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Glial and neuronal control of brain blood flow
Open accessAbstract
Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these cells control blood flow is crucial for understanding how neural computation is powered, for interpreting functional imaging scans of brains, and for developing treatments for neurological disorders. It is now recognized that neurotransmitter-mediated signalling has a key role in regulating cerebral blood flow, that much of this control is mediated by astrocytes, that oxygen modulates blood flow regulation, and that blood flow may be controlled by capillaries as well as by arterioles. These conceptual shifts in our understanding of cerebral blood flow control have important implications for the development of new therapeutic approaches.
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“This process can be adjusted on demand either through modulation of neurovascular coupling15–17 or via neuronal signaling to astrocytes18.”
From Energy paradox in REM sleep: balancing supply and consumption in brain metabolism (2026) · cites this paper as [16]
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“As neural activity elevates, local oxygen consumption and demand increases, triggering vasodilation of arterioles and capillaries to increase cerebral blood flow (124), which supplies oxygenated hemoglobin in excess of the metabolic rate of oxygen consumption (125).”
From Electrophysiological source imaging: A noninvasive window to brain dynamics (2018) · cites this paper as [124]
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“Such a cascade of metabolic and vascular events, known as the neurovascular coupling, involves complex signaling among neurons, astrocytes, and the local vasculature (124, 126, 127), and remains a topic of active research enabled by emerging tools (128).”
From Electrophysiological source imaging: A noninvasive window to brain dynamics (2018) · cites this paper as [124]
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“PVMs were found most abundantly in association with pial and parenchymal vessels larger than 20 μm in diameter, particularly pial arterioles, a key site for flow regulation (7), the length of which was covered 70%-80% by PVMs (Supplemental Figure 1, A-E; supplemental material available online with this article; doi:10.1172/JCI86950DS1).”
From Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension (2016) · cites this paper as [7]
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Metadata
- Authors
- Attwell, D., Buchan, A. M., Charpak, S., Lauritzen, M., MacVicar, B. A., & Newman, E. A.
- Affiliations
- University College London (GB)
- John Radcliffe Hospital (GB)
- Centre National de la Recherche Scientifique (FR)
- University of Copenhagen (DK)
- University of British Columbia (CA)
- University of Minnesota (US)
- ORCID
- Venue
- Nature
- Published
- 2010-11-10
- Volume
- 468
- Issue
- 7321
- Pages
- 232-243
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3206737
- OpenAlex
- W2163234334
- Cited by
- 2,511
- References
- 135
- Citations by year
- 2026: 144 · 2025: 163 · 2024: 163 · 2023: 147 · 2022: 176 · 2021: 197 · 2020: 180 · 2019: 177 · 2018: 177 · 2017: 172 · 2016: 156 · 2015: 174 · 2014: 146 · 2013: 147 · 2012: 120
- FWCI
- 9.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Wellcome Trust
- Canadian Institutes of Health Research
- National Eye Institute (R01EY004077, P30EY011374)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- cerebral autoregulation, astrocytes, neurons, neurotransmitter signalling, oxygen sensing, capillary blood flow, arterioles, neurovascular coupling, functional neuroimaging, neurological disorders
- MeSH terms
- Alzheimer Disease, Brain, Brain Ischemia, Cerebrovascular Circulation, Humans, Neuroglia, Neurons, Nitric Oxide, Oxygen, Signal Transduction, Neurotransmitter Agents
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