Glial and neuronal control of brain blood flow

Neurophysiological investigation of the basis of the fMRI signal

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Interplay between Cortical Spreading Depolarization and Seizures

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An Energy Budget for Signaling in the Grey Matter of the Brain

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Nonoxidative Glucose Consumption During Focal Physiologic Neural Activity

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Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation

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Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease

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P-450 Metabolites of Arachidonic Acid in the Control of Cardiovascular Function

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Pathophysiology of the migraine aura: The spreading depression theory

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A Fast One‐Step Extraction and UPLC–MS/MS Analysis for E2/D2 Series Prostaglandins and Isoprostanes

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Astrocyte signaling and neurodegeneration

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Pharmacologically induced impairment of neurovascular coupling responses alters gait coordination in mice

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Novel Mechanistic Insights and Potential Therapeutic Impact of TRPC6 in Neurovascular Coupling and Ischemic Stroke

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Control of cerebrovascular patterning by neural activity during postnatal development

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The Role of Glia in Stress

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Cerebral vascular structure in the motor cortex of adult mice is stable and is not altered by voluntary exercise

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Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states

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A novel serum free primary astrocyte culture method that mimic quiescent astrocyte phenotype

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IGF1R signaling regulates astrocyte-mediated neurovascular coupling in mice: implications for brain aging

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Notch signaling via Hey1 and Id2b regulates Müller glia's regenerative response to retinal injury

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Inhaled nitric oxide: role in the pathophysiology of cardio-cerebrovascular and respiratory diseases

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Present and New Treatment Strategies in the Management of Glaucoma

Kolko, M. (2015) · The Open Ophthalmology Journal · doi:10.2174/1874364101509010089 · Cited by 54

Primary Somatosensory Cortices Contain Altered Patterns of Regional Cerebral Blood Flow in the Interictal Phase of Migraine

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Nitric oxide

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Regional gray matter volume increases following 7 days of voluntary wheel running exercise: A longitudinal VBM study in rats

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The role of amino acid transporters in GSH synthesis in the blood–brain barrier and central nervous system

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Montmorency Tart cherries (Prunus cerasus L.) modulate vascular function acutely, in the absence of improvement in cognitive performance

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Glutamate Induces Blood–Brain Barrier Permeability through Activation ofN-Methyl-D-Aspartate Receptors

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Brain function characteristics of chronic fatigue syndrome: A task fMRI study

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Stroke and the neurovascular unit: glial cells, sex differences, and hypertension

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Differential restoration of functional hyperemia by antihypertensive drug classes in hypertension-related cerebral small vessel disease

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Cognitive Dysfunction after Heart Disease: A Manifestation of the Heart‐Brain Axis

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The Pathobiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Case for Neuroglial Failure

Renz‐Polster, H., Tremblay, M., Bienzle, D., & Fischer, J. E. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.888232 · Cited by 56

Impaired Neurovascular Coupling and Increased Functional Connectivity in the Frontal Cortex Predict Age‐Related Cognitive Dysfunction

Mukli, P., Pinto, C. B., Owens, C. D., Csípő, T., Lipécz, Á., Szarvas, Z., Péterfi, A., Pinaffi‐Langley, A. C. D. C., Hoffmeister, J. R., Rácz, F. S., et al. (2023) · Advanced Science · doi:10.1002/advs.202303516 · Cited by 53

Carbonic anhydrase, its inhibitors and vascular function

García‐Llorca, A., Carta, F., Supuran, C. T., & Eysteinsson, Þ. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1338528 · Cited by 54

Neurotoxic effects of per- and polyfluoroalkyl substances (PFAS) mixture exposure in mice: Accumulations in brain and associated changes of behaviors, metabolome, and transcriptome

He, Q., Yang, Q., Wu, L., He, Y., Zeng, N., & Wang, Z. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.137699 · Cited by 54

Expression of Gls and Gls2 glutaminase isoforms in astrocytes

Cardona, C., Sánchez‐Mejías, E., Dávila, J. C., Martín‐Rufián, M., Campos-Sandoval, J. A., Vitórica, J., Alonso, F. J., Matés, J. M., Segura, J. A., Norenberg, M. D., et al. (2014) · Glia · doi:10.1002/glia.22758 · Cited by 58

Prostaglandin E 2 , a Postulated Astrocyte-Derived Neurovascular Coupling Agent, Constricts Rather than Dilates Parenchymal Arterioles

Dabertrand, F., Hannah, R. M., Pearson, J. M., Hill‐Eubanks, D. C., Brayden, J. E., & Nelson, M. T. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.9 · Cited by 53

Quantitative separation of arterial and venous cerebral blood volume increases during voluntary locomotion

Huo, B., Gao, Y., & Drew, P. J. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.10.030 · Cited by 56

Constancy and trade-offs in the neuroanatomical and metabolic design of the cerebral cortex

Karbowski, J. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00009 · Cited by 54

Pharmacologic inhibition of reactive gliosis blocks TNF-α-mediated neuronal apoptosis

Livne‐Bar, I., Lam, S., Chan, D. W.-H., Guo, X., Askar, I., Nahirny, A., Flanagan, J. G., & Sivak, J. M. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.277 · Cited by 56

Abnormal Capillary Vasodynamics Contribute to Ictal Neurodegeneration in Epilepsy

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A strocyte disruption of neurovascular communication is linked to cortical damage in an animal model of multiple sclerosis

Eilam, R., Segal, M., Malach, R., Sela, M., Arnon, R., & Aharoni, R. (2018) · Glia · doi:10.1002/glia.23304 · Cited by 55

Cerebrovascular Resistance: The Basis of Cerebrovascular Reactivity

Duffin, J., Sobczyk, O., McKetton, L., Crawley, A. P., Poublanc, J., Venkatraghavan, L., Sam, K., Mutch, W. A. C., Mikulis, D. J., & Fisher, J. A. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00409 · Cited by 55

Anesthesia differentially modulates neuronal and vascular contributions to the BOLD signal

van Alst, T. M., Wachsmuth, L., Datunashvili, M., Albers, F., Just, N., Budde, T., & Faber, C. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.03.057 · Cited by 56

Inhibition of a SNARE-Sensitive Pathway in Astrocytes Attenuates Damage following Stroke

Hines, D. J., & Haydon, P. G. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5495-12.2013 · Cited by 52

Reduced Glutamate in the Medial Prefrontal Cortex Is Associated With Emotional and Cognitive Dysregulation in People With Chronic Pain

Naylor, B., Hesam‐Shariati, N., McAuley, J. H., Boag, S., Newton-John, T. R. O., Rae, C. D., & Gustin, S. M. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01110 · Cited by 52

Network-driven anomalous transport is a fundamental component of brain microvascular dysfunction

Goirand, F., Borgne, T. L., & Lorthois, S. (2021) · Nature Communications · doi:10.1038/s41467-021-27534-8 · Cited by 55

Impact of impaired cerebral blood flow autoregulation on cognitive impairment

Wang, S., Tang, C., Liu, Y., Border, J. J., Roman, R. J., & Fan, F. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.1077302 · Cited by 54

FDA‐approved carbonic anhydrase inhibitors reduce amyloid β pathology and improve cognition, by ameliorating cerebrovascular health and glial fitness

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Optimization and Reliability of Multiple Postlabeling Delay Pseudo-Continuous Arterial Spin Labeling during Rest and Stimulus-Induced Functional Task Activation

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Spontaneous Calcium Waves in Bergman Glia Increase with Age and Hypoxia and may Reduce Tissue Oxygen

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Ependymal Ciliary Dysfunction and Reactive Astrocytosis in a Reorganized Subventricular Zone after Stroke

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Glial cell response after aneurysmal subarachnoid hemorrhage — Functional consequences and clinical implications

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In vivo variation in same-day estimates of metabotropic glutamate receptor subtype 5 binding using [ 11 C]ABP688 and [ 18 F]FPEB

DeLorenzo, C., Gallezot, J., Gardus, J. D., Yang, J., Planeta, B. M., Nabulsi, N., Ogden, R. T., Labaree, D. C., Huang, Y. H., Mann, J. J., et al. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16673646 · Cited by 52

Monitoring cerebral hemodynamic change during transcranial ultrasound stimulation using optical intrinsic signal imaging

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Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis

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Low on energy? An energy supply-demand perspective on stress and depression

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Targeting Transcription Factor Nrf2 (Nuclear Factor Erythroid 2-Related Factor 2) for the Intervention of Vascular Cognitive Impairment and Dementia

Yang, T., & Zhang, F. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314804 · Cited by 52

Cardiac and Carotid Markers Link With Accelerated Brain Atrophy

Sabayan, B., van Buchem, M. A., Sigurdsson, S. O., Zhang, Q., Meirelles, O., Harris, T. B., Gudnason, V. G., Arai, A. E., & Launer, L. J. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.308018 · Cited by 51

Heterogeneity of white matter astrocytes in the human brain

Bugiani, M., Plug, B. C., Man, J. H. K., Breur, M., & van der Knaap, M. S. (2021) · Acta Neuropathologica · doi:10.1007/s00401-021-02391-3 · Cited by 55

Astrocytes produce nitric oxide via nitrite reduction in mitochondria to regulate cerebral blood flow during brain hypoxia

Christie, I. N., Theparambil, S. M., Braga, A., Doronin, M., Hosford, P. S., Brazhe, A., Mascarenhas, A., Nizari, S., Hadjihambi, A., Wells, J. A., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113514 · Cited by 52

Cerebral hemodynamics of the aging brain: risk of Alzheimer disease and benefit of aerobic exercise

Tarumi, T., & Zhang, R. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00006 · Cited by 59

The Energy Demand of Fast Neuronal Network Oscillations: Insights from Brain Slice Preparations

Kann, O. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2011.00090 · Cited by 52

Evaluation of neuron-glia integrity by in vivo proton magnetic resonance spectroscopy: Implications for psychiatric disorders

Xu, H., Zhang, H., Zhang, J., Huang, Q., Shen, Z., & Wu, R. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.027 · Cited by 58

Assessing test–retest reliability of phase contrast MRI for measuring cerebrospinal fluid and cerebral blood flow dynamics

Sakhare, A. R., Barisano, G., & Pa, J. (2019) · Magnetic Resonance in Medicine · doi:10.1002/mrm.27752 · Cited by 51

Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum

Chipman, P. H., Fung, C. C. A., Fernández, A. P., Sawant, A., Tedoldi, A., Kawai, A., Gautam, S. G., Kurosawa, M., Abe, M., Sakimura, K., et al. (2021) · eLife · doi:10.7554/elife.70818 · Cited by 55

Human Astrocytes Exhibit Tumor Microenvironment-, Age-, and Sex-Related Transcriptomic Signatures

Krawczyk, M. C., Haney, J. R., Pan, L., Caneda, C., Khankan, R. R., Reyes, S. D., Chang, J. W., Morselli, M., Vinters, H. V., Wang, A., et al. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0407-21.2021 · Cited by 51

Impaired dynamics of precapillary sphincters and pericytes at first-order capillaries predict reduced neurovascular function in the aging mouse brain

Cai, C., Zambach, S. A., Grubb, S., Tao, L., He, C., Lind, B. L., Thomsen, K. J., Zhang, X., Hald, B. O., Nielsen, R. M., et al. (2023) · Nature Aging · doi:10.1038/s43587-022-00354-1 · Cited by 50

Cerebral blood flow alteration in neuroprotection following cerebral ischaemia

Sutherland, B. A., Papadakis, M., Chen, R., & Buchan, A. M. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.209601 · Cited by 50

Neurotrophic growth factor responses to lower body resistance training in older adults

Walsh, J. J., Scribbans, T. D., Bentley, R. F., Kellawan, J. M., Gurd, B. J., & Tschakovsky, M. E. (2015) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2015-0410 · Cited by 54

‘Spreading depression of Leão’ and its emerging relevance to acute brain injury in humans

Lauritzen, M., & Strong, A. J. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16657092 · Cited by 51

Intravenous Heroin Induces Rapid Brain Hypoxia and Hyperglycemia that Precede Brain Metabolic Response

Solis, E., Cameron-Burr, K. T., Shaham, Y., & Kiyatkin, E. A. (2017) · eNeuro · doi:10.1523/eneuro.0151-17.2017 · Cited by 50

Bessel Beam Illumination Reduces Random and Systematic Errors in Quantitative Functional Studies Using Light-Sheet Microscopy

Müllenbroich, M. C., Turrini, L., Silvestri, L., Alterini, T., Gheisari, A., Tiso, N., Vanzi, F., Sacconi, L., & Pavone, F. S. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00315 · Cited by 50

Group 1 metabotropic glutamate receptors trigger glutamate-induced intracellular Ca2+ signals and nitric oxide release in human brain microvascular endothelial cells

Negri, S., Faris, P. S., Pellavio, G., Botta, L., Orgiu, M., Forcaia, G., Sancini, G., Laforenza, U., & Moccia, F. D. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03284-1 · Cited by 52

Cerebral Pressure Autoregulation in Brain Injury and Disorders–A Review on Monitoring, Management, and Future Directions

Wettervik, T. S., Fahlström, M., Enblad, P., & Lewén, A. (2021) · World Neurosurgery · doi:10.1016/j.wneu.2021.11.027 · Cited by 49

High-temporal resolution functional PET/MRI reveals coupling between human metabolic and hemodynamic brain response

Hahn, A., Reed, M. B., Vraka, C., Godbersen, G. M., Klug, S., Komorowski, A., Falb, P., Nics, L., Traub‐Weidinger, T., Hacker, M., et al. (2023) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-023-06542-4 · Cited by 49

The Role of Activated Microglia and Resident Macrophages in the Neurovascular Unit during Cerebral Ischemia: Is the Jury Still Out?

Barakat, R., & Redzic, Z. B. (2015) · Medical Principles and Practice · doi:10.1159/000435858 · Cited by 51

Subarachnoid Hemorrhage, Spreading Depolarizations and Impaired Neurovascular Coupling

Koide, M., Sukhotinsky, I., Ayata, C., & Wellman, G. C. (2013) · Stroke Research and Treatment · doi:10.1155/2013/819340 · Cited by 49

Longitudinal Hemodynamic Changes Within the Optic Nerve Head in Experimental Glaucoma

Cull, G. A., Burgoyne, C. F., Fortune, B. A., & Wang, L. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-12013 · Cited by 49

Retinal neurovascular coupling in patients with glaucoma and ocular hypertension and its association with the level of glaucomatous damage

Gugleta, K., Waldmann, N., Polunina, A., Kochkorov, A., Katamay, R., Flammer, J., & Orgül, S. (2013) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-013-2276-9 · Cited by 49

Astrocyte Ca2+Signaling Drives Inversion of Neurovascular Coupling after Subarachnoid Hemorrhage

Pappas, A. C., Koide, M., & Wellman, G. C. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1551-15.2015 · Cited by 49

Advance in spinal cord ischemia reperfusion injury: Blood–spinal cord barrier and remote ischemic preconditioning

Yu, Q., Huang, J., Hu, J., & Zhu, H. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.03.046 · Cited by 50

Astrocytes as a target for neuroprotection: Modulation by progesterone and dehydroepiandrosterone

Arbo, B. D., Benetti, F., & Ribeiro, M. F. M. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.03.010 · Cited by 52

Unravelling the effect of experimental pain on the corticomotor system using transcranial magnetic stimulation and electroencephalography

Martel, M., Harvey, M.-P., Houde, F., Balg, F., Goffaux, P., & Léonard, G. (2017) · Experimental Brain Research · doi:10.1007/s00221-017-4880-0 · Cited by 49

Methodological challenges in the comparison of infant fMRI across age groups

Cusack, R., McCuaig, O., & Linke, A. C. (2017) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2017.11.003 · Cited by 52

Ablating astrocyte insulin receptors leads to delayed puberty and hypogonadism in mice

Manaserh, I. H., Chikkamenahalli, L. L., Ravi, S., Dube, P. R., Park, J. J., & Hill, J. W. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000189 · Cited by 50

Role of astrocyte purinergic signaling in epilepsy

Nikolic, L. M., Nobili, P., Shen, W., & Audinat, É. (2019) · Glia · doi:10.1002/glia.23747 · Cited by 51

O2-Dependent Protein Internalization Underlies Astrocytic Sensing of Acute Hypoxia by Restricting Multimodal TRPA1 Channel Responses

Uchiyama, M., Nakao, A., Kurita, Y., Fukushi, I., Takeda, K., Numata, T., Tran, H. N., Sawamura, S., Ebert, M., Kurokawa, T., et al. (2020) · Current Biology · doi:10.1016/j.cub.2020.06.047 · Cited by 49

Rude mechanicals in brain haemodynamics: non-neural actors that influence blood flow

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Noradrenaline released from locus coeruleus axons contracts cerebral capillary pericytes via α 2 adrenergic receptors

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Lactate as a determinant of neuronal excitability, neuroenergetics and beyond

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Pericytes in the brain and heart: functional roles and response to ischaemia and reperfusion

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Endothelial cells as key players in cerebral small vessel disease

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Interneuron Deficit Associates Attenuated Network Synchronization to Mismatch of Energy Supply and Demand in Aging Mouse Brains

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Chronic dietary n-6 PUFA deprivation leads to conservation of arachidonic acid and more rapid loss of DHA in rat brain phospholipids

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Spatial organization of astrocytes in ferret visual cortex

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Computational Pipeline for NIRS-EEG Joint Imaging of tDCS-Evoked Cerebral Responses—An Application in Ischemic Stroke

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Histamine and astrocyte function

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FGF family members differentially regulate maturation and proliferation of stem cell-derived astrocytes

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The renin-angiotensin system and the retinal neurovascular unit: A role in vascular regulation and disease

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The Effect of Exosomes Derived from Bone Marrow Stem Cells in Combination with Rosuvastatin on Functional Recovery and Neuroprotection in Rats After Ischemic Stroke

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Sex differences in the structure and function of rat middle cerebral arteries

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Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice

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Acute feedback control of astrocytic glycolysis by lactate

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PGC-1α signaling coordinates susceptibility to metabolic and oxidative injury in the inner retina

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Astrocytic neogenin/netrin-1 pathway promotes blood vessel homeostasis and function in mouse cortex

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CO2 signaling mediates neurovascular coupling in the cerebral cortex

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Chapter 18 Astrocyte Control of Blood Flow

Gordon, G. R., Mulligan, S. J., MacVicar, B. A., & Macvicar, B. A. (2016)

Genetic targeting of astrocytes in the gliovascular unit of the adult brain

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Tuning Brain Blood Flow

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Role of Astrocytes in Matching Blood Flow to Neuronal Activity

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