The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Circadian rhythms persist without transcription in a eukaryote
Open accessAbstract
Circadian rhythms are ubiquitous in eukaryotes, and coordinate numerous aspects of behaviour, physiology and metabolism, from sleep/wake cycles in mammals to growth and photosynthesis in plants. This daily timekeeping is thought to be driven by transcriptional–translational feedback loops, whereby rhythmic expression of ‘clock’ gene products regulates the expression of associated genes in approximately 24-hour cycles. The specific transcriptional components differ between phylogenetic kingdoms. The unicellular pico-eukaryotic alga Ostreococcus tauri possesses a naturally minimized clock, which includes many features that are shared with plants, such as a central negative feedback loop that involves the morning-expressed CCA1 and evening-expressed TOC1 genes. Given that recent observations in animals and plants have revealed prominent post-translational contributions to timekeeping, a reappraisal of the transcriptional contribution to oscillator function is overdue. Here we show that non-transcriptional mechanisms are sufficient to sustain circadian timekeeping in the eukaryotic lineage, although they normally function in conjunction with transcriptional components. We identify oxidation of peroxiredoxin proteins as a transcription-independent rhythmic biomarker, which is also rhythmic in mammals. Moreover we show that pharmacological modulators of the mammalian clock mechanism have the same effects on rhythms in Ostreococcus. Post-translational mechanisms, and at least one rhythmic marker, seem to be better conserved than transcriptional clock regulators. It is plausible that the oldest oscillator components are non-transcriptional in nature, as in cyanobacteria, and are conserved across kingdoms.
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Cites
Reconstitution of Circadian Oscillation of Cyanobacterial KaiC Phosphorylation in Vitro
Nakajima, M., Imai, K., Ito, H., Nishiwaki, T., Murayama, Y., Iwasaki, H., Oyama, T., & Kondo, T. (2005) · Science · doi:10.1126/science.1108451 · Cited by 1,107
McClung, C. R. (2006) · The Plant Cell · doi:10.1105/tpc.106.040980 · Cited by 838
Circadian clocks in human red blood cells
O’Neill, J. S., & Reddy, A. B. (2011) · Nature · doi:10.1038/nature09702 · Cited by 825
Self-citationThe Circadian System in Higher Plants
Harmer, S. L. (2009) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.043008.092054 · Cited by 719
Circadian orchestration of the hepatic proteome
Reddy, A. B., Karp, N. A., Maywood, E. S., Sage, E. A., Deery, M., O'Neill, J. S., Wong, G. K. Y., Chesham, J., Odell, M., Lilley, K. S., et al. (2006) · Current Biology · doi:10.1016/j.cub.2006.04.026 · Cited by 548
Self-citationControl of Mammalian Circadian Rhythm by CKIε-Regulated Proteasome-Mediated PER2 Degradation
Eide, E. J., Woolf, M. F., Kang, H., Woolf, P., Hurst, W., Camacho, F., Vielhaber, E. L., Giovanni, A., & Virshup, D. M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.7.2795-2807.2005 · Cited by 495
Typical 2‐Cys peroxiredoxins – structures, mechanisms and functions
Hall, A., Karplus, P. A., & Poole, L. B. (2009) · The FEBS Journal · doi:10.1111/j.1742-4658.2009.06985.x · Cited by 465
cAMP-dependent signaling as a core component of the mammalian circadian pacemaker
O'Neill, J. S., Maywood, E. S., Chesham, J. E., Takahashi, J. S., & Hastings, M. H. (2008) · Science · doi:10.1126/science.1152506 · Cited by 418
Self-citationEdwards, K. D., Anderson, P. E., Hall, A., Salathia, N. S., Locke, J. C. W., Lynn, J. R., Straume, M., Smith, J. Q., & Millar, A. J. (2006) · The Plant Cell · doi:10.1105/tpc.105.038315 · Cited by 310
Self-citationHirota, T., Lewis, W. G., Liu, A. C., Lee, J. W., Schultz, P. G., & Kay, S. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811410106 · Cited by 283
Cited by
Chemistry and biology of reactive oxygen species in signaling or stress responses
Dickinson, B. C., & Chang, C. J. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.607 · Cited by 1,821
Circadian control of the immune system
Scheiermann, C., Kunisaki, Y., & Frenette, P. S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3386 · Cited by 1,135
Extrapineal melatonin: sources, regulation, and potential functions
Acuña-Castroviejo, D., Escames, G., Venegas, C., Díaz-Casado, M. E., Lima-Cabello, E., López, L. C., Rosales-Corral, S., Tan, D.-X., & Reiter, R. J. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1579-2 · Cited by 1,076
Peroxiredoxins are conserved markers of circadian rhythms
Edgar, R. S., Green, E. W., Zhao, Y., van Ooijen, G., Olmedo, M., Qin, X., Xu, Y., Pan, M., Valekunja, U. K., Feeney, K. A., et al. (2012) · Nature · doi:10.1038/nature11088 · Cited by 914
Self-citationMolecular components of the mammalian circadian clock
Buhr, E. D., & Takahashi, J. S. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25950-0_1 · Cited by 738
Metadata
- Authors
- O’Neill, J. S., van Ooijen, G., Dixon, L. E., Troein, C., Corellou, F., Bouget, F.-Y., Reddy, A. B., & Millar, A. J.
- Venue
- Nature
- Published
- 2011-01
- Volume
- 469
- Issue
- 7331
- Pages
- 554-558
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2086131827
- Cited by
- 527
- References
- 26
- FWCI
- 26.47
- Type
- journal article
- Language
- en
- Open access
- green
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- O’Neill, J. S., van Ooijen, G., Dixon, L. E., Troein, C., Corellou, F., Bouget, F.-Y., Reddy, A. B., & Millar, A. J. (2011). Circadian rhythms persist without transcription in a eukaryote. Nature. https://doi.org/10.1038/nature09654
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