The DOI matches its Crossref record; 75 of the 76 references it cites were found in a registry or an index.
Puzzles, promises and a cure for ageing
Open accessAbstract
Recent discoveries in the science of ageing indicate that lifespan in model organisms such as yeast, nematodes, flies and mice is plastic and can be manipulated by genetic, nutritional or pharmacological intervention. A better understanding of the targets of such interventions, as well as the proximate causes of ageing-related degeneration and disease, is essential before we can evaluate if abrogation of human senescence is a realistic prospect.
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“The time-dependent accumulation of cellular damage is widely considered the general cause of aging (Gems and Partridge, 2013; Kirkwood, 2005; Vijg and Campisi, 2008).”
From The Hallmarks of Aging (2013) · cites this paper as Vijg and Campisi, 2008
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“Although there is no scientific reason why such efforts could not be successful, the possibility is essentially constrained by the myriad of genetic variants that collectively determine species-specific lifespan16.”
From Evidence for a limit to human lifespan (2016) · cites this paper as [16]
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Citations
Cites
The ENCODE Project Consortium (2007) · Nature · doi:10.1038/nature05874 · Cited by 5,223
Cellular senescence: when bad things happen to good cells
Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441
Self-citationResveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
Epigenetic differences arise during the lifetime of monozygotic twins
Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500398102 · Cited by 3,602
Nothing in Biology Makes Sense except in the Light of Evolution
Dobzhansky, T. (1973) · The American Biology Teacher · doi:10.2307/4444260 · Cited by 3,219
Kirkwood, T. B. L. (1977) · Nature · doi:10.1038/270301a0 · Cited by 2,007
Understanding the odd science of aging
Kirkwood, T. B. L. (2005) · Cell · doi:10.1016/j.cell.2005.01.027 · Cited by 1,984
AN UNSOLVED PROBLEM OF BIOLOGY
(1953) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1953.tb84985.x · Cited by 1,806
Krtolica, A., Parrinello, S., Lockett, S., Desprez, P.-Y., & Campisi, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211053698 · Cited by 1,730
Self-citationMitochondrial Respiratory-Chain Diseases
DiMauro, S., & Schon, E. A. (2003) · New England Journal of Medicine · doi:10.1056/nejmra022567 · Cited by 1,672
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Items 401–406 of 406
Ruzanova, V. S., Grivtsova, L. U., Oshikhmina, S. G., Proskurina, A. S., Ritter, G. S., Долгова, Е. В., Kirikovich, S. S., Levites, E. V., Efremov, Y. R., Dubatolova, T. D., et al. (2026) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vjgb-26-39
America: A Unified Optimal Procedures Life Schedule
Tiwari, S. (2026) · International Conference on Emerging and Intelligent Technologies and Systems (EITS) · doi:10.1109/eits70066.2026.11609591
Human Longevity and Immunogenetic Architecture: A Biogerontological Perspective
Fatma Sıla, A. Y. A. N., & Başıbüyük, H. H. (2026) · Ageing & Longevity · doi:10.47855/jal9020-2026-1-6
Metadata
- Authors
- Vijg, J., & Campisi, J.
- Affiliations
- Buck Institute for Research on Aging (US)
- Corresponding author
- Vijg, Jan
- Campisi, Judith
- Venue
- Nature
- Published
- 2008-08
- Volume
- 454
- Issue
- 7208
- Pages
- 1065-1071
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC2774752
- OpenAlex
- W2006287843
- Cited by
- 407
- References
- 76
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 10 · 2023: 14 · 2022: 19 · 2021: 20 · 2020: 16 · 2019: 21 · 2018: 14 · 2017: 14 · 2016: 23 · 2015: 28 · 2014: 24 · 2013: 32 · 2012: 31
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institute on Aging (P30AG025708, P01AG017242)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- aging, human lifespan, senescence, anti-aging interventions, model organisms, dietary intervention, pharmacological interventions, age-related diseases
- MeSH terms
- Aging, Animals, Disease, Biological Evolution, Humans, Life Expectancy, Longevity, Phenotype
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