The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

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Items 601–700 of 1,105

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2. Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma
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3. Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas
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4. Changing Trends in Computational Drug Repositioning
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5. Genome‐wide cooperation of EMT transcription factor ZEB1 with YAP and AP‐1 in breast cancer
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6. SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures
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7. Peptide Hydrogels – Versatile Matrices for 3D Cell Culture in Cancer Medicine
   Peter Worthington, Darrin J. Pochan, Sigrid A. Langhans · 2015 · Frontiers in Oncology
8. Differential network entropy reveals cancer system hallmarks
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9. Computational models for predicting drug responses in cancer research
   Francisco J Azuaje · 2016 · Briefings in Bioinformatics
10. Analysis of Racial/Ethnic Representation in Select Basic and Applied Cancer Research Studies
    Santiago Xavier Guerrero, Andrés López‐Cortés, Alberto Indacochea, Jennyfer M. Garcí­a-Cárdenas, Ana Karina Zambrano, Alejandro Cabrera‐Andrade, Patricia Guevara‐Ramírez, Diana Abigail González, Paola Leone, César Paz‐y‐Miño · 2018 · Scientific Reports
11. Capmatinib (INC280) Is Active Against Models of Non–Small Cell Lung Cancer and Other Cancer Types with Defined Mechanisms of MET Activation
    Sabrina Baltschukat, Barbara Schacher Engstler, Alan Huang, Huai-Xiang Hao, Angela Tam, Hui Qin Wang, Jinsheng Liang, Matthew T. DiMare, Hyo-Eun Carrie Bhang, Youzhen Wang et al. · 2019 · Clinical Cancer Research
12. The Schlafen Family of Proteins and Their Regulation by Interferons
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13. Dystrophin is a tumor suppressor in human cancers with myogenic programs
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14. Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation
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15. Small-molecule targeting of brachyury transcription factor addiction in chordoma
    Tanaz Sharifnia, Mathias J. Wawer, Ting Chen, Qingyuan Huang, Barbara A. Weir, Ann E. Sizemore, Matthew A. Lawlor, Amy B. Goodale, Glenn S. Cowley, Francisca Vázquez et al. · 2019 · Nature Medicine
16. The UCSC Cancer Genomics Browser: update 2013
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17. Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties
    Xiangqian Kong, Jie Chen, Wenbing Xie, Stephen M. Brown, Yi Cai, Kaichun Wu, Daiming Fan, Yongzhan Nie, Srinivasan Yegnasubramanian, Rochelle L. Tiedemann et al. · 2019 · Cancer Cell
18. Potential Applications of NRF2 Modulators in Cancer Therapy
    Emiliano Panieri, Aleksandra Buha Djordjević, Pelin Telkoparan‐Akillilar, Dilek Cevik, Demetrios Kouretas, Aristidis S. Veskoukis, Zoi Skaperda, Aristidis Michael Tsatsakis, David Wallace, Síbel Süzen et al. · 2020 · Antioxidants
19. Epithelial-to-Mesenchymal Transition Defines Feedback Activation of Receptor Tyrosine Kinase Signaling Induced by MEK Inhibition in <i>KRAS</i> -Mutant Lung Cancer
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20. SLFN11 inhibits checkpoint maintenance and homologous recombination repair
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21. Uridine-derived ribose fuels glucose-restricted pancreatic cancer
    Zeribe C. Nwosu, Matthew H. Ward, Peter Sajjakulnukit, Pawan Poudel, Chanthirika Ragulan, Steven Kasperek, Megan D. Radyk, Damien Sutton, Rosa Elena Menjivar, Anthony C. Andren et al. · 2023 · Nature
22. ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells
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23. TRIM37 controls cancer-specific vulnerability to PLK4 inhibition
    Franz Meitinger, Midori Ohta, Kian-Yong Lee, Sadanori Watanabe, Robert Lowell Davis, John V. Anzola, Ruth Kabeche, David A. Jenkins, Andrew K. Shiau, Arshad B. Desai et al. · 2020 · Nature
24. The RNA Atlas expands the catalog of human non-coding RNAs
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25. KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer
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26. TCRD and pharos 2021: mining the human proteome for disease biology
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27. The TPM3‐NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition
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28. Leveraging big data to transform target selection and drug discovery
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29. Targeting the PI3K/AKT/mTOR Pathway in Bladder Cancer
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30. DeepDSC: A Deep Learning Method to Predict Drug Sensitivity of Cancer Cell Lines
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31. Rational Cell Culture Optimization Enhances Experimental Reproducibility in Cancer Cells
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32. Organoid cultures for cancer modeling
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33. Looking beyond the hype: applied AI and machine learning in translational medicine
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34. Reciprocal expression of INSM1 and YAP1 defines subgroups in small cell lung cancer
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35. TET1-Mediated Hypomethylation Activates Oncogenic Signaling in Triple-Negative Breast Cancer
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36. Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity
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37. Integrated Machine Learning and Bioinformatic Analyses Constructed a Novel Stemness-Related Classifier to Predict Prognosis and Immunotherapy Responses for Hepatocellular Carcinoma Patients
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38. Activation of MAPK Pathways due to DUSP4 Loss Promotes Cancer Stem Cell-like Phenotypes in Basal-like Breast Cancer
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39. Biomarkers of Response to Akt Inhibitor MK-2206 in Breast Cancer
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40. Evaluating the molecule-based prediction of clinical drug responses in cancer
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41. CD44 Promotes PD-L1 Expression and Its Tumor-Intrinsic Function in Breast and Lung Cancers
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42. Synthetic lethality-mediated precision oncology via the tumor transcriptome
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43. Coordinate Direct Input of Both KRAS and IGF1 Receptor to Activation of PI3 kinase in <i>KRAS</i> -Mutant Lung Cancer
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44. SynLethDB: synthetic lethality database toward discovery of selective and sensitive anticancer drug targets
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45. Characterization of the Usage of the Serine Metabolic Network in Human Cancer
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46. Omics and Drug Response
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47. MSH2 Loss in Primary Prostate Cancer
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48. G2M Cell Cycle Pathway Score as a Prognostic Biomarker of Metastasis in Estrogen Receptor (ER)-Positive Breast Cancer
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49. Designing Transformative Clinical Trials in the Cancer Genome Era
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50. Anticancer Effects of Niclosamide in Human Glioblastoma
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51. Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis
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52. H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma
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53. Towards artificial intelligence-enabled extracellular vesicle precision drug delivery
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54. PharmacoDB: an integrative database for mining in vitro anticancer drug screening studies
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55. Managing drug resistance in cancer: lessons from HIV therapy
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56. The transcription factor Grainy head primes epithelial enhancers for spatiotemporal activation by displacing nucleosomes
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57. Machine learning in the prediction of cancer therapy
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58. Harnessing big ‘omics’ data and AI for drug discovery in hepatocellular carcinoma
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59. Anticancer drug sensitivity prediction in cell lines from baseline gene expression through recursive feature selection
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60. CellMinerCDB for Integrative Cross-Database Genomics and Pharmacogenomics Analyses of Cancer Cell Lines
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61. Modeling clear cell renal cell carcinoma and therapeutic implications
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62. Evolving Strategies for Target Selection for Antibody-Drug Conjugates
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63. FAS-antisense 1 lncRNA and production of soluble versus membrane Fas in B-cell lymphoma
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64. Anti-SIRPα antibodies as a potential new tool for cancer immunotherapy
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65. A comprehensive assessment of RNA-seq protocols for degraded and low-quantity samples
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66. CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2
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67. Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours
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68. Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells
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69. Patient-specific driver gene prediction and risk assessment through integrated network analysis of cancer omics profiles
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70. The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer
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71. Discovery and Characterization of SY-1365, a Selective, Covalent Inhibitor of CDK7
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72. Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies
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73. The Cancer Cell Map Initiative: Defining the Hallmark Networks of Cancer
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74. A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies
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75. GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification
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76. Decreased Expression of Fructose-1,6-bisphosphatase Associates with Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma
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77. Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition
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78. FOXA1, GATA3 and PPARɣ Cooperate to Drive Luminal Subtype in Bladder Cancer: A Molecular Analysis of Established Human Cell Lines
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79. Long noncoding RNA expression profiling in cancer: Challenges and opportunities
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80. Predicting Cancer Drug Response using a Recommender System
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81. Gene expression based inference of cancer drug sensitivity
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82. DNA damage induces p53-independent apoptosis through ribosome stalling
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83. Aurora A ligand complex
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84. MERTK receptor tyrosine kinase is a therapeutic target in melanoma
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85. Targeting an IKBKE cytokine network impairs triple-negative breast cancer growth
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86. Methods, Tools and Current Perspectives in Proteogenomics
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87. NADPH Oxidases: Insights into Selected Functions and Mechanisms of Action in Cancer and Stem Cells
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88. Novel Immune-Related Gene Signature for Risk Stratification and Prognosis of Survival in Lower-Grade Glioma
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89. Notch promotes recurrence of dormant tumor cells following HER2/neu-targeted therapy
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90. Squalene epoxidase is a bona fide oncogene by amplification with clinical relevance in breast cancer
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91. DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors
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92. Oncogene-like addiction to aneuploidy in human cancers
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93. KnockTF: a comprehensive human gene expression profile database with knockdown/knockout of transcription factors
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94. BRCAness, SLFN11, and RB1 loss predict response to topoisomerase I inhibitors in triple-negative breast cancers
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95. The specificity of asciminib, a potential treatment for chronic myeloid leukemia, as a myristate-pocket binding ABL inhibitor and analysis of its interactions with mutant forms of BCR-ABL1 kinase
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96. Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance
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97. PD-L1 expression is associated with epithelial-mesenchymal transition in head and neck squamous cell carcinoma
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98. Novel orally bioavailable EZH1/2 dual inhibitors with greater antitumor efficacy than an EZH2 selective inhibitor
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99. Paraoxonase 2 Facilitates Pancreatic Cancer Growth and Metastasis by Stimulating GLUT1-Mediated Glucose Transport
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100. Drug-perturbation-based stratification of blood cancer
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