The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Restoration of vision after transplantation of photoreceptors
Open accessAbstract
Cell transplantation is a potential strategy for treating blindness caused by the loss of photoreceptors. Although transplanted rod-precursor cells are able to migrate into the adult retina and differentiate to acquire the specialized morphological features of mature photoreceptor cells, the fundamental question remains whether transplantation of photoreceptor cells can actually improve vision. Here we provide evidence of functional rod-mediated vision after photoreceptor transplantation in adult Gnat1−/− mice, which lack rod function and are a model of congenital stationary night blindness. We show that transplanted rod precursors form classic triad synaptic connections with second-order bipolar and horizontal cells in the recipient retina. The newly integrated photoreceptor cells are light-responsive with dim-flash kinetics similar to adult wild-type photoreceptors. By using intrinsic imaging under scotopic conditions we demonstrate that visual signals generated by transplanted rods are projected to higher visual areas, including V1. Moreover, these cells are capable of driving optokinetic head tracking and visually guided behaviour in the Gnat1−/− mouse under scotopic conditions. Together, these results demonstrate the feasibility of photoreceptor transplantation as a therapeutic strategy for restoring vision after retinal degeneration.
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Cites
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Retinal repair by transplantation of photoreceptor precursors
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Self-citationRapid Quantification of Adult and Developing Mouse Spatial Vision Using a Virtual Optomotor System
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Phototransduction in transgenic mice after targeted deletion of the rod transducin α-subunit
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Self-formation of optic cups and storable stratified neural retina from human ESCs
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Functional architecture of the retina: Development and disease
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Cuenca, N., Fernández-Sánchez, L., Campello, L., Maneu, V., De la Villa, P., Lax, P., & Pinilla, I. (2014) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2014.07.001 · Cited by 401
A polymer optoelectronic interface restores light sensitivity in blind rat retinas
Ghezzi, D., Antognazza, M. R., Maccarone, R., Bellani, S., Lanzarini, E., Martino, N., Mete, M., Pertile, G., Bisti, S., Lanzani, G., et al. (2013) · Nature Photonics · doi:10.1038/nphoton.2013.34 · Cited by 331
Pearson, R. A., Gonzalez-Cordero, A., West, E. L., Ribeiro, J. R., Aghaizu, N., Goh, D., Sampson, R. D., Georgiadis, A., Waldron, P. V., Duran, Y., et al. (2016) · Nature Communications · doi:10.1038/ncomms13029 · Cited by 309
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Metadata
- Authors
- Pearson, R. A., Barber, A. C., Rizzi, M., Hippert, C., Xue, T., West, E. L., Duran, Y., Smith, A. J., Chuang, J. Z., Azam, S. A., Luhmann, U. F. O., Benucci, A., Sung, C. H., Bainbridge, J. W., Carandini, M., Yau, K.-W., Sowden, J. C., & Ali, R. R.
- Venue
- Nature
- Published
- 2012-04-18
- Volume
- 485
- Issue
- 7396
- Pages
- 99-103
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2070628315
- Cited by
- 493
- References
- 22
- FWCI
- 18.24
- Type
- journal article
- Language
- en
- Open access
- green
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- Pearson, R. A., Barber, A. C., Rizzi, M., Hippert, C., Xue, T., West, E. L., Duran, Y., Smith, A. J., Chuang, J. Z., Azam, S. A., Luhmann, U. F. O., Benucci, A., Sung, C. H., Bainbridge, J. W., Carandini, M., Yau, K.-W., Sowden, J. C., & Ali, R. R. (2012). Restoration of vision after transplantation of photoreceptors. Nature. https://doi.org/10.1038/nature10997
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