Remodeling neurodegeneration: somatic cell reprogramming-based models of adult neurological disorders

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

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Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

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Multiplex Genome Engineering Using CRISPR/Cas Systems

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The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

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RNA-Guided Human Genome Engineering via Cas9

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Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

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Direct conversion of fibroblasts to functional neurons by defined factors

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Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA

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Epigenetic memory in induced pluripotent stem cells

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The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

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A more efficient method to generate integration-free human iPS cells

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Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

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Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

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Generation of Human Induced Pluripotent Stem Cells by Direct Delivery of Reprogramming Proteins

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Induced pluripotent stem cells from a spinal muscular atrophy patient

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Modelling schizophrenia using human induced pluripotent stem cells

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Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

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A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

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Somatic coding mutations in human induced pluripotent stem cells

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Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

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Induction of human neuronal cells by defined transcription factors

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The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS

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Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

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The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

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Genetic engineering of human pluripotent cells using TALE nucleases

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Unconventional Translation of C9ORF72 GGGGCC Expansion Generates Insoluble Polypeptides Specific to c9FTD/ALS

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Direct generation of functional dopaminergic neurons from mouse and human fibroblasts

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Reference maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines

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Copy number variation and selection during reprogramming to pluripotency

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MicroRNA-mediated conversion of human fibroblasts to neurons

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Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture

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Genetic Animal Models of Parkinson's Disease

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Regulation of synaptic connectivity by glia.

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Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells

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LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress

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Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

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Direct conversion of human fibroblasts to dopaminergic neurons

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Strategies and New Developments in the Generation of Patient-Specific Pluripotent Stem Cells

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Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations

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Generation of Regionally Specified Neural Progenitors and Functional Neurons from Human Embryonic Stem Cells under Defined Conditions

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Mash1regulates neurogenesis in the ventral telencephalon

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Basic helix-loop-helix factors in cortical development.

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Neural induction, the default model and embryonic stem cells

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Conversion of Mouse and Human Fibroblasts into Functional Spinal Motor Neurons

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Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

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Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells

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Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors

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Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors

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Modeling familial Alzheimer's disease with induced pluripotent stem cells

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Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis

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Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome

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Direct reprogramming of mouse fibroblasts to neural progenitors

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Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits

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Disease‐specific phenotypes in dopamine neurons from human iPS‐based models of genetic and sporadic Parkinson's disease

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Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells

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Direct Reprogramming of Mouse and Human Fibroblasts into Multipotent Neural Stem Cells with a Single Factor

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Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cells

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Direct Reprogramming of Fibroblasts into Neural Stem Cells by Defined Factors

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Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson’s disease

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A TALEN Genome-Editing System for Generating Human Stem Cell-Based Disease Models

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Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression

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A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration

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A functionally characterized test set of human induced pluripotent stem cells

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Human Embryonic Stem Cell-Derived Motor Neurons Are Sensitive to the Toxic Effect of Glial Cells Carrying an ALS-Causing Mutation

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Direct Conversion of Fibroblasts into Stably Expandable Neural Stem Cells

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Direct Reprogramming of Adult Human Fibroblasts to Functional Neurons under Defined Conditions

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Presenilins and -Secretase: Structure, Function, and Role in Alzheimer DiseasePreprint

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Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease

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Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity.Preprint

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Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells

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Genetic Correction of Huntington’s Disease Phenotypes in Induced Pluripotent Stem Cells

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Mitochondrial Parkin Recruitment Is Impaired in Neurons Derived from Mutant PINK1 Induced Pluripotent Stem Cells

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Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors

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The Seeds of Neurodegeneration: Prion-like Spreading in ALS

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Role for glia in synaptogenesis

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Understanding the role of TDP-43 and FUS/TLS in ALS and beyond

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Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy

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Direct Lineage Conversion of Terminally Differentiated Hepatocytes to Functional Neurons

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Additional file 2 of Edaravone activates the GDNF/RET neurotrophic signaling pathway and protects mRNA-induced motor neurons from iPS cells

Li, Q., Feng, Y., Xue, Y., Zhan, X., Fu, Y., Gui, G., Zhou, W., Richard, J., Taga, A., Li, P. P., et al. (2022) · Figshare · doi:10.6084/m9.figshare.18132532

Additional file 6 of Edaravone activates the GDNF/RET neurotrophic signaling pathway and protects mRNA-induced motor neurons from iPS cells

Li, Q., Feng, Y., Xue, Y., Zhan, X., Fu, Y., Gui, G., Zhou, W., Richard, J., Taga, A., Li, P. P., et al. (2022) · Figshare · doi:10.6084/m9.figshare.18132544

Additional file 5 of Edaravone activates the GDNF/RET neurotrophic signaling pathway and protects mRNA-induced motor neurons from iPS cells

Li, Q., Feng, Y., Xue, Y., Zhan, X., Fu, Y., Gui, G., Zhou, W., Richard, J., Taga, A., Li, P. P., et al. (2022) · Figshare · doi:10.6084/m9.figshare.18132541

Additional file 3 of Edaravone activates the GDNF/RET neurotrophic signaling pathway and protects mRNA-induced motor neurons from iPS cells

Li, Q., Feng, Y., Xue, Y., Zhan, X., Fu, Y., Gui, G., Zhou, W., Richard, J., Taga, A., Li, P. P., et al. (2022) · Figshare · doi:10.6084/m9.figshare.18132535

Additional file 4 of Edaravone activates the GDNF/RET neurotrophic signaling pathway and protects mRNA-induced motor neurons from iPS cells

Li, Q., Feng, Y., Xue, Y., Zhan, X., Fu, Y., Gui, G., Zhou, W., Richard, J., Taga, A., Li, P. P., et al. (2022) · Figshare · doi:10.6084/m9.figshare.18132538

Additional file 1 of Edaravone activates the GDNF/RET neurotrophic signaling pathway and protects mRNA-induced motor neurons from iPS cells

Li, Q., Feng, Y., Xue, Y., Zhan, X., Fu, Y., Gui, G., Zhou, W., Richard, J., Taga, A., Li, P. P., et al. (2022) · Figshare · doi:10.6084/m9.figshare.18132529

Additional file 7 of Edaravone activates the GDNF/RET neurotrophic signaling pathway and protects mRNA-induced motor neurons from iPS cells

Li, Q., Feng, Y., Xue, Y., Zhan, X., Fu, Y., Gui, G., Zhou, W., Richard, J., Taga, A., Li, P. P., et al. (2022) · Figshare · doi:10.6084/m9.figshare.18132550

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