The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

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5. Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes
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6. AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies
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9. Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death
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10. Drug repurposing for cancer therapy
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11. Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR–Cas9 library
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12. POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer
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13. Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood
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14. MOLI: multi-omics late integration with deep neural networks for drug response prediction
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15. Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers
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16. ARID1B is a specific vulnerability in ARID1A-mutant cancers
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17. Pharmacogenomic agreement between two cancer cell line data sets
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18. Toward better drug repositioning: prioritizing and integrating existing methods into efficient pipelines
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19. Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract
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20. Molecular aspects of cancer cell resistance to chemotherapy
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21. Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy
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22. An unbiased oncology compound screen to identify novel combination strategies
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24. Ovarian Cancer Cell Line Panel (OCCP): Clinical Importance of In Vitro Morphological Subtypes
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26. Targeting Epigenetic Readers in Cancer
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27. CancerPPD: a database of anticancer peptides and proteins
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28. Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors
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29. A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation
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30. Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis
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31. Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models
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32. Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies
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33. A review of computational drug repositioning: strategies, approaches, opportunities, challenges, and directions
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34. Tumor microenvironment and cancer therapy resistance
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35. Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies
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36. Three‐dimensional models of cancer for pharmacology and cancer cell biology: Capturing tumor complexity in vitro/ex vivo
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37. <scp>AMP</scp> ‐activated protein kinase: a cellular energy sensor that comes in 12 flavours
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38. High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells
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39. Machine learning and integrative analysis of biomedical big data
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40. Drug-Induced Death Signaling Strategy Rapidly Predicts Cancer Response to Chemotherapy
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41. Cell-Cycle Regulation Accounts for Variability in Ki-67 Expression Levels
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42. Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer
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43. BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia
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44. Organoid cultures for the analysis of cancer phenotypes
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45. Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents
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46. Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility
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48. KRAS mutation in pancreatic cancer
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50. Phenotypic drug discovery: recent successes, lessons learned and new directions
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54. Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies
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55. A Genome-Scale RNA Interference Screen Implicates NF1 Loss in Resistance to RAF Inhibition
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56. CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions
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57. The cornucopia of meaningful leads: Applying deep adversarial autoencoders for new molecule development in oncology
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58. DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia
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59. Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment
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60. The Implications of Clonal Genome Evolution for Cancer Medicine
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61. Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss
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62. Ten things you should know about protein kinases: IUPHAR R eview 14
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63. Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis
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64. A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis
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65. Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers
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66. FGFR Genetic Alterations Predict for Sensitivity to NVP-BGJ398, a Selective Pan-FGFR Inhibitor
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67. PARP Inhibitor Activity Correlates with SLFN11 Expression and Demonstrates Synergy with Temozolomide in Small Cell Lung Cancer
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68. Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage
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69. Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers
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70. A Curated Resource for Phosphosite-specific Signature Analysis
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71. Cancer Cell Lines Are Useful Model Systems for Medical Research
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72. The need for complex 3D culture models to unravel novel pathways and identify accurate biomarkers in breast cancer
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73. Pharmacological and genomic profiling identifies NF-κB-targeted treatment strategies for mantle cell lymphoma
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74. The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes
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75. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers
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76. Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer
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77. Preclinical mouse solid tumour models: status quo, challenges and perspectives
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78. Machine learning for multi-omics data integration in cancer
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79. Molecular Subtypes in Head and Neck Cancer Exhibit Distinct Patterns of Chromosomal Gain and Loss of Canonical Cancer Genes
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80. Comprehensive metabolomics expands precision medicine for triple-negative breast cancer
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81. PD ‐L1 expression is mainly regulated by interferon gamma associated with JAK ‐ STAT pathway in gastric cancer
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82. In silico methods for drug repurposing and pharmacology
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83. A machine learning approach to integrate big data for precision medicine in acute myeloid leukemia
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84. First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway
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85. Intron retention is a source of neoepitopes in cancer
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86. Promise of personalized omics to precision medicine
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87. Circular RNA circHIPK3 modulates autophagy via MIR124-3p-STAT3-PRKAA/AMPKα signaling in STK11 mutant lung cancer
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88. Cancer Drug Response Profile scan (CDRscan): A Deep Learning Model That Predicts Drug Effectiveness from Cancer Genomic Signature
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89. Loss of KDM6A activates super-enhancers to induce gender-specific squamous-like pancreatic cancer and confers sensitivity to BET inhibitors
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90. An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance
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91. Metrics other than potency reveal systematic variation in responses to cancer drugs
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92. Notch Signaling Is Activated in Human Hepatocellular Carcinoma and Induces Tumor Formation in Mice
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93. Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses
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94. Targeting the PI3K/AKT/mTOR pathway in estrogen receptor-positive breast cancer
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95. LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures
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96. Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance
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97. Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling
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98. The Generation and Application of Patient-Derived Xenograft Model for Cancer Research
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99. The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy
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100. Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition
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