Activity-dependent PSA expression regulates inhibitory maturation and onset of critical period plasticity
Open accessAbstract
Functional maturation of GABAergic innervation in the developing visual cortex is regulated by neural activity and sensory inputs and in turn influences the critical period of ocular dominance plasticity. Here we show that polysialic acid (PSA), presented by the neural cell adhesion molecule, has a role in the maturation of GABAergic innervation and ocular dominance plasticity. Concentrations of PSA significantly decline shortly after eye opening in the adolescent mouse visual cortex; this decline is hindered by visual deprivation. The developmental and activity-dependent regulation of PSA expression is inversely correlated with the maturation of GABAergic innervation. Premature removal of PSA in visual cortex results in precocious maturation of perisomatic innervation by basket interneurons, enhanced inhibitory synaptic transmission, and earlier onset of ocular dominance plasticity. The developmental and activity-dependent decline of PSA expression therefore regulates the timing of the maturation of GABAergic inhibition and the onset of ocular dominance plasticity.
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An accelerated maturation of the PV network has been shown to trigger an early onset of the critical period.
“An accelerated maturation of the PV network has been shown to trigger an early onset of the critical period (18,59).”
From MeCP2 regulates the timing of critical period plasticity that shapes functional connectivity in primary visual cortex (2015) · cites this paper as [59]
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- Authors
- Di Cristo, G., Chattopadhyaya, B., Kuhlman, S. J., Fu, Y., Bélanger, M.-C., Wu, C. Z., Rutishauser, U., Maffei, L., & Huang, Z. J.
- Affiliations
- Cold Spring Harbor Laboratory (US)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Huang, Z Josh
- Venue
- Nature Neuroscience
- Published
- 2007-11-18
- Volume
- 10
- Issue
- 12
- Pages
- 1569-1577
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2041958086
- Cited by
- 201
- References
- 51
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 8 · 2022: 4 · 2021: 15 · 2020: 16 · 2019: 8 · 2018: 12 · 2017: 16 · 2016: 15 · 2015: 8 · 2014: 14 · 2013: 16 · 2012: 13
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- Figshare (submittedVersion, cc-by)
- KiltHub Repository
- Funders
- National Institutes of Health
- National Eye Institute (R01 EY 13564-01, R01EY013564)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- polysialic acid, CD56, GABAergic inhibition, ocular dominance plasticity, critical period, visual cortex development, visual deprivation, activity-dependent regulation, synaptic inhibition, eye opening
- MeSH terms
- Age Factors, Analysis of Variance, Anesthetics, Local, Animals, Animals, Newborn, Critical Period, Psychological, Evoked Potentials, Visual, gamma-Aminobutyric Acid, Glutamate Decarboxylase, Glycoside Hydrolases, Neural Inhibition, Neuronal Plasticity, Photic Stimulation, Sensory Deprivation, Sialic Acids, Tetrodotoxin, Visual Cortex, Visual Pathways, Gene Expression Regulation, Developmental, Neural Cell Adhesion Molecules, Green Fluorescent Proteins, Mice, In Vitro Techniques
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