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A Virulence Locus of Pseudomonas aeruginosa Encodes a Protein Secretion Apparatus
Open accessAbstract
Bacterial pathogens frequently use protein secretion to mediate interactions with their hosts. Here we found that a virulence locus (HSI-I) of Pseudomonas aeruginosa encodes a protein secretion apparatus. The apparatus assembled in discrete subcellular locations and exported Hcp1, a hexameric protein that forms rings with a 40 angstrom internal diameter. Regulatory patterns of HSI-I suggested that the apparatus functions during chronic infections. We detected Hcp1 in pulmonary secretions of cystic fibrosis (CF) patients and Hcp1-specific antibodies in their sera. Thus, HSI-I likely contributes to the pathogenesis of P. aeruginosa in CF patients. HSI-I–related loci are widely distributed among bacterial pathogens and may play a general role in mediating host interactions.
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Cited by
Secretion systems in Gram-negative bacteria: Structural and mechanistic insights
Costa, T. R. D., Felisberto-Rodrigues, C., Meir, A., Prevost, M. S., Redzej, A., Trokter, M., & Waksman, G. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3456 · Cited by 1,132
Type VII secretion — mycobacteria show the way
Abdallah, A. M., Gey van Pittius, N. C., DiGiuseppe Champion, P. A., Cox, J., Luirink, J., Vandenbroucke-Grauls, C. M. J. E., Appelmelk, B. J., & Bitter, W. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1773 · Cited by 763
Type VI secretion delivers bacteriolytic effectors to target cells
Russell, A. B., Hood, R. D., Bui, N. K., LeRoux, M., Vollmer, W., & Mougous, J. D. (2011) · Nature · doi:10.1038/nature10244 · Cited by 710
Self-citationBoyer, F., Fichant, G., Berthod, J., Vandenbrouck, Y., & Attree, I. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-104 · Cited by 580
Biofilm-Specific Antibiotic Resistance
Mah, T.-F. (2012) · Future Microbiology · doi:10.2217/fmb.12.76 · Cited by 504
Metadata
- Authors
- Mougous, J. D., Cuff, M. E., Raunser, S., Shen, A., Zhou, M., Gifford, C. A., Goodman, A. L., Joachimiak, G., Ordoñez, C. L., Lory, S., Walz, T., Joachimiak, A., & Mekalanos, J. J.
- Venue
- Science
- Published
- 2006-06-09
- Volume
- 312
- Issue
- 5779
- Pages
- 1526-1530
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2108920131
- Cited by
- 1,103
- References
- 0
- FWCI
- 16.21
- Type
- journal article
- Language
- en
- Open access
- green
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- Mougous, J. D., Cuff, M. E., Raunser, S., Shen, A., Zhou, M., Gifford, C. A., Goodman, A. L., Joachimiak, G., Ordoñez, C. L., Lory, S., Walz, T., Joachimiak, A., & Mekalanos, J. J. (2006). A Virulence Locus of Pseudomonas aeruginosa Encodes a Protein Secretion Apparatus. Science. https://doi.org/10.1126/science.1128393
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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