Distinct stem cells contribute to mammary gland development and maintenance

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Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

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Generation of a functional mammary gland from a single stem cell

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Purification and unique properties of mammary epithelial stem cells

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Epidermal homeostasis: a balancing act of stem cells in the skin

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Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesisPreprint

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An entire functional mammary gland may comprise the progeny from a single cell

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Early restriction of peripheral and proximal cell lineages during formation of the lung

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Cyclin D1-Dependent Induction of Luminal Inflammatory Breast Tumors by Activated Notch3

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Cellular Plasticity of Mammary Epithelial Cells Underlies Heterogeneity of Breast Cancer

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Expression of LGR5 in mammary myoepithelial cells and in triple-negative breast cancers

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Identification of gene sets and pathways associated with lactation performance in mice

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Mammary basal cells: Stars of the show

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Future application of hair follicle stem cells: capable in differentiation into sweat gland cells

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Diverse roles for axon guidance pathways in adult tissue architecture and function

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Bovine milk-derived cells express transcriptome markers of pluripotency and secrete bioactive factors with regenerative and antimicrobial activity

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In the beginning: The establishment of the mammary lineage during embryogenesis

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PTEN is required to maintain luminal epithelial homeostasis and integrity in the adult mammary gland

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Induced Expression of Cancer Stem Cell Markers ALDH1A3 and Sox-2 in Hierarchical Reconstitution of Apoptosis-resistant Human Breast Cancer Cells

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Comparative Transcriptome Analysis of Milk Somatic Cells During Lactation Between Two Intensively Reared Dairy Sheep Breeds

Michailidou, S., Gelasakis, A. Ι., Banos, G., Arsenos, G., & Argiriou, A. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.700489 · Cited by 16

Aberrant phosphorylation inactivates Numb in breast cancer causing expansion of the stem cell pool

Filippone, M. G., Freddi, S., Zecchini, S., Restelli, S., Colaluca, I. N., Bertalot, G., Pece, S., Tosoni, D., & Fiore, P. P. D. (2022) · The Journal of Cell Biology · doi:10.1083/jcb.202112001 · Cited by 15

TGFβ signaling limits lineage plasticity in prostate cancer

Hao, Y., Bjerke, G. A., Pietrzak, K., Melhuish, T. A., Han, Y., Turner, S., Frierson, H. F., & Wotton, D. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007409 · Cited by 15

Statistical theory of branching morphogenesis

Hannezo, É., & Simons, B. D. (2018) · Development Growth & Differentiation · doi:10.1111/dgd.12570 · Cited by 15

Integrin-interacting protein Kindlin-2 induces mammary tumors in transgenic mice

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Mammary Epithelial Cell Lineage Changes During Cow’s Life

Finot, L., Chanat, E., & Dessauge, F. (2019) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-019-09427-1 · Cited by 15

A STAT3 of Addiction: Adipose Tissue, Adipocytokine Signalling and STAT3 as Mediators of Metabolic Remodelling in the Tumour Microenvironment

Kadye, R., Stoffels, M., Fanucci, S., Mbanxa, S., & Prinsloo, E. (2020) · Cells · doi:10.3390/cells9041043 · Cited by 15

CD151 represses mammary gland development by maintaining the niches of progenitor cells

Yin, Y., Deng, X., Liu, Z., Baldwin, L. A., Lefringhouse, J., Zhang, J., Hoff, J. J., Erfani, S., Rucker, E. B., O’Connor, K. L., et al. (2014) · Cell Cycle · doi:10.4161/15384101.2015.945823 · Cited by 15

Nrf2 Hyperactivation as a Driver of Radiotherapy Resistance and Suppressed Antitumor Immunity in Head and Neck Squamous Cell Carcinoma

Patel, R., Saab, K., Luo, L., Ma, Y., Osman, R. A., Williams, N. T., Everitt, J. I., Żelazowski, M. J., Castro, P. D., Decker, W. K., et al. (2025) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-25-0112 · Cited by 14

Células madre tumorales: una diana terapéutica en el cáncer de mama

Eguiara, A., Elorriaga, K., Rezola, R., & Martín, Á. G. (2012) · Revista de Senología y Patología Mamaria · doi:10.1016/s0214-1582(12)70024-5 · Cited by 14

Cell Reprogramming in Tumorigenesis and Its Therapeutic Implications for Breast Cancer

Chu, P., Hou, M., Lai, J.-C., Chen, L.-F., & Lin, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081827 · Cited by 14

Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells

Steiner, I., Flores-Téllez, T. D. N. J., Mével, R., Ali, A., Wang, P., Schofield, P. G., Behan, C., Forsythe, N., Ashton, G., Taylor, C., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112377 · Cited by 14

Epithelial plasticity enhances regeneration of committed taste receptor cells following nerve injury

Adpaikar, A. A., Lee, J., Lee, D., Cho, H.-Y., Ohshima, H., Moon, S. J., & Jung, H.-S. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00924-8 · Cited by 14

T helper 1 effector memory CD4+ T cells protect the skin from poxvirus infection

Harbour, J. C., Abdelbary, M. A., Schell, J. B., Fancher, S. P., McLean, J. J., Nappi, T. J., Liu, S., Nice, T. J., Xia, Z., Früh, K., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112407 · Cited by 14

Impact of Progesterone on Stem/Progenitor Cells in the Human Breast

Hilton, H. N., & Clarke, C. L. (2015) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-015-9339-y · Cited by 14

The Co-factor of LIM Domains (CLIM/LDB/NLI) Maintains Basal Mammary Epithelial Stem Cells and Promotes Breast Tumorigenesis

Salmans, M., Yu, Z., Watanabe, K., Cam, E., Sun, P., Smyth, P., Dai, X., & D, B. A. M. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004520 · Cited by 14

Stem Cell Maintenance of the Mammary Gland: It Takes Two

Keller, P. J., Arendt, L. M., & Kuperwasser, C. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.11.008 · Cited by 14

Mammary gland-derived nestin-positive cell populations can be isolated from human male and female donors

Richter, A. M., Nissen, N., Mailänder, P., Stang, F. H., Siemers, F., Kruse, C., & Danner, S. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt229 · Cited by 14

Spatially correlated phenotyping reveals K5-positive luminal progenitor cells and p63-K5/14-positive stem cell-like cells in human breast epithelium

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Notch controls urothelial integrity in the mouse bladder

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Spatially distinct epithelial and mesenchymal cell subsets along progressive lineage restriction in the branching embryonic mammary gland

Carabaña, C., Sun, W., Ramos, C. V., Huyghe, M., Perkins, M., Maillot, A., Journot, R. P., Hartani, F., Faraldo, M. M., Lloyd‐Lewis, B., et al. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00115-3 · Cited by 13

Derivation of Myoepithelial Progenitor Cells from Bipotent Mammary Stem/Progenitor Cells

Zhao, X., Malhotra, G. K., Band, H., & Band, V. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035338 · Cited by 13

Obesity reduces mammary epithelial cell TGFβ1 activity through macrophage‐mediated extracellular matrix remodeling

Chamberlin, T., Thompson, V., Hillers‐Ziemer, L. E., Walton, B. N., & Arendt, L. M. (2020) · The FASEB Journal · doi:10.1096/fj.202000228rr · Cited by 13

Single-cell organogenesis captures complex breast tissue formation in three dimensions

Rauner, G., Traugh, N. C., Trepicchio, C. J., Parrish, M. E., Mushayandebvu, K., & Kuperwasser, C. (2025) · Development · doi:10.1242/dev.204813 · Cited by 13

Emergency back-up for lung repair

Rawlins, E. L. (2015) · Nature · doi:10.1038/517556a · Cited by 14

Cancer Stem Cells

Woodward, W. A., & Hill, R. P. (2016) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-662-49651-0_2 · Cited by 13

Regulation of Mammary Luminal Cell Fate and Tumorigenesis by p38α

Barrantes, I. D. B., Attolini, C. S., Slobodnyuk, K., Igea, A., Gregorio, S., Gawrzak, S., Gomis, R. R., & Nebreda, Á. R. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.11.021 · Cited by 13

The MMTV-Wnt1 murine model produces two phenotypically distinct subtypes of mammary tumors with unique therapeutic responses to an EGFR inhibitor

Pfefferle, A. D., Darr, D. B., Calhoun, B. C., Mott, K. R., Rosen, J. M., & Perou, C. M. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.037192 · Cited by 14

Cytokeratin 5 determines maturation of the mammary myoepithelium

Deckwirth, V., Rajakylä, E. K., Cattavarayane, S., Acheva, A., Schaible, N., Krishnan, R., Valle‐Delgado, J. J., Österberg, M., Björkenheim, P., Sukura, A., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102413 · Cited by 13

Pregnancy protection of breast cancer: new insights reveal unanswered questions

Medina, D. (2013) · Breast Cancer Research · doi:10.1186/bcr3414 · Cited by 13

Mammary mechanobiology: mechanically-activated ion channels in lactation and involutionPreprint

Stewart, T. A., Hughes, K., Stevenson, A. J., Marino, N., Ju, A. L., Morehead, M., & Davis, F. M. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/649038 · Cited by 13

A Genome-wide Library of MADM Mice for Single-Cell Genetic Mosaic AnalysisPreprint

Contreras, X., Davaatseren, A., Amberg, N., Hansen, A. H., Sonntag, J., Andersen, L., Bernthaler, T., Heger, A., Johnson, R. L., Schwarz, L. A., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.05.136192 · Cited by 12

Organoid Cultures for the Study of Mammary Biology and Breast Cancer: The Promise and ChallengesPreprint

Muthuswamy, S. K., & Brugge, J. S. (2023) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041661 · Cited by 13

Investigation on the suitability of milk-derived primary bovine mammary epithelial cells grown on permeable membrane supports as an in vitro model for lactation

Walter, L., Fry, R. C., Logan, A., & Leury, B. J. (2020) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-020-00457-2 · Cited by 12

Mechanosensitive TRPV4 channel guides maturation and organization of the bilayered mammary epithelium

Kärki, T., Koskimäki, S., Guenther, C., Jonatan, P., Rajakylä, E. K., & Sari, T. (2024) · Scientific Reports · doi:10.1038/s41598-024-57346-x · Cited by 12

Breast Cancer Stem Cell Correlates as Predicative Factors for Radiation Therapy

Wolfe, A. R., & Woodward, W. A. (2015) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2015.05.009 · Cited by 13

Spatially coordinated cell cycle activity and motility govern bifurcation of mammary branches

Myllymäki, S.-M., Kaczyńska, B., Lan, Q., & Mikkola, M. L. (2023) · The Journal of Cell Biology · doi:10.1083/jcb.202209005 · Cited by 12

Transformation of enriched mammary cell populations with polyomavirus middle T antigen influences tumor subtype and metastatic potential

Drobysheva, D., Smith, B., McDowell, M., Guillen, K. P., Ekiz, H. A., & Welm, B. E. (2015) · Breast Cancer Research · doi:10.1186/s13058-015-0641-9 · Cited by 12

BRCA1‐associated mammary tumorigenesis is dependent on estrogen rather than progesterone signaling

van de Ven, M., Liu, X., van der Burg, E., Klarenbeek, S., Alexi, X., Zwart, W. T., Dijcks, F. A., Bouwman, P., & Jonkers, J. (2018) · The Journal of Pathology · doi:10.1002/path.5105 · Cited by 13

Tumor suppressor control of the cancer stem cell niche

Kramer, K. M., Wu, J., & Crowe, D. L. (2015) · Oncogene · doi:10.1038/onc.2015.475 · Cited by 12

Intraductal cisplatin treatment in a BRCA-associated breast cancer mouse model attenuates tumor development but leads to systemic tumors in aged female mice

de Groot, J. S., van Diest, P. J., van Amersfoort, M., Vlug, E. J., Pan, X., ter Hoeve, N. D., Rosing, H., Beijnen, J. H., Youssef, S. A., de Bruin, A., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.18490 · Cited by 12

Patient-Derived Tumor Organoids to Model Cancer Cell Plasticity and Overcome Therapeutic Resistance

Coppo, R., & Inoue, M. (2025) · Cells · doi:10.3390/cells14181464 · Cited by 12

UBE2N Is Essential for Maintenance of Skin Homeostasis and Suppression of Inflammation

Lee, M. F. J., Hammouda, M. B., Miao, W., Okafor, A. E., Jin, Y. J., Sun, H., Jain, V., Markovtsov, V. V., Diao, Y., Gregory, S. G., et al. (2024) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2024.04.017 · Cited by 11

Identifying the murine mammary cell target of metformin exposure

Shehata, M., Kim, H., Vellanki, R. N., Waterhouse, P. D., Mahendralingam, M. J., Casey, A. E., Koritzinsky, M., & Khokha, R. (2019) · Communications Biology · doi:10.1038/s42003-019-0439-x · Cited by 11

Breast tumor IGF1R regulates cell adhesion and metastasis: alignment of mouse single cell and human breast cancer transcriptomics

Obr, A. E., Bulatowicz, J. J., Chang, Y., Ciliento, V., Lemenze, A. D., Maingrette, K., Shang, Q., Gallagher, E. J., LeRoith, D., & Wood, T. L. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.990398 · Cited by 11

Using Organoids to Tap Mammary Gland Diversity for Novel Insight

Rauner, G. (2024) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-024-09559-z · Cited by 11

A Mystery Wrapped in an Enigma: Matrigel Enhancement of Mammary Cell Growth and Morphogenesis

Lewis, M. T., Landua, J. D., Adams, H., & Medina, D. (2012) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-012-9249-1 · Cited by 11

Expression of Luminal Progenitor Marker CD117 in the Human Breast Gland

Kim, J., & Villadsen, R. (2018) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155418788845 · Cited by 11

Baicalin Promotes Mammary Gland Development via Steroid-Like Activities

Chen, W., Wei, W., Yu, L., Zhang, X., Huang, F., Zheng, Q., Wang, L., & Cai, C. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.682469 · Cited by 11

Embryonic Mammary Gland Development

Tickle, C. A., & Jung, H.-S. (2016) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0026057 · Cited by 11

Laminin matrix adhesion regulates basal mammary epithelial cell identity

Englund, J. I., Bui, H. M., Dinç, D. D., Paavolainen, O., McKenna, T., Laitinen, S., Munne, P., Klefström, J. T., Peuhu, E., & Katajisto, P. (2022) · Journal of Cell Science · doi:10.1242/jcs.260232 · Cited by 10

Zdhhc1- and Zdhhc2-mediated Gpm6a palmitoylation is essential for maintenance of mammary stem cell activity

Chen, W., Guo, L., Wei, W., Cai, C., & Wu, G. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114762 · Cited by 10

Lysine metabolism is a novel metabolic tumor suppressor pathway in breast cancer

Wu, J., Kramer, K., & Crowe, D. L. (2023) · Oncogene · doi:10.1038/s41388-023-02766-8 · Cited by 10

Bipotency of thymic epithelial progenitors comes in sequence

Peterson, P., & Laan, M. (2013) · European Journal of Immunology · doi:10.1002/eji.201343323 · Cited by 10

Deletion of the Nuclear Localization Sequences and C-Terminus of PTHrP Impairs Embryonic Mammary Development but also Inhibits PTHrP Production

Boras-Granic, K., Dann, P. R., VanHouten, J. N., Karaplis, A. C., & Wysolmerski, J. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090418 · Cited by 10

Cell-intrinsic TLR2/MyD88 pathway in breast and colon cancer

Kuo, A. H., & Scheeren, F. A. (2014) · Cell Cycle · doi:10.4161/15384101.2014.989947 · Cited by 10

Alveolar progenitor cells in the mammary gland are dependent on the β4 integrin

Walker, M. R., Amante, J. J., Li, J., Liu, H., Zhu, L. J., Feltri, M. L., Goel, H. L., & Mercurio, A. M. (2019) · Developmental Biology · doi:10.1016/j.ydbio.2019.10.001 · Cited by 10

Glandular stem cells in the skin during development, homeostasis, wound repair and regeneration

Lin, M., & Lu, C. P.-J. (2021) · Experimental Dermatology · doi:10.1111/exd.14319 · Cited by 10

How should we define mammary stem cells?

Watson, C. J. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.03.012 · Cited by 10

Dietary suppression of the mammary CD29hiCD24+ epithelial subpopulation and its cytokine/chemokine transcriptional signatures modifies mammary tumor risk in MMTV-Wnt1 transgenic mice

Rahal, O. M., Machado, H. L., Montales, M. T. E., Pabona, J. M. P., Heard, M. E., Nagarajan, S., & Simmen, R. C. M. (2013) · Stem Cell Research · doi:10.1016/j.scr.2013.08.006 · Cited by 10

Anti-glucose-6-phosphate isomerase, anti-cyclic citrullinated peptide antibodies and HLA-DRB1 genotypes in Japanese patients with early rheumatoid arthritis.

Furuya, T., Matsumoto, I., Tsuchiya, N., Hakoda, M., Ichikawa, N., Yago, T., Higami, K., Nanke, Y., Sumida, T., Kamatani, N., et al. (2008) · PubMed · Cited by 10

Lineage Tracing in the Mammary Gland Using Cre/lox Technology and Fluorescent Reporter Alleles

van Amerongen, R. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2519-3_11 · Cited by 10

Lineage Tracing of Mammary Stem and Progenitor Cells

van de Moosdijk, A. A. A., Fu, N. Y., Rios, A. C., Visvader, J. E., & van Amerongen, R. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6475-8_15 · Cited by 10

Macrophages stimulate mammary stem cells

Kannan, N., & Eaves, C. J. (2018) · Science · doi:10.1126/science.aau1394 · Cited by 10

Isolation and In Vitro Characterization of Epidermal Stem Cells

Moestrup, K. S., Andersen, M. S., & Jensen, K. B. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-6756-8_6 · Cited by 9

Molecular and cellular basis of the dose-rate-dependent adverse effects of radiation exposure in animal models. Part I: Mammary gland and digestive tract

Suzuki, K., Imaoka, T., Tomita, M., Sasatani, M., Doi, K., Tanaka, S., Kai, M., Yamada, Y., & Kakinuma, S. (2023) · Journal of Radiation Research · doi:10.1093/jrr/rrad002 · Cited by 9

FGD5 in basal cells induces CXCL14 secretion that initiates a feedback loop to promote murine mammary epithelial growth and differentiation

Zhang, T., Zhao, C., Li, Y., Wu, J., Wang, F., Yu, J., Wang, Z., Gao, Y., Zhao, L., Liu, Y., et al. (2024) · Developmental Cell · doi:10.1016/j.devcel.2024.05.007 · Cited by 9

Protein tyrosine phosphatase 1B restrains mammary alveologenesis and secretory differentiation

Milani, E. S., Brinkhaus, H., Dueggeli, R., Klebba, I., Mueller, U., Stadler, M. B., Kohler, H., Smalley, M. J., & Bentires‐Alj, M. (2012) · Development · doi:10.1242/dev.082941 · Cited by 9

From Cloning Neural Development Genes to Functional Studies in Mice, 30 Years of Advancements

Joyner, A. L. (2016) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2015.11.035 · Cited by 9

Unraveling Heterogeneity in Epithelial Cell Fates of the Mammary Gland and Breast Cancer

Samocha, A. J., Doh, H. M., Kessenbrock, K., & Roose, J. P. (2019) · Cancers · doi:10.3390/cancers11101423 · Cited by 12

AP-2γ Is Required for Maintenance of Multipotent Mammary Stem Cells

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