Cited by 201Neuroscience and Neuropharmacology ResearchVisual perception and processing mechanismsNeurogenesis and neuroplasticity mechanisms

Activity-dependent PSA expression regulates inhibitory maturation and onset of critical period plasticity

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Di Cristo, Graziella, Chattopadhyaya, Bidisha, Kuhlman, Sandra J, Fu, Yu, Bélanger, Marie-Claude, Wu, Cai Zhi, Rutishauser, Urs, Maffei, Lamberto +1 more·2007·Nature Neuroscience

Abstract

Functional maturation of GABAergic innervation in the developing visual cortex is regulated by neural activity and sensory inputs and in turn influences the critical period of ocular dominance plasticity. Here we show that polysialic acid (PSA), presented by the neural cell adhesion molecule, has a role in the maturation of GABAergic innervation and ocular dominance plasticity. Concentrations of PSA significantly decline shortly after eye opening in the adolescent mouse visual cortex; this decline is hindered by visual deprivation. The developmental and activity-dependent regulation of PSA expression is inversely correlated with the maturation of GABAergic innervation. Premature removal of PSA in visual cortex results in precocious maturation of perisomatic innervation by basket interneurons, enhanced inhibitory synaptic transmission, and earlier onset of ocular dominance plasticity. The developmental and activity-dependent decline of PSA expression therefore regulates the timing of the maturation of GABAergic inhibition and the onset of ocular dominance plasticity.

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Crossref · 10.1038/nn2008

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Authors
Di Cristo, G., Chattopadhyaya, B., Kuhlman, S. J., Fu, Y., Bélanger, M.-C., Wu, C. Z., Rutishauser, U., Maffei, L., & Huang, Z. J.
Affiliations
  • Cold Spring Harbor Laboratory (US)
  • Centre Hospitalier Universitaire Sainte-Justine (CA)
  • Memorial Sloan Kettering Cancer Center (US)
Corresponding author
Huang, Z Josh
Venue
Nature Neuroscience
Published
2007-11-18
Volume
10
Issue
12
Pages
1569-1577
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W2041958086
Cited by
201
References
51
Citations by year
2026: 2 · 2025: 4 · 2024: 5 · 2023: 8 · 2022: 4 · 2021: 15 · 2020: 16 · 2019: 8 · 2018: 12 · 2017: 16 · 2016: 15 · 2015: 8 · 2014: 14 · 2013: 16 · 2012: 13
FWCI
3.83
Type
journal article
Language
en
Open access
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
  • Figshare (submittedVersion, cc-by)
  • KiltHub Repository
Funders
  • National Institutes of Health
  • National Eye Institute (R01 EY 13564-01, R01EY013564)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
polysialic acid, CD56, GABAergic inhibition, ocular dominance plasticity, critical period, visual cortex development, visual deprivation, activity-dependent regulation, synaptic inhibition, eye opening
MeSH terms
Age Factors, Analysis of Variance, Anesthetics, Local, Animals, Animals, Newborn, Critical Period, Psychological, Evoked Potentials, Visual, gamma-Aminobutyric Acid, Glutamate Decarboxylase, Glycoside Hydrolases, Neural Inhibition, Neuronal Plasticity, Photic Stimulation, Sensory Deprivation, Sialic Acids, Tetrodotoxin, Visual Cortex, Visual Pathways, Gene Expression Regulation, Developmental, Neural Cell Adhesion Molecules, Green Fluorescent Proteins, Mice, In Vitro Techniques

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