Cited by 854Cancer Cells and MetastasisDevelopmental Biology and Gene RegulationMesenchymal stem cell research

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Distinct stem cells contribute to mammary gland development and maintenance

Van Keymeulen, Alexandra, Rocha, Ana Sofia, Ousset, Marielle, Beck, Benjamin, Bouvencourt, Gaëlle, Rock, Jason, Sharma, Neha, Dekoninck, Sophie, Blanpain, Cédric·2011·Nature

DOI 10.1038/nature10573

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Abstract

The mammary epithelium is composed of several cell lineages including luminal, alveolar and myoepithelial cells. Transplantation studies have suggested that the mammary epithelium is maintained by the presence of multipotent mammary stem cells. To define the cellular hierarchy of the mammary gland during physiological conditions, we performed genetic lineage-tracing experiments and clonal analysis of the mouse mammary gland during development, adulthood and pregnancy. We found that in postnatal unperturbed mammary gland, both luminal and myoepithelial lineages contain long-lived unipotent stem cells that display extensive renewing capacities, as demonstrated by their ability to clonally expand during morphogenesis and adult life as well as undergo massive expansion during several cycles of pregnancy. The demonstration that the mammary gland contains different types of long-lived stem cells has profound implications for our understanding of mammary gland physiology and will be instrumental in unravelling the cells at the origin of breast cancers.

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RETRACTED ARTICLE: Regulation of estrogen receptor signaling in breast carcinogenesis and breast cancer therapy
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Authors: Van Keymeulen, A., Rocha, A. S., Ousset, M., Beck, B., Bouvencourt, G., Rock, J., Sharma, N., Dekoninck, S., & Blanpain, C.
Affiliations: Université Libre de Bruxelles (BE)
Duke Medical Center (US)
Corresponding author: Blanpain, Cédric
ORCID: Rocha, Ana Sofia
Ousset, Marielle
Beck, Benjamin
Rock, Jason
Sharma, Neha
Blanpain, Cédric
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2011-10-09
Volume: 479
Issue: 7372
Pages: 189-193
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature10573
OpenAlex: W2082161467
Cited by: 854
References: 38
Citations by year: 2026: 24 · 2025: 38 · 2024: 41 · 2023: 44 · 2022: 30 · 2021: 55 · 2020: 62 · 2019: 51 · 2018: 73 · 2017: 55 · 2016: 54 · 2015: 91 · 2014: 83 · 2013: 81 · 2012: 68
FWCI: 36.95
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
HAL (submittedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Keywords: mammary stem cells, mammary gland development, mammary epithelium, cellular hierarchy, lineage tracing, clonal expansion, multipotent stem cells, luminal cells, myoepithelial cells, alveolar cells, mammary gland morphogenesis, pregnancy, lactation
MeSH terms: Aging, Animals, Cell Differentiation, Epithelium, Female, Homeostasis, Lactation, Mammary Glands, Animal, Pregnancy, Stem Cells, Cell Transplantation, Cell Lineage, Multipotent Stem Cells, Mice

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Distinct stem cells contribute to mammary gland development and maintenance

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