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Cited by 668

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Reversing pathological neural activity using targeted plasticity

Open access
Engineer, Navzer D., Riley, Jonathan R., Seale, Jonathan D., Vrana, Will A., Shetake, Jai A., Sudanagunta, Sindhu P., Borland, Michael S., Kilgard, Michael P.·2011·Nature
DOI 10.1038/nature09656
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Abstract

Brain changes in response to nerve damage or cochlear trauma can generate pathological neural activity that is believed to be responsible for many types of chronic pain and tinnitus. Several studies have reported that the severity of chronic pain and tinnitus is correlated with the degree of map reorganization in somatosensory and auditory cortex, respectively. Direct electrical or transcranial magnetic stimulation of sensory cortex can temporarily disrupt these phantom sensations. However, there is as yet no direct evidence for a causal role of plasticity in the generation of pain or tinnitus. Here we report evidence that reversing the brain changes responsible can eliminate the perceptual impairment in an animal model of noise-induced tinnitus. Exposure to intense noise degrades the frequency tuning of auditory cortex neurons and increases cortical synchronization. Repeatedly pairing tones with brief pulses of vagus nerve stimulation completely eliminated the physiological and behavioural correlates of tinnitus in noise-exposed rats. These improvements persisted for weeks after the end of therapy. This method for restoring neural activity to normal may be applicable to a variety of neurological disorders.

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Metadata

Authors
Engineer, N. D., Riley, J. R., Seale, J. D., Vrana, W. A., Shetake, J. A., Sudanagunta, S. P., Borland, M. S., & Kilgard, M. P.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2011-01-12
Volume
470
Issue
7332
Pages
101-104
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/nature09656
OpenAlex
W1978441796
Cited by
668
References
31
FWCI
25.93
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Reversing pathological neural activity using targeted plasticity. https://app.cochat.ai/papers/10.1038/nature09656
The paper
Engineer, N. D., Riley, J. R., Seale, J. D., Vrana, W. A., Shetake, J. A., Sudanagunta, S. P., Borland, M. S., & Kilgard, M. P. (2011). Reversing pathological neural activity using targeted plasticity. Nature. https://doi.org/10.1038/nature09656

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.