Cited by 560Pain Management and TreatmentTactile and Sensory InteractionsPain Mechanisms and Treatments

Effect of sensory discrimination training on cortical reorganisation and phantom limb pain

Flor, Herta, Denke, Claudia, Schaefer, Michael, Grüsser, Sabine·2001·The Lancet

Abstract

Phantom limb pain is a frequent consequence of the amputation of a body part. Based on the finding that phantom limb pain is closely associated with plastic changes in the primary somatosensory cortex and animal data showing that behaviourally relevant training alters the cortical map, we devised a sensory discrimination training programme for patients with intractable phantom limb pain. Compared with a control group of medically treated patients, the training group had significant reductions in phantom limb pain (p=0.002) and cortical reorganisation (p=0.05) that were positively associated with improved sensory discrimination ability.

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Crossref · 10.1016/s0140-6736(00)04890-x

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Authors
Flor, H., Denke, C., Schaefer, M., & Grüsser, S.
Affiliations
  • Central Institute of Mental Health (DE)
  • Humboldt-Universität zu Berlin (DE)
Corresponding author
Flor, Herta
Venue
The Lancet
Publisher
Elsevier BV
Published
2001-06
Volume
357
Issue
9270
Pages
1763-1764
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
OpenAlex
W2131479747
Cited by
560
References
5
Citations by year
2026: 7 · 2025: 15 · 2024: 18 · 2023: 27 · 2022: 31 · 2021: 27 · 2020: 23 · 2019: 22 · 2018: 17 · 2017: 41 · 2016: 37 · 2015: 27 · 2014: 29 · 2013: 34 · 2012: 34
FWCI
10.31
Type
journal article
Language
en
Open access
closed
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Keywords
phantom limb pain, cortical reorganization, primary somatosensory cortex, cortical plasticity, amputation, refractory pain, sensory discrimination
MeSH terms
Adult, Aged, Amputation Stumps, Arm, Discrimination Learning, Electric Stimulation, Electroencephalography, Female, Humans, Male, Middle Aged, Phantom Limb, Somatosensory Cortex, Pain Management

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