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Antibiotics in early life alter the murine colonic microbiome and adiposity
Open accessAbstract
Antibiotics administered in low doses have been widely used as growth promoters in the agricultural industry since the 1950s, yet the mechanisms for this effect are unclear. Because antimicrobial agents of different classes and varying activity are effective across several vertebrate species, we proposed that such subtherapeutic administration alters the population structure of the gut microbiome as well as its metabolic capabilities. We generated a model of adiposity by giving subtherapeutic antibiotic therapy to young mice and evaluated changes in the composition and capabilities of the gut microbiome. Administration of subtherapeutic antibiotic therapy increased adiposity in young mice and increased hormone levels related to metabolism. We observed substantial taxonomic changes in the microbiome, changes in copies of key genes involved in the metabolism of carbohydrates to short-chain fatty acids, increases in colonic short-chain fatty acid levels, and alterations in the regulation of hepatic metabolism of lipids and cholesterol. In this model, we demonstrate the alteration of early-life murine metabolic homeostasis through antibiotic manipulation.
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“In humans, members belonging to the Lachnospiraceae family have been shown to be protective against C. difficle (Petrof, 2013) and metabolic disorders (Cho et al., 2012).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Cho et al., 2012
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“Subsequently, it was discovered that disruptions to the microbiome early in life can promote heightened adiposity5.”
From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [5]
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“In addition, by investigating the effect of early antibiotics on intestinal microbiota, a study revealed that the composition of intestinal microbiota changed significantly and the metabolism of SCFAs was altered after treatment with subtherapeutic antibiotic therapy.56”
From The role of gut dysbiosis in Parkinson’s disease: mechanistic insights and therapeutic options (2021) · cites this paper as [56]
In the citing paper
“Difficulty in maintaining new (non-native) microbiota in recipient mice, whether germ-free or those in which gut microbiota suppression was initially performed with oral mixture of poorly absorbed antibiotics, has been reported in other studies (30-32).”
From Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation (2015) · cites this paper as [31]
In the citing paper
“The use of antibiotics in early life is associated with obesity in both people and mice”
From Diet–microbiota interactions as moderators of human metabolism (2016) · cites this paper as [66]
In the citing paper
“Several lines of evidence support the role of gut microbiota in obesity.”
From Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook (2015) · cites this paper as [80]
In the citing paper
“Lean and obese individuals show marked differences in the gut microbiome.80”
From Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook (2015) · cites this paper as [80]
In the citing paper
“antibiotic administration increases bone density in young mice (11,12)”
From Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics (2016) · cites this paper as [11]
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“Exposure to antibiotics during weaning changed gut microbial communities with increasing metabolic capacity to produce acetate, propionate, and butyrate in C57BL/6J mice.”
From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [5]
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“Influx of these SCFAs to the liver resulted in substantial changes in the regulation of hepatic lipid metabolism and obese phenotype5.”
From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [5]
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Cites
Basic local alignment search tool
Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990) · Journal of Molecular Biology · doi:10.1006/jmbi.1990.9999 · Cited by 98,669
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887
Search and clustering orders of magnitude faster than BLAST
Edgar, R. C. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq461 · Cited by 21,098
Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
Wang, Q., Garrity, G. M., Tiedje, J. M., & Cole, J. R. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00062-07 · Cited by 20,145
FastTree 2 – Approximately Maximum-Likelihood Trees for Large Alignments
Price, M. N., Dehal, P. S., & Arkin, A. P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009490 · Cited by 14,894
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Bioconductor: open software development for computational biology and bioinformatics
Gentleman, R. C., Carey, V. J., Bates, D. M., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge, Y., Gentry, J., et al. (2004) · Genome biology · doi:10.1186/gb-2004-5-10-r80 · Cited by 12,082
Gentleman R: R: A language for data analysis and graphics
Ihaka, R., & Gentleman, R. (1996) · Journal of Computational and Graphical Statistics · doi:10.1080/10618600.1996.10474713 · Cited by 11,747
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
Research works printed but not linked: 2
- Ley, R. E. et al. Obesity alters gut microbial ecology. Proc. Natl Acad. Sci. USA 102, 11070–11075 (2005) · DOI · Paper page
- Gentleman, R. C. et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 5, R80 (2004) · DOI
Cited by
Sorted by citations
Items 401–500 of 1,001
Angelakis, E., Million, M., Sallah, K., Lagier, J., Armougom, F., Giorgi, R., & Raoult, D. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02437-14 · Cited by 100
RetractedHernández, E., Bargiela, R., Diez, M. S., Friedrichs, A. K., Pérez‐Cobas, A. E., Gosalbes, M. J., Knecht, H., Martínez‐Martínez, M., Seifert, J., von Bergen�, M., et al. (2013) · Gut Microbes · doi:10.4161/gmic.25321 · Cited by 98
Jensen, M. L., Thymann, T., Cilieborg, M. S., Lykke, M., Mølbak, L., Jensen, B. B., Schmidt, M. H., Kelly, D., Mulder, I. E., Burrin, D. G., et al. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00213.2013 · Cited by 98
The Human Microbiome and the Missing Heritability Problem
Sandoval‐Motta, S., Aldana, M., Martínez‐Romero, E., & Frank, A. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00080 · Cited by 97
Antibiotics, gut microbiome and obesity
Leong, K. S. W., Derraik, J. G. B., Hofman, P. L., & Cutfield, W. S. (2017) · Clinical Endocrinology · doi:10.1111/cen.13495 · Cited by 98
Pincus, N. B., Reckhow, J. D., Saleem, D., Jammeh, M. L., Datta, S. K., & Myles, I. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124280 · Cited by 97
Urinary Triclosan is Associated with Elevated Body Mass Index in NHANES
Lankester, J., Patel, C. J., Cullen, M. R., Ley, C., & Parsonnet, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080057 · Cited by 96
Helicobacter pylori infection is associated with an altered gastric microbiota in children
Brawner, K. M., Kumar, R., Serrano, C. A., Ptacek, T., Lefkowitz, E. J., Morrow, C. D., Zhi, D., Kyanam-Kabir-Baig, K., Smythies, L. E., Harris, P. R., et al. (2017) · Mucosal Immunology · doi:10.1038/mi.2016.131 · Cited by 96
Characteristics of the intestinal flora of specific pathogen free chickens with age
Yu, X., Shuling, N., Tie, K., Qiuyang, Z., Deng, H., Gao, C., Tianhe, Y., Lei, L., & Xin, F. (2019) · Microbial Pathogenesis · doi:10.1016/j.micpath.2019.05.014 · Cited by 96
Shao, X., Ding, X., Wang, B., Li, L., An, X., Yao, Q., Song, R., & Zhang, J. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00170 · Cited by 96
Tang, Z.-Z., & Chen, G. (2018) · Biostatistics · doi:10.1093/biostatistics/kxy025 · Cited by 95
Muhammad, A., Fang, Y., Hou, Y., & Shi, Z. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02291 · Cited by 95
Microbiomic Signatures of Psoriasis: Feasibility and Methodology Comparison
Statnikov, A., Alekseyenko, A. V., Li, Z., Henaff, M., Perez-Perez, G. I., Blaser, M. J., & Aliferis, C. (2013) · Scientific Reports · doi:10.1038/srep02620 · Cited by 95
Self-citationWhat Is a Host? Attributes of Individual Susceptibility
Casadevall, A., & Pirofski, L. (2017) · Infection and Immunity · doi:10.1128/iai.00636-17 · Cited by 94
Interactions Between Food and Gut Microbiota: Impact on Human Health
Wu, Y., Wan, J., Choe, U., Pham, Q., Schoene, N. W., He, Q., Li, B., Yu, L. L., & Wang, T. T. Y. (2019) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-032818-121303 · Cited by 96
Jin, Y., Wu, Y., Zeng, Z., Jin, C., Wu, S., Wang, Y., & Fu, Z. (2016) · Toxicological Sciences · doi:10.1093/toxsci/kfw150 · Cited by 93
Exposure to the fungicide propamocarb causes gut microbiota dysbiosis and metabolic disorder in mice
Wu, S., Jin, C., Wang, Y., Fu, Z., & Jin, Y. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.10.129 · Cited by 93
Microbial Population Changes and Their Relationship with Human Health and Disease
Álvarez‐Mercado, A. I., Navarro-Oliveros, M., Robles-Sánchez, C., Plaza‐Díaz, J., Sáez‐Lara, M. J., Muñoz‐Quezada, S., Fontana, L., & Abadía‐Molina, F. (2019) · Microorganisms · doi:10.3390/microorganisms7030068 · Cited by 93
Microbiome diurnal rhythmicity and its impact on host physiology and disease risk
Nobs, S. P., Tuganbaev, T., & Elinav, E. (2019) · EMBO Reports · doi:10.15252/embr.201847129 · Cited by 91
Developmental Regulation of Drug-Processing Genes in Livers of Germ-Free Mice
Selwyn, F. P., Cheng, S. L., Bammler, T. K., Prasad, B., Vrana, M., Klaassen, C. D., & Cui, J. Y. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv110 · Cited by 92
Cometabolism of Microbes and Host: Implications for Drug Metabolism and Drug-Induced Toxicity
Li, H., & Jia, W. P. (2013) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2013.157 · Cited by 92
Self-citationEffects of domestication on the gut microbiota parallel those of human industrialization
Reese, A. T., Chadaideh, K. S., Diggins, C. E., Schell, L. D., Beckel, M., Callahan, P., Ryan, R., Thompson, M. E., & Carmody, R. N. (2021) · eLife · doi:10.7554/elife.60197 · Cited by 91
Gastrointestinal Organoids: Understanding the Molecular Basis of the Host–Microbe Interface
Hill, D. R., & Spence, J. R. (2016) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.11.007 · Cited by 90
Regulation of bone mass by the gut microbiota is dependent on NOD1 and NOD2 signaling
Ohlsson, C., Nigro, G., Boneca, I. G., Bäckhed, F., Sansonetti, P. J., & Sjögren, K. (2017) · Cellular Immunology · doi:10.1016/j.cellimm.2017.05.003 · Cited by 90
Liu, J., Yue, T., Luo, Z., Cao, J., Yan, Z., Jin, L., Wan, T., Shuai, C., Wang, Z., Zhou, Y., et al. (2020) · Disease Models & Mechanisms · doi:10.1242/dmm.043620 · Cited by 90
Wang, S., Li, X., Zhang, M., Jiang, H., Wang, R., Qian, Y., & Li, M. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112932 · Cited by 89
Sexual dimorphism of cardiometabolic dysfunction: Gut microbiome in the play?
Cross, T.-W. L., Kasahara, K., & Rey, F. E. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.05.016 · Cited by 87
Clinical reviews in allergy and immunology
Leung, D. Y. M., Ledford, D. K., Wechsler, M. E., Fulkerson, P. C., Bochner, B. S., Gauvreau, G. M., Gleich, G. J., Henkel, T., Kolbeck, R., Mathur, S. K., et al. (2012) · Cited by 87
Ocansey, D. K. W., Wang, L., Wang, J., Yan, Y., Qian, H., Zhang, X., Xu, W., & Mao, F. (2019) · Clinical and Translational Medicine · doi:10.1186/s40169-019-0251-8 · Cited by 87
Jiang, Z., He, L., Li, D., Zhuo, L., Chen, L., Shi, R.-Q., Luo, J., Feng, Y., Liang, Y., Li, D., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01246-5 · Cited by 91
Mor, A., Antonsen, S., Kahlert, J. A., Holsteen, V., Jørgensen, S. L., Holm‐Pedersen, J., Sørensen, H. T., Pedersen, O. B., & Ehrenstein, V. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.129 · Cited by 87
McPhee, J. B., & Schertzer, J. D. (2015) · Clinical Science · doi:10.1042/cs20150431 · Cited by 86
Major shifts in gut microbiota during development and its relationship to growth in ostriches
Videvall, E., Song, S. J., Bensch, H. M., Strandh, M., Engelbrecht, A., Serfontein, N., Hellgren, O., Olivier, A., Cloete, S. W. P., Knight, R. D., et al. (2019) · Molecular Ecology · doi:10.1111/mec.15087 · Cited by 86
Xu, L., Surathu, A., Raplee, I., Chockalingam, A., Stewart, S. R., Walker, L., Sacks, L. V., Patel, V. P., Li, Z., & Rouse, R. L. (2020) · BMC Genomics · doi:10.1186/s12864-020-6665-2 · Cited by 86
Keerthisinghe, T. P., Wang, F., Wang, M., Yang, Q. Z., Li, J., Yang, J., Lin, X., Dong, W., & Fang, M. (2020) · Environment International · doi:10.1016/j.envint.2020.105705 · Cited by 86
Dodiya, H. B., Frith, M., Sidebottom, A. M., Cao, Y., Koval, J., Chang, E. B., & Sisodia, S. S. (2020) · Scientific Reports · doi:10.1038/s41598-020-64797-5 · Cited by 86
Role of disease-associated tolerance in infectious superspreaders
Gopinath, S., Lichtman, J. S., Bouley, D. M., Elias, J. E., & Monack, D. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409968111 · Cited by 86
Probiotics in the next-generation sequencing era
Suez, J., Zmora, N., & Elinav, E. (2019) · Gut Microbes · doi:10.1080/19490976.2019.1586039 · Cited by 85
New approach methodologies for exposure science
Wambaugh, J. F., Bare, J., Carignan, C. C., Dionisio, K. L., Dodson, R. E., Jolliet, O., Liu, X., Meyer, D. E., Newton, S., Phillips, K. A., et al. (2019) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2019.07.001 · Cited by 85
Gut Microbiota and Bone Diseases: A Growing Partnership
Chen, Y., Wang, X., Zhang, C., Liu, Z., Li, C., & Ren, Z. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.877776 · Cited by 87
Impact of the gut microbiota on rodent models of human disease
Hansen, A. K., Hansen, C. H. F., Krych, Ł., & Nielsen, D. S. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i47.17727 · Cited by 85
Chattha, K. S., Vlasova, A. N., Kandasamy, S., Rajashekara, G., & Saif, L. J. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300678 · Cited by 85
Mikkelsen, S. U., Allin, K. H., & Knop, F. K. (2016) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12637 · Cited by 85
Gut Microbiota and Bone Health
Quach, D., & Britton, R. A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-66653-2_4 · Cited by 85
Wang, L., Ai, C., Wen, C., Qin, Y., Liu, Z., Wang, L., Gong, Y., Su, C., Wang, Z., & Song, S. (2020) · Food & Function · doi:10.1039/d0fo00668h · Cited by 85
Gut Microbiota Influence in Hematological Malignancies: From Genesis to Cure
Uribe‐Herranz, M., Klein-González, N., Rodríguez‐Lobato, L. G., Juan, M., & de Larrea, C. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031026 · Cited by 84
Zhang, G., Wang, Q., Tao, W., Jiang, W., Elinav, E., Wang, Y., & Zhu, S. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00903-4 · Cited by 84
Soderborg, T. K., Borengasser, S. J., Barbour, L. A., & Friedman, J. E. (2016) · Diabetologia · doi:10.1007/s00125-016-3880-0 · Cited by 84
Theriot, C. M., & Young, V. B. (2013) · Gut Microbes · doi:10.4161/gmic.27131 · Cited by 83
Early Life Antibiotic Exposure and Weight Development in Children
Mbakwa, C. A., Scheres, L. M. J., Penders, J., Mommers, M., Thijs, C. T., & Arts, I. C. W. (2016) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.06.015 · Cited by 83
Are we using too many antibiotics during pregnancy?
Ledger, W. J., & Blaser, M. J. (2013) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.12371 · Cited by 83
Self-citationQuan, J., Cai, G., Yang, M. J., Zeng, Z., Ding, R., Wang, X., Zhuang, Z., Zhou, S., Li, S., Yang, H., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00052 · Cited by 82
Gao, X., Jia, R., Xie, L., Kuang, L., Feng, L., & Wan, C. (2015) · BMC Pediatrics · doi:10.1186/s12887-015-0384-x · Cited by 82
Vanillin Alleviates High Fat Diet-Induced Obesity and Improves the Gut Microbiota Composition
Guo, J., Han, X., Zhan, J., You, Y., & Huang, W. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02733 · Cited by 82
Obstructive Sleep Apnea and Systemic Hypertension: Gut Dysbiosis as the Mediator?
Mashaqi, S., & Gozal, D. (2019) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.7990 · Cited by 81
Brettle, H., Tran, V., Drummond, G. R., Franks, A. E., Petrovski, S., Vinh, A., & Jelinic, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.971048 · Cited by 81
Associations Between Nutrition, Gut Microbiome, and Health in A Novel Nonhuman Primate Model
Clayton, J. B., Al‐Ghalith, G. A., Long, H. T., Tuan, B. V., Cabana, F., Huang, H., Vangay, P., Ward, T., Minh, V. V., Tam, N. A., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-29277-x · Cited by 81
Gadde, U. D., Oh, S., Lillehoj, H. S., & Lillehoj, E. P. (2018) · Scientific Reports · doi:10.1038/s41598-018-22004-6 · Cited by 80
RetractedAdvances in the Involvement of Gut Microbiota in Pathophysiology of NAFLD
Jiang, X., Zheng, J., Zhang, S., Wang, B., Wu, C., & Guo, X. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00361 · Cited by 80
Jin, S., Zhao, D., Cai, C., Song, D., Shen, J., Xu, A., Qiao, Y., Ran, Z., & Zheng, Q. (2017) · Scientific Reports · doi:10.1038/srep43662 · Cited by 80
Shi, Y., Kellingray, L., Zhai, Q., Gall, G. L., Narbad, A., Zhao, J., Zhang, H., & Chen, W. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01948 · Cited by 80
Preventive Effects and Mechanisms of Garlic on Dyslipidemia and Gut Microbiome Dysbiosis
Chen, K., Xie, K., Liu, Z., Nakasone, Y., Sakao, K., Hossain, M. A., & Hou, D.-X. (2019) · Nutrients · doi:10.3390/nu11061225 · Cited by 79
The Sporobiota of the Human Gut
Egan, M., Dempsey, E. M., Ryan, C. A., Ross, R. P., & Stanton, C. (2021) · Gut Microbes · doi:10.1080/19490976.2020.1863134 · Cited by 79
Yu, H., Wang, Y., Zeng, X., Cai, S., Wang, G., Liu, L., Huang, S., Li, N., Liu, H., Ding, X., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201901717r · Cited by 79
Human intestinal metagenomics: state of the art and future
Blottière, H. M., de Vos, W. M., Ehrlich, S. D., & Dore, J. M. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.06.006 · Cited by 78
Koh, H., Blaser, M. J., & Li, H. (2017) · Microbiome · doi:10.1186/s40168-017-0262-x · Cited by 78
Self-citationBrown, K., Abbott, D. W., Uwiera, R. R. E., & Inglis, G. D. (2017) · Gut Microbes · doi:10.1080/19490976.2017.1408763 · Cited by 78
Association between the Gut Microbiota and Obesity
Mitev, K., & Taleski, V. (2019) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2019.586 · Cited by 78
Gut microbes in metabolic disturbances. Promising role for therapeutic manipulations?
Portincasa, P., Khalil, M., Graziani, A., Frühbeck, G., Baffy, G., Garruti, G., Ciaula, A. D., & Bonfrate, L. (2023) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2023.10.002 · Cited by 78
Million, M., Thuny, F., Angelakis, E., Casalta, J.-P., Giorgi, R., Habib, G., & Raoult, D. (2013) · Nutrition and Diabetes · doi:10.1038/nutd.2013.28 · Cited by 78
Korpela, K., Salonen, A., Virta, L. J., Kumpu, M., Kekkonen, R. A., & de Vos, W. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154012 · Cited by 78
Osteomicrobiology: The influence of gut microbiota on bone in health and disease
Jones, R. M., Mullé, J. G., & Pacifici, R. (2017) · Bone · doi:10.1016/j.bone.2017.04.009 · Cited by 79
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Ramasethu, J., & Kawakita, T. (2017) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2017.07.001 · Cited by 78
Guss, J. D., Taylor, E., Rouse, Z., Roubert, S., Higgins, C. H., Thomas, C. J., Baker, S. P., Vashishth, D., Donnelly, E., Shea, M. K., et al. (2019) · Bone · doi:10.1016/j.bone.2019.06.010 · Cited by 77
Tarabichi, Y., Li, K., Hu, S., Nguyen, C., Wang, X., Elashoff, D., Saira, K., Frank, B., Bihan, M., Ghedin, E., et al. (2015) · Microbiome · doi:10.1186/s40168-015-0133-2 · Cited by 77
Self-citationEarly sexual dimorphism in the developing gut microbiome of northern elephant seals
Stoffel, M. A., Acevedo‐Whitehouse, K. A., Morales‐Durán, N., Grosser, S., Chakarov, N., Krüger, O., Nichols, H. J., Elorriaga-Verplancken, F. R., & Hoffman, J. I. (2020) · Molecular Ecology · doi:10.1111/mec.15385 · Cited by 77
Microbial metabolite delta-valerobetaine is a diet-dependent obesogen
Liu, K., Owens, J. A., Saeedi, B. J., Cohen, C. E., Bellissimo, M. P., Naudin, C. R., Darby, T. M., Druzak, S., Maner-Smith, K. M., Orr, M. C., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00502-8 · Cited by 79
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Lee, J., Lee, J., Kim, K., Lee, J., Jung, Y., Hyeon, J. S., Seo, A., Jin, W., Weon, B., Shin, N., et al. (2024) · Kidney International · doi:10.1016/j.kint.2024.01.040 · Cited by 76
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Chen, S., Li, X., Liu, L., Liu, C., & Han, X. (2017) · The FASEB Journal · doi:10.1096/fj.201700741rr · Cited by 75
Yu, M., Mu, C., Zhang, C., Yang, Y., Su, Y., & Zhu, W. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01166 · Cited by 76
Schugar, R. C., Gliniak, C. M., Osborn, L. J., Massey, W. J., Sangwan, N., Horak, A. J., Banerjee, R., Orabi, D., Helsley, R. N., Brown, A. L., et al. (2022) · eLife · doi:10.7554/elife.63998 · Cited by 75
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Shen, T. D. (2017) · Nestlé Nutrition Institute Workshop series · doi:10.1159/000455220 · Cited by 74
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Behera, J., Ison, J., Voor, M. J., & Tyagi, N. (2021) · Theranostics · doi:10.7150/thno.63749 · Cited by 74
Karlsson, F. H., Nookaew, I., & Nielsen, J. (2014) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003706 · Cited by 74
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Cao, Y. L., Pan, Q., Cai, W., Shen, F., Chen, G., Xu, L., & Fan, J. (2016) · PubMed · Cited by 74
Effects of oral florfenicol and azithromycin on gut microbiota and adipogenesis in mice
Li, R., Wang, H., Shi, Q., Wang, N., Zhang, Z., Xiong, C., Liu, J., Chen, Y., Jiang, L., & Jiang, Q. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181690 · Cited by 74
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Shi, Y., & Long, F. (2017) · eLife · doi:10.7554/elife.31649 · Cited by 73
Yang, Y., Shi, Y., Wiklund, P., Tan, X., Wu, N., Zhang, X., Tikkanen, O., Zhang, C., Munukka, E., & Cheng, S. (2017) · Nutrients · doi:10.3390/nu9080792 · Cited by 72
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Börnigen, D., Morgan, X. C., Franzosa, E. A., Ren, B., Xavier, R. J., Garrett, W. S., & Huttenhower, C. (2013) · Genome Medicine · doi:10.1186/gm469 · Cited by 72
Knoop, K. A., Gustafsson, J. K., McDonald, K. G., Kulkarni, D. H., Kassel, R., & Newberry, R. D. (2017) · Gut Microbes · doi:10.1080/19490976.2017.1299846 · Cited by 72
Yu, M., Zhang, C., Yang, Y., Mu, C., Su, Y., Yu, K., & Zhu, W. (2017) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-017-0192-2 · Cited by 72
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Cornejo-Pareja, I. M., Martín‐Núñez, G. M., ROCA-RODRIGUEZ, M. M., Cardona, F., Coín‐Aragüez, L., Sánchez‐Alcoholado, L., Gutiérrez‐Repiso, C., Muñoz‐Garach, A., Fernández‐García, J. C., Moreno‐Indias, I., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8040451 · Cited by 71
Leptin Acts Independently of Food Intake to Modulate Gut Microbial Composition in Male Mice
Rajala, M. W., Patterson, C. M., Opp, J. S., Foltin, S. K., Young, V. B., & Myers, M. G. (2014) · Endocrinology · doi:10.1210/en.2013-1085 · Cited by 71
Associations of Prenatal and Childhood Antibiotic Exposure With Obesity at Age 4 Years
Leong, K. S. W., McLay, J., Derraik, J. G. B., Gibb, S., Shackleton, N., Taylor, R. W., Glover, M., Audas, R., Taylor, B. J., Milne, B. J., et al. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.19681 · Cited by 71
Antibiotic administration and the development of obesity in children
Principi, N., & Esposito, S. (2016) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2015.12.017 · Cited by 70
Metadata
- Authors
- Cho, I., Yamanishi, S., Cox, L., Methé, B. A., Zavadil, J., Li, K., Gao, Z., Mahana, D., Raju, K., Teitler, I., Li, H., Alekseyenko, A. V., & Blaser, M. J.
- Affiliations
- New York University (US)
- J. Craig Venter Institute (US)
- VA NY Harbor Healthcare System (US)
- Corresponding author
- Blaser, Martin J.
- ORCID
- Venue
- Nature
- Published
- 2012-08
- Volume
- 488
- Issue
- 7413
- Pages
- 621-626
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3553221
- OpenAlex
- W2003836872
- Cited by
- 1,613
- References
- 67
- Citations by year
- 2026: 29 · 2025: 65 · 2024: 94 · 2023: 92 · 2022: 109 · 2021: 158 · 2020: 191 · 2019: 142 · 2018: 139 · 2017: 162 · 2016: 122 · 2015: 106 · 2014: 98 · 2013: 88 · 2012: 15
- FWCI
- 39.50
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health (UL1TR000038)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK090989, T-R01 DK090989)
- National Center for Research Resources (UL1RR029893)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- growth promoters, gut microbiota, colonic microbiota, adiposity, short-chain fatty acids, carbohydrate metabolism, lipid metabolism, cholesterol metabolism, metabolic homeostasis, livestock feed additives
- MeSH terms
- Age Factors, Animals, Anti-Bacterial Agents, Body Composition, Body Weight, Bone Development, Cecum, Cholesterol, Colon, Fatty Acids, Volatile, Feces, Female, Gastric Inhibitory Polypeptide, Liver, Male, Mice, Inbred C57BL, Weaning, Bone Density, Polymerase Chain Reaction, Adiposity, Lipid Metabolism, Mice, Metagenome
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