The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
Glial and neuronal control of brain blood flow
Open accessAbstract
Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these cells control blood flow is crucial for understanding how neural computation is powered, for interpreting functional imaging scans of brains, and for developing treatments for neurological disorders. It is now recognized that neurotransmitter-mediated signalling has a key role in regulating cerebral blood flow, that much of this control is mediated by astrocytes, that oxygen modulates blood flow regulation, and that blood flow may be controlled by capillaries as well as by arterioles. These conceptual shifts in our understanding of cerebral blood flow control have important implications for the development of new therapeutic approaches.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“This process can be adjusted on demand either through modulation of neurovascular coupling15–17 or via neuronal signaling to astrocytes18.”
From Energy paradox in REM sleep: balancing supply and consumption in brain metabolism (2026) · cites this paper as [16]
In the citing paper
“As neural activity elevates, local oxygen consumption and demand increases, triggering vasodilation of arterioles and capillaries to increase cerebral blood flow (124), which supplies oxygenated hemoglobin in excess of the metabolic rate of oxygen consumption (125).”
From Electrophysiological source imaging: A noninvasive window to brain dynamics (2018) · cites this paper as [124]
In the citing paper
“Such a cascade of metabolic and vascular events, known as the neurovascular coupling, involves complex signaling among neurons, astrocytes, and the local vasculature (124, 126, 127), and remains a topic of active research enabled by emerging tools (128).”
From Electrophysiological source imaging: A noninvasive window to brain dynamics (2018) · cites this paper as [124]
In the citing paper
“PVMs were found most abundantly in association with pial and parenchymal vessels larger than 20 μm in diameter, particularly pial arterioles, a key site for flow regulation (7), the length of which was covered 70%-80% by PVMs (Supplemental Figure 1, A-E; supplemental material available online with this article; doi:10.1172/JCI86950DS1).”
From Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension (2016) · cites this paper as [7]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Neurophysiological investigation of the basis of the fMRI signal
Logothetis, N. K., Pauls, J., Augath, M., Trinath, T., & Oeltermann, A. (2001) · Nature · doi:10.1038/35084005 · Cited by 6,551
Interplay between Cortical Spreading Depolarization and Seizures
Kramer, D. R., Fujii, T., Ohiorhenuan, I. E., & Liu, C. Y. (2017) · Stereotactic and Functional Neurosurgery · doi:10.1159/000452841 · Cited by 3,721
An Energy Budget for Signaling in the Grey Matter of the Brain
Attwell, D., & Laughlin, S. B. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200110000-00001 · Cited by 3,543
Self-citationNonoxidative Glucose Consumption During Focal Physiologic Neural Activity
Fox, P. T., Raichle, M. E., Mintun, M. A., & Dence, C. (1988) · Science · doi:10.1126/science.3260686 · Cited by 1,796
Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation
Zonta, M., Angulo, M. C., Gobbo, S., Rosengarten, B., Hossmann, K.-A., Pozzan, T., & Carmignoto, G. (2002) · Nature Neuroscience · doi:10.1038/nn980 · Cited by 1,446
Cerebral ischemia. II. The no-reflow phenomenon.
Ames, A., Rl, W., Kowada, M., Thurston, J. M., & Majno, G. (1968) · PubMed · Cited by 1,371
Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease
Girouard, H., & Iadecola, C. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00966.2005 · Cited by 1,311
P-450 Metabolites of Arachidonic Acid in the Control of Cardiovascular Function
Roman, R. J. (2002) · Physiological Reviews · doi:10.1152/physrev.00021.2001 · Cited by 1,307
Identification of Epoxyeicosatrienoic Acids as Endothelium-Derived Hyperpolarizing Factors
Campbell, W. B., Gebremedhin, D., Pratt, P. F., & Harder, D. R. (1996) · Circulation Research · doi:10.1161/01.res.78.3.415 · Cited by 1,221
Pathophysiology of the migraine aura: The spreading depression theory
Lauritzen, M. (1994) · Brain · doi:10.1093/brain/117.1.199 · Cited by 1,151
Self-citationBidirectional control of CNS capillary diameter by pericytes
Peppiatt, C. M., Howarth, C., Mobbs, P., & Attwell, D. (2006) · Nature · doi:10.1038/nature05193 · Cited by 1,150
Self-citationAstrocyte-mediated control of cerebral blood flow
Takano, T., Tian, G.-F., Peng, W., Lou, N., Libionka, W., Han, X., & Nedergaard, M. (2005) · Nature Neuroscience · doi:10.1038/nn1623 · Cited by 1,137
Markram, H., Lübke, J., Frotscher, M., Roth, A., & Sakmann, B. (1997) · The Journal of Physiology · doi:10.1113/jphysiol.1997.sp022031 · Cited by 960
The neural basis of functional brain imaging signals
Attwell, D., & Iadecola, C. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02264-6 · Cited by 957
Self-citationCalcium transients in astrocyte endfeet cause cerebrovascular constrictions
Mulligan, S. J., & MacVicar, B. A. (2004) · Nature · doi:10.1038/nature02827 · Cited by 872
Self-citationAlterations in the BOLD fMRI signal with ageing and disease: a challenge for neuroimaging
D’Esposito, M., Deouell, L. Y., & Gazzaley, A. H. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1246 · Cited by 852
A Model for the Coupling between Cerebral Blood Flow and Oxygen Metabolism during Neural Stimulation
Buxton, R. B., & Frank, L. R. (1997) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199701000-00009 · Cited by 808
Yemişçi, M., Özdemir, Y., Vural, A., Can, A., Topalkara, K., & Dalkara, T. (2009) · Nature Medicine · doi:10.1038/nm.2022 · Cited by 805
Brain metabolism dictates the polarity of astrocyte control over arterioles
Gordon, G. R., Choi, H. B., Rungta, R. L., Ellis‐Davies, G. C. R., & MacVicar, B. A. (2008) · Nature · doi:10.1038/nature07525 · Cited by 770
Self-citationThe proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling
Nicole, O., Docagne, F., Ali, C., Margaill, I., Carmeliet, P., MacKenzie, E. T., Vivien, D., & Buisson, A. (2001) · Nature Medicine · doi:10.1038/83358 · Cited by 764
Cerebral hypoperfusion and clinical onset of dementia: the Rotterdam Study
Ruitenberg, A., den Heijer, T., Bakker, S. L. M., van Swieten, J. C., Koudstaal, P. J., Hofman, A., & Breteler, M. M. B. (2005) · Annals of Neurology · doi:10.1002/ana.20493 · Cited by 733
Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice
Kuchibhotla, K. V., Lattarulo, C. R., Hyman, B. T., & Bacskai, B. J. (2009) · Science · doi:10.1126/science.1169096 · Cited by 729
Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo
Wang, X., Lou, N., Xu, Q., Tian, G.-F., Peng, W. G., Han, X., Kang, J., Takano, T., & Nedergaard, M. (2006) · Nature Neuroscience · doi:10.1038/nn1703 · Cited by 685
Hippocampal AstrocytesIn SituRespond to Glutamate Released from Synaptic Terminals
Porter, J. T., & McCarthy, K. D. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-16-05073.1996 · Cited by 672
Sheṕro, D., & Morel-Laurens, N. (1993) · The FASEB Journal · doi:10.1096/fasebj.7.11.8370472 · Cited by 652
Tuned Responses of Astrocytes and Their Influence on Hemodynamic Signals in the Visual Cortex
Schummers, J., Yu, H., & Sur, M. (2008) · Science · doi:10.1126/science.1156120 · Cited by 651
Glial Cells Dilate and Constrict Blood Vessels: A Mechanism of Neurovascular Coupling
Metea, M. R., & Newman, E. A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4048-05.2006 · Cited by 637
Self-citationJohnson, N. A., Jahng, G., Weiner, M. W., Miller, B. L., Chui, H. C., Jagust, W. J., Gorno‐Tempini, M. L., & Schuff, N. W. (2005) · Radiology · doi:10.1148/radiol.2343040197 · Cited by 596
Cortical GABA Interneurons in Neurovascular Coupling: Relays for Subcortical Vasoactive Pathways
Cauli, B., Tong, X., Rancillac, A., Serluca, N., Lambolez, B., Rossier, J., & Hamel, É. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3065-04.2004 · Cited by 589
Dreier, J. P., Woitzik, J., Fabricius, M. E., Bhatia, R., Major, S., Drenckhahn, C., Lehmann, T., Sarrafzadeh, A. S., Willumsen, L., Hartings, J. A., et al. (2006) · Brain · doi:10.1093/brain/awl297 · Cited by 563
Self-citationHippocampal Astrocytes In Situ Respond to Glutamate Released from Synaptic Terminals
Porter, J. T., & McCarthy, K. D. (2021) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/s4kv-rg05 · Cited by 561
Extracellular ion concentrations during spreading depression and ischemia in the rat brain cortex
Hansen, A. J., & Zeuthen, T. (1981) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1981.tb06920.x · Cited by 557
Local potassium signaling couples neuronal activity to vasodilation in the brain
Filosa, J. A., Bonev, A. D., Straub, S. V., Meredith, A. L., Wilkerson, M. K., Aldrich, R. W., & Nelson, M. T. (2006) · Nature Neuroscience · doi:10.1038/nn1779 · Cited by 556
Update on Mechanism and Catalytic Regulation in the NO Synthases
Stuehr, D. J., Santolini, J., Wang, Z., Wei, C., & Adak, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r400017200 · Cited by 533
Hamilton, N. B. (2010) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2010.00005 · Cited by 513
Cortical spreading depression causes and coincides with tissue hypoxia
Takano, T., Tian, G.-F., Peng, W., Lou, N., Lovatt, D., Hansen, A. J., Kasischke, K. A., & Nedergaard, M. (2007) · Nature Neuroscience · doi:10.1038/nn1902 · Cited by 472
Spreading depolarizations occur in human ischemic stroke with high incidence
Dohmen, C., Sakowitz, O. W., Fabricius, M. E., Bosche, B., Reithmeier, T., Ernestus, R.-I., Brinker, G., Dreier, J. P., Woitzik, J., Strong, A. J., et al. (2008) · Annals of Neurology · doi:10.1002/ana.21390 · Cited by 436
Geraldes, P., Hiraoka‐Yamamoto, J., Matsumoto, M., Clermont, A. C., Leitges, M., Marette, A., Aiello, L. P., Kern, T. S., & King, G. L. (2009) · Nature Medicine · doi:10.1038/nm.2052 · Cited by 433
Small modulation of ongoing cortical dynamics by sensory input during natural vision.
Fiser, J., Chiu, C., & Weliky, M. (2004) · Nature · doi:10.1038/nature02907 · Cited by 423
Fabricius, M., Fuhr, S., Bhatia, R., Boutelle, M., Hashemi, P., Strong, A. J., & Lauritzen, M. (2006) · Brain · doi:10.1093/brain/awh716 · Cited by 420
Self-citationDoes the Release of Potassium from Astrocyte Endfeet Regulate Cerebral Blood Flow?
Paulson, O. B., & Newman, E. A. (1987) · Science · doi:10.1126/science.3616619 · Cited by 414
Self-citationWhat is the real physiological NO concentration in vivo?
Hall, C. N., & Garthwaite, J. (2009) · Nitric Oxide · doi:10.1016/j.niox.2009.07.002 · Cited by 378
Mathiesen, C., Caesar, K., Akgören, N., & Lauritzen, M. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.555be.x · Cited by 375
Self-citationMintun, M. A., Lundstrom, B. N., Snyder, A. Z., Vlassenko, A. G., Shulman, G. L., & Raichle, M. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111164398 · Cited by 362
Barnett, J. W., Chow, J. M., Ives, D., Chiou, M., Mackenzie, R., Osen, E., Nguyen, B. Q., Tsing, S., Bach, C., Freire, J., et al. (1994) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(94)90148-1 · Cited by 340
Oxygen radicals in cerebral ischemia
Nelson, C., Wei, E. P., Povlishock, J. T., Kontos, H. A., & Moskowitz, M. A. (1992) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1992.263.5.h1356 · Cited by 333
Knot, H. J., Zimmermann, P. A., & Nelson, M. T. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021318 · Cited by 332
Electrogenic glutamate uptake in glial cells is activated by intracellular potassium
Barbour, B., Brew, H. M., & Attwell, D. (1988) · Nature · doi:10.1038/335433a0 · Cited by 327
Self-citationHillman, E. M. C., Devor, A., Bouchard, M. B., Dunn, A. K., Krauss, G. W., Skoch, J. M., Bacskai, B. J., Dale, A. M., & Boas, D. A. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.11.032 · Cited by 290
Reading vascular changes in brain imaging: is dendritic calcium the key?
Lauritzen, M. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1589 · Cited by 274
Self-citationPharmacological Approaches To Repair the Injured Spinal Cord
Baptiste, D. C., & Fehlings, M. G. (2006) · Journal of Neurotrauma · doi:10.1089/neu.2006.23.318 · Cited by 268
Coupling of Neural Activity to Blood Flow in Olfactory Glomeruli Is Mediated by Astrocytic Pathways
Petzold, G. C., Albeanu, D. F., Sato, T. F., & Murthy, V. N. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.029 · Cited by 263
Cyclooxygenase-2 Contributes to Functional Hyperemia in Whisker-Barrel Cortex
Niwa, K., Araki, E., Morham, S. G., Ross, M. E., & Iadecola, C. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-02-00763.2000 · Cited by 260
The Neurotoxicity of Tissue Plasminogen Activator?
Kaur, J., Zhao, Z., Klein, G., Lo, E. H., & Buchan, A. M. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000137868.50767.e8 · Cited by 242
Self-citationPiilgaard, H., & Lauritzen, M. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.73 · Cited by 225
Self-citationA vascular anatomical network model of the spatio-temporal response to brain activation
Boas, D. A., Jones, S. R., Devor, A., Huppert, T. J., & Dale, A. M. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2007.12.061 · Cited by 224
Winship, I. R., Plaa, N., & Murphy, T. H. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4801-06.2007 · Cited by 221
Lin, A.-L., Fox, P. T., Hardies, J., Duong, T. Q., & Gao, J.-H. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909711107 · Cited by 213
Nitric oxide: a modulator, but not a mediator, of neurovascular coupling in rat somatosensory cortex
Lindauer, U., Megow, D., Matsuda, H., & Dirnagl, U. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.2.h799 · Cited by 213
Chow, N., Bell, R. D., Deane, R., Streb, J. W., Chen, J., Brooks, A., Van Nostrand, W., Miano, J. M., & Zlokovic, B. V. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608251104 · Cited by 209
Nielsen, A. N., & Lauritzen, M. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.00773.x · Cited by 207
Self-citationHigh-Resolution In Vivo Imaging of the Neurovascular Unit during Spreading Depression
Chuquet, J., Hollender, L., & Nimchinsky, E. A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0721-07.2007 · Cited by 203
MHC class II molecules, cathepsins, and La/SSB proteins in lacrimal acinar cell endomembranes
Yang, T., Zeng, H., Zhang, J., Okamoto, C. T., Warren, D. W., Wood, R. L., Bachmann, M. P., & Mircheff, A. K. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.277.5.c994 · Cited by 198
Identification of a Putative Microvascular Oxygen Sensor
Harder, D. R., Narayanan, J., Birks, E. K., Liard, J. F., Imig, J. D., Lombard, J. H., Lange, A. R., & Roman, R. J. (1996) · Circulation Research · doi:10.1161/01.res.79.1.54 · Cited by 185
Madsen, P. L., Cruz, N. F., Sokoloff, L., & Dienel, G. A. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199904000-00005 · Cited by 174
Zou, M., Leist, M., & Ullrich, V. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65390-4 · Cited by 163
Mangia, S., Giove, F., Tkáč, I., Logothetis, N. K., Henry, P.-G., Olman, C. A., Maraviglia, B., Di Salle, F., & Uğurbil, K. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.134 · Cited by 161
Kocharyan, A., Fernandes, P., Tong, X., Vaucher, E., & Hamel, É. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600558 · Cited by 146
Cytochrome P450 epoxygenases as EDHF synthase(s)
Fleming, I. (2004) · Pharmacological Research · doi:10.1016/j.phrs.2003.11.016 · Cited by 145
Offenhauser, N., Thomsen, K., Caesar, K., & Lauritzen, M. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.082776 · Cited by 145
Self-citationWahl, M., Schilling, L., Parsons, A. A., & Kaumann, A. J. (1994) · Brain Research · doi:10.1016/0006-8993(94)91234-3 · Cited by 143
Ma, J., Ayata, C., Huang, P. L., Fishman, M. C., & Moskowitz, M. A. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.270.3.h1085 · Cited by 143
Tone-dependent vascular responses to astrocyte-derived signals
Blanco, V., Stern, J. E., & Filosa, J. A. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.91451.2007 · Cited by 141
Akgören, N., Fabricius, M. E., & Lauritzen, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.13.5903 · Cited by 134
Self-citationPark, L., Anrather, J., Forster, C. L., Kazama, K., Carlson, G. A., & Iadecola, C. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000105800.49957.1e · Cited by 129
Peng, X., Carhuapoma, J. R., Bhardwaj, A., Alkayed, N. J., Falck, J. R., Harder, D. R., Traystman, R. J., & Koehler, R. C. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01130.2000 · Cited by 128
GABA uptake-dependent Ca 2+ signaling in developing olfactory bulb astrocytes
Doengi, M., Hirnet, D., Coulon, P., Pape, H., Deitmer, J. W., & Lohr, C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809513106 · Cited by 125
Physiology and Pathobiology of the Pericyte‐Containing Retinal Microvasculature: New Developments
Puro, D. G. (2007) · Microcirculation · doi:10.1080/10739680601072099 · Cited by 125
Role of adenosine in regulation of regional cerebral blood flow in sensory cortex
Ko, K. R., Ngai, A. C., & Winn, H. R. (1990) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1990.259.6.h1703 · Cited by 122
EP4 prostanoid receptor‐mediated vasodilatation of human middle cerebral arteries
Davis, R. J., Murdoch, C. E., Ali, M., Purbrick, S., Ravid, R., Baxter, G. S., Tilford, N., Sheldrick, R. L. G., Clark, K. L., & Coleman, R. A. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705645 · Cited by 121
Caesar, K., Hashemi, P., Douhou, A., Bonvento, G., Boutelle, M. G., Walls, A. B., & Lauritzen, M. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.144154 · Cited by 119
Self-citationNitric oxide-dependent and -independent components of cerebrovasodilation elicited by hypercapnia
Iadecola, C., & Zhang, F. (1994) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1994.266.2.r546 · Cited by 117
The Relationship between Blood Flow and Neuronal Activity in the Rodent Olfactory Bulb
Chaigneau, E. M., Tiret, P., Lecoq, J. A., Ducros, M. G., Knöpfel, T., & Charpak, S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3141-06.2007 · Cited by 110
Self-citationPowers, W. J., Hirsch, I. B., & Cryer, P. E. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.270.2.h554 · Cited by 103
Expression of COX-2 by Normal and Reactive Astrocytes in the Adult Rat Central Nervous System
Hirst, W. D., Young, K. A., Newton, R. C., Allport, V. C., Marriott, D. R., & Wilkin, G. P. (1999) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1998.0731 · Cited by 102
Hashemi, P., Bhatia, R., Nakamura, H., Dreier, J. P., Graf, R., Strong, A. J., & Boutelle, M. G. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.108 · Cited by 101
Behm, D. J., Ogbonna, A. C., Wu, C. W., Burns-Kurtis, C. L., & Douglas, S. A. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.145102 · Cited by 101
Busija, D. W., Bari, F., Domoki, F., & Louis, T. M. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.011 · Cited by 100
Enager, P., Piilgaard, H., Offenhauser, N., Kocharyan, A., Fernandes, P., Hamel, É., & Lauritzen, M. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.23 · Cited by 100
Self-citationArginine-nitric oxide pathway and cerebrovascular regulation in cortical spreading depression
Fabricius, M. E., Akgören, N., & Lauritzen, M. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.269.1.h23 · Cited by 100
Self-citationRole of cGMP versus 20-HETE in the vasodilator response to nitric oxide in rat cerebral arteries
Sun, C., Falck, J. R., Okamoto, H., Harder, D. R., & Roman, R. J. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.279.1.h339 · Cited by 100
Lovick, T. A., Brown, L. A., & Key, B. J. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00737-4 · Cited by 99
Wagerle, L. C., & Mishra, O. P. (1988) · Circulation Research · doi:10.1161/01.res.62.5.1019 · Cited by 97
Key role of tissue plasminogen activator in neurovascular coupling
Park, L., Gallo, E. F., Anrather, J., Wang, G., Norris, E. H., Paul, J., Strickland, S., & Iadecola, C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708823105 · Cited by 96
Neurovascular Coupling in Rat Brain Operates Independent of Hemoglobin Deoxygenation
Lindauer, U., Leithner, C., Kaasch, H., Rohrer, B., Foddis, M., Füchtemeier, M., Offenhauser, N., Steinbrink, J. M., Royl, G., Kohl‐Bareis, M., et al. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.259 · Cited by 95
Neurovascular Coupling Is Not Mediated by Potassium Siphoning from Glial Cells
Metea, M. R., Kofuji, P., & Newman, E. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3204-06.2007 · Cited by 93
Self-citationMechanisms involved in the cerebrovascular dilator effects of cortical spreading depression
Busija, D. W., Bari, F., Domoki, F., Horiguchi, T., & SHIMIZU, K. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.09.008 · Cited by 93
Putative Cyclooxygenase-3 Expression in Rat Brain Cells
Kis, B., Snipes, J. A., Isse, T., Nagy, K. A., & Busija, D. W. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000090681.07515.81 · Cited by 92
Yang, G., Chen, G., Ebner, T. J., & Iadecola, C. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.277.6.r1760 · Cited by 90
Nitric oxide and adenosine mediate vasodilation during functional activation in cerebellar cortex
Li, J., & Iadecola, C. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90049-3 · Cited by 89
Magnetic Resonance Studies of Brain Function and Neurochemistry
Uǧurbil, K., Adriany, G., Andersen, P., Chen, W., Rolf Gruetter, A., Hu, X. P., Merkle, H., Kim, D., Kim, S., Strupp, J., et al. (2000) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.2.1.633 · Cited by 88
Pharmacological Uncoupling of Activation Induced Increases in CBF and CMRO 2
Leithner, C., Royl, G., Offenhauser, N., Füchtemeier, M., Kohl‐Bareis, M., Villringer, A., Dirnagl, U., & Lindauer, U. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.211 · Cited by 86
Peng, X., Zhang, C., Alkayed, N. J., Harder, D. R., & Koehler, R. C. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200405000-00004 · Cited by 85
NADH: sensor of blood flow need in brain, muscle, and other tissues
Ido, Y., Chang, K. C., Woolsey, T. A., & Williamson, J. R. (2001) · The FASEB Journal · doi:10.1096/fj.00-0652fje · Cited by 85
Hauck, E. F., Apostel, S., Hoffmann, J. F., Heimann, A., & Kempski, O. S. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200404000-00003 · Cited by 82
Nonlinear Neurovascular Coupling in Rat Sensory Cortex by Activation of Transcallosal Fibers
Hoffmeyer, H., Enager, P., Thomsen, K., & Lauritzen, M. (2007) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1038/sj.jcbfm.9600372 · Cited by 81
Self-citationOdor-Evoked Oxygen Consumption by Action Potential and Synaptic Transmission in the Olfactory Bulb
Lecoq, J. A., Tiret, P., Najac, M., Shepherd, G. M., Greer, C. A., & Charpak, S. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4817-08.2009 · Cited by 80
Self-citationTian, R., Vogel, P., Lassen, N. A., Mulvany, M. J., Andreasen, F., & Aalkjær, C. (1995) · Circulation Research · doi:10.1161/01.res.76.2.269 · Cited by 79
Change of cerebrovascular reactivity after cortical spreading depression in cats and rats
Wahl, M., Lauritzen, M., & Schilling, L. (1987) · Brain Research · doi:10.1016/0006-8993(87)90682-2 · Cited by 77
Self-citationYang, G., Zhang, Y., Ross, M. E., & Iadecola, C. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00043.2003 · Cited by 77
Kågström, E., Smith, M., & Siesjö, B. K. (1983) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1983.tb07272.x · Cited by 73
Akgören, N., Dalgaard, P., & Lauritzen, M. (1996) · Brain Research · doi:10.1016/0006-8993(95)01354-7 · Cited by 71
Self-citationMakani, S., & Chesler, M. (2009) · Journal of Neurophysiology · doi:10.1152/jn.00948.2009 · Cited by 69
Lawrence, K. S., Ye, F. Q., Lewis, B. K., Frank, J. A., & McLaughlin, A. C. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10502 · Cited by 66
Cerebral autoregulation and gas exchange studied using a human cardiopulmonary model
Lu, K., Clark, J. W., Ghorbel, F. H., Robertson, C. S., Ware, D. L., Zwischenberger, J. B., & Bidani, A. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00594.2003 · Cited by 63
Effects of ischemia on brain blood flow and oxygen consumption of newborn pigs
Leffler, C. W., Busija, D. W., Mirro, R., Armstead, W. M., & Beasley, D. G. (1989) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1989.257.6.h1917 · Cited by 61
Astrup, J., Heuser, D., Lassen, N. A., Nilsson, B., Norberg, K., & Siesjd, B. K. (1978) · Novartis Foundation symposium · doi:10.1002/9780470720370.ch16 · Cited by 61
Golanov, E. V., & Reis, D. J. (1994) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1994.61 · Cited by 59
AMINO ACID RELEASE FROM THE CEREBRAL CORTEX DURING SPREADING DEPRESSION AND ASPHYXIATION*
Harreveld, A. V., & Kooiman, M. (1965) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1965.tb04243.x · Cited by 54
Assessing the physiological concentration and targets of nitric oxide in brain tissue
Hall, C. N., & Attwell, D. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.154724 · Cited by 52
Self-citationCipolla, M. J., Lessov, N. S., & Clark, W. M. (2000) · Stroke · doi:10.1161/01.str.31.4.940 · Cited by 50
Galiuto, L., Rebuzzi, A. G., & Crea, F. (2009) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2008.11.003 · Cited by 50
Sun, J., Druhan, L. J., & Zweier, J. L. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.01.003 · Cited by 47
Theilen, H., Schröck, H., & Kuschinsky, W. (1994) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1994.138 · Cited by 47
Caesar, K., Akgören, N., Mathiesen, C., & Lauritzen, M. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.00281.x · Cited by 45
Self-citationNitric oxide synthase inhibition does not affect somatosensory evoked potentials in the rat
Lindauer, U., Megow, D., Schultze, J., Weber, J. R., & Dirnagl, U. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)13044-5 · Cited by 45
Effects of reactive oxygen and nitrogen species on cyclooxygenase-1 and -2 activities
Fujimoto, Y., Uno, E., & Sakuma, S. (2004) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2004.06.002 · Cited by 44
Juránek, I., Suzuki, H., & Yamamoto, S. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s0005-2760(98)00159-3 · Cited by 44
The cortical energy needed for conscious perception
Schölvinck, M. L., Howarth, C., & Attwell, D. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.01.032 · Cited by 35
Self-citationScheckenbach, K. E. L., Dreier, J. P., Dirnagl, U., & Lindauer, U. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.07.007 · Cited by 34
Akgören, N., Mathiesen, C., Rubin, I., & Lauritzen, M. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.273.3.h1166 · Cited by 28
Self-citationTakata, F., Dohgu, S., Nishioku, T., Takahashi, H., Harada, E., Makino, I., Nakashima, M., Yamauchi, A., & Kataoka, Y. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.10.082 · Cited by 24
Ou, J. W., Kumar, Y., Alioua, A., Sailer, C. A., Stefani, E., & Toro, L. (2009) · Glia · doi:10.1002/glia.20847 · Cited by 20
Altered NO Function Contributes to Impairment of uPA and tPA Cerebrovasodilation after Brain Injury
Armstead, W. M., Cines, D. B., & Higazi, A. A. (2004) · Journal of Neurotrauma · doi:10.1089/neu.2004.21.1204 · Cited by 18
Effects of prostaglandins E1 and E2 on cultured smooth muscle cells and strips of rat aorta
Serebryakov, V. N., Zakharenko, S. S., Snetkov, V. A., & Takeda, K. (1994) · Prostaglandins · doi:10.1016/0090-6980(94)90053-1 · Cited by 17
Cited by
Sorted by citations
Daneman, R., & Prat, A. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020412 · Cited by 3,437
Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
Leng, F., & Edison, P. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-020-00435-y · Cited by 3,179
Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises
Armulik, A., Genové, G., & Betsholtz, C. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.07.001 · Cited by 2,653
The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease
Iadecola, C. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.030 · Cited by 2,480
Brain energy metabolism: focus on Astrocyte-neuron metabolic cooperation
Bélanger, M., Allaman, I., & Magistretti, P. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.016 · Cited by 2,313
Metadata
- Authors
- Attwell, D., Buchan, A. M., Charpak, S., Lauritzen, M., MacVicar, B. A., & Newman, E. A.
- Affiliations
- University College London (GB)
- John Radcliffe Hospital (GB)
- Centre National de la Recherche Scientifique (FR)
- University of Copenhagen (DK)
- University of British Columbia (CA)
- University of Minnesota (US)
- ORCID
- Venue
- Nature
- Published
- 2010-11-10
- Volume
- 468
- Issue
- 7321
- Pages
- 232-243
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3206737
- OpenAlex
- W2163234334
- Cited by
- 2,511
- References
- 135
- Citations by year
- 2026: 144 · 2025: 163 · 2024: 163 · 2023: 147 · 2022: 176 · 2021: 197 · 2020: 180 · 2019: 177 · 2018: 177 · 2017: 172 · 2016: 156 · 2015: 174 · 2014: 146 · 2013: 147 · 2012: 120
- FWCI
- 9.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Wellcome Trust
- Canadian Institutes of Health Research
- National Eye Institute (R01EY004077, P30EY011374)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- cerebral autoregulation, astrocytes, neurons, neurotransmitter signalling, oxygen sensing, capillary blood flow, arterioles, neurovascular coupling, functional neuroimaging, neurological disorders
- MeSH terms
- Alzheimer Disease, Brain, Brain Ischemia, Cerebrovascular Circulation, Humans, Neuroglia, Neurons, Nitric Oxide, Oxygen, Signal Transduction, Neurotransmitter Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
