The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Second messenger role for Mg2+ revealed by human T-cell immunodeficiency
Open accessAbstract
Summary The magnesium ion, Mg2+, is essential for all life as a cofactor for ATP, polyphosphates such as DNA and RNA, and metabolic enzymes, but whether it plays a role in intracellular signaling similar to Ca2+ is unknown. In this study, we identify mutations in the magnesium transporter gene, MAGT1, in a novel X-linked human immunodeficiency characterized by CD4 lymphopenia, severe chronic viral infections, and defective T lymphocyte activation. We demonstrate that a rapid transient Mg2+ influx is induced by antigen receptor stimulation in T cells or growth factor stimulation in non-lymphoid cells. MagT1 deficiency abrogates the Mg2+ influx leading to impaired responses to antigen receptor engagement including defective activation of phospholipase Cγ and a markedly impaired Ca2+ influx in T cells but not B cells. These observations reveal a role for Mg2+ as an intracellular second messenger and identify MagT1 as a possible target for novel therapeutics.
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Cites
PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection
Petrovas, C., Casazza, J. P., Brenchley, J. M., Price, D. A., Gostick, E., Adams, W. C., Precopio, M. L., Schacker, T., Roederer, M., Douek, D. C., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061496 · Cited by 889
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Structural and catalytic chemistry of magnesium-dependent enzymes
Cowan, J. A. (2002) · Biometals · doi:10.1023/a:1016022730880 · Cited by 428
Life after the thymus: CD31+ and CD31− human naive CD4+ T-cell subsets
Kohler, S., & Thiel, A. (2009) · Blood · doi:10.1182/blood-2008-02-139154 · Cited by 307
Phospholipase Cγ1 is essential for T cell development, activation, and tolerance
Fu, G., Chen, Y., Yu, M., Podd, A., Schuman, J., He, Y., Di, L., Yassai, M., Haribhai, D., North, P. E., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20090880 · Cited by 133
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de Baaij, J. H. F., Hoenderop, J. G. J., & Bindels, R. J. M. (2015) · Physiological Reviews · doi:10.1152/physrev.00012.2014 · Cited by 1,726
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Ion channels and transporters in lymphocyte function and immunity
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Mitochondrial Mg2+ homeostasis decides cellular energy metabolism and vulnerability to stress
Yamanaka, R., Tabata, S., Shindo, Y., Hotta, K., Suzuki, K., Soga, T., & Oka, K. (2016) · Scientific Reports · doi:10.1038/srep30027 · Cited by 154
Hou, H., Wang, L., Fu, T., Papasergi, M., Yule, D. I., & Xia, H. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01871-z · Cited by 65
DUSP4-mediated accelerated T-cell senescence in idiopathic CD4 lymphopenia
Bignon, A., Régent, A., Klipfel, L., Desnoyer, A., de la Grange, P., Martinez, V., Lortholary, O., Dalloul, A., Mouthon, L., & Balabanian, K. (2015) · Blood · doi:10.1182/blood-2014-08-598565 · Cited by 51
Koldenkova, V. P., Matsuda, T., & Nagai, T. (2015) · Journal of Biomedical Optics · doi:10.1117/1.jbo.20.10.101203 · Cited by 21
Dissecting mammalian immunity through mutation
Siggs, O. M. (2014) · Immunology & Cell Biology · doi:10.1038/icb.2014.8 · Cited by 20
Metadata
- Authors
- Li, F.-Y., Chaigne-Delalande, B., Kanellopoulou, C., Davis, J. C., Matthews, H. F., Douek, D. C., Cohen, J. I., Uzel, G., Su, H. C., & Lenardo, M. J.
- Venue
- Nature
- Published
- 2011-07
- Volume
- 475
- Issue
- 7357
- Pages
- 471-476
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1976111921
- Cited by
- 560
- References
- 5
- FWCI
- 28.80
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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