The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Live imaging of stem cell and progeny behaviour in physiological hair-follicle regeneration
Open accessAbstract
Tissue development and regeneration depend on cell–cell interactions and signals that target stem cells and their immediate progeny. However, the cellular behaviours that lead to a properly regenerated tissue are not well understood. Using a new, non-invasive, intravital two-photon imaging approach we study physiological hair-follicle regeneration over time in live mice. By these means we have monitored the behaviour of epithelial stem cells and their progeny during physiological hair regeneration and addressed how the mesenchyme influences their behaviour. Consistent with earlier studies, stem cells are quiescent during the initial stages of hair regeneration, whereas the progeny are more actively dividing. Moreover, stem cell progeny divisions are spatially organized within follicles. In addition to cell divisions, coordinated cell movements of the progeny allow the rapid expansion of the hair follicle. Finally, we show the requirement of the mesenchyme for hair regeneration through targeted cell ablation and long-term tracking of live hair follicles. Thus, we have established an in vivo approach that has led to the direct observation of cellular mechanisms of growth regulation within the hair follicle and that has enabled us to precisely investigate functional requirements of hair-follicle components during the process of physiological regeneration.
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Cites
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Cited by
Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin
Ma, S., Zhang, B., LaFave, L. M., Earl, A. S., Chiang, Z., Hu, Y., Ding, J., Brack, A., Kartha, V. K., Tay, T., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.056 · Cited by 1,146
Molecular regulation of stem cell quiescence
Cheung, T. H., & Rando, T. A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3591 · Cited by 1,148
Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later
Bond, A. M., Ming, G.-L., & Song, H. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.09.003 · Cited by 791
“…will also become possible to directly image the behavior of individual adult NSCs in vivo to explore how experience impacts NSC activation and division directly, as was achieved in adult fish (Barbosa et al., 2015) and for other adult somatic stem cells (Ritsma et al., 2014; Rompolas et al., 2012).”
BackgroundPlasticity of epithelial stem cells in tissue regeneration
Blanpain, C., & Fuchs, E. (2014) · Science · doi:10.1126/science.1242281 · Cited by 589
Skin wound healing in humans and mice: Challenges in translational research
Zomer, H. D., & Trentin, A. G. (2018) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2017.12.009 · Cited by 534
Metadata
- Authors
- Rompolas, P., Deschene, E. R., Zito, G., Gonzalez, D. G., Saotome, I., Haberman, A. M., & Greco, V.
- Venue
- Nature
- Published
- 2012-07
- Volume
- 487
- Issue
- 7408
- Pages
- 496-499
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2016776882
- Cited by
- 379
- References
- 20
- FWCI
- 32.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Rompolas, P., Deschene, E. R., Zito, G., Gonzalez, D. G., Saotome, I., Haberman, A. M., & Greco, V. (2012). Live imaging of stem cell and progeny behaviour in physiological hair-follicle regeneration. Nature. https://doi.org/10.1038/nature11218
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