The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Peroxiredoxins are conserved markers of circadian rhythms
Open accessAbstract
Cellular life emerged ∼3.7 billion years ago. With scant exception, terrestrial organisms have evolved under predictable daily cycles owing to the Earth’s rotation. The advantage conferred on organisms that anticipate such environmental cycles has driven the evolution of endogenous circadian rhythms that tune internal physiology to external conditions. The molecular phylogeny of mechanisms driving these rhythms has been difficult to dissect because identified clock genes and proteins are not conserved across the domains of life: Bacteria, Archaea and Eukaryota. Here we show that oxidation–reduction cycles of peroxiredoxin proteins constitute a universal marker for circadian rhythms in all domains of life, by characterizing their oscillations in a variety of model organisms. Furthermore, we explore the interconnectivity between these metabolic cycles and transcription–translation feedback loops of the clockwork in each system. Our results suggest an intimate co-evolution of cellular timekeeping with redox homeostatic mechanisms after the Great Oxidation Event ∼2.5 billion years ago.
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Molecular Bases for Circadian Clocks
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Self-citationPeroxiredoxin Evolution and the Regulation of Hydrogen Peroxide Signaling
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Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors
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Cited by
Sies, H. (2017) · Redox Biology · doi:10.1016/j.redox.2016.12.035 · Cited by 2,148
Cellular mechanisms and physiological consequences of redox-dependent signalling
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Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease
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The two‐process model of sleep regulation: a reappraisal
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Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis
Thaiss, C. A., Zeevi, D., Levy, M., Zilberman-Schapira, G., Suez, J., Tengeler, A. C., Abramson, L., Katz, M. N., Korem, T., Zmora, N., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.048 · Cited by 1,449
Metadata
- Authors
- Edgar, R. S., Green, E. W., Zhao, Y., van Ooijen, G., Olmedo, M., Qin, X., Xu, Y., Pan, M., Valekunja, U. K., Feeney, K. A., Maywood, E. S., Hastings, M. H., Baliga, N. S., Merrow, M., Millar, A. J., Johnson, C. H., Kyriacou, C. P., O’Neill, J. S., & Reddy, A. B.
- Venue
- Nature
- Published
- 2012-05-16
- Volume
- 485
- Issue
- 7399
- Pages
- 459-464
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2167636534
- Cited by
- 914
- References
- 62
- FWCI
- 30.91
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Edgar, R. S., Green, E. W., Zhao, Y., van Ooijen, G., Olmedo, M., Qin, X., Xu, Y., Pan, M., Valekunja, U. K., Feeney, K. A., Maywood, E. S., Hastings, M. H., Baliga, N. S., Merrow, M., Millar, A. J., Johnson, C. H., Kyriacou, C. P., O’Neill, J. S., & Reddy, A. B. (2012). Peroxiredoxins are conserved markers of circadian rhythms. Nature. https://doi.org/10.1038/nature11088
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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