The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Chd1 regulates open chromatin and pluripotency of embryonic stem cells
Open accessAbstract
An open chromatin largely devoid of heterochromatin is a hallmark of stem cells. It remains unknown whether an open chromatin is necessary for the differentiation potential of stem cells, and which molecules are needed to maintain open chromatin. Here we show that the chromatin remodelling factor Chd1 is required to maintain the open chromatin of pluripotent mouse embryonic stem cells. Chd1 is a euchromatin protein that associates with the promoters of active genes, and downregulation of Chd1 leads to accumulation of heterochromatin. Chd1-deficient embryonic stem cells are no longer pluripotent, because they are incapable of giving rise to primitive endoderm and have a high propensity for neural differentiation. Furthermore, Chd1 is required for efficient reprogramming of fibroblasts to the pluripotent stem cell state. Our results indicate that Chd1 is essential for open chromatin and pluripotency of embryonic stem cells, and for somatic cell reprogramming to the pluripotent state.
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A bivalent chromatin structure marks key developmental genes in embryonic stem cells
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Self-citationModel-based analysis of oligonucleotide arrays: Expression index computation and outlier detection.
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Rational siRNA design for RNA interference
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Self-citationChanging potency by spontaneous fusion
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Cited by
Chromatin remodelling during development
Ho, L., & Crabtree, G. R. (2010) · Nature · doi:10.1038/nature08911 · Cited by 1,114
ATP-dependent chromatin remodeling: genetics, genomics and mechanisms
Hargreaves, D. C., & Crabtree, G. R. (2011) · Cell Research · doi:10.1038/cr.2011.32 · Cited by 923
Open chromatin in pluripotency and reprogramming
Gaspar-Maia, A., Alajem, A., Meshorer, E., & Ramalho-Santos, M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3036 · Cited by 573
Self-citationChromatin accessibility: a window into the genome
Tsompana, M., & Buck, M. J. (2014) · Epigenetics & Chromatin · doi:10.1186/1756-8935-7-33 · Cited by 447
Functional implications of genome topology
Cavalli, G., & Misteli, T. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2474 · Cited by 415
Metadata
- Authors
- Gaspar-Maia, A., Alajem, A., Polesso, F., Sridharan, R., Mason, M. J., Heidersbach, A., Ramalho-Santos, J., McManus, M. T., Plath, K., Meshorer, E., & Ramalho-Santos, M.
- Venue
- Nature
- Published
- 2009-07-08
- Volume
- 460
- Issue
- 7257
- Pages
- 863-868
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2079599988
- Cited by
- 509
- References
- 6
- FWCI
- 21.84
- Type
- journal article
- Language
- en
- Open access
- green
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- Gaspar-Maia, A., Alajem, A., Polesso, F., Sridharan, R., Mason, M. J., Heidersbach, A., Ramalho-Santos, J., McManus, M. T., Plath, K., Meshorer, E., & Ramalho-Santos, M. (2009). Chd1 regulates open chromatin and pluripotency of embryonic stem cells. Nature. https://doi.org/10.1038/nature08212
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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