Cited by 74
The mitochondrial unfolded protein response regulates hippocampal neural stem cell aging
Wang, C.-L., Ohkubo, R., Mu, W., Chen, W., Fan, J. L., Song, Z., Maruichi, A., Sudmant, P. H., Pisco, A. O., Dubal, D. B., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.04.012 · Cited by 76
Age- and Temperature-Dependent Somatic Mutation Accumulation in Drosophila melanogaster
Garcia, A. M., Calder, R. B., Dollé, M. E. T., Lundell, M., Kapahi, P., & Vijg, J. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000950 · Cited by 62
Self-citation
Proteomic and metabolomic analysis of H2O2-induced premature senescent human mesenchymal stem cells
Kim, J. S., Kim, E.-J., Kim, H. J., Yang, J.-Y., Hwang, G., & Kim, C. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.02.012 · Cited by 70
The thyroid hormone receptor β induces DNA damage and premature senescence
Zambrano, A., García-Carpizo, V., Gallardo, M. E., Villamuera, R., Gómez-Ferrerı́a, M. A., Pascual, A., Buisine, N., Sachs, L. M., Garesse, R., & Aranda, A. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201305084 · Cited by 70
Targeting glucose metabolism for healthy aging
Brewer, R. A., Gibbs, V. K., & Smith, D. L. (2016) · Nutrition and Healthy Aging · doi:10.3233/nha-160007 · Cited by 69
Replication stress as a driver of cellular senescence and aging
Herr, L. M., Schaffer, E. D., Fuchs, K. F., Datta, A., & Brosh, R. M. (2024) · Communications Biology · doi:10.1038/s42003-024-06263-w · Cited by 72
Do different neurons age differently? Direct genome-wide analysis of aging in single identified cholinergic neurons
Moroz, L. L. (2010) · Frontiers in Aging Neuroscience · doi:10.3389/neuro.24.006.2010 · Cited by 67
Caloric Restriction Mimetic 2-Deoxyglucose Antagonizes Doxorubicin-induced Cardiomyocyte Death by Multiple Mechanisms
Chen, K., Xu, X., Kobayashi, S., Timm, D. J., Jepperson, T. N., & Liang, Q. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.225805 · Cited by 66
Stress granules counteract senescence by sequestration of PAI‐1
Omer, A., Patel, D. M., Lian, X. J., Sadek, J., Marco, S. D., Pause, A., Gorospe, M., & Gallouzi, I. (2018) · EMBO Reports · doi:10.15252/embr.201744722 · Cited by 69
Genetics vs. entropy: Longevity factors suppress the NF-κB-driven entropic aging process
Salminen, A., & Kaarniranta, K. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.11.001 · Cited by 67
Centenarian Studies: Important Contributors to Our Understanding of the Aging Process and Longevity
Willcox, D. C., Willcox, B. J., & Poon, L. W. (2010) · Current Gerontology and Geriatrics Research · doi:10.1155/2010/484529 · Cited by 70
The Rarity of Survival to Old Age Does Not Drive the Evolution of Senescence
Wensink, M. J., Caswell, H., & Baudisch, A. (2016) · Evolutionary Biology · doi:10.1007/s11692-016-9385-4 · Cited by 64
A Prospective Analysis of Genetic Variants Associated with Human Lifespan
Wright, K. M., Rand, K. A., Kermany, A. R., Noto, K., Curtis, D., Garrigan, D., Slinkov, D., Dorfman, I., Granka, J. M., Byrnes, J., et al. (2019) · G3 Genes Genomes Genetics · doi:10.1534/g3.119.400448 · Cited by 63
What can long-lived mutants tell us about mechanisms causing aging and lifespan variation in natural environments?
Briga, M., & Verhulst, S. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.09.002 · Cited by 61
Metabotyping of Long-Lived Mice using 1H NMR Spectroscopy
Wijeyesekera, A., Selman, C., Barton, R. H., Holmes, E. C., Nicholson, J. K., & Withers, D. J. (2012) · Journal of Proteome Research · doi:10.1021/pr2010154 · Cited by 65
Cinnamomum cassia Bark in Two Herbal Formulas Increases Life Span in Caenorhabditis elegans via Insulin Signaling and Stress Response Pathways
Yu, Y.-B., Dosanjh, L. E., Lao, L., Tan, M., Shim, B. S., & Luo, Y. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009339 · Cited by 60
Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans
Keowkase, R., Aboukhatwa, M. A., & Luo, Y. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.04.008 · Cited by 58
Why the disposable soma theory cannot explain why women live longer and why we age
Blagosklonny, M. V. (2010) · Aging · doi:10.18632/aging.100253 · Cited by 56
Predicting Successful Aging in a Population-Based Sample of Georgia Centenarians
Arnold, J., Dai, J., Nahapetyan, L., Arte, A., Johnson, M. A., Hausman, D. B., Rodgers, W. L., Hensley, R. B., Martin, P., MacDonald, M. M., et al. (2010) · Current Gerontology and Geriatrics Research · doi:10.1155/2010/989315 · Cited by 57
Human life is unlimited – but short
Rootzén, H., & Zholud, D. (2017) · Extremes · doi:10.1007/s10687-017-0305-5 · Cited by 63
Change and Aging Senescence as an Adaptation
Martins, A. C. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024328 · Cited by 54
The Roles and Pharmacological Effects of FGF21 in Preventing Aging-Associated Metabolic Diseases
Yan, J., Nie, Y., Cao, J., Luo, M., Yan, M., Chen, Z., & He, B. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.655575 · Cited by 53
The Scientific Quest for Lasting Youth: Prospects for Curing Aging
de Magalhães, J. P. (2014) · Rejuvenation Research · doi:10.1089/rej.2014.1580 · Cited by 54
On the cause of aging and control of lifespan
Gladyshev, V. N. (2012) · BioEssays · doi:10.1002/bies.201200092 · Cited by 51
Aging Research in Yeast
Breitenbach, M., Laun, P., & Jazwinski, S. M. (2011) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-2561-4 · Cited by 55
Aging as Disease
Winter, G. D. (2014) · Medicine Health Care and Philosophy · doi:10.1007/s11019-014-9600-y · Cited by 48
DIGE analysis of rat skeletal muscle proteins using nonionic detergent phase extraction of young adult versus aged gastrocnemius tissue
Donoghue, P. M., Staunton, L., Mullen, E., Manning, G., & Ohlendieck, K. (2010) · Journal of Proteomics · doi:10.1016/j.jprot.2010.01.014 · Cited by 48
An analysis of aging-related genes derived from the Genotype-Tissue Expression project (GTEx)
Jia, K., Cui, C., Gao, Y., Zhou, Y., & Cui, Q. (2018) · Cell Death Discovery · doi:10.1038/s41420-018-0093-y · Cited by 50
The Impact of H2S on Obesity-Associated Metabolic Disturbances
Comas, F., & Moreno‐Navarrete, J. M. (2021) · Antioxidants · doi:10.3390/antiox10050633 · Cited by 51
Wisdom, Resilience, and Well-Being in Later Life
Jeste, D. V., Alexopoulos, G. S., Blazer, D. G., Lavretsky, H., Sachdev, P. S., & Reynolds, C. F. (2024) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-081423-031855 · Cited by 54
MicroRNAs in C. elegans Aging: Molecular Insurance for Robustness?
Ibáñez‐Ventoso, C., & Driscoll, M. (2009) · Current Genomics · doi:10.2174/138920209788185243 · Cited by 48
The Role of mTOR Signaling in Controlling Mammalian Life Span: What a Fungicide Teaches Us About Longevity
Sharp, Z. D., & Strong, R. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp212 · Cited by 46
Microglial Turnover in Ageing-Related Neurodegeneration: Therapeutic Avenue to Intervene in Disease Progression
Azam, S., Haque, M. E., Kim, I., & Choi, D. (2021) · Cells · doi:10.3390/cells10010150 · Cited by 46
Biomarkers of skin aging
Kanaki, T., Makrantonaki, E., & Zouboulis, C. C. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9392-x · Cited by 49
Potential of telomerase activation in extending health span and longevity
de Jesus, B. B., & Blasco, M. A. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.09.004 · Cited by 48
Identification of Mutations that Delay Somatic or Reproductive Aging ofCaenorhabditis elegans
Hughes, S. E., Huang, C., & Kornfeld, K. (2011) · Genetics · doi:10.1534/genetics.111.130450 · Cited by 44
STAT3 promotes a youthful epigenetic state in articular chondrocytes
Sarkar, A., Liu, N. Q., Magallanes, J., Tassey, J., Lee, S., Shkhyan, R., Lee, Y., Lu, J., Ouyang, Y., Tang, H., et al. (2023) · Aging Cell · doi:10.1111/acel.13773 · Cited by 42
Anti-senescence efficacy of radio-electric asymmetric conveyer technology
Maioli, M., Rinaldi, S., Santaniello, S., Castagna, A., Pigliaru, G., Delitala, A., Margotti, M. L., Bagella, L., Fontani, V., & Ventura, C. (2013) · AGE · doi:10.1007/s11357-013-9537-8 · Cited by 43
Accelerated ageing: from mechanism to therapy through animal models
Osorio, F. G., Obaya, Á. J., López-Otı́n, C., & Freije, J. M. P. (2008) · Transgenic Research · doi:10.1007/s11248-008-9226-z · Cited by 43
Association between Dietary Fiber Intake and Physical Performance in Older Adults: A Nationwide Study in Taiwan
Wu, I., Chang, H., Hsu, C., Chiu, Y., Yu, S., Tsai, Y., Shen, S.-C., Kuo, K. N., Chen, C., Liu, K., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080209 · Cited by 42
Signal Transduction, Ageing and Disease
Zhang, L. J., Yousefzadeh, M. J., Suh, Y., Niedernhofer, L. J., & Robbins, P. D. (2019) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-3681-2_9 · Cited by 40
Strategies for identifying synthetic peptides to act as inhibitors of NADPH oxidases, or “All that you did and did not want to know about Nox inhibitory peptides”
Dahan, I. M., & Pick, E. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1007-4 · Cited by 36
An empirical evaluation of hierarchical feature selection methods for classification in bioinformatics datasets with gene ontology-based features
Wan, C., & Freitas, A. A. (2017) · Artificial Intelligence Review · doi:10.1007/s10462-017-9541-y · Cited by 37
Radix Tetrastigma flavonoid ameliorates inflammation and prolongs the lifespan of Caenorhabditis elegans through JNK, p38 and Nrf2 pathways
Li, Y., Chu, Q., Liu, Y., Ye, X., Jiang, Y., & Zheng, X. (2019) · Free Radical Research · doi:10.1080/10715762.2019.1613534 · Cited by 36
Embryonic anti-aging niche.
Conboy, I. M., Yousef, H., & Conboy, M. J. (2011) · Aging · doi:10.18632/aging.100333 · Cited by 33
Rapamycin for longevity: the pros, the cons, and future perspectives
Roark, K. M., & Iffland, P. H. (2025) · Frontiers in Aging · doi:10.3389/fragi.2025.1628187 · Cited by 37
Obstructive Sleep Apnea-hypopnea Syndrome as a Novel Potential Risk for Aging
Li, Y., & Wang, Y. (2021) · Aging and Disease · doi:10.14336/ad.2020.0723 · Cited by 37
Selenite protects C aenorhabditis elegans from oxidative stress via DAF ‐16 and TRXR ‐1
Li, W.-H., Shi, Y., Chang, C., Huang, C., & Liao, V. H. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300404 · Cited by 34
Micromanaging aging with miRNAs: new messages from the nuclear envelope
Ugalde, A. P., Español, Y., & López-Otín, C. (2011) · Nucleus · doi:10.4161/nucl.2.6.17986 · Cited by 34
Curcumin protects dopaminergic neurons against inflammation-mediated damage and improves motor dysfunction induced by single intranigral lipopolysaccharide injection
Sharma, N., Sharma, S., & Nehru, B. (2017) · Inflammopharmacology · doi:10.1007/s10787-017-0346-z · Cited by 35
Proteomic Analysis of Alzheimers Disease Cerebrospinal Fluid from Neuropathologically Diagnosed Subjects
Maarouf, C. L., Andacht, T. M., Kokjohn, T. A., Castaño, E. M., Sue, L. I., Beach, T. G., & Roher, A. E. (2009) · Current Alzheimer Research · doi:10.2174/156720509788929318 · Cited by 33
Engineering Hierarchical Recognition‐Mediated Senolytics for Reliable Regulation of Cellular Senescence and Anti‐Atherosclerosis Therapy
Xia, Y., Li, J., Wang, L., Xie, Y., Zhang, L., Han, X., Tan, W., & Liu, Y. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202214169 · Cited by 34
Murine models of accelerated aging and musculoskeletal disease
Hambright, W. S., Niedernhofer, L. J., Huard, J., & Robbins, P. D. (2019) · Bone · doi:10.1016/j.bone.2019.03.002 · Cited by 32
Nuclear Envelope Regulation of Signaling Cascades
Choi, J. C., & Worman, H. J. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-8032-8_9 · Cited by 34
Hallmarks of aging and Alzheimer’s Disease pathogenesis: Paving the route for new therapeutic targets
Bellelli, F., Angioni, D., Arosio, B., Vellas, B. J., & Barreto, P. D. S. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102699 · Cited by 34
Longevity mutants do not establish any “new science” of ageing
Holliday, R., & Rattan, S. I. S. (2010) · Biogerontology · doi:10.1007/s10522-010-9288-1 · Cited by 31
Hypermethylation of gene promoters in peripheral blood leukocytes in humans long term after radiation exposure
Kuzmina, N. S., Lapteva, N. S., & Rubanovich, A. V. (2015) · Environmental Research · doi:10.1016/j.envres.2015.12.008 · Cited by 31
Epigenetic changes during ageing and their underlying mechanisms
Braga, D. L., Mousovich‐Neto, F., Tonon-da-Silva, G., Salgueiro, W. G., & Mori, M. A. (2020) · Biogerontology · doi:10.1007/s10522-020-09874-y · Cited by 33
Supportive care in elderly cancer patients
Balducci, L. (2009) · Current Opinion in Oncology · doi:10.1097/cco.0b013e32832b4f25 · Cited by 31
CISD2 plays a role in age-related diseases and cancer
Liao, H.-Y., Liao, B., & Zhang, H. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111472 · Cited by 33
Forum on aging and skeletal health: Summary of the proceedings of an ASBMR workshop
Khosla, S., Bellido, T., Drezner, M. K., Gordon, C. M., Harris, T. B., Kiel, D. P., Kream, B. E., LeBoff, M. S., Lian, J. B., Peterson, C. A., et al. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.488 · Cited by 31
A single nucleotide polymorphism of the adenosine deaminase, RNA-specific gene is associated with the serum triglyceride level, abdominal circumference, and serum adiponectin concentration
Oguro, R., Kamide, K., Katsuya, T., Akasaka, H., Sugimoto, K., Congrains, A., Arai, Y., Hirose, N., Saitoh, S., Ohishi, M., et al. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.12.004 · Cited by 30
Organoruthenium(II) Complexes Ameliorates Oxidative Stress and Impedes the Age Associated Deterioration in Caenorhabditis elegans through JNK-1/DAF-16 Signalling
Devagi, G., Mohankumar, A., Shanmugam, G., Nivitha, S., Dallemer, F., Kalaivani, P., Sundararaj, P., & Prabhakaran, R. (2018) · Scientific Reports · doi:10.1038/s41598-018-25984-7 · Cited by 29
Exercise to Mend Aged-tissue Crosstalk in Bone Targeting Osteoporosis & Osteoarthritis
Little, S. E., Rubin, J. E., Diekman, B. O., Rubin, C. T., McGrath, C., Pagnotti, G. M., Klett, E. L., & Styner, M. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.08.011 · Cited by 30
Serum levels of lipid metabolites in age‐related macular degeneration
Orban, T., Johnson, W. M., Dong, Z., Maeda, T., Maeda, A., Sakai, T., Tsuneoka, H., Mieyal, J. J., & Palczewski, K. (2015) · The FASEB Journal · doi:10.1096/fj.15-275289 · Cited by 29
Development and Aging
Morange, M. (2011) · Biological Theory · doi:10.1007/s13752-011-0010-6 · Cited by 32
Discovery of Functional Gene Variants Associated With Human Longevity: Opportunities and Challenges
Tazearslan, C., Cho, M., & Suh, Y. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr200 · Cited by 30
Effect of radiotherapy on the expression of cardiovascular disease-related miRNA-146a, -155, -221 and -222 in blood of women with breast cancer
Esplugas, R., Arenas, M., Serra, N., Bellés, M., Bonet, M., Gascón, M., Vallvé, J.-C., & Linares, V. (2019) · PLoS ONE · doi:10.1371/journal.pone.0217443 · Cited by 30
HMGB1, an evolving pleiotropic protein critical for cellular and tissue homeostasis: Role in aging and age-related diseases
Ruggieri, E., Domenico, E. D., Locatelli, A. G., Isopo, F., Damanti, S., LORENZO, R. D., Milan, E., Musco, G., Rovere, P. Q., Cenci, S., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102550 · Cited by 27
Monascus-Fermented Dioscorea Enhances Oxidative Stress Resistance via DAF-16/FOXO in Caenorhabditis elegans
Shi, Y., Yu, C., Liao, V. H., & Pan, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039515 · Cited by 27
Innovating Aging: Promises and Pitfalls on the Road to Life Extension
Vijg, J., & de Grey, A. D. N. J. (2014) · Gerontology · doi:10.1159/000357670 · Cited by 30
Self-citation
Peripheral Circulating Exosomal miRNAs Potentially Contribute to the Regulation of Molecular Signaling Networks in Aging
Zhang, H., & Jin, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21061908 · Cited by 27
Mitochondrial Acetylation and Genetic Models of Parkinson's Disease
Auburger, G. W. J., Gispert, S., & Jendrach, M. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-394625-6.00006-4 · Cited by 27
Strategic outline of interventions targeting extracellular matrix for promoting healthy longevity
Park, J. Y. C., King, A., Björk, V., English, B. W., Fedintsev, A., & Ewald, C. Y. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00060.2023 · Cited by 32
Aging in the wild: Insights from free-living and non-model organisms
Fletcher, Q. E., & Selman, C. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.09.015 · Cited by 26
The identification of age-associated cancer markers by an integrative analysis of dynamic DNA methylation changes
Wang, Y., Zhang, J., Xiao, X., Liu, H., Wang, F., Li, S., Wen, Y., Wei, Y., Su, J., Zhang, Y., et al. (2016) · Scientific Reports · doi:10.1038/srep22722 · Cited by 27
Cross-linking of structural proteins in ageing skin: an in situ assay for the detection of amine oxidase activity
Langton, A. K., Griffiths, C. E. M., Sherratt, M. J., & Watson, R. E. B. (2012) · Biogerontology · doi:10.1007/s10522-012-9394-3 · Cited by 25
Regulatory Roles of miRNAs in Aging
Caravia, X. M., & López-Otı́n, C. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-22380-3_11 · Cited by 27
Drug-induced premature senescence model in human dental follicle stem cells
Zhai, Y., Wei, R., Liu, J., Wang, H., Cai, W., Zhao, M., Hu, Y., Wang, S., Yang, T., Liu, X., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.14085 · Cited by 26
The Resveratrol Rice DJ526 Callus Significantly Increases the Lifespan of Drosophila (Resveratrol Rice DJ526 Callus for Longevity)
Khan, M., Park, S., Kim, H., Lee, K.-J., Kim, D. H., Baek, S.-H., & Hong, S. (2019) · Nutrients · doi:10.3390/nu11050983 · Cited by 25
Magnesium Lithospermate B fromSalvia miltiorrhizaB unge Ameliorates Aging‐Induced Renal Inflammation and SenescenceviaNADPH Oxidase‐Mediated Reactive Oxygen Generation
Park, C. H., Shin, S. H., Lee, E. K., Kim, S., Kim, M., Roh, S., Yokozawa, T., & Chung, H. Y. (2017) · Phytotherapy Research · doi:10.1002/ptr.5789 · Cited by 24
Single 30 min treadmill exercise session suppresses the production of pro-inflammatory cytokines and oxidative stress in obese female adolescents
Pranoto, A., Rejeki, P. S., Miftahussurur, M., Setiawan, H. K., Yosika, G. F., Munir, M., Maesaroh, S., Purwoto, S. P., Waritsu, C., & Yamaoka, Y. (2023) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2022-0196 · Cited by 29
Progress & Prospects: Gene therapy in aging
Rattan, S. I. S., & Singh, R. (2008) · Gene Therapy · doi:10.1038/gt.2008.166 · Cited by 24
Effects of metformin on retinoblastoma growth in vitro and in vivo
Brodowska, K., Theodoropoulou, S., zu Hörste, M. M., Paschalis, E. I., Takeuchi, K., SCOTT, G., Ramsey, D. J., Kiernan, E. A., Hoang, M. V., Cichy, J., et al. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2650 · Cited by 24
Autophagy drives epidermal deterioration in a Drosophila model of tissue aging
Scherfer, C., Han, V. C., Wang, Y., Anderson, A. E., & Galko, M. J. (2013) · Aging · doi:10.18632/aging.100549 · Cited by 23
Diabetes, Insulin and Alzheimer's Disease
Craft, S., & Christen, Y. (2010) · Research and perspectives in Alzheimer's disease · doi:10.1007/978-3-642-04300-0 · Cited by 24
Age is an independent risk factor for increased morbidity in elective colorectal cancer surgery despite an ERAS protocol
Chan, D. K. H., Ang, J. J., Tan, J. K. H., & Chia, D. K. A. (2020) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-020-01930-y · Cited by 23

Authors: Vijg, J., & Campisi, J.
Affiliations: Buck Institute for Research on Aging (US)
Corresponding author: Vijg, Jan
Campisi, Judith
ORCID: Vijg, Jan
Campisi, Judith
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2008-08
Volume: 454
Issue: 7208
Pages: 1065-1071
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature07216
PMC: PMC2774752
OpenAlex: W2006287843
Cited by: 407
References: 76
Citations by year: 2026: 6 · 2025: 14 · 2024: 10 · 2023: 14 · 2022: 19 · 2021: 20 · 2020: 16 · 2019: 21 · 2018: 14 · 2017: 14 · 2016: 23 · 2015: 28 · 2014: 24 · 2013: 32 · 2012: 31
FWCI: 3.47
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institute on Aging (P30AG025708, P01AG017242)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Keywords: aging, human lifespan, senescence, anti-aging interventions, model organisms, dietary intervention, pharmacological interventions, age-related diseases
MeSH terms: Aging, Animals, Disease, Biological Evolution, Humans, Life Expectancy, Longevity, Phenotype

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Puzzles, promises and a cure for ageing

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks