The DOI matches its Crossref record; 99 of the 104 references it cites were found in a registry or an index.
Regulation of synaptic connectivity by glia.
Open accessAbstract
The human brain contains more than 100 trillion (10(14)) synaptic connections, which form all of its neural circuits. Neuroscientists have long been interested in how this complex synaptic web is weaved during development and remodelled during learning and disease. Recent studies have uncovered that glial cells are important regulators of synaptic connectivity. These cells are far more active than was previously thought and are powerful controllers of synapse formation, function, plasticity and elimination, both in health and disease. Understanding how signalling between glia and neurons regulates synaptic development will offer new insight into how the nervous system works and provide new targets for the treatment of neurological diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Evidence now shows that astrocytes are directly involved in synaptic connections and control, ranging from ionic balance to the genesis and behavior of synapses”
From Interlaminar and varicose-projection astrocytes: toward a new understanding of the primate brain (2024) · cites this paper as Eroglu and Barres, 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Classical Complement Cascade Mediates CNS Synapse Elimination
Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., Micheva, K. D., Mehalow, A. K., Huberman, A. D., Stafford, B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.036 · Cited by 3,313 · cited 1×
“A recent study showed that the classical complement cascade, which is part of the innate immune system, helps to mediate synapse elimination in the developing CN”
BackgroundSelf-citationCahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4178-07.2008 · Cited by 3,129 · cited 1×
“Recent gene-expression analysis of astrocytes in vivo showed that astrocytes produce messenger RNAs that encode several synaptic adhesion proteins, such as neurexins, neuroligins and cadherin”
BackgroundSelf-citationTripartite synapses: glia, the unacknowledged partner
Araque, A., Parpura, V., Sanzgiri, R. P., & Haydon, P. G. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01349-6 · Cited by 2,529 · cited 1×
“The extensive structural and functional association of perisynaptic glia with the synapse gave rise to the concept of the 'tripartite synapse', in which synapses are defined as comprising the presynaptic and postsynaptic specializations of the neurons and the glial process that ensheaths the”
BackgroundSynaptic scaling mediated by glial TNF-α
Stellwagen, D., & Malenka, R. C. (2006) · Nature · doi:10.1038/nature04671 · Cited by 1,715 · cited 1×
“Interestingly, even though TNF-α increased the cell-surface expression of AMPA receptors, long-term potentiation and long-term depression were not affected in its absenc”
BackgroundCNS synaptogenesis promoted by glia-derived cholesterol
Mauch, D. H., Nägler, K., Schumacher, S., Göritz, C., Müller, E.-C., Otto, A., & Pfrieger, F. W. (2001) · Science · doi:10.1126/science.294.5545.1354 · Cited by 1,711
Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis
Christopherson, K. S., Ullian, E. M., Stokes, C. C. A., Mullowney, C. E., Hell, J. W., Agah, A., Lawler, J., Mosher, D. F., Bornstein, P., & Barres, B. A. (2005) · Cell · doi:10.1016/j.cell.2004.12.020 · Cited by 1,688
Self-citationProtoplasmic Astrocytes in CA1 Stratum Radiatum Occupy Separate Anatomical Domains
Bushong, E. A., Martone, M. E., Jones, Y. Z., & Ellisman, M. H. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00183.2002 · Cited by 1,578
Uniquely Hominid Features of Adult Human Astrocytes
Oberheim, N. A., Takano, T., Han, X., He, W., Lin, J. H. C., Wang, F., Xu, Q., Wyatt, J. D., Pilcher, W., Ojemann, J. G., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4707-08.2009 · Cited by 1,488 · cited 1×
“For example, the human brain contains several more populations of astrocytes than the rodent brain, and human astrocytes are up to threefold larger and more ramified than their rodent counterpart”
BackgroundControl of Synapse Number by Glia
Ullian, E. M., Sapperstein, S. K., Christopherson, K. S., & Barres, B. A. (2001) · Science · doi:10.1126/science.291.5504.657 · Cited by 1,380 · cited 1×
“Under these conditions, RGCs show little spontaneous synapse activity and form few synapses, whereas RGCs cultured in the presence of a feeding layer of astrocytes or astrocyte-conditioned medium show about tenfold more excitatory synapse activity and a fivefold to sevenfold increase in the number of synapse”
BackgroundSelf-citationThe Mystery and Magic of Glia: A Perspective on Their Roles in Health and Disease
Barres, B. A. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.013 · Cited by 1,352 · cited 1×
“There are several types in the central nervous system (CNS), including astrocytes, oligodendrocytes and microgli”
BackgroundSelf-citation
Flagged first, then by citations
5 of the 104 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 201–300 of 692
Hisaoka‐Nakashima, K., Kajitani, N., Kaneko, M., Shigetou, T., Kasai, M., Matsumoto, C., Yokoe, T., Azuma, H., Takebayashi, M., Morioka, N., et al. (2016) · Brain Research · doi:10.1016/j.brainres.2015.12.057 · Cited by 67
Mechanisms Involved in Spinal Cord Central Synapse Loss in a Mouse Model of Spinal Muscular Atrophy
Tarabal, O., Caraballo-Miralles, V., Cardona-Rossinyol, A., Correa, F. J., Olmos, G., Lladó, J., Esquerda, J. E., & Calderó, J. (2014) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000074 · Cited by 75
Glial Cells Decipher Synaptic Competition at the Mammalian Neuromuscular Junction
Darabid, H., Arbour, D., & Robitaille, R. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2935-12.2013 · Cited by 67
Electrochemistry at the Synapse
Shin, M., Wang, Y., Borgus, J. R., & Venton, B. (2019) · Annual Review of Analytical Chemistry · doi:10.1146/annurev-anchem-061318-115434 · Cited by 63
“Neurosci 7(1):21–25 [PubMed: 26521705] 109.”
BackgroundInfluentialSon, S. M., Kang, S., Choi, H., & Mook‐Jung, I. (2015) · Molecular Neurodegeneration · doi:10.1186/s13024-015-0054-3 · Cited by 64
“Astrocytes have an important role in maintaining neuronal homeostasis by providing energy and eliminating waste [34].”
BackgroundSynapses between NG2 glia and neurons
Sakry, D., Karram, K., & Trotter, J. (2011) · Journal of Anatomy · doi:10.1111/j.1469-7580.2011.01359.x · Cited by 65
“Even though astrocytes participate in the establishment and function of neuron–neuron synapses, via the so-called tripartite synapse (Halassa et al. 2007; Eroglu & Barres, 2010; Faissner et al. 2010), a direct and exclusive synaptic contact between a neuron and a glial cell is unique to NG2+ glia.”
BackgroundThe role of GFAP and vimentin in learning and memory
Wilhelmsson, U., Pozo-Rodrigálvarez, A., Kalm, M., de Pablo, Y., Widestrand, Å., Pekna, M., & Pekny, M. (2019) · Biological Chemistry · doi:10.1515/hsz-2019-0199 · Cited by 65
“Astrocytes in the central nervous system (CNS) participate in and control many aspects of CNS plasticity both in health and disease (Eroglu and Barres, 2010; Pekna et al., 2012; Pekny and Pekna, 2014; Pekny et al., 2016, 2019; Stogsdill et al., 2017; Verkhratsky and Nedergaard, 2018).”
BackgroundCarter, B. S., Meng, F., & Thompson, R. C. (2012) · Physiological Genomics · doi:10.1152/physiolgenomics.00097.2012 · Cited by 68
“For example, astrocytes are now known to be intricate contributors to many fundamental brain processes, including energy metabolism (5), metabolite transport (25), the blood brain barrier (1), synapse regulation (20), intercellular communication and gliotransmission (54), and injury response (6).”
BackgroundAstrocytes in the tempest of multiple sclerosis
Miljković, D. M., Timotijević, G. S., & Stojković, M. M. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.047 · Cited by 60
“From neuroscientist’s point of view, maybe the most intriguing finding is that astrocytes intensively contribute to neurotransmission and regulation of sleeping, learning and memory [6,7].”
BackgroundOlivera-Bravo, S., Fernández, A., Sarlabós, M. N., Rosillo, J., Casanova, G., Jiménez, M., & Barbeito, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020831 · Cited by 62
“Astrocytes participate in guiding the migration of developing axons and neuroblasts [1,2], are essential for the generation and pruning of synapses [3], and for the blood brain barrier formation [4].”
BackgroundVivi, E., & Benedetto, B. D. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02534-4 · Cited by 83
“An over-abundance of unpruned weak synaptic inputs appears to negatively affects the synchronized development of E/I inputs, ultimately disrupting the connectivity of brain circuits in the limbic system [13, 110, 111].”
BackgroundSöllvander, S., Nikitidou, E., Streubel-Gallasch, L., Zyśk, M., Söderberg, L., Sehlin, D., Lannfelt, L., & Erlandsson, A. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1134-4 · Cited by 72
Deciphering sex differences in the immune system and depression
Rainville, J. R., Tsyglakova, M., & Hodes, G. E. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.12.004 · Cited by 73
Emerging from an unresponsive wakefulness syndrome: Brain plasticity has to cross a threshold level
Bagnato, S., Boccagni, C., Santangelo, A., Fingelkurts, A. A., Fingelkurts, A. A., & Galardi, G. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.09.007 · Cited by 65
“The human brain contains more than 100 trillion (10 14 ) synaptic connections that form all of its neural circuits (Eroglu and Barres, 2010).”
BackgroundMicroglia maintain the normal structure and function of the hippocampal astrocyte network
Du, Y., Brennan, F. H., Popovich, P. G., & Zhou, M. (2022) · Glia · doi:10.1002/glia.24179 · Cited by 61
“Although microglia are known to regulate synapse formation and synaptic plasticity (Araque et al., 2014; Eroglu & Barres, 2010), whether microglia also regulate astrocyte syncytial isopotentiality, and how this might relate to synaptic transmission, is unknown.”
BackgroundNeuroinflammation in neurodegeneration via microbial infections
Tran, V. T. A., Lee, L. P., & Cho, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.907804 · Cited by 72
“Astrocytes are the most common glial cells in the CNS, which help maintain the BBB function, and support synaptic activities by releasing neurotransmitters and eliminating neurotoxic molecules, thus helping in the maintenance of a healthy brain (100).”
BackgroundComșa, I. M., Potempa, K., Versari, L., Fischbacher, T., Gesmundo, A., & Alakuijala, J. (2021) · IEEE Transactions on Neural Networks and Learning Systems · doi:10.1109/tnnls.2021.3071976 · Cited by 83
Qiang, L., Fujita, R., & Abeliovich, A. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.002 · Cited by 59
“For example, Studer and colleagues (Fasano et al., 2010; Kriks et al., 2011) described the efficient production of multipotent neural stem cells with a ventral floor plate phenotype—as defined by a transcription factor expression profile and competence in the generation of several ventral…”
Su, Y., Zhou, Y., Bennett, M. L., Li, S., Carceles‐Cordon, M., Lu, L., Huh, S., Jimenez, D. V., Kennedy, B. C., Kessler, S. K., et al. (2023) · Cell stem cell · doi:10.1016/j.stem.2022.12.007 · Cited by 14
“The molecular characterization of hippocampal glia remains elusive in rodents, and much less is known in humans (Eroglu and Barres, 2010).”
The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia
Nehme, R., Pietiläinen, O., Artomov, M., Tegtmeyer, M., Valakh, V., Lehtonen, L., Bell, C., Singh, T., Trehan, A., Sherwood, J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31436-8 · Cited by 58
Astrocyte-secreted neurocan controls inhibitory synapse formation and function
Irala, D., Wang, S., Sakers, K., Nagendren, L., Severino, F. P. U., Bindu, D. S., Savage, J. T., & Eroğlu, Ç. (2024) · Neuron · doi:10.1016/j.neuron.2024.03.007 · Cited by 95
Self-citationMicroglia mediated neuroinflammation in autism spectrum disorder
Liao, X., Yang, J., Wang, H., & Li, Y. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.07.013 · Cited by 79
Kostović, I., Išasegi, I. Ž., & Krsnik, Ž. (2018) · Journal of Anatomy · doi:10.1111/joa.12920 · Cited by 67
“…early astroglia are involved in both the formation of synapses (Dermietzel & Spray, 1993; Araque et al. 1999; Elmariah, 2005; Sutor & Hagerty, 2005; Bruzzone & Dermietzel, 2006; Eroglu & Barres, 2010; Faissner et al. 2010; Allen, 2014) and ECM production (Wiese et al. 2012; Oberheim et al. 2012).”
BackgroundMatias, I. C. P., Diniz, L. P., Buosi, A. S., Neves, G. A., Stipursky, J., & Gomes, F. C. A. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00184 · Cited by 64
“Currently, strong evidences point to glial cells, especially astrocytes, as active participants in synapse formation and function during development and adulthood (Eroglu and Barres, 2010; Diniz et al., 2014a).”
BackgroundSmall-Molecule-Based Lineage Reprogramming Creates Functional Astrocytes
Tian, E., Sun, G., Sun, G., Chao, J., Ye, P., Warden, C., Riggs, A. D., & Shi, Y. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.042 · Cited by 61
“5-fold showed that the transcriptional program role of astrocytes in synaptogenesis (Hama et al., 2004; Eroglu and Barres, 2010).”
BackgroundInfluentialAstrocytes: The Housekeepers and Guardians of the CNS
Verkhratsky, A., Parpura, V., Li, B., & Scuderi, C. (2021) · Advances in neurobiology · doi:10.1007/978-3-030-77375-5_2 · Cited by 80
“Without astrocytes, synapses do not form in vitro, and similarly astrocytes are necessary for synapse formation in vivo (Pfrieger and Barres 1997; Eroglu and Barres 2010).”
BackgroundPsychedelic‐inspired approaches for treating neurodegenerative disorders
Saeger, H. N., & Olson, D. E. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15544 · Cited by 72
“…molecules and digestive enzymes, retraction of their surveilling processes, and increased phagocytic activity to neutralize and clear the triggering insult (Alvarez et al. 2013; Eroglu & Barres, 2010; Jessen et al., 2015; Liddelow & Barres, 2017; Rouach et al., 2008; Sofroniew & Vinters, 2010).”
BackgroundSharma, S., Chitranshi, N., Wall, R. V., Basavarajappa, D. K., Gupta, V., Mirzaei, M., Graham, S. L., Klistorner, A. I., & You, Y. (2021) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2021.06.001 · Cited by 66
Niu, X., Jiang, X., Xu, G.-D., Zheng, G.-M., Tang, Z., Yin, N., Li, X.-Q., Yang, Y.-Y., & Lv, P.-Y. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27332 · Cited by 56
“Shh/ Ptch1/Smo/Gli activation has been found in cortical astrocytes and appears to have numerous roles in maintaining normal brain function, including roles for regulating synapse formation and synaptic plasticity (Eroglu & Barres, 2010; Harwell et al., 2012).”
BackgroundUse it and/or lose it—experience effects on brain remodeling across time after stroke
Allred, R. P., Kim, S. Y., & Jones, T. A. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00379 · Cited by 55
Don't forget astrocytes when targeting Alzheimer's disease
Sadick, J. S., & Liddelow, S. A. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14568 · Cited by 60
Role of Glial Cells in Axonal Regeneration
Toy, D., & Namgung, U. (2013) · Experimental Neurobiology · doi:10.5607/en.2013.22.2.68 · Cited by 53
“Moreover, recent studies suggest that both astrocytes and Schwann cells are involved in synapse formation [85, 86].”
ResultCrawford, D. C., Jiang, X., Taylor, A., & Mennerick, S. J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2604-12.2012 · Cited by 57
“For more information, please contact vanam@wustl.edu.”
BackgroundMethodInfluentialChen, L., Lv, X., Guo, Q., Lv, S., Lü, N., Xu, W., Yu, J. M., & Zhang, Y. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15994 · Cited by 68
Chooi, W. H., & Chew, S. Y. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.01.030 · Cited by 54
Salma, J., & McDermott, J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3609-11.2012 · Cited by 54
“Neuronal apoptosis fulfills a crucial role for normal organization of the brain through the elimination of excess neurons and synaptic connections (Contestabile, 2002; Kano and Hashimoto, 2009; Eroglu and Barres, 2010).”
BackgroundYang, L., Jin, P., Wang, X., Zhou, Q. W., Lin, X., & Xi, S. (2018) · NeuroToxicology · doi:10.1016/j.neuro.2018.09.006 · Cited by 59
Marathe, S. V., D’almeida, P., Virmani, G., Bathini, P., & Alberi, L. A. (2018) · Journal of Experimental Neuroscience · doi:10.1177/1179069518789149 · Cited by 62
Oligodendrocytes as Regulators of Neuronal Networks during Early Postnatal Development
Doretto, S., Malerba, M., Ramos, M., Ikrar, T., Kinoshita, C., Mei, C. D., Tirotta, E., Xu, X., & Borrelli, E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019849 · Cited by 54
“Thus, it is interesting to note that oligodendrocytes can regulate axonal growth at distance, suggesting that either physical contacts between oligodendrocytes and neurons or diffusible factors from these or other glial cells [5,39,40] might affect neurite growth at distal sites.”
BackgroundYoo, J., Lee, J., Ahn, B., Han, J., & Lim, M. H. (2025) · Chemical Science · doi:10.1039/d4sc06762b · Cited by 78
“137 Meanwhile, microglia, the primary immune cells of the CNS, constantly monitor their microenvironment and secrete pro-in ammatory mediators, such as tumor necrosis factor-a (TNF-a ) and interleukin-1 b (IL-1 b ), in response to injury or infection.”
On the research of time past: the hunt for the substrate of memory
Queenan, B. N., Ryan, T. J., Gazzaniga, M. S., & Gallistel, C. R. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13348 · Cited by 55
VanderWall, K. B., Vij, R., Ohlemacher, S. K., Sridhar, A., Fligor, C. M., Feder, E. M., Edler, M. C., Baucum, A. J., Cummins, T. R., & Meyer, J. S. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.12.010 · Cited by 46
“…with all astrocytes sharing the common function of supporting neurons through the regulation of homeostasis as well as aiding in synaptic formation and maturity (Clarke and Barres, 2013; Eroglu and Barres, 2010; Pellerin and Magistretti, 1994; Pfrieger and Barres, 1997; Ullian et al., 2004).”
BackgroundInfluentialSynaptic Plasticity on Motoneurons After Axotomy: A Necessary Change in Paradigm
Álvarez, F. J., Rotterman, T. M., Akhter, E. T., Lane, A. R., ENGLISH, A. W., & Cope, T. C. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00068 · Cited by 59
Glia Modulate a Neuronal Circuit for Locomotion Suppression during Sleep in C. elegans
Katz, M., Corson, F., Iwanir, S., Biron, D., & Shaham, S. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.036 · Cited by 52
“CEPsh glia also promote synaptogenesis (Colón-Ramos et al., 2007), an important function of vertebrate astrocytes (Eroglu and Barres, 2010).”
BackgroundExploring DMT: Endogenous role and therapeutic potential
Schimmelpfennig, J., & Jankowiak-Siuda, K. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110314 · Cited by 55
Neurophotonic tools for microscopic measurements and manipulation: status report
Abdelfattah, A. S., Allu, S., Campbell, R. E., Cheng, X., Čižmár, T., Costantini, I., Emiliani, V., Fomin-Thunemann, N., Gilad, A., Fernández-Alfonso, T., et al. (2022) · Neurophotonics · doi:10.1117/1.nph.9.s1.013001 · Cited by 49
Homer1 Scaffold Proteins Govern Ca2+ Dynamics in Normal and Reactive Astrocytes
Buscemi, L., Ginet, V., Lopatář, J., Montana, V., Pucci, L., Spagnuolo, P., Zehnder, T., Grubišić, V., Truttman, A., Sala, C., et al. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw078 · Cited by 52
Jukkola, P. I., Guerrero, T., Gray, V., & Gu, C. (2013) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-1-70 · Cited by 49
“Astrocytes outnumber neurons in human brain and spinal cord [4] and fulfill important roles in regulating synapse formation and function [5], and axon myelination [6,7], as well as neurovascular coupling [8].”
BackgroundMcCullough, S. D., Xu, X., Dent, S., Bekiranov, S., Roeder, R. G., & Grant, P. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218331110 · Cited by 47
“Astrocytes play a crucial role in the regulation of synaptic formation and function by ensheathing axon–dendrite connections to form a structure known as the tripartite synapse (9).”
BackgroundLeslie, J. R., Imai, F., Fukuhara, K., Takegahara, N., Rizvi, T. A., Friedel, R. H., Wang, F., Kumanogoh, A., & Yoshida, Y. (2011) · Development · doi:10.1242/dev.066076 · Cited by 49
“In addition to their passive and supportive roles, glial cells also guide synapse formation, influence synaptic function and mediate synaptic elimination (Eroglu and Barres, 2010).”
BackgroundSynaptic plasticity and cognitive function are disrupted in the absence of Lrp4
Gomez, A. M., Froemke, R. C., & Burden, S. J. (2014) · eLife · doi:10.7554/elife.04287 · Cited by 47
“Because glia are known to regulate the efficiency of synaptic transmission (Eroglu and Barres, 2010), a potential defect in glia–neuron signaling could contribute to a failure of synaptic transmission, postsynaptic integration, and/or synapse formation on CA1 apical dendrites.”
Gustafsson, G., Lindström, V., Rostami, J., Nordström, E. K. L., Lannfelt, L., Bergström, J. J. E., Ingelsson, M., & Erlandsson, A. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-1018-z · Cited by 48
Targeting astrocytes in bipolar disorder
Peng, L., Li, B., & Verkhratsky, A. (2016) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2016.1171144 · Cited by 45
“synaptic maturation, maintenance, and extinction [10,15,16].”
Culley, D. J., Cotran, E., Karlsson, E., Palanisamy, A., Boyd, J. D., Xie, Z., & Crosby, G. (2013) · British Journal of Anaesthesia · doi:10.1093/bja/aet169 · Cited by 47
Glial glutamate transport modulates dendritic spine head protrusions in the hippocampus
Verbich, D., Prenosil, G., Chang, P. K. ‐., Murai, K. K., & McKinney, R. A. (2012) · Glia · doi:10.1002/glia.22335 · Cited by 48
Astroglia in Alzheimer’s Disease
Verkhratsky, A., Parpura, V., Rodriguez, J. J., & Zorec, R. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-9913-8_11 · Cited by 96
Ma, M., Li, H., Wu, J., Zhang, Y., Shen, H., Li, X., Wang, Z., & Chen, G. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01990-7 · Cited by 58
Jebelli, J. D., Hooper, C., & Pocock, J. M. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.08.049 · Cited by 43
Bambico, F. R., & Belzung, C. (2012) · Current topics in behavioral neurosciences · doi:10.1007/7854_2012_234 · Cited by 61
“glia in the depressive PFC, which has also been recently established empirically (Rajkowska and Miguel-Hidalgo 2007), could also exacerbate this occurrence by the insufficiency of glutamate clearance and reuptake through glial transporter molecules, although glia-secreted factors also facilitate by themselves synaptog…”
BackgroundSpatial constraints dictate glial territories at murine neuromuscular junctions
Brill, M. S., Lichtman, J. W., Thompson, W. J., Zuo, Y., & Misgeld, T. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201108005 · Cited by 47
Lundquist, A. J., Parizher, J., Petzinger, G. M., & Jakowec, M. W. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24430 · Cited by 50
“One‐way ANOVA with Dunnett's multiple comparisons [Color figure can be viewed at wileyonlinelibrary.com] Christopherson et al., 2005; Eroglu & Barres, 2010).”
BackgroundMethodBrambilla, L., Guidotti, G., Martorana, F., Iyer, A. M., Aronica, E., Valori, C. F., & Rossi, D. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw161 · Cited by 47
How is flexible electronics advancing neuroscience research?
Chen, Y., Rommelfanger, N. J., Mahdi, A. I., Wu, X., Keene, S. T., Obaid, A., Salleo, A., Wang, H., & Hong, G. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120559 · Cited by 58
The Role of Astrocytes in the Development of the Cerebellum
Araújo, A. P. B., Carpi-Santos, R., & Gomes, F. C. A. (2019) · The Cerebellum · doi:10.1007/s12311-019-01046-0 · Cited by 55
Wang, X., Lippi, G., Carlson, D. M., & Berg, D. K. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12436 · Cited by 43
Snider, S. E., Vunck, S. A., van den Oord, E. J. C. G., Adkins, D. E., McClay, J. L., & Beardsley, P. M. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.01.013 · Cited by 47
“One proposed mechanism involves the ability of glial cells to regulate neurotransmission and synaptic strength by affecting the cell surface delivery and retention of glutamatergic NMDA and AMPA receptors (Eroglu and Barres, 2010).”
BackgroundOlfactory bulb astrocytes mediate sensory circuit processing through Sox9 in the mouse brain
Ung, K., Huang, T.-W., Lozzi, B., Woo, J., Hanson, E., Pekarek, B. T., Tepe, B., Sardar, D., Cheng, Y.-T., Liu, G., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25444-3 · Cited by 48
Brüll, M. (2020) · ALTEX · doi:10.14573/altex.1911111 · Cited by 44
“They also control synapse formation and elimination (Chung et al., 2015; Eroglu and Barres, 2010; Wilton et al., 2019; Jay et al., 2019; Klapper et al., 2019).”
BackgroundImmunity Against Bacterial Infection of the Central Nervous System: An Astrocyte Perspective
Geyer, S., Jacobs, M., & Hsu, N. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00057 · Cited by 68
“Astrocytes are of neuro-ectodermal origin and are strategically located at the interface between blood vessels and the brain parenchyma where they have a dynamic role in maintaining CNS homeostasis, particularly to regulate synapse formation and support neuronal function in both healthy and injured brain (Eroglu and B…”
BackgroundCalcium Signaling Deficits in Glia and Autophagic Pathways Contributing to Neurodegenerative Disease
Mustaly-Kalimi, S., Littlefield, A. M., & Stutzmann, G. E. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7266 · Cited by 47
“In turn, astrocytes can modulate neuronal synaptic activity by manipulating the local extracellular Ca 2 + environment and affect vesicle release thresholds among other fundamental release properties (48, 169).”
Roles of Glial Cells in Sculpting Inhibitory Synapses and Neural Circuits
Um, J. W. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00381 · Cited by 45
“Synapse elimination is crucial for normal synapse development across the CNS and PNS (Eroglu and Barres, 2010; Neniskyte and Gross, 2017).”
Neural plasticity and network remodeling: From concepts to pathology
Cohen, E. J., Quarta, E., Bravi, R., Granato, A., & Minciacchi, D. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2016.12.048 · Cited by 45
Gomes, P., Tzouanou, F., Skolariki, K., Vamvaka-Iakovou, A., Nogueras‐Ortiz, C. J., Tsirtsaki, K., Waites, C. L., Vlamos, P., Sousa, N., Costa‐Silva, B., et al. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114183 · Cited by 57
“Glial cells have been shown to play an important role in this process (Eroglu and Barres, 2010) in a complement-dependent manner and are triggered by neuronal activity (Hong et al., 2016; Schafer et al., 2012).”
Mia, M. M., & Singh, M. K. (2022) · FEBS Journal · doi:10.1111/febs.16449 · Cited by 50
Loss of Glial Neurofascin155 Delays Developmental Synapse Elimination at the Neuromuscular Junction
Roche, S. L., Sherman, D. L., Dissanayake, K. N., Soucy, G., Desmazières, A., Lamont, D. J., Peles, E., Julien, J., Wishart, T. M., Ribchester, R. R., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1725-14.2014 · Cited by 43
Maes, M., Vojdani, A., Sirivichayakul, S., Barbosa, D., & Kanchanatawan, B. (2020) · Molecular Neurobiology · doi:10.1007/s12035-021-02343-8 · Cited by 40
“In the brain, C1q tags unwanted cells and weak synapses for elimination through glial phagocytosis and, therefore, controls synapse elimination and, consequently, C1qderived synaptic loss may drive neurodegenerative processes [59].”
BackgroundRaabe, F. J., Galinski, S., Papiol, S., Falkai, P., Schmitt, A., & Rossner, M. J. (2018) · Schizophrenia · doi:10.1038/s41537-018-0066-4 · Cited by 48
Memi, F., Zečević, N., & Radonjić, N. V. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1621-5 · Cited by 44
“2016; Eroglu and Barres 2010) as well as the formation and maintenance of the blood–brain barrier (BBB).”
BackgroundGeng, Z., Dong, J., Chen, J., & Han, Y. M. (2017) · Engineering Applications of Artificial Intelligence · doi:10.1016/j.engappai.2017.03.011 · Cited by 43
Human dermal fibroblasts in psychiatry research
Kalman, J. L., Garbett, K. A., Janka, Z., & Mirnics, K. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.01.067 · Cited by 45
Coccini, T., Manzo, L., Bellotti, V., & Simone, U. D. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/259765 · Cited by 42
“Astrocytes communicate with neurons to enable synapse formation, synaptic transmission, plasticity, and synaptic homeostasis [48, 49].”
Potential neurotoxic activity of diverse molecules released by astrocytes
Murray, T. E., Richards, C. M., Robert-Gostlin, V. N., Bernath, A. K., Lindhout, I. A., & Klegeris, A. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.08.015 · Cited by 40
Two macrophages, osteoclasts and microglia: from development to pleiotropy
Lee, J., Lee, I., Iimura, T., & Kong, S. W. (2021) · Bone Research · doi:10.1038/s41413-020-00134-w · Cited by 46
Contributions of monocytes to nervous system disorders
Garré, J. M., & Yang, G. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1672-3 · Cited by 53
Tissue-like Neural Probes for Understanding and Modulating the Brain
Hong, G., Viveros, R. D., Zwang, T. J., Yang, X., & Lieber, C. M. (2018) · Biochemistry · doi:10.1021/acs.biochem.8b00122 · Cited by 46
The Special Case of Human Astrocytes
Verkhratsky, A., Bush, N., Nedergaard, M., & Butt, A. (2018) · Neuroglia · doi:10.3390/neuroglia1010004 · Cited by 39
Glia actively sculpt sensory neurons by controlled phagocytosis to tune animal behavior
Raiders, S. A., Black, E. C., Bae, A. J., MacFarlane, S., Klein, M., Shaham, S., & Singhvi, A. (2021) · eLife · doi:10.7554/elife.63532 · Cited by 42
Contreras, J. A., Aslanyan, V., Sweeney, M. D., Sanders, L. M. J., Sagare, A. P., Zloković, B. V., Toga, A. W., Han, S. D., Morris, J. C., Fagan, A. M., et al. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.10.013 · Cited by 42
“Activated glial cells are believed to modulate synaptic transmission (Bacci et al., 1999; Eroglu and Barres, 2010), and conversely, synaptic activity can induce activation of neuroimmune cells, resulting in neurogenic neuroinflammation (Tian et al.”
Gabbi, P., Ribeiro, L. R., Martins, G. J., Cardoso, A. S., Haupental, F., Rodrigues, F. S., Machado, A. K., Brum, J. S., Duarte, M. M. F., Schetinger, M. R. C., et al. (2017) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw121 · Cited by 39
“However, MMA injection did increase the CWME in the 21-day-old (F[1,32] 1⁄4 42.”
InfluentialAutism and EMF? Plausibility of a pathophysiological link part II
Herbert, M. R., & Sage, C. (2013) · Pathophysiology · doi:10.1016/j.pathophys.2013.08.002 · Cited by 28
“[194] [195] [196] [197].”
Gene expression-based modeling of human cortical synaptic density
Goyal, M. S., & Raichle, M. E. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303453110 · Cited by 37
“, C1QA), another related to fragile X syndrome (FMR1), and others that also have been implicated in the processes of synaptic elimination (21).”
BackgroundInfluentialThe use of iPSC technology for modeling Autism Spectrum Disorders
Russo, F. B., Brito, A., de Freitas, A. M., Castanha, A. G., Freitas, B. C. D., & Beltrão-Braga, P. C. B. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104483 · Cited by 41
Astrogliopathology in the infectious insults of the brain
Zorec, R., Avšič‐Županc, T., & Verkhratsky, A. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.08.003 · Cited by 45
“In addition astroglial cradle controls synaptogenesis through release of numerous trophic factors such as trombospondins, glypicans or hevins, and is involved in synaptic extinction [4, 27].”
Yuferov, V. P., Zhang, Y., Liang, Y., Zhao, C., Randesi, M., & Kreek, M. J. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00257 · Cited by 35
“release several neuroactive molecules, such as glutamate, Dserine, ATP, GABA, TNFa, that can actively regulatemany aspects of neuronal function, including neurotransmitter release, gene regulation, dendriticmorphology, and synaptic connectivity (57).”
BackgroundMagistri, M., Khoury, N., Mazza, E. M. C., Velmeshev, D., Lee, J. K., Bicciato, S., Tsoulfas, P., & Faghihi, M. A. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13382 · Cited by 46
“C1q-like protein 1 (C1QL1) is a synaptic molecules that is expressed by neurons and is involved in activitydependent synapse plasticity and formation (Eroglu & Barres, 2010).”
BackgroundLeptin potentiates astrogenesis in the developing hypothalamus
Rottkamp, D. M., Rudenko, I. A., Maier, M. T., Roshanbin, S., Yulyaningsih, E., Perez, L., Valdearcos, M., Chua, S. C., Koliwad, S. K., & Xu, A. W. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.08.005 · Cited by 38
Essential Role of Astrocytes in Learning and Memory
Escalada, P., Ezkurdia, A., Ramírez, M. J., & Solas, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031899 · Cited by 46
Genetic Mechanisms Underlying the Evolution of Connectivity in the Human Cortex
Schmidt, E. R. E., & Polleux, F. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.787164 · Cited by 49
“For example, it has become increasingly clear that a variety of glial cells, such as astrocytes, oligodendrocytes, and microglia, play an essential role in the formation and function of neuronal circuits (Eroglu and Barres, 2010; Wilton et al., 2019).”
BackgroundPrenatal inflammation and risk for schizophrenia: A role for immune proteins in neurodevelopment
Allswede, D. M., & Cannon, T. D. (2018) · Development and Psychopathology · doi:10.1017/s0954579418000317 · Cited by 46
Liao, Z., Tao, Y., Guo, X.-M., Cheng, D., Wang, F., Liu, X., & Ma, L. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00396 · Cited by 39
“In addition, gliotransmitters released by astrocytes might generate complicated functions to scale synaptic strength, modulating synaptic plasticity (Perea et al., 2009; Eroglu and Barres, 2010; Araque et al., 2014).”
Background
Metadata
- Authors
- Eroglu, C., & Barres, B. A.
- Affiliations
- Stanford Medicine (US)
- ORCID
- Barres, Ben A.
- Venue
- Nature
- Published
- 2010-11
- Volume
- 468
- Issue
- 7321
- Pages
- 223-231
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4431554
- OpenAlex
- W1973477241
- Cited by
- 813
- References
- 104
- Citations by year
- 2026: 21 · 2025: 46 · 2024: 48 · 2023: 52 · 2022: 54 · 2021: 60 · 2020: 52 · 2019: 52 · 2018: 66 · 2017: 54 · 2016: 50 · 2015: 50 · 2014: 55 · 2013: 58 · 2012: 58
- FWCI
- 4.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Alfred P. Sloan Foundation
- National Institute on Drug Abuse (R01DA015043)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- glial cells, synaptic connectivity, synaptogenesis, synaptic pruning, synaptic plasticity, synaptic development, learning, neurological disorders
- MeSH terms
- Animals, Axons, Central Nervous System Diseases, Drosophila melanogaster, Humans, Synaptic Transmission, Neuroglia, Synapses
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
