The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors
Open accessAbstract
Photoreceptor replacement by transplantation is proposed as a treatment for blindness. Transplantation of healthy photoreceptor precursor cells into diseased murine eyes leads to the presence of functional photoreceptors within host retinae that express an array of donor-specific proteins. The resulting improvement in visual function was understood to be due to donor cells integrating within host retinae. Here, however, we show that while integration occurs the majority of donor-reporter-labelled cells in the host arises as a result of material transfer between donor and host photoreceptors. Material transfer does not involve permanent donor–host nuclear or cell–cell fusion, or the uptake of free protein or nucleic acid from the extracellular environment. Instead, RNA and/or protein are exchanged between donor and host cells in vivo. These data require a re-evaluation of the mechanisms underlying rescue by photoreceptor transplantation and raise the possibility of material transfer as a strategy for the treatment of retinal disorders.
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Cites
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Self-citationFusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
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Generation of Destabilized Green Fluorescent Protein as a Transcription Reporter
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Nuclear Architecture of Rod Photoreceptor Cells Adapts to Vision in Mammalian Evolution
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Self-citation
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Roska, B., & Sahel, J.-A. (2018) · Nature · doi:10.1038/s41586-018-0076-4 · Cited by 161
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Kruczek, K., & Swaroop, A. (2020) · Stem Cells · doi:10.1002/stem.3239 · Cited by 148
Self-citationFusion-independent satellite cell communication to muscle fibers during load-induced hypertrophy
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Molecular Therapies for Inherited Retinal Diseases—Current Standing, Opportunities and Challenges
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Bioengineering strategies for restoring vision
Cehajic-Kapetanovic, J., Singh, M. S., Zrenner, E., & MacLaren, R. E. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00836-4 · Cited by 79
Metadata
- Authors
- Pearson, R. A., Gonzalez-Cordero, A., West, E. L., Ribeiro, J. R., Aghaizu, N., Goh, D., Sampson, R. D., Georgiadis, A., Waldron, P. V., Duran, Y., Naeem, A., Kloc, M., Cristante, E., Kruczek, K., Warre-Cornish, K., Sowden, J. C., Smith, A. J., & Ali, R. R.
- Venue
- Nature Communications
- Published
- 2016-10-04
- Volume
- 7
- Issue
- 1
- Pages
- 13029-13029
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2528283452
- Cited by
- 309
- References
- 53
- FWCI
- 16.70
- Type
- journal article
- Language
- en
- Open access
- gold
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- Pearson, R. A., Gonzalez-Cordero, A., West, E. L., Ribeiro, J. R., Aghaizu, N., Goh, D., Sampson, R. D., Georgiadis, A., Waldron, P. V., Duran, Y., Naeem, A., Kloc, M., Cristante, E., Kruczek, K., Warre-Cornish, K., Sowden, J. C., Smith, A. J., & Ali, R. R. (2016). Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors. Nature Communications. https://doi.org/10.1038/ncomms13029
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
