H3K27 Demethylases, at Long Last
Open accessAbstract
Methylation of lysine 27 on histone H3 (H3K27me) by the Polycomb complex (PRC2) proteins is associated with gene silencing in many developmental processes. A cluster of recent papers (Agger et al., 2007; De Santa et al., 2007; Lan et al., 2007; Lee et al., 2007) identify the JmjC-domain proteins UTX and JMJD3 as H3K27-specific demethylases that remove this methyl mark, enabling the activation of genes involved in animal body patterning and the inflammatory response.
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KDM6A/B mediate removal of the suppressive chromatin modification H3K27me3, which is associated with silenced genes.
“KDM6A/B mediate the removal of the suppressive chromatin modification H3K27me3, which is associated with silenced genes26.”
From Epigenetic regulation of brain region-specific microglia clearance activity (2018) · cites this paper as [26]
Enrichment of mRNAs encoding KDM6A/B in cerebellar microglia and up-regulation of Kdm6a/b upon exposure to dying cells in vitro point to a possible role of PRC2/H3K27me3 in suppressing clearance-promoting genes in striatal microglia.
“Enrichment of mRNAs encoding the H3K27me3-specific demethylases, KDM6A/B26 in cbMg (Supplementary Fig. 5b, Supplementary Table 3) as well as the up-regulation of Kdm6a/b in microglia upon exposure to dying cells in vitro (Fig. 3c, Supplementary Fig. 10g) point to the possible role of PRC2/H3K27me3 in suppressing clearance-promoting genes in stMg.”
From Epigenetic regulation of brain region-specific microglia clearance activity (2018) · cites this paper as [26]
Among genes rapidly induced in microglia upon exposure to apoptotic cells were the cerebellar microglia-enriched Kdm6a/b, which encode histone demethylases.
“Among the genes that become rapidly induced in microglia upon exposure to apoptotic cells were the cbMg-enriched Kdm6a/b, which encode histone demethylases26 (Fig. 3c, Supplementary Fig. 10g).”
From Epigenetic regulation of brain region-specific microglia clearance activity (2018) · cites this paper as [26]
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- Authors
- Swigut, T., & Wysocka, J.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Wysocka, Joanna
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2007-10
- Volume
- 131
- Issue
- 1
- Pages
- 29-32
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1971180847
- Cited by
- 327
- References
- 18
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 15 · 2023: 11 · 2022: 19 · 2021: 21 · 2020: 15 · 2019: 18 · 2018: 17 · 2017: 12 · 2016: 17 · 2015: 20 · 2014: 19 · 2013: 18 · 2012: 26
- FWCI
- 8.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2116 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
- Keywords
- H3K27 demethylase, H3K27 methylation, polycomb repressive complex 2, JmjC domain proteins, KDM6A, JMJD3, histone demethylation, gene silencing, gene activation, body patterning, inflammation
- MeSH terms
- Animals, Gene Expression Regulation, Immune System, Methylation, Oxidoreductases, N-Demethylating, Repressor Proteins, Homeodomain Proteins, Body Patterning, Gene Silencing, Epigenesis, Genetic, Jumonji Domain-Containing Histone Demethylases, Polycomb-Group Proteins
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