Cited by 1,057Cell death mechanisms and regulationNF-κB Signaling PathwaysInflammasome and immune disorders

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RIP3 mediates the embryonic lethality of caspase-8-deficient mice

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Kaiser, William J., Upton, Jason W., Long, Alyssa B., Livingston-Rosanoff, Devon, Daley-Bauer, Lisa P., Hakem, Razqallah, Caspary, Tamara, Mocarski, Edward S.·2011·Nature

DOI 10.1038/nature09857PMC PMC3060292

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Abstract

Apoptosis and necroptosis are complementary pathways controlled by common signalling adaptors, kinases and proteases; among these, caspase-8 (Casp8) is critical for death receptor-induced apoptosis. This caspase has also been implicated in non-apoptotic pathways that regulate Fas-associated via death domain (FADD)-dependent signalling and other less defined biological processes as diverse as innate immune signalling and myeloid or lymphoid differentiation patterns. Casp8 suppresses RIP3-RIP1 (also known as RIPK3-RIPK1) kinase complex-dependent necroptosis that follows death receptor activation as well as a RIP3-dependent, RIP1-independent necrotic pathway that has emerged as a host defence mechanism against murine cytomegalovirus. Disruption of Casp8 expression leads to embryonic lethality in mice between embryonic days 10.5 and 11.5 (ref. 7). Thus, Casp8 may naturally hold alternative RIP3-dependent death pathways in check in addition to promoting apoptosis. We find that RIP3 is responsible for the mid-gestational death of Casp8-deficient embryos. Remarkably, Casp8(-/-)Rip3(-/-) double mutant mice are viable and mature into fertile adults with a full immune complement of myeloid and lymphoid cell types. These mice seem immunocompetent but develop lymphadenopathy by four months of age marked by accumulation of abnormal T cells in the periphery, a phenotype reminiscent of mice with Fas-deficiency (lpr/lpr; also known as Fas). Thus, Casp8 contributes to homeostatic control in the adult immune system; however, RIP3 and Casp8 are together completely dispensable for mammalian development.

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Authors: Kaiser, W. J., Upton, J. W., Long, A. B., Livingston-Rosanoff, D., Daley-Bauer, L. P., Hakem, R., Caspary, T., & Mocarski, E. S.
Affiliations: Emory University (US)
University Health Network (CA)
Corresponding author: Kaiser, William J.
ORCID: Kaiser, William J.
Upton, Jason W.
Long, Alyssa B.
Hakem, Razqallah
Caspary, Tamara
Mocarski, Edward S.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2011-03
Volume: 471
Issue: 7338
Pages: 368-372
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature09857
PMC: PMC3060292
OpenAlex: W2042577315
Cited by: 1,057
References: 31
Citations by year: 2026: 37 · 2025: 60 · 2024: 56 · 2023: 51 · 2022: 66 · 2021: 61 · 2020: 70 · 2019: 55 · 2018: 68 · 2017: 59 · 2016: 88 · 2015: 75 · 2014: 120 · 2013: 69 · 2012: 71
FWCI: 40.08
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Georgia Cancer Coalition
National Institutes of Health (DP5OD012198)
National Institute of General Medical Sciences (T32GM008169)
National Institute of Allergy and Infectious Diseases (R01AI030363, R01AI20211, R01AI020211, R56AI030363, R21AI030363, AI30363)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords: caspase-8, necroptosis, embryonic lethality, death receptor signaling, FADD, Fas, RIPK1, apoptosis, lymphoid development, innate immunity, programmed cell death
MeSH terms: Animals, Cell Line, Embryo, Mammalian, Female, Immunocompetence, Lymphatic Diseases, Male, Mice, Inbred C57BL, Necrosis, Apoptosis, Gene Deletion, Mice, Knockout, GTPase-Activating Proteins, Embryo Loss, Mice, Caspase 8, Receptor-Interacting Protein Serine-Threonine Kinases, Caspase Inhibitors

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RIP3 mediates the embryonic lethality of caspase-8-deficient mice

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