The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Distinct stem cells contribute to mammary gland development and maintenance
Abstract
The mammary epithelium is composed of several cell lineages including luminal, alveolar and myoepithelial cells. Transplantation studies have suggested that the mammary epithelium is maintained by the presence of multipotent mammary stem cells. To define the cellular hierarchy of the mammary gland during physiological conditions, we performed genetic lineage-tracing experiments and clonal analysis of the mouse mammary gland during development, adulthood and pregnancy. We found that in postnatal unperturbed mammary gland, both luminal and myoepithelial lineages contain long-lived unipotent stem cells that display extensive renewing capacities, as demonstrated by their ability to clonally expand during morphogenesis and adult life as well as undergo massive expansion during several cycles of pregnancy. The demonstration that the mammary gland contains different types of long-lived stem cells has profound implications for our understanding of mammary gland physiology and will be instrumental in unravelling the cells at the origin of breast cancers.
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“Lineage tracing experiments have also facilitated the identification of long-lived stem cells in the mammary epithelium36,37 and in glandular epithelia such as that found in the prostate38.”
From Molecular regulation of stem cell quiescence (2013) · cites this paper as [36]
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Metadata
- Authors
- Van Keymeulen, A., Rocha, A. S., Ousset, M., Beck, B., Bouvencourt, G., Rock, J., Sharma, N., Dekoninck, S., & Blanpain, C.
- Affiliations
- Université Libre de Bruxelles (BE)
- Duke Medical Center (US)
- Corresponding author
- Blanpain, Cédric
- Venue
- Nature
- Published
- 2011-10-09
- Volume
- 479
- Issue
- 7372
- Pages
- 189-193
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2082161467
- Cited by
- 854
- References
- 38
- Citations by year
- 2026: 24 · 2025: 38 · 2024: 41 · 2023: 44 · 2022: 30 · 2021: 55 · 2020: 62 · 2019: 51 · 2018: 73 · 2017: 55 · 2016: 54 · 2015: 91 · 2014: 83 · 2013: 81 · 2012: 68
- FWCI
- 36.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- HAL (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Keywords
- mammary stem cells, mammary gland development, mammary epithelium, cellular hierarchy, lineage tracing, clonal expansion, multipotent stem cells, luminal cells, myoepithelial cells, alveolar cells, mammary gland morphogenesis, pregnancy, lactation
- MeSH terms
- Aging, Animals, Cell Differentiation, Epithelium, Female, Homeostasis, Lactation, Mammary Glands, Animal, Pregnancy, Stem Cells, Cell Transplantation, Cell Lineage, Multipotent Stem Cells, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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