The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Gene therapy for red–green colour blindness in adult primates
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“the hue components of red-green color vision in all primates might represent an improvement in the function of the pre-existing blue-yellow system that was split in two by the addition of the third cone population (Mancuso et al., 2009).”
From The genetics of normal and defective color vision (2011) · cites this paper as Mancuso et al., 2009
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“They could also discriminate among other color combinations that dichromats find impossible to tell apart.”
From The genetics of normal and defective color vision (2011) · cites this paper as Mancuso, Hauswirth, Li, Connor, Kuchenbecker, Mauck, Neitz & Neitz, 2009
The cited source says what the claim attributes to it.
In the citing paper
“The treated animals discriminated colors in the red and green range from each other and as different from gray.”
From The genetics of normal and defective color vision (2011) · cites this paper as Mancuso, Hauswirth, Li, Connor, Kuchenbecker, Mauck, Neitz & Neitz, 2009
The cited source says what the claim attributes to it.
In the citing paper
“a new and different explanation has been offered for the newly acquired color vision in the treated squirrel monkeys--that they might be taking advantage of preexisting blue-yellow color vision circuits (Mancuso et al., 2009, Mancuso, Neitz, Hauswirth, Li, Connor, Kuchenbecker, Mauck & Neitz, 2010b, Shapley, 2009).”
From The genetics of normal and defective color vision (2011) · cites this paper as Mancuso et al., 2009
In the citing paper
“Gene therapy was performed on adult squirrel monkeys that were missing the L-opsin gene and were colorblind since birth (Mancuso, Hauswirth, Li, Connor, Kuchenbecker, Mauck, Neitz & Neitz, 2009).”
From The genetics of normal and defective color vision (2011) · cites this paper as Mancuso, Hauswirth, Li, Connor, Kuchenbecker, Mauck, Neitz & Neitz, 2009
In the citing paper
“The addition of a third opsin in adult red–green color deficient primates was sufficient to produce trichromatic color vision behavior”
From The genetics of normal and defective color vision (2011) · cites this paper as Mancuso, Hauswirth, Li, Connor, Kuchenbecker, Mauck, Neitz & Neitz, 2009
In the citing paper
“L-opsin was added to a subset of M cones, providing the receptoral basis for trichromatic color vision.”
From The genetics of normal and defective color vision (2011) · cites this paper as Mancuso, Hauswirth, Li, Connor, Kuchenbecker, Mauck, Neitz & Neitz, 2009
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis
Maguire, A. M., Simonelli, F., Pierce, E. A., Pugh, E. N., Mingozzi, F., Bennicelli, J., Banfi, S., Marshall, K. A., Testa, F., Surace, E. M., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802315 · Cited by 2,145
Research works printed but not linked: 20
- Wiesel, T. N. & Hubel, D. H. Single-cell responses in striate cortex of kittens deprived of vision in one eye. J. Neurophysiol. 26, 1003–1017 (1963) · DOI · Paper page
- Jacobs, G. H. A perspective on color vision in platyrrhine monkeys. Vision Res. 38, 3307–3313 (1998) · DOI
- Li, Q., Timmers, A. M., Guy, J., Pang, J. & Hauswirth, W. W. Cone-specific expression using a human red opsin promoter in recombinant AAV. Vision Res. 48, 332–338 (2007) · DOI
- Reffin, J. P., Astell, S. & Mollon, J. D. in Colour Vision Deficiencies X (eds Drum, B., Moreland, J. D. and Serra, A.) 69–76 (Kluwer Academic Publishers, 1991) · DOI
- Regan, B. C., Reffin, J. P. & Mollon, J. D. Luminance noise and the rapid determination of discrimination ellipses in colour deficiency. Vision Res. 34, 1279–1299 (1994) · DOI
- Mancuso, K., Neitz, M. & Neitz, J. An adaptation of the Cambridge Colour Test for use with animals. Vis. Neurosci. 23, 695–701 (2006) · DOI
- Kuchenbecker, J. A., Sahay, M., Tait, D. M., Neitz, M. & Neitz, J. Topography of the long- to middle-wavelength sensitive cone ratio in the human retina assessed with a wide-field color multifocal electroretinogram. Vis. Neurosci. 25, 301–306 (2008) · DOI
- Mancuso, K. et al. Recombinant adeno-associated virus targets passenger gene expression to cones in primate retina. J. Opt. Soc. Am. A Opt. Image Sci. Vis. 24, 1411–1416 (2007) · DOI
- Nathans, J., Piantanida, T. P., Eddy, R. L., Shows, T. B. & Hogness, D. S. Molecular genetics of inherited variation in human color vision. Science 232, 203–210 (1986) · DOI
- Shapley, R. Specificity of cone connections in the retina and color vision. Focus on “Specificity of cone inputs to macaque retinal ganglion cells”. J. Neurophysiol. 95, 587–588 (2006) · DOI
- De Valois, R. L. & De Valois, K. K. A multi-stage color model. Vision Res. 33, 1053–1065 (1993) · DOI
- Jacobs, G. H., Williams, G. A., Cahill, H. & Nathans, J. Emergence of novel color vision in mice engineered to express a human cone photopigment. Science 315, 1723–1725 (2007) · DOI · Paper page
- Makous, W. Comment on “emergence of novel color vision in mice engineered to express a human cone photopigment”. Science 318, 196 (2007) · DOI · Paper page
- Bainbridge, J. W. & Ali, R. R. Success in sight: the eyes have it! Ocular gene therapy trials for LCA look promising. Gene Ther. 15, 1191–1192 (2008) · DOI
- Cideciyan, A. V. et al. Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics. Proc. Natl Acad. Sci. USA 105, 15112–15117 (2008) · DOI
- Wang, Y. et al. A locus control region adjacent to the human red and green visual pigment genes. Neuron 9, 429–440 (1992) · DOI · Paper page
- Mauck, M. C. et al. Longitudinal evaluation of expression of virally delivered transgenes in gerbil cone photoreceptors. Vis. Neurosci. 25, 273–282 (2008) · DOI
- Nathans, J., Thomas, D. & Hogness, D. S. Molecular genetics of human color vision: the genes encoding blue, green, and red pigments. Science 232, 193–202 (1986) · DOI
- Neitz, M., Neitz, J. & Jacobs, G. H. Spectral tuning of pigments underlying red-green color vision. Science 252, 971–974 (1991) · DOI · Paper page
- Büning, H., Perabo, L., Coutelle, O., Quadt-Humme, S. & Hallek, M. Recent developments in adeno-associated virus vector technology. J. Gene Med. 10, 717–733 (2008) · DOI
Cited by
Sorted by citations
The genetics of normal and defective color vision
Neitz, J., & Neitz, M. (2011) · Vision Research · doi:10.1016/j.visres.2010.12.002 · Cited by 377
Self-citationDosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey
Vandenberghe, L. H., Bell, P., Maguire, A. M., Cearley, C. N., Xiao, R., Calcedo, R., Wang, L., Castle, M. J., Maguire, A. C., Grant, R., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002103 · Cited by 242
Intravitreal injection of AAV2 transduces macaque inner retina
Yin, L., Greenberg, K., Hunter, J. J., Dalkara, D., Kolstad, K. D., Masella, B. D., Wolfe, R., Visel, M., Stone, D., Libby, R. T., et al. (2011) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.10-6250 · Cited by 212
Pharmaceutical development of AAV-based gene therapy products for the eye
Rodrigues, G. A., Shalaev, E., Karami, T. K., Cunningham, J., Slater, N. K. H., & Rivers, H. M. (2019) · Pharmaceutical Research · doi:10.1007/s11095-018-2554-7 · Cited by 213
Novel adeno-associated viral vectors for retinal gene therapy.
Vandenberghe, L. H., & Auricchio, A. (2012) · Gene Therapy · doi:10.1038/gt.2011.151 · Cited by 131
Allocating structure to function: the strong links between neuroplasticity and natural selection
Anderson, M. L., & Finlay, B. L. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00918 · Cited by 115
“…that normally arises by the mutation of one opsin in about two thirds of female New World monkeys in the absence of any known brain changes (Jacobs, 2012), and the rapid emergence of behavioral trichromacy after “knock-in” of a third opsin into normally dichromatic monkeys (Mancuso et al., 2009).”
BackgroundBanin, E., Gootwine, E., Obolensky, A., Ezra-Elia, R., Ejzenberg, A., Zelinger, L., Honig, H., Rosov, A., Yamin, E., Sharon, D., et al. (2015) · Molecular Therapy · doi:10.1038/mt.2015.114 · Cited by 113
Self-citationBoye, S. E., Alexander, J. J., Boye, S. L., Witherspoon, C. D., Sandefer, K. J., Conlon, T. J., Erger, K., Sun, J., Ryals, R., Chiodo, V. A., et al. (2012) · Human Gene Therapy · doi:10.1089/hum.2012.125 · Cited by 117
Self-citationBeltran, W. A., Boye, S. L., Boye, S. E., Chiodo, V. A., Lewin, A. S., Hauswirth, W. W., & Aguirre, G. D. (2010) · Gene Therapy · doi:10.1038/gt.2010.56 · Cited by 96
Self-citationAAV-mediated photoreceptor transduction of the pig cone-enriched retina
Mussolino, C., della Corte, M., Rossi, S., Viola, F., Di Vicino, U., Marrocco, E., Neglia, S., Doria, M., Testa, F., Giovannoni, R., et al. (2011) · Gene Therapy · doi:10.1038/gt.2011.3 · Cited by 102
AAV9 targets cone photoreceptors in the nonhuman primate retina
Vandenberghe, L. H., Bell, P., Maguire, A. M., Xiao, R., Hopkins, T. B., Grant, R., Bennett, J., & Wilson, J. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053463 · Cited by 97
Gene therapy for ocular diseases
Liu, M. M., Tuo, J., & Chan, C.-C. (2011) · British Journal of Ophthalmology · doi:10.1136/bjo.2009.174912 · Cited by 82
Boye, S. L., Bennett, A., Scalabrino, M. L., McCullough, K. T., Van Vliet, K., Choudhury, S., Ruan, Q., Peterson, J., Agbandje-McKenna, M., & Boye, S. E. (2016) · Journal of Virology · doi:10.1128/jvi.00200-16 · Cited by 79
Carvalho, L. S., Xiao, R., Wassmer, S. J., Langsdorf, A., Zinn, E., Pacouret, S., Shah, S., Comander, J. I., Kim, L. A., Lim, L., et al. (2018) · Human Gene Therapy · doi:10.1089/hum.2017.154 · Cited by 63
Peden, M. C., Min, J., Meyers, C., Lukowski, Z., Li, Q., Boye, S. L., Levine, M., Hauswirth, W. W., Ratnakaram, R., Dawson, W., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017140 · Cited by 63
Self-citationChan, Y. K., Dick, A. D., Hall, S. M., Langmann, T., Scribner, C. L., Mansfield, B. C., & for the Ocular Gene Therapy Inflammation Working Group (2021) · Translational Vision Science & Technology · doi:10.1167/tvst.10.4.3 · Cited by 56
Charbel Issa, P., De Silva, S. R., Lipinski, D. M., Singh, M. S., Mouravlev, A., You, Q., Barnard, A. R., Hankins, M. W., During, M. J., & MacLaren, R. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060361 · Cited by 53
Tummala, G., Crain, A., Rowlan, J., & Pepple, K. L. (2021) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.62.2.41 · Cited by 36
Correction: AAV9 Targets Cone Photoreceptors in the Nonhuman Primate Retina
Vandenberghe, L. H., Bell, P., Maguire, A. M., Xiao, R., Hopkins, T. B., Grant, R., Bennett, J., & Wilson, J. M. (2013) · PLoS ONE · doi:10.1371/annotation/64b90996-4634-4c63-b737-634397b0b445 · Cited by 16
Testing vision is not testing for vision
Peli, E. (2020) · Translational Vision Science & Technology · doi:10.1167/tvst.9.13.32 · Cited by 14
Metadata
- Authors
- Mancuso, K., Hauswirth, W. W., Li, Q., Connor, T. B., Kuchenbecker, J. A., Mauck, M. C., Neitz, J., & Neitz, M.
- Venue
- Nature
- Published
- 2009-09-16
- Volume
- 461
- Issue
- 7265
- Pages
- 784-787
- ISSN
- 0028-0836
- 1476-4687
- PMC
- PMC2782927
- Cited by
- 265
- References
- 1
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
