The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Differential natural killer cell–mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes
Open accessAbstract
Decline of peak viremia during acute HIV-1 infection occurs before the development of vigorous adaptive immunity, and the level of decline correlates inversely with the rate of AIDS progression, implicating a potential role for the innate immune response in determining disease outcome. The combined expression of an activating natural killer (NK) cell receptor, the killer immunoglobulin-like receptor (KIR) 3DS1, and its presumed ligand, human leukocyte antigen (HLA)–B Bw4-80I, has been associated in epidemiological studies with a slow progression to AIDS. We examined the functional ability of NK cells to differentially control HIV-1 replication in vitro based on their KIR and HLA types. NK cells expressing KIR3DS1 showed strong, significant dose- and cell contact–dependent inhibition of HIV-1 replication in target cells expressing HLA-B Bw4-80I compared with NK cells that did not express KIR3DS1. Furthermore, KIR3DS1+ NK cells and NKLs were preferentially activated, and lysed HIV-1 infected target cells in an HLA-B Bw4-80I–dependent manner. These data provide the first functional evidence that variation at the KIR locus influences the effectiveness of NK cell activity in the containment of viral replication.
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The biology of human natural killer-cell subsets
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Control of Viremia in Simian Immunodeficiency Virus Infection by CD8 + Lymphocytes
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CD107a as a functional marker for the identification of natural killer cell activity
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Licensing of natural killer cells by host major histocompatibility complex class I molecules
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Human NK Cell Education by Inhibitory Receptors for MHC Class I
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Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS
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Self-citationHLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection
Khakoo, S. I., Thio, C. L., Martin, M. P., Brooks, C. R., Gao, X., Astemborski, J., Cheng, J., Goedert, J. J., Vlahov, D., Hilgartner, M., et al. (2004) · Science · doi:10.1126/science.1097670 · Cited by 1,179
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Cited by
Functions of natural killer cells
Vivier, E., Tomasello, E., Baratin, M., Walzer, T., & Ugolini, S. (2008) · Nature Immunology · doi:10.1038/ni1582 · Cited by 3,943
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Björkström, N. K., Strunz, B., & Ljunggren, H.-G. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-021-00558-3 · Cited by 503
Balancing natural killer cell activation through paired receptors
Martinet, L., & Smyth, M. J. (2015) · Nature Reviews Immunology · doi:10.1038/nri3799 · Cited by 485
Evolutionary struggles between NK cells and viruses
Lanier, L. L. (2008) · Nature Reviews Immunology · doi:10.1038/nri2276 · Cited by 451
HIV-1 adaptation to NK-cell-mediated immune pressure
Alter, G., Heckerman, D., Schneidewind, A., Fadda, L., Kadie, C. M., Carlson, J. M., Oniangue-Ndza, C., Martin, M., Li, B., Khakoo, S. I., et al. (2011) · Nature · doi:10.1038/nature10237 · Cited by 347
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Metadata
- Authors
- Alter, G., Martin, M. P., Teigen, N., Carr, W. H., Suscovich, T. J., Schneidewind, A., Streeck, H., Waring, M., Meier, A., Brander, C., Lifson, J. D., Allen, T. M., Carrington, M., & Altfeld, M.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2007-11-19
- Volume
- 204
- Issue
- 12
- Pages
- 3027-3036
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2128306333
- Cited by
- 455
- References
- 46
- FWCI
- 11.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Alter, G., Martin, M. P., Teigen, N., Carr, W. H., Suscovich, T. J., Schneidewind, A., Streeck, H., Waring, M., Meier, A., Brander, C., Lifson, J. D., Allen, T. M., Carrington, M., & Altfeld, M. (2007). Differential natural killer cell–mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20070695
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