Control of Mammalian Circadian Rhythm by CKIε-Regulated Proteasome-Mediated PER2 Degradation

Coordination of circadian timing in mammals

Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379 · see citing works

Mechanisms Underlying Ubiquitination

Pickart, C. M. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.503 · Cited by 3,731 · see citing works

The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator

Preitner, N., Damiola, F., Luis-Lopez-Molina, Zakany, J., Duboule, D., Albrecht, U., & Schibler, U. (2002) · Cell · doi:10.1016/s0092-8674(02)00825-5 · Cited by 2,198 · see citing works

A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells

Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001 · see citing works

Resetting central and peripheral circadian oscillators in transgenic rats

Yamazaki, S., Numano, R., Abe, M., Hida, A., Takahashi, R.-I., Ueda, M., Block, G. D., Sakaki, Y., Menaker, M., & Tei, H. (2000) · Science · doi:10.1126/science.288.5466.682 · Cited by 1,907 · see citing works

An h <i>Per2</i> Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome

Toh, K. L., Jones, C. R., He, Y., Eide, E. J., Hinz, W. A., Virshup, D. M., Ptáček, L. J., & Fu, Y.-H. (2001) · Science · doi:10.1126/science.1057499 · Cited by 1,460 · see citing works

Posttranslational Mechanisms Regulate the Mammalian Circadian Clock

Lee, C., Etchegaray, J., Cagampang, F. R. A., Loudon, A. S. I., & Reppert, S. M. (2001) · Cell · doi:10.1016/s0092-8674(01)00610-9 · Cited by 1,158 · see citing works

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domain

Treier, M., Staszewski, L. M., & Bohmann, D. (1994) · Cell · doi:10.1016/s0092-8674(94)90502-9 · Cited by 928 · see citing works

Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau

Lowrey, P. L., Shimomura, K., Antoch, M. P., Yamazaki, S., Zemenides, P. D., Ralph, M. R., Menaker, M., & Takahashi, J. S. (2000) · Science · doi:10.1126/science.288.5465.483 · Cited by 860 · see citing works

double-time Is a Novel Drosophila Clock Gene that Regulates PERIOD Protein Accumulation

Price, J. L., Blau, J., Rothenfluh, A., Abodeely, M., Kloss, B., & Young, M. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81224-6 · Cited by 839 · see citing works

The Drosophila Clock Gene double-time Encodes a Protein Closely Related to Human Casein Kinase Iε

Kloss, B., Price, J. L., Sáez, L., Blau, J., Rothenfluh, A., Wesley, C. S., & Young, M. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81225-8 · Cited by 682 · see citing works

A Novel Human WD Protein, h-βTrCP, that Interacts with HIV-1 Vpu Connects CD4 to the ER Degradation Pathway through an F-Box Motif

Margottin-Goguet, F., Bour, S. P., Durand, H., Selig, L., Bénichou, S., Richard, V., Thomas, D., Strebel, K., & Bénarous, R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80056-8 · Cited by 670 · see citing works

The F-box protein β-TrCP associates with phosphorylated β-catenin and regulates its activity in the cell

Hart, M. J., Concordet, J., Lassot, I., Albert, I., Santos, R., Durand, H., Perret, C., Rubinfeld, B., Margottin-Goguet, F., Bénarous, R., et al. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80091-8 · Cited by 670 · see citing works

Identification of the receptor component of the IκBα–ubiquitin ligase

Yaron, A., Hatzubai, A., Davis, M., Lavon, I., Amit, S., Manning, A. M., Andersen, J., Mann, M., Mercurio, F., & Ben‐Neriah, Y. (1998) · Nature · doi:10.1038/25159 · Cited by 654 · see citing works

The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases

Jackson, P. K., Eldridge, A. G., Freed, E., Furstenthal, L., Hsu, J. Y., Kaiser, B. K., & Reimann, J. D. R. (2000) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01834-1 · Cited by 635 · see citing works

Structure of a β-TrCP1-Skp1-β-Catenin Complex

Wu, G., Xu, G., Schulman, B. A., Jeffrey, P. D., Harper, J. W., & Pavletich, N. P. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00234-x · Cited by 612 · see citing works

A Role for the Segment Polarity Gene shaggy/GSK-3 in the Drosophila Circadian Clock

Martinek, S., Inonog, S., Manoukian, A. S., & Young, M. W. (2001) · Cell · doi:10.1016/s0092-8674(01)00383-x · Cited by 513 · see citing works

Multiple signaling pathways elicit circadian gene expression in cultured Rat-1 fibroblasts

Balsalobre, A., Marcacci, L., & Schibler, U. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00758-2 · Cited by 485 · see citing works

M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCF ^β-TrCP

Watanabe, N., Arai, H., Nishihara, Y., Taniguchi, M., Watanabe, N., Hunter, T., & Osada, H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307700101 · Cited by 472 · see citing works

Light and circadian rhythmicity regulate MAP kinase activation in the suprachiasmatic nuclei

Obrietan, K. H., Impey, S., & Storm, D. R. (1998) · Nature Neuroscience · doi:10.1038/3695 · Cited by 369 · see citing works

Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime

Ko, H. W., Jiang, J., & Edery, I. (2002) · Nature · doi:10.1038/nature01272 · Cited by 328 · see citing works

Nuclear Entry of the Circadian Regulator mPER1 Is Controlled by Mammalian Casein Kinase I ɛ

Vielhaber, E. L., Eide, E. J., Rivers, A. M., Gao, Z.-H., & Virshup, D. M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.13.4888-4899.2000 · Cited by 308 · see citing works

The Circadian Regulatory Proteins BMAL1 and Cryptochromes Are Substrates of Casein Kinase Iε

Eide, E. J., Vielhaber, E. L., Hinz, W. A., & Virshup, D. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111466200 · Cited by 301 · see citing works

GENETICS OF THE MAMMALIAN CIRCADIAN SYSTEM: Photic Entrainment, Circadian Pacemaker Mechanisms, and Posttranslational Regulation

Lowrey, P. L., & Takahashi, J. S. (2000) · Annual Review of Genetics · doi:10.1146/annurev.genet.34.1.533 · Cited by 293 · see citing works

Control of Intracellular Dynamics of Mammalian Period Proteins by Casein Kinase I ε (CKIε) and CKIδ in Cultured Cells

Akashi, M., Tsuchiya, Y., Yoshino, T., & Nishida, E. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.6.1693-1703.2002 · Cited by 292 · see citing works

The F-box protein Slimb controls the levels of clock proteins Period and Timeless

Grima, B., Lamouroux, A., Chélot, E., Papin, C., Limbourg‐Bouchon, B., & Rouyer, F. (2002) · Nature · doi:10.1038/nature01122 · Cited by 288 · see citing works

A role for CK2 in the Drosophila circadian oscillator

Akten, B., Jauch, E., Genova, G., Kim, E. Y., Edery, I., Raabe, T., & Jackson, F. R. (2003) · Nature Neuroscience · doi:10.1038/nn1007 · Cited by 280 · see citing works

Nucleocytoplasmic shuttling and mCRY‐dependent inhibition of ubiquitylation of the mPER2 clock protein

Yagita, K., Tamanini, F., Yasuda, M., Hoeijmakers, J. H. J., van der Horst, G. T. J., & Okamura, H. (2002) · The EMBO Journal · doi:10.1093/emboj/21.6.1301 · Cited by 271 · see citing works

Posttranslational Regulation of Drosophila PERIOD Protein by Protein Phosphatase 2A

Sathyanarayanan, S., Zheng, X., Xiao, R., & Sehgal, A. (2004) · Cell · doi:10.1016/s0092-8674(04)00128-x · Cited by 271 · see citing works

A Role for the Proteasome in the Light Response of the Timeless Clock Protein

Naidoo, N. N., Song, W., Hunter-Ensor, M., & Sehgal, A. (1999) · Science · doi:10.1126/science.285.5434.1737 · Cited by 269 · see citing works

Involvement of the MAP kinase cascade in resetting of the mammalian circadian clockPreprint

Akashi, M., & Nishida, E. (2000) · Genes & Development · doi:10.1101/gad.14.6.645 · Cited by 269 · see citing works

Regulators of Serine / Threonine Protein Phosphatases at the Dawn of a Clinical Era?

Honkanen, R. E., & Golden, T. A. (2002) · Current Medicinal Chemistry · doi:10.2174/0929867023368836 · Cited by 261 · see citing works

ATF4 Degradation Relies on a Phosphorylation-Dependent Interaction with the SCFβTrCPUbiquitin Ligase

Lassot, I., Ségéral, E., Berlioz‐Torrent, C., Durand, H., Groussin, L., Hai, T., Bénarous, R., & Margottin-Goguet, F. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.6.2192-2202.2001 · Cited by 254 · see citing works

Phosphorylation of the Neurospora clock protein FREQUENCY determines its degradation rate and strongly influences the period length of the circadian clock

Liu, Y., Loros, J., & Dunlap, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.1.234 · Cited by 210 · see citing works

Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless.

Price, J. L., Dembinska, M. E., Young, M. W., & Rosbash, M. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00075.x · Cited by 210 · see citing works

FWD1‐mediated degradation of FREQUENCY in Neurospora establishes a conserved mechanism for circadian clock regulation

He, Q., Cheng, P., Yang, Y., He, Q., Yu, H., & Liu, Y. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg425 · Cited by 177 · see citing works

Circadian gene expression in mammalian fibroblasts revealed by real-time luminescence reporting: Temperature compensation and damping

Izumo, M., Johnson, C. H., & Yamazaki, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2536313100 · Cited by 161 · see citing works

Human casein kinase Iδ phosphorylation of human circadian clock proteins period 1 and 2

Camacho, F., Cilio, M., Guo, Y., Virshup, D. M., Patel, K., Khorkova, O., Styren, S. D., Morse, B., Yao, Z., & Keesler, G. A. (2001) · FEBS Letters · doi:10.1016/s0014-5793(00)02434-0 · Cited by 153 · see citing works

E-box function in a period gene repressed by light

Vallone, D., Gondi, S. B., Whitmore, D., & Foulkes, N. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305436101 · Cited by 149 · see citing works

Crystal Structure of a Conformation-selective Casein Kinase-1 Inhibitor

Mashhoon, N., DeMaggio, A. J., Tereshko, V. A., Bergmeier, S. C., Egli, M., Hoekstra, M. F., & Kuret, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001713200 · Cited by 149 · see citing works

The p42/44 Mitogen-activated Protein Kinase Pathway Couples Photic Input to Circadian Clock Entrainment

Butcher, G. Q., Dziema, H., Collamore, M., Burgoon, P. W., & Obrietan, K. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203301200 · Cited by 147 · see citing works

Regulation of the Neurospora circadian clock by casein kinase IIPreprint

Yang, Y., Cheng, P., & Liu, Y. (2002) · Genes & Development · doi:10.1101/gad.965102 · Cited by 144 · see citing works

Phosphorylation and destabilization of human period I clock protein by human casein kinase Iε

Keesler, G. A., Camacho, F., Guo, Y. X., Virshup, D. M., Mondadori, C., & Yao, Z. (2000) · Neuroreport · doi:10.1097/00001756-200004070-00011 · Cited by 136 · see citing works

GFP fluorescence reports Period 1 circadian gene regulation in the mammalian biological clock

Kuhlman, S. J., Quintero, J. E., & McMahon, D. G. (2000) · Neuroreport · doi:10.1097/00001756-200005150-00024 · Cited by 132 · see citing works

A Phytochrome-Associated Protein Phosphatase 2A Modulates Light Signals in Flowering Time Control in Arabidopsis

Kim, D., Kang, J., Yang, S., Chung, K.-S., Song, P., & Park, C. (2002) · The Plant Cell · doi:10.1105/tpc.005306 · Cited by 127 · see citing works

Identification of Inhibitory Autophosphorylation Sites in Casein Kinase I ε

Gietzen, K. F., & Virshup, D. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.45.32063 · Cited by 126 · see citing works

Regulation of Casein Kinase Iϵ Activity by Wnt Signaling

Swiatek, W., Tsai, I.-C., Klimowski, L., Pepler, A., Barnette, J. E., Yost, H. J., & Virshup, D. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m304682200 · Cited by 106 · see citing works

Phosphorylation of FREQUENCY Protein by Casein Kinase II Is Necessary for the Function of the Neurospora Circadian Clock

Yang, Y., Cheng, P., He, Q., Wang, L., & Liu, Y. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.17.6221-6228.2003 · Cited by 100 · see citing works

CASEIN KINASE I: ANOTHER COG IN THE CIRCADIAN CLOCKWORKS

Eide, E. J., & Virshup, D. M. (2001) · Chronobiology International · doi:10.1081/cbi-100103963 · Cited by 90 · see citing works

Mechanism of Regulation of Casein Kinase I Activity by Group I Metabotropic Glutamate Receptors

Liu, F., Virshup, D. M., Nairn, A. C., & Greengard, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204499200 · Cited by 88 · see citing works

Drosophila doubletime Mutations Which either Shorten or Lengthen the Period of Circadian Rhythms Decrease the Protein Kinase Activity of Casein Kinase I

Preuss, F., Fan, J.-Y., Kalive, M., Bao, S., Schuenemann, E., Bjes, E. S., & Price, J. L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.24.2.886-898.2004 · Cited by 85 · see citing works

Phosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblasts

Miyazaki, K., Nagase, T., Mesaki, M., Narukawa, J., Ohara, O., & Ishida, N. (2004) · Biochemical Journal · doi:10.1042/bj20031308 · Cited by 61 · see citing works

Negative Control of Circadian Clock Regulator E4BP4 by Casein Kinase Iϵ-Mediated Phosphorylation

Doi, M., Okano, T., Yujnovsky, I., Sassone‐Corsi, P., & Fukada, Y. (2004) · Current Biology · doi:10.1016/j.cub.2004.05.043 · Cited by 43 · see citing works

Identification of Casein Kinase I Substrates by in Vitro Expression Cloning Screening

Gao, Z.-H., Metherall, J. E., & Virshup, D. M. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2168 · Cited by 28 · see citing works

Molecular components of the mammalian circadian clock

Ko, C. H., & Takahashi, J. S. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl207 · Cited by 1,657 · see citing works

The genetics of mammalian circadian order and disorder: implications for physiology and disease

Takahashi, J. S., Hong, H.-K., Ko, C. H., & McDearmon, E. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2430 · Cited by 1,611 · see citing works

Molecular mechanisms and physiological importance of circadian rhythms

Patke, A., Young, M. W., & Axelrod, S. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0179-2 · Cited by 1,388 · see citing works

SIRT1 regulates circadian clock gene expression through PER2 deacetylation

Asher, G., Gatfield, D., Stratmann, M., Reinke, H., Dibner, C., Kreppel, F., Mostoslavsky, R., Alt, F. W., & Schibler, U. (2008) · Cell · doi:10.1016/j.cell.2008.06.050 · Cited by 1,376 · see citing works

Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer

Frescas, D., & Pagano, M. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2396 · Cited by 886 · see citing works

Post-translational modifications regulate the ticking of the circadian clock

Gallego, M., & Virshup, D. M. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2106 · Cited by 863 · see citing works

Molecular components of the mammalian circadian clock

Buhr, E. D., & Takahashi, J. S. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25950-0_1 · Cited by 738 · see citing works

Retinoid-Related Orphan Receptors (RORs): Critical Roles in Development, Immunity, Circadian Rhythm, and Cellular Metabolism

Jetten, A. M. (2009) · Nuclear Receptor Signaling · doi:10.1621/nrs.07003 · Cited by 675 · see citing works

Circadian Rhythms: Mechanisms and Therapeutic Implications

Levi, F., & Schibler, U. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105208 · Cited by 645 · see citing works

Genetics of Circadian Rhythms in Mammalian Model Organisms

Lowrey, P. L., & Takahashi, J. S. (2011) · Advances in genetics · doi:10.1016/b978-0-12-387690-4.00006-4 · Cited by 578 · see citing works

Circadian Mutant Overtime Reveals F-box Protein FBXL3 Regulation of Cryptochrome and Period Gene Expression

Siepka, S. M., Yoo, S. H., Park, J., Song, W., Kumar, V., Hu, Y., Lee, C., & Takahashi, J. S. (2007) · Cell · doi:10.1016/j.cell.2007.04.030 · Cited by 536 · see citing works

Circadian rhythms persist without transcription in a eukaryote

O'Neill, J. S., Gerben Van Ooijen, A., Dixon, L. E., Troein, C., Corellou, F., Bouget, F., Reddy, A. B., & Millar, A. J. (2011) · Nature · doi:10.1038/nature09654 · Cited by 514 · see citing works

Metabolism and Circadian Rhythms—Implications for Obesity

Froy, O. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0014 · Cited by 505 · see citing works

Circadian Rhythms and Metabolic Syndrome

Maury, E., Ramsey, K. M., & Bass, J. T. (2010) · Circulation Research · doi:10.1161/circresaha.109.208355 · Cited by 502 · see citing works

The After-Hours Mutant Reveals a Role for Fbxl3 in Determining Mammalian Circadian Period

Godinho, S. I. H., Maywood, E. S., Shaw, L. E., Tucci, V., Barnard, A. R., Busino, L., Pagano, M., Kendall, R., Quwailid, M. M., Romero, M. R., et al. (2007) · Science · doi:10.1126/science.1141138 · Cited by 468 · see citing works

Modeling of a Human Circadian Mutation Yields Insights into Clock Regulation by PER2

Xu, Y., Toh, K. L., Jones, C. R., Shin, J., Fu, Y., & Ptáček, L. J. (2007) · Cell · doi:10.1016/j.cell.2006.11.043 · Cited by 405 · see citing works

Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS)Preprint

Vanselow, K., Vanselow, J. T., Westermark, P. O., Reischl, S., Maier, B., Korte, T., Herrmann, A., Herzel, H., Schlösser, A., & Kramer, A. (2006) · Genes & Development · doi:10.1101/gad.397006 · Cited by 383 · see citing works

Interplay of Circadian Clocks and Metabolic Rhythms

Wijnen, H., & Young, M. W. (2006) · Annual Review of Genetics · doi:10.1146/annurev.genet.40.110405.090603 · Cited by 335 · see citing works

Circadian Rhythm Disruption in Cancer Biology

Savvidis, C., & Koutsilieris, M. (2012) · Molecular Medicine · doi:10.2119/molmed.2012.00077 · Cited by 316 · see citing works

The relationship between nutrition and circadian rhythms in mammals

Froy, O. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.03.001 · Cited by 286 · see citing works

Molecular Circadian Rhythms in Central and Peripheral Clocks in Mammals

Dardente, H., Dardente, H., & Cermakian, N. (2007) · Chronobiology International · doi:10.1080/07420520701283693 · Cited by 284 · see citing works

Circadian Clocks and Metabolism

Marcheva, B., Ramsey, K. M., Peek, C. B., Affinati, A., Maury, E., & Bass, J. (2013) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-25950-0_6 · Cited by 282 · see citing works

Interaction between circadian rhythms and stress

Koch, C. E., Leinweber, B., Drengberg, B. C., Blaum, C. M., & Oster, H. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.09.001 · Cited by 256 · see citing works

Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes

Meng, Q., Maywood, E. S., Bechtold, D. A., Lu, W., Li, J., Gibbs, J. E., Dupré, S. M., Chesham, J. E., Rajamohan, F., Knafels, J. D., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005101107 · Cited by 253 · see citing works

Multisite Protein Kinase A and Glycogen Synthase Kinase 3β Phosphorylation Leads to Gli3 Ubiquitination by SCF ^βTrCP

Tempé, D., Casas, M., Karaz, S., Blanchet-Tournier, M.-F., & Concordet, J.-P. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02183-05 · Cited by 249 · see citing works

High-Throughput Chemical Screen Identifies a Novel Potent Modulator of Cellular Circadian Rhythms and Reveals CKIα as a Clock Regulatory Kinase

Hirota, T., Lee, J. W., Lewis, W. G., Zhang, E. E., Breton, G., Liu, X., Garcia, M. E., Peters, E. C., Etchegaray, J., Traver, D. J., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000559 · Cited by 248 · see citing works

Cell autonomy and synchrony of suprachiasmatic nucleus circadian oscillators

Mohawk, J. A., & Takahashi, J. S. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.05.003 · Cited by 247 · see citing works

CKIε/δ-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock

Isojima, Y., Nakajima, M., Ukai, H., Fujishima, H., Yamada, R. G., Masumoto, K., Kiuchi, R., Ishida, M., Ukai‐Tadenuma, M., Minami, Y., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908733106 · Cited by 246 · see citing works

Activation of 5′-AMP-activated Kinase with Diabetes Drug Metformin Induces Casein Kinase Iɛ (CKIɛ)-dependent Degradation of Clock Protein mPer2

Um, J. H., Yang, S., Yamazaki, S., Kang, H., Viollet, B., Foretz, M., & Chung, J. H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c700070200 · Cited by 244 · see citing works

Mammalian circadian clock and metabolism – the epigenetic link

Bellet, M. M., & Sassone‐Corsi, P. (2010) · Journal of Cell Science · doi:10.1242/jcs.051649 · Cited by 237 · see citing works

Casein Kinase 1 Delta Regulates the Pace of the Mammalian Circadian Clock

Etchegaray, J., Machida, K., Noton, E., Constance, C. M., Dallmann, R., Napoli, M. N. D., DeBruyne, J. P., Lambert, C. M., Yu, E. A., Reppert, S. M., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00338-09 · Cited by 237 · see citing works

Rhythmic PER Abundance Defines a Critical Nodal Point for Negative Feedback within the Circadian Clock Mechanism

Chen, R., Schirmer, A. E., Lee, Y., Lee, H.-M., Kumar, V., Yoo, S. H., Takahashi, J. S., & Lee, C. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.10.012 · Cited by 225 · see citing works

The role of circadian clock genes in mental disorders

Lamont, E. W., Coutu, D. L., Cermakian, N., & Boivin, D. B. (2007) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2007.9.3/elamont · Cited by 224 · see citing works

A large-scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clockPreprint

Maier, B., Wendt, S. L., Vanselow, J. T., Wallach, T. E., Reischl, S., Oehmke, S., Schlösser, A., & Kramer, A. (2009) · Genes & Development · doi:10.1101/gad.512209 · Cited by 221 · see citing works

Circadian Rhythms, the Molecular Clock, and Skeletal Muscle

Harfmann, B. D., Schroder, E. A., & Esser, K. A. (2015) · Journal of Biological Rhythms · doi:10.1177/0748730414561638 · Cited by 211 · see citing works

CKI and CKII mediate the FREQUENCY-dependent phosphorylation of the WHITE COLLAR complex to close the Neurospora circadian negative feedback loopPreprint

He, Q., Cha, J., He, Q., Lee, H.-C., Yang, Y., & Liu, Y. (2006) · Genes & Development · doi:10.1101/gad.1463506 · Cited by 209 · see citing works

The ubiquitin proteasome system in neuropathology

Lehman, N. L. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0560-x · Cited by 206 · see citing works

THE CROSSTALK BETWEEN PHYSIOLOGY AND CIRCADIAN CLOCK PROTEINS

Duguay, D., & Cermakian, N. (2009) · Chronobiology International · doi:10.3109/07420520903497575 · Cited by 201 · see citing works

Ser-557-phosphorylated mCRY2 Is Degraded upon Synergistic Phosphorylation by Glycogen Synthase Kinase-3β

Harada, Y., Sakai, M., Kurabayashi, N., Hirota, T., & Fukada, Y. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506225200 · Cited by 199 · see citing works

Systems Biology of Mammalian Circadian Clocks

Ukai, H., & Ueda, H. R. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-073109-130051 · Cited by 195 · see citing works

The intricate dance of post-translational modifications in the rhythm of life

Hirano, A., Fu, Y., & Ptáček, L. J. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3326 · Cited by 191 · see citing works

Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening

Chen, Z., Yoo, S. H., Park, Y. S., Kim, K.-H., Wei, S., Buhr, E. D., Ye, Z., Pan, H., & Takahashi, J. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118034108 · Cited by 189 · see citing works

Post-translational modifications in circadian rhythms

Mehra, A., Baker, C. L., Loros, J., & Dunlap, J. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.06.006 · Cited by 186 · see citing works

Circadian regulation of lipid metabolism

Gooley, J. (2016) · Proceedings of the Nutrition Society · doi:10.1017/s0029665116000288 · Cited by 162 · see citing works

The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1

Lee, H.-M., Chen, R., Kim, H., Etchegaray, J., Weaver, D. R., & Lee, C. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107178108 · Cited by 185 · see citing works

Selective Inhibition of Casein Kinase 1ϵ Minimally Alters Circadian Clock Period

Walton, K. M., Fisher, K., Rubitski, D., Marconi, M., Meng, Q.-J., Sládek, M., Adams, J., Bass, M., Chandrasekaran, R., Butler, T., et al. (2009) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.151415 · Cited by 184 · see citing works

p53 regulates Period2 expression and the circadian clock

Miki, T., Matsumoto, T., Zhao, Z., & Lee, C. C. (2013) · Nature Communications · doi:10.1038/ncomms3444 · Cited by 184 · see citing works

Circadian Rhythms and Hormonal Homeostasis: Pathophysiological Implications

Gnocchi, D., & Bruscalupi, G. (2017) · Biology · doi:10.3390/biology6010010 · Cited by 184 · see citing works

NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging

Levine, D. C., Hong, H., Weidemann, B. J., Ramsey, K. M., Affinati, A. H., Schmidt, M. S., Cedernaes, J., Omura, C., Braun, R., Lee, C., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.04.010 · Cited by 182 · see citing works

Circadian rhythm regulates the function of immune cells and participates in the development of tumors

Zeng, Y., Guo, Z., Wu, M., Chen, F., & Chen, L. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01960-1 · Cited by 184 · see citing works

Period 2 Mutation Accelerates ApcMin/+ Tumorigenesis

Wood, P. A., Yang, X., Taber, A., Oh, E.-Y., Ansell, C. M., Ayers, S. E., Al-Assaad, Z., Carnevale, K. A., Berger, F. G., Peña, M. M. O., et al. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0196 · Cited by 181 · see citing works

Mammalian circadian signaling networks and therapeutic targets

Liu, A. C., Lewis, W. G., & Kay, S. A. (2007) · Nature Chemical Biology · doi:10.1038/nchembio.2007.37 · Cited by 177 · see citing works

An Inhibitor of Casein Kinase Iϵ Induces Phase Delays in Circadian Rhythms under Free-Running and Entrained Conditions

Badura, L., Swanson, T., Adamowicz, W., Adams, J., Cianfrogna, J., Fisher, K., Holland, J., Kleiman, R., Nelson, F., Reynolds, L., et al. (2007) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.122846 · Cited by 176 · see citing works

An opposite role for tau in circadian rhythms revealed by mathematical modeling

Gallego, M., Eide, E. J., Woolf, M. F., Virshup, D. M., & Forger, D. B. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604511103 · Cited by 176 · see citing works

β-TrCP1-Mediated Degradation of PERIOD2 Is Essential for Circadian Dynamics

Reischl, S., Vanselow, K., Westermark, P. O., Thierfelder, N., Maier, B., Herzel, H., & Kramer, A. (2007) · Journal of Biological Rhythms · doi:10.1177/0748730407303926 · Cited by 176 · see citing works

A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period

Zhou, M., Kim, J. K., Eng, G. W. L., Forger, D. B., & Virshup, D. M. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.08.022 · Cited by 174 · see citing works

The COP9 signalosome regulates the Neurospora circadian clock by controlling the stability of the SCF FWD-1 complexPreprint

He, Q., Cheng, P., He, Q., & Liu, Y. (2005) · Genes & Development · doi:10.1101/gad.1322205 · Cited by 174 · see citing works

Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1

Li, C., Ao, J., Fu, J., Lee, D.-F., Xu, J., Lonard, D. M., & O’Malley, B. W. (2011) · Oncogene · doi:10.1038/onc.2011.151 · Cited by 173 · see citing works

CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch

Narasimamurthy, R., Hunt, S. R., Lu, Y., Fustin, J., Okamura, H., Partch, C. L., Forger, D. B., Kim, J. K., & Virshup, D. M. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1721076115 · Cited by 173 · see citing works

Essential roles of CKIδ and CKIε in the mammalian circadian clock

Lee, H.-M., Chen, R., Lee, Y., Yoo, S. H., & Lee, C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906651106 · Cited by 172 · see citing works

Kinases and phosphatases in the mammalian circadian clock

Reischl, S., & Kramer, A. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.02.038 · Cited by 167 · see citing works

Molecular mechanisms underlying alcohol-drinking behaviours

Ron, D., & Barak, S. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.85 · Cited by 165 · see citing works

An Autonomous Circadian Clock in the Inner Mouse Retina Regulated by Dopamine and GABA

Ruan, G.-X., Allen, G. C., Yamazaki, S., & McMahon, D. G. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060249 · Cited by 164 · see citing works

Integration of Light and Temperature in the Regulation of Circadian Gene Expression in Drosophila

Boothroyd, C. E., Wijnen, H., Naef, F., Sáez, L., & Young, M. W. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030054 · Cited by 163 · see citing works

BMAL1 Shuttling Controls Transactivation and Degradation of the CLOCK/BMAL1 Heterodimer

Kwon, I., Lee, J., Chang, S. H., Jung, N. C., Lee, B. J., Son, G. H., Kim, K., & Lee, K. H. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00337-06 · Cited by 163 · see citing works

Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation

Zhao, X., Hirota, T., Han, X., Cho, H., Chong, L.-W., Lamia, K. A., Liu, S., Atkins, A. R., Banayo, E., Liddle, C., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.012 · Cited by 159 · see citing works

The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clockPreprint

Chiu, J. C., Vanselow, J. T., Kramer, A., & Edery, I. (2008) · Genes & Development · doi:10.1101/gad.1682708 · Cited by 157 · see citing works

Circadian Rhythms, Aging, and Life Span in Mammals

Froy, O. (2011) · Physiology · doi:10.1152/physiol.00012.2011 · Cited by 156 · see citing works

Circadian rhythms and cancers: the intrinsic links and therapeutic potentials

Zhou, L., Zhang, Z., Nice, E. C., Huang, C., Zhang, W., & Tang, Y. C. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01238-y · Cited by 156 · see citing works

Regulation of Circadian Clocks by Redox Homeostasis

Stangherlin, A., & Reddy, A. B. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.r113.457564 · Cited by 152 · see citing works

Decoupling circadian clock protein turnover from circadian period determination

Larrondo, L. F., Olivares-Yáñez, C., Baker, C. L., Loros, J., & Dunlap, J. (2015) · Science · doi:10.1126/science.1257277 · Cited by 151 · see citing works

A role of the circadian system and circadian proteins in aging

KONDRATOV, R. (2007) · Ageing Research Reviews · doi:10.1016/j.arr.2007.02.003 · Cited by 149 · see citing works

Circadian and circalunar clock interactions in a marine annelid

Zantke, J., Ishikawa-Fujiwara, T., Arboleda, E., Lohs, C., Schipany, K., Hallay, N., Straw, A. D., Todo, T., & Tessmar-Raible, K. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.031 · Cited by 148 · see citing works

The times they’re a-changing: Effects of circadian desynchronization on physiology and disease

Golombek, D. A., Casiraghi, L. P., Agostino, P. V., Paladino, N., Duhart, J. M., Plano, S. A., & Chiesa, J. J. (2013) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2013.03.007 · Cited by 147 · see citing works

Targeting REV-ERBα for therapeutic purposes: promises and challenges

Wang, S., Li, F., Lin, Y., & Wu, B. (2020) · Theranostics · doi:10.7150/thno.43834 · Cited by 145 · see citing works

Effect of feeding regimens on circadian rhythms: Implications for agingand longevity

Froy, O., & Miskin, R. (2010) · Aging · doi:10.18632/aging.100116 · Cited by 141 · see citing works

Roles of CLOCK Phosphorylation in Suppression of E-Box-Dependent Transcription

Yoshitane, H., Takao, T., Satomi, Y., Du, N., Okano, T., & Fukada, Y. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01864-08 · Cited by 140 · see citing works

Circadian Rhythms in Neurospora crassa and Other Filamentous Fungi

Liu, Y., & Bell‐Pedersen, D. (2006) · Eukaryotic Cell · doi:10.1128/ec.00133-06 · Cited by 139 · see citing works

Circadian gene expression is resilient to large fluctuations in overall transcription rates

Dibner, C., Sage, D., Unser, M. A., Bauer, C. R., d’Eysmond, T., Naef, F., & Schibler, U. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.262 · Cited by 137 · see citing works

The Neurospora crassa Circadian Clock

Heintzen, C., & Liu, Y. (2007) · Advances in genetics · doi:10.1016/s0065-2660(06)58002-2 · Cited by 137 · see citing works

Diurnal Regulation of Lipid Metabolism and Applications of Circadian Lipidomics

Gooley, J. J., & Chua, E. C.-P. (2014) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2014.04.001 · Cited by 136 · see citing works

DYRK1A and Glycogen Synthase Kinase 3β, a Dual-Kinase Mechanism Directing Proteasomal Degradation of CRY2 for Circadian Timekeeping

Kurabayashi, N., Hirota, T., Sakai, M., Sanada, K., & Fukada, Y. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01047-09 · Cited by 134 · see citing works

Interdependence of nutrient metabolism and the circadian clock system: Importance for metabolic health

Ribas‐Latre, A., & Eckel‐Mahan, K. L. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2015.12.006 · Cited by 133 · see citing works

Interactive Features of Proteins Composing Eukaryotic Circadian Clocks

Crane, B. R., & Young, M. W. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060713-035644 · Cited by 125 · see citing works

Chronobesity: role of the circadian system in the obesity epidemic

Laermans, J., & Depoortere, I. (2015) · Obesity Reviews · doi:10.1111/obr.12351 · Cited by 126 · see citing works

Ligand modulation of REV-ERBα function resets the peripheral circadian clock in a phasic manner

Meng, Q., McMaster, A., Beesley, S., Lu, W., Gibbs, J. E., Parks, D. J., Collins, J. L., Farrow, S. N., Donn, R. P., Ray, D. W., et al. (2008) · Journal of Cell Science · doi:10.1242/jcs.035048 · Cited by 126 · see citing works

A systematic forward genetic analysis identified components of the Chlamydomonas circadian systemPreprint

Matsuo, T., Okamoto, K., Onai, K., Niwa, Y., Shimogawara, K., & Ishiura, M. (2008) · Genes & Development · doi:10.1101/gad.1650408 · Cited by 126 · see citing works

Two Ck1δ transcripts regulated by m6A methylation code for two antagonistic kinases in the control of the circadian clock

Fustin, J., Kojima, R., Itoh, K., Chang, H., Ye, S., Zhuang, B., Oji, A., Gibo, S., Narasimamurthy, R., Virshup, D. M., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1721371115 · Cited by 124 · see citing works

IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation

Cheong, J. K., Hung, N. T., Wang, H., Tan, P. B. O., Voorhoeve, P. M., Lee, S. H., & Virshup, D. M. (2011) · Oncogene · doi:10.1038/onc.2010.627 · Cited by 123 · see citing works

Involvement of the Protein Kinase CK2 in the Regulation of Mammalian Circadian Rhythms

Tsuchiya, Y., Akashi, M., Matsuda, M., Goto, K., Miyata, Y., Node, K., & Nishida, E. (2009) · Science Signaling · doi:10.1126/scisignal.2000305 · Cited by 122 · see citing works

Circadian-relevant genes are highly polymorphic in autism spectrum disorder patients

Yang, Z., Matsumoto, A., Nakayama, K., Jimbo, E. F., Kojima, K., Nagata, K., Iwamoto, S., & Yamagata, T. (2015) · Brain and Development · doi:10.1016/j.braindev.2015.04.006 · Cited by 121 · see citing works

MicroRNAs shape circadian hepatic gene expression on a transcriptome-wide scale

Du, N., Arpat, A. B., Matos, M. D., & Gatfield, D. (2014) · eLife · doi:10.7554/elife.02510 · Cited by 120 · see citing works

From circadian clock gene expression to pathologies

Lamont, E. W., James, F. O., Boivin, D. B., & Cermakian, N. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2006.11.002 · Cited by 120 · see citing works

PPAR-γ integrates obesity and adipocyte clock through epigenetic regulation of Bmal1

Wang, S., Lin, Y., Gao, L., Yang, Z., Lin, J., Ren, S., Li, F., Chen, J., Wang, Z., Dong, Z., et al. (2022) · Theranostics · doi:10.7150/thno.69054 · Cited by 117 · see citing works

Lipids around the Clock: Focus on Circadian Rhythms and Lipid Metabolism

Gnocchi, D., Pedrelli, M., Hurt-Camejo, E., & Parini, P. (2015) · Biology · doi:10.3390/biology4010104 · Cited by 115 · see citing works

Circadian Dbp Transcription Relies on Highly Dynamic BMAL1-CLOCK Interaction with E Boxes and Requires the Proteasome

Stratmann, M., Suter, D. M., Molina, N., Naef, F., & Schibler, U. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.08.012 · Cited by 115 · see citing works

A DOUBLETIME Kinase Binding Domain on the Drosophila PERIOD Protein Is Essential for Its Hyperphosphorylation, Transcriptional Repression, and Circadian Clock Function

Kim, E. Y., Ko, H. W., Yu, W., Hardin, P. E., & Edery, I. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02339-06 · Cited by 112 · see citing works

The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks

Andreatta, G., & Tessmar-Raible, K. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.03.009 · Cited by 111 · see citing works

Circadian rhythm and its role in malignancy

Rana, S., & Mahmood, S. (2010) · Journal of Circadian Rhythms · doi:10.1186/1740-3391-8-3 · Cited by 111 · see citing works

Abnormal expressions of circadian-clock and circadian clock-controlled genes in the livers and kidneys of long-term, high-fat-diet-treated mice

Hsieh, M.-C., Yang, S.-C., Tseng, H.-L., Hwang, L.-L., Chen, C.-T., & Shieh, K.-R. (2010) · International Journal of Obesity · doi:10.1038/ijo.2009.228 · Cited by 108 · see citing works

Protein phosphatase 1 regulates the stability of the circadian protein PER2

Gallego, M., Kang, H., & Virshup, D. M. (2006) · Biochemical Journal · doi:10.1042/bj20060678 · Cited by 87 · see citing works

Involvement of the Protein Kinase CK2 in the Regulation of Mammalian Circadian Rhythms

Tsuchiya, Y., Akashi, M., Matsuda, M., Goto, K., Miyata, Y., Node, K., & Nishida, E. (2009) · Science Signaling · doi:10.1126/scisignal.2000305 · Cited by 122 · see citing works

Mutation of a PER2 phosphodegron perturbs the circadian phosphoswitch

Masuda, S., Narasimamurthy, R., Yoshitane, H., Kim, J. K., Fukada, Y., & Virshup, D. M. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2000266117 · Cited by 73 · see citing works

Phosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblasts

Miyazaki, K., Nagase, T., Mesaki, M., Narukawa, J., Ohara, O., & Ishida, N. (2004) · Biochemical Journal · doi:10.1042/bj20031308 · Cited by 61 · see citing works

Control of Intracellular Dynamics of Mammalian Period Proteins by Casein Kinase I ε (CKIε) and CKIδ in Cultured Cells

Akashi, M., Tsuchiya, Y., Yoshino, T., & Nishida, E. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.6.1693-1703.2002 · Cited by 292 · see citing works