The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Bidirectional plasticity in fast-spiking GABA circuits by visual experience
Abstract
Experience-dependent plasticity in the brain requires balanced excitation-inhibition. How individual circuit elements contribute to plasticity outcome in complex neocortical networks remains unknown. Here we report an intracellular analysis of ocular dominance plasticity-the loss of acuity and cortical responsiveness for an eye deprived of vision in early life. Unlike the typical progressive loss of pyramidal-cell bias, direct recording from fast-spiking cells in vivo reveals a counterintuitive initial shift towards the occluded eye followed by a late preference for the open eye, consistent with a spike-timing-dependent plasticity rule for these inhibitory neurons. Intracellular pharmacology confirms a dynamic switch of GABA (gamma-aminobutyric acid) impact to pyramidal cells following deprivation in juvenile mice only. Together these results suggest that the bidirectional recruitment of an initially binocular GABA circuit may contribute to experience-dependent plasticity in the developing visual cortex.
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“First, intact PNNs may structurally limit the robust synaptic plasticity directly upon PV-cells (48–50).”
From Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons (2015) · cites this paper as [48]
In the citing paper
“These networks are associated with plasticity from early life throughout adulthood [70][71][72][73].”
From Parvalbumin interneuron vulnerability and brain disorders (2021) · cites this paper as [71]
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Self-citation
Metadata
- Authors
- Yazaki-Sugiyama, Y., Kang, S., Câteau, H., Fukai, T., & Hensch, T. K.
- Affiliations
- RIKEN Center for Brain Science (JP)
- Japan Science and Technology Agency (JP)
- Corresponding author
- Hensch, Takao K.
- Venue
- Nature
- Published
- 2009-11
- Volume
- 462
- Issue
- 7270
- Pages
- 218-221
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2017144698
- Cited by
- 200
- References
- 37
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 3 · 2023: 6 · 2022: 8 · 2021: 9 · 2020: 5 · 2019: 7 · 2018: 14 · 2017: 15 · 2016: 11 · 2015: 13 · 2014: 17 · 2013: 28 · 2012: 20
- FWCI
- 7.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- experience-dependent plasticity, ocular dominance, monocular deprivation, fast-spiking interneurons, GABAergic circuits, excitation-inhibition balance, spike-timing-dependent plasticity, visual cortex development, binocular vision, pyramidal neurons, bidirectional plasticity
- MeSH terms
- Action Potentials, Aging, Animals, gamma-Aminobutyric Acid, Interneurons, Mice, Inbred C57BL, Models, Neurological, Neuronal Plasticity, Neurons, Photic Stimulation, Visual Cortex, Visual Pathways, Visual Perception, Pyramidal Cells, Receptors, GABA, Dominance, Ocular, Mice
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