The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
A polymer optoelectronic interface restores light sensitivity in blind rat retinas
Open accessAbstract
Interfacing organic electronics with biological substrates offers new possibilities for biotechnology by taking advantage of the beneficial properties exhibited by organic conducting polymers. These polymers have been used for cellular interfaces in several applications, including cellular scaffolds, neural probes, biosensors and actuators for drug release. Recently, an organic photovoltaic blend has been used for neuronal stimulation via a photo-excitation process. Here, we document the use of a single-component organic film of poly(3-hexylthiophene) (P3HT) to trigger neuronal firing upon illumination. Moreover, we demonstrate that this bio–organic interface restores light sensitivity in explants of rat retinas with light-induced photoreceptor degeneration. These findings suggest that all-organic devices may play an important future role in subretinal prosthetic implants. The popular organic semiconductor P3HT, which is commonly used in polymer solar cells and photodetectors, is demonstrated to be able to act as a biocompatible optoelectronic interface for the retina of blind rats.
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Cites
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Metadata
- Authors
- Ghezzi, D., Antognazza, M. R., Maccarone, R., Bellani, S., Lanzarini, E., Martino, N., Mete, M., Pertile, G., Bisti, S., Lanzani, G., & Benfenati, F.
- Venue
- Nature Photonics
- Published
- 2013-03-17
- Volume
- 7
- Issue
- 5
- Pages
- 400-406
- ISSN
- 1749-4885 (ISSN-L)
- 1749-4893
- OpenAlex
- W2139186810
- Cited by
- 331
- References
- 41
- FWCI
- 10.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Ghezzi, D., Antognazza, M. R., Maccarone, R., Bellani, S., Lanzarini, E., Martino, N., Mete, M., Pertile, G., Bisti, S., Lanzani, G., & Benfenati, F. (2013). A polymer optoelectronic interface restores light sensitivity in blind rat retinas. Nature Photonics. https://doi.org/10.1038/nphoton.2013.34
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