The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
HIV-1 adaptation to NK-cell-mediated immune pressure
Open accessAbstract
Natural killer (NK) cells have an important role in the control of viral infections, recognizing virally infected cells through a variety of activating and inhibitory receptors. Epidemiological and functional studies have recently suggested that NK cells can also contribute to the control of HIV-1 infection through recognition of virally infected cells by both activating and inhibitory killer immunoglobulin-like receptors (KIRs). However, it remains unknown whether NK cells can directly mediate antiviral immune pressure in vivo in humans. Here we describe KIR-associated amino-acid polymorphisms in the HIV-1 sequence of chronically infected individuals, on a population level. We show that these KIR-associated HIV-1 sequence polymorphisms can enhance the binding of inhibitory KIRs to HIV-1-infected CD4+ T cells, and reduce the antiviral activity of KIR-positive NK cells. These data demonstrate that KIR-positive NK cells can place immunological pressure on HIV-1, and that the virus can evade such NK-cell-mediated immune pressure by selecting for sequence polymorphisms, as was previously described for virus-specific T cells and neutralizing antibodies. NK cells might therefore have a previously underappreciated role in contributing to viral evolution.
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Cites
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Up on the tightrope: natural killer cell activation and inhibition
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Self-citationEpistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS
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Self-citationHLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection
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Self-citationInnate partnership of HLA-B and KIR3DL1 subtypes against HIV-1
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Self-citationHIV and SIV CTL escape: implications for vaccine design
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Cited by
Domingo, E., Sheldon, J., & Perales, C. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05023-11 · Cited by 1,009
Natural killer cells act as rheostats modulating antiviral T cells
Waggoner, S. N., Cornberg, M., Selin, L. K., & Welsh, R. M. (2012) · Nature · doi:10.1038/nature10624 · Cited by 607
Yan, N., & Chen, Z. J. (2012) · Nature Immunology · doi:10.1038/ni.2229 · Cited by 532
Natural killer cells in antiviral immunity
Björkström, N. K., Strunz, B., & Ljunggren, H.-G. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-021-00558-3 · Cited by 503
Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell–mediated deletion
Peppa, D., Gill, U. S., Reynolds, G., Easom, N. J. W., Pallett, L. J., Schurich, A., Micco, L., Nebbia, G., Singh, H. D., Adams, D. H., et al. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20121172 · Cited by 342
Metadata
- Authors
- Alter, G., Heckerman, D., Schneidewind, A., Fadda, L., Kadie, C. M., Carlson, J. M., Oniangue-Ndza, C., Martin, M., Li, B., Khakoo, S. I., Carrington, M., Allen, T. M., & Altfeld, M.
- Venue
- Nature
- Published
- 2011-08
- Volume
- 476
- Issue
- 7358
- Pages
- 96-100
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1993071851
- Cited by
- 347
- References
- 26
- FWCI
- 15.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Alter, G., Heckerman, D., Schneidewind, A., Fadda, L., Kadie, C. M., Carlson, J. M., Oniangue-Ndza, C., Martin, M., Li, B., Khakoo, S. I., Carrington, M., Allen, T. M., & Altfeld, M. (2011). HIV-1 adaptation to NK-cell-mediated immune pressure. Nature. https://doi.org/10.1038/nature10237
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