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Cited by 405Visual perception and processing mechanismsNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

Tumor Necrosis Factor-α Mediates One Component of Competitive, Experience-Dependent Plasticity in Developing Visual Cortex

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Kaneko, Megumi, Stellwagen, David, Malenka, Robert C., Stryker, Michael P.·2008·Neuron
DOI 10.1016/j.neuron.2008.04.023PMC PMC2884387
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Abstract

Rapid, experience-dependent plasticity in developing visual cortex is thought to be competitive. After monocular visual deprivation, the reduction in response of binocular neurons to one eye is matched by a corresponding increase to the other. Chronic optical imaging in mice deficient in TNFalpha reveals the normal initial loss of deprived-eye responses, but the subsequent increase in response to the open eye is absent. This mutation also blocks homeostatic synaptic scaling of mEPSCs in visual cortex in vitro, without affecting LTP. In monocular cortex, thought not to be subject to competition, responses in TNFalpha mutants are as reduced as in the binocular zone. Pharmacological inhibition of endogenous TNFalpha in wild-type mice phenocopies the knockout. These findings suggest that experience-dependent competition in developing visual cortex is the outcome of two distinct, noncompetitive processes, a loss of deprived-eye responses followed by an apparently homeostatic increase in responses dependent on TNFalpha signaling.

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  • When one eye is deprived of patterned vision during the classical critical period using lid suture, cortical neurons rapidly (within 2 or 3 days) lose responsiveness to the deprived eye, and then more slowly (over 4-6 days) gain responsiveness to the nondeprived eye.

    “When one eye is deprived of patterned vision during the classical critical period (using lid suture) there is a change in the ability of the two eyes to drive neurons within the binocular portion of visual cortex: cortical neurons rapidly (within 2 or 3 days) lose responsiveness to the deprived eye, and then more slowly (over 4 -6 days) gain responsiveness to the nondeprived eye (Frenkel and Bear”

    From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Kaneko et al. 2008

  • A role for homeostatic plasticity has been suggested to contribute to ocular dominance plasticity in rodent visual cortex.

    “A role for homeostatic plasticity has recently been suggested to contribute to ocular dominance plasticity in rodent visual cortex (Mrsic-Flogel et al. 2007;Kaneko et al. 2008).”

    From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Kaneko et al. 2008

  • The delayed potentiation in visual cortex following lid suture requires TNFa and Arc signaling.

    “Interestingly, the delayed potentiation in visual cortex following lid suture requires TNFa and Arc signaling (Kaneko et al. 2008;McCurry et al. 2011) as does synaptic scaling in vitro (Shepherd et al. 2006;Stellwagen and Malenka 2006;Steinmetz and Turrigiano 2010); however, both these manipulations likely affect many forms of plasticity, so it still remains to be seen if synaptic scaling”

    From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Kaneko et al. 2008

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Authors
Kaneko, M., Stellwagen, D., Malenka, R. C., & Stryker, M. P.
Affiliations
  • University of California, San Francisco (US)
  • Stanford Medicine (US)
Corresponding author
Stryker, Michael P.
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2008-06
Volume
58
Issue
5
Pages
673-680
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2008.04.023
PMC
PMC2884387
OpenAlex
W1965513983
Cited by
405
References
3
Citations by year
2026: 9 · 2025: 11 · 2024: 15 · 2023: 17 · 2022: 22 · 2021: 16 · 2020: 22 · 2019: 17 · 2018: 34 · 2017: 39 · 2016: 12 · 2015: 22 · 2014: 22 · 2013: 32 · 2012: 19
FWCI
16.19
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Alliance for Research on Schizophrenia and Depression
  • National Institutes of Health
  • National Institute of Mental Health (P50MH077972)
  • National Eye Institute (R01EY002874)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
TNF-α, experience-dependent plasticity, visual cortex development, homeostatic synaptic scaling, long-term potentiation, binocular neurons
MeSH terms
Analysis of Variance, Animals, Animals, Newborn, Neuronal Plasticity, Organ Culture Techniques, Sensory Deprivation, Tumor Necrosis Factor-alpha, Visual Cortex, Visual Pathways, Long-Term Potentiation, Mice, Knockout, Patch-Clamp Techniques, Excitatory Amino Acid Antagonists, Dominance, Ocular, Mice

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