The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
Glial and neuronal control of brain blood flow
Open accessAbstract
Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these cells control blood flow is crucial for understanding how neural computation is powered, for interpreting functional imaging scans of brains, and for developing treatments for neurological disorders. It is now recognized that neurotransmitter-mediated signalling has a key role in regulating cerebral blood flow, that much of this control is mediated by astrocytes, that oxygen modulates blood flow regulation, and that blood flow may be controlled by capillaries as well as by arterioles. These conceptual shifts in our understanding of cerebral blood flow control have important implications for the development of new therapeutic approaches.
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“This process can be adjusted on demand either through modulation of neurovascular coupling15–17 or via neuronal signaling to astrocytes18.”
From Energy paradox in REM sleep: balancing supply and consumption in brain metabolism (2026) · cites this paper as [16]
In the citing paper
“As neural activity elevates, local oxygen consumption and demand increases, triggering vasodilation of arterioles and capillaries to increase cerebral blood flow (124), which supplies oxygenated hemoglobin in excess of the metabolic rate of oxygen consumption (125).”
From Electrophysiological source imaging: A noninvasive window to brain dynamics (2018) · cites this paper as [124]
In the citing paper
“Such a cascade of metabolic and vascular events, known as the neurovascular coupling, involves complex signaling among neurons, astrocytes, and the local vasculature (124, 126, 127), and remains a topic of active research enabled by emerging tools (128).”
From Electrophysiological source imaging: A noninvasive window to brain dynamics (2018) · cites this paper as [124]
In the citing paper
“PVMs were found most abundantly in association with pial and parenchymal vessels larger than 20 μm in diameter, particularly pial arterioles, a key site for flow regulation (7), the length of which was covered 70%-80% by PVMs (Supplemental Figure 1, A-E; supplemental material available online with this article; doi:10.1172/JCI86950DS1).”
From Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension (2016) · cites this paper as [7]
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Citations
Cites
Neurophysiological investigation of the basis of the fMRI signal
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Interplay between Cortical Spreading Depolarization and Seizures
Kramer, D. R., Fujii, T., Ohiorhenuan, I. E., & Liu, C. Y. (2017) · Stereotactic and Functional Neurosurgery · doi:10.1159/000452841 · Cited by 3,721
An Energy Budget for Signaling in the Grey Matter of the Brain
Attwell, D., & Laughlin, S. B. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200110000-00001 · Cited by 3,543
Self-citationNonoxidative Glucose Consumption During Focal Physiologic Neural Activity
Fox, P. T., Raichle, M. E., Mintun, M. A., & Dence, C. (1988) · Science · doi:10.1126/science.3260686 · Cited by 1,796
Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation
Zonta, M., Angulo, M. C., Gobbo, S., Rosengarten, B., Hossmann, K.-A., Pozzan, T., & Carmignoto, G. (2002) · Nature Neuroscience · doi:10.1038/nn980 · Cited by 1,446
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Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease
Girouard, H., & Iadecola, C. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00966.2005 · Cited by 1,311
P-450 Metabolites of Arachidonic Acid in the Control of Cardiovascular Function
Roman, R. J. (2002) · Physiological Reviews · doi:10.1152/physrev.00021.2001 · Cited by 1,307
Identification of Epoxyeicosatrienoic Acids as Endothelium-Derived Hyperpolarizing Factors
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Pathophysiology of the migraine aura: The spreading depression theory
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Astrocytes, emerging stars of energy homeostasis
Camandola, S. (2018) · Cell Stress · doi:10.15698/cst2018.10.157 · Cited by 25
On astrocyte-neuron interactions: broad insights from the striatum
Khakh, B. S. (2025) · Neuron · doi:10.1016/j.neuron.2025.08.009 · Cited by 23
Yin, H., Lu, Z., Deng, Y., Tian, X., & Gong, Q. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102952 · Cited by 6
Energy paradox in REM sleep: balancing supply and consumption in brain metabolism
Takahashi, Y., Ikoma, Y., & Matsui, K. (2026) · Communications Biology · doi:10.1038/s42003-026-10646-6 · Cited by 1
Metadata
- Authors
- Attwell, D., Buchan, A. M., Charpak, S., Lauritzen, M., MacVicar, B. A., & Newman, E. A.
- Affiliations
- University College London (GB)
- John Radcliffe Hospital (GB)
- Centre National de la Recherche Scientifique (FR)
- University of Copenhagen (DK)
- University of British Columbia (CA)
- University of Minnesota (US)
- ORCID
- Venue
- Nature
- Published
- 2010-11-10
- Volume
- 468
- Issue
- 7321
- Pages
- 232-243
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3206737
- OpenAlex
- W2163234334
- Cited by
- 2,511
- References
- 135
- Citations by year
- 2026: 144 · 2025: 163 · 2024: 163 · 2023: 147 · 2022: 176 · 2021: 197 · 2020: 180 · 2019: 177 · 2018: 177 · 2017: 172 · 2016: 156 · 2015: 174 · 2014: 146 · 2013: 147 · 2012: 120
- FWCI
- 9.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Wellcome Trust
- Canadian Institutes of Health Research
- National Eye Institute (R01EY004077, P30EY011374)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- cerebral autoregulation, astrocytes, neurons, neurotransmitter signalling, oxygen sensing, capillary blood flow, arterioles, neurovascular coupling, functional neuroimaging, neurological disorders
- MeSH terms
- Alzheimer Disease, Brain, Brain Ischemia, Cerebrovascular Circulation, Humans, Neuroglia, Neurons, Nitric Oxide, Oxygen, Signal Transduction, Neurotransmitter Agents
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