The Association between Cardiorespiratory Fitness and Gut Microbiota Composition in Premenopausal Women
Open accessAbstract
The aim of this study was to investigate the association between cardiorespiratory fitness and gut microbiota composition in premenopausal women. The participants consisted of 71 premenopausal Finnish women (aged 19–49 years). Gut microbiota were analyzed using flow cytometry, 16S rRNA gene hybridization and DNA-staining. Maximum oxygen uptake (VO2max) was assessed by respiratory gas analyzer and body composition by Bioimpdance. We found that participants with low VO2max had lower Bacteroides, but higher Eubacterium rectale-Clostridium coccoides than the high VO2max group (p < 0.05 for all). VO2max was inversely associated with EreC (r = −0.309, p = 0.01) but not with other bacteria. VO2max also negatively correlated with fat% (r = −0.755, p < 0.001), triglycerides (r = −0.274, p = 0.021) and leptin (r = −0.574, p < 0.001). By contrast, EreC was positively associated with fat% (r = 0.382, p = 0.002), dietary fat intake (r = 0.258, p = 0.034), triglycerides (r = 0.390, p = 0.002) and leptin (r = 0.424, p = 0.001), but negatively with carbohydrate intake (r = −0.252, p = 0.034) and HDL (r = −0.26, p = 0.028). After adjusting for age and dietary intake, all the significant associations remained. However, after adjusting for fat%, the associations between VO2max and EreC disappeared. Our results suggest that cardiorespiratory fitness is associated with gut microbiota composition, independent of age and carbohydrate or fat intake. The association between VO2max and EreC, however, appears to be mediated by body fatness.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In premenopausal women, cardiorespiratory fitness was associated with gut microbiota composition, independent of age and carbohydrate or fat intake.
“In a cross-sectional study in premenopausal women, cardiorespiratory fitness was associated with gut microbiota composition, independent of age and carbohydrate or fat intake [94].”
From The athletic gut microbiota (2020) · cites this paper as [94]
After adjusting for age and dietary intake, all significant associations between cardiorespiratory fitness and gut microbiota remained.
“After adjusting for age and dietary intake, all significant associations remained.”
From The athletic gut microbiota (2020) · cites this paper as [94]
Aerobic capacity was inversely associated with Eubacterium rectale-Clostridium coccoides but not with other bacteria.
“Aerobic capacity was inversely associated with Eubacterium rectale-Clostridium coccoides but not with other bacteria.”
From The athletic gut microbiota (2020) · cites this paper as [94]
Participants with low VO2max had lower Bacteroides, but higher Eubacterium rectale-Clostridium coccoides than the high VO2max group.
“Participants with low VO2max had lower Bacteroides, but higher Eubacterium rectale-Clostridium coccoides than the high VO2max group.”
From The athletic gut microbiota (2020) · cites this paper as [94]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works
Phylogenetic identification and in situ detection of individual microbial cells without cultivation
Amann, R., Ludwig, W., & Schleifer, K. (1995) · Microbiological reviews · doi:10.1128/mr.59.1.143-169.1995 · Cited by 9,508 · see citing works
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176 · see citing works
Richness of human gut microbiome correlates with metabolic markers
Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662 · see citing works
Amann, R., Binder, B. J., Olson, R. J., Chisholm, S. W., Devereux, R., & Stahl, D. A. (1990) · Applied and Environmental Microbiology · doi:10.1128/aem.56.6.1919-1925.1990 · Cited by 3,998 · see citing works
The impact of the gut microbiota on human health: an integrative view
Clemente, J. C., Ursell, L. K., Parfrey, L. W., & Knight, R. (2012) · Cell · doi:10.1016/j.cell.2012.01.035 · Cited by 3,710 · see citing works
The Human Intestinal Microbiome in Health and Disease
Lynch, S. V., & Pedersen, O. (2016) · New England Journal of Medicine · doi:10.1056/nejmra1600266 · Cited by 3,637 · see citing works
Caspi, R., Billington, R., Ferrer, L., Foerster, H., Fulcher, C. A., Keseler, I. M., Kothari, A., Krummenacker, M., Latendresse, M., Mueller, L. A., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv1164 · Cited by 3,395 · see citing works
Gut metagenome in European women with normal, impaired and diabetic glucose control
Karlsson, F. H., Tremaroli, V., Nookaew, I., Bergström, G., Behre, C. J., Fagerberg, B., Nielsen, J., & Bäckhed, F. (2013) · Nature · doi:10.1038/nature12198 · Cited by 3,115 · see citing works
Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults
Larsen, N., Vogensen, F. K., van den Berg, F. W. J., Nielsen, D. S., Andreasen, A. S., Pedersen, B. K., Al-Soud, W. A., Sørensen, S. J., Hansen, L. H., & Jakobsen, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009085 · Cited by 2,952 · see citing works
Physical fitness in childhood and adolescence: a powerful marker of health
Ortega, F. B., Ruiz, J. R., Castillo, M. J., & Sjöstróm, M. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803774 · Cited by 2,885 · see citing works
Microbiota and SCFA in lean and overweight healthy subjects
Schwiertz, A., Taras, D., Schäfer, K., Beijer, S., Bos, N. A., Donus, C., & Hardt, P. D. (2010) · Obesity · doi:10.1038/oby.2009.167 · Cited by 2,457 · see citing works
Amann, R., Krumholz, L. R., & Stahl, D. A. (1990) · Journal of Bacteriology · doi:10.1128/jb.172.2.762-770.1990 · Cited by 2,207 · see citing works
The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon
Donohoe, D. R., Garge, N., Zhang, X., Sun, W., O'Connell, T. M., Bunger, M. K., & Bultman, S. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.018 · Cited by 2,003 · cited 1× · see citing works
“SCFAs serve as energy substrates for the epithelial cells of the gut and provide part of the dietary energy [29,32], while other studies have shown that microbial pathways which generate SCFAs were enriched in metagenomics studies of obese subjects, and levels of SCFAs were elevated in overweight or obese people and a…”
BackgroundSelf-citationAntibiotics in early life alter the murine colonic microbiome and adiposity
Cho, I., Yamanishi, S., Cox, L., Methé, B. A., Zavadil, J., Li, K., Gao, Z., Mahana, D., Raju, K., Teitler, I., et al. (2012) · Nature · doi:10.1038/nature11400 · Cited by 1,613 · see citing works
Exercise and associated dietary extremes impact on gut microbial diversity
Clarke, S. F., Murphy, E. F., O'Sullivan, O., Lucey, A. J., Humphreys, M., Hogan, A., Hayes, P., O'Reilly, M., Jeffery, I. B., Wood-Martin, R., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-306541 · Cited by 1,439 · see citing works
Human colonic microbiota associated with diet, obesity and weight loss
Duncan, S. H., Lobley, G. E., Holtrop, G., Ince, J., Johnstone, A. M., Louis, P., & Flint, H. J. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.155 · Cited by 1,222 · see citing works
Caspi, R., Altman, T., Billington, R., Dreher, K., Foerster, H., Fulcher, C. A., Holland, T. A., Keseler, I. M., Kothari, A., Kubo, A., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1103 · Cited by 1,204 · see citing works
Gut Microbiota and Metabolic Endotoxemia in Young Obese Mexican Subjects
Radilla-Vázquez, R. B., Parra‐Rojas, I., Martínez-Hernández, N. E., Márquez‐Sandoval, F., Illades‐Aguiar, B., & Castro-Alarcón, N. (2016) · Obesity Facts · doi:10.1159/000442479 · Cited by 1,200 · see citing works
Estrogen–gut microbiome axis: Physiological and clinical implications
Baker, J. M., Al‐Nakkash, L., & Herbst‐Kralovetz, M. M. (2017) · Maturitas · doi:10.1016/j.maturitas.2017.06.025 · Cited by 1,024 · see citing works
Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity
Liou, A. P., Paziuk, M., Luevano, J.-M., Machineni, S., Turnbaugh, P. J., & Kaplan, L. M. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005687 · Cited by 1,007 · see citing works
Duncan, S. H., Belenguer, A., Holtrop, G., Johnstone, A. M., Flint, H. J., & Lobley, G. E. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.02340-06 · Cited by 941 · see citing works
Guinane, C. M., & Cotter, P. D. (2013) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x13482996 · Cited by 846 · see citing works
The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids
Fu, J., Bonder, M. J., Cenit, M. C., Tigchelaar, E. F., Maatman, A., Dekens, J. A. M., Brandsma, E., Marczynska, J., Imhann, F., Weersma, R. K., et al. (2015) · Circulation Research · doi:10.1161/circresaha.115.306807 · Cited by 748 · see citing works
Jiang, W., Wu, N., Wang, X., Chi, Y., Zhang, Y., Qiu, X., Hu, Y. C., Li, J., & Liu, Y. (2015) · Scientific Reports · doi:10.1038/srep08096 · Cited by 650 · see citing works
Self-citationGérard, P. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2061-5 · Cited by 512 · see citing works
Estaki, M., Pither, J., Baumeister, P., Little, J. P., Gill, S. K., Ghosh, S., Ahmadi-Vand, Z., Marsden, K. R., & Gibson, D. L. (2016) · Microbiome · doi:10.1186/s40168-016-0189-7 · Cited by 476 · see citing works
Fecal microbiota in early rheumatoid arthritis.
Vaahtovuo, J., Munukka, E., Korkeamäki, M., Luukkainen, R., & Toivanen, P. (2008) · PubMed · Cited by 426 · see citing works
Self-citationTechniques used to characterize the gut microbiota: a guide for the clinician
Fraher, M. H., O'Toole, P. W., & Quigley, E. M. M. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.44 · Cited by 385 · see citing works
The maximum oxygen intake. An international reference standard of cardiorespiratory fitness.
Shephard, R. J., Allen, C., Benadé, A. J. S., Davies, C. T. M., di Prampero, P. E., Hedman, R., Merriman, J. E., Myhre, K., & Simmons, R. (1968) · Europe PMC (PubMed Central) · Cited by 353 · see citing works
MATSUMOTO, M., INOUE, R., TSUKAHARA, T., USHIDA, K., CHIJI, H., MATSUBARA, N., & HARA, H. (2008) · Bioscience, Biotechnology, and Biochemistry · doi:10.1271/bbb.70474 · Cited by 352 · see citing works
Kelly, T. N., Bazzano, L. A., Ajami, N. J., He, H., Zhao, J., Petrosino, J. F., Correa, A., & He, J. (2016) · Circulation Research · doi:10.1161/circresaha.116.309219 · Cited by 345 · see citing works
Potential benefits and hazards of physical activity and exercise on the gastrointestinal tract
Peters, H. P. F., de Vries, W. R., Henegouwen, G. P. V. B., & Akkermans, L. M. A. (2001) · Gut · doi:10.1136/gut.48.3.435 · Cited by 336 · see citing works
Understanding the interactions between bacteria in the human gut through metabolic modeling
Shoaie, S., Karlsson, F. H., Mardinoğlu, A., Nookaew, I., Bordel, S., & Nielsen, J. (2013) · Scientific Reports · doi:10.1038/srep02532 · Cited by 260 · see citing works
De Schryver, A. M., Keulemans, Y. C., Peters, H. P., Akkermans, L. M., Smout, A. J., De Vries, W. R., & Van Berge-Henegouwen, G. P. (2005) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520510011641 · Cited by 203 · see citing works
Rigottier‐Gois, L., Bourhis, A.-G. L., Gramet, G., Rochet, V., & Dore, J. M. (2003) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2003.tb01063.x · Cited by 163 · see citing works
Rigottier‐Gois, L., Rochet, V., Garrec, N., Suau, A., & Dore, J. M. (2003) · Systematic and Applied Microbiology · doi:10.1078/072320203322337399 · Cited by 101 · see citing works
Women With and Without Metabolic Disorder Differ in Their Gut Microbiota Composition
Munukka, E., Wiklund, P., Pekkala, S., Völgyi, E., Xu, L., Cheng, S., Lyytikäinen, A., Marjomäki, V., Alén, M., Vaahtovuo, J., et al. (2012) · Obesity · doi:10.1038/oby.2012.8 · Cited by 100 · see citing works
Self-citationSerum metabolic profiles in overweight and obese women with and without metabolic syndrome
Wiklund, P., Pekkala, S., Autio, R., Munukka, E., Xu, L., Saltevo, J. T., Cheng, S., Kujala, U. M., Alén, M., & Cheng, S. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-40 · Cited by 88 · see citing works
Self-citationTan, X. W., Alén, M., Cheng, S. M., Mikkola, T. M., Tenhunen, J., Lyytikäinen, A., Wiklund, P., Cong, F., Saarinen, A. J., Tarkka, I. M., et al. (2015) · Journal of Sleep Research · doi:10.1111/jsr.12283 · Cited by 87 · see citing works
Self-citationCheng, S., Wiklund, P., Autio, R., Borra, R., Ojanen, X., Xu, L., Törmäkangas, T., & Alén, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0138889 · Cited by 86 · see citing works
Self-citationIs the GI System Built For Exercise?
GISOLFI, C. V. (2000) · Physiology · doi:10.1152/physiologyonline.2000.15.3.114 · Cited by 84 · see citing works
Habitual exercise program protects murine intestinal, skeletal, and cardiac muscles against aging
Rosa, E. F., Silva, A. C., Ihara, S. S. M., Mora, O. A., Aboulafia, J., & Nouailhetas, V. L. A. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00417.2005 · Cited by 77 · see citing works
Gut-adipose tissue axis in hepatic fat accumulation in humans
Munukka, E., Pekkala, S., Wiklund, P., Rasool, O., Borra, R., Kong, L., Ojanen, X., Cheng, S. M., Roos, C., Tuomela, S., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.02.020 · Cited by 63 · see citing works
Self-citationVaahtovuo, J., Korkeamäki, M., Munukka, E., Viljanen, M. K., & Toivanen, P. (2005) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2005.03.017 · Cited by 44 · see citing works
Self-citationImpact of a very low-energy diet on the fecal microbiota of obese individuals
Simões, C. D., Maukonen, J., Scott, K. P., Virtanen, K. A., Pietiläinen, K. H., & Saarela, M. (2014) · European Journal of Nutrition · doi:10.1007/s00394-013-0645-0 · Cited by 39 · see citing works
Lyytikäinen, A., Lamberg-Allardt, C. J. E., Kannas, L. K., & Cheng, S. (2005) · Public Health Nutrition · doi:10.1079/phn2004703 · Cited by 35 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors
Fiuza-Luces, C., Santos-Lozano, A., Joyner, M., Carrera-Bastos, P., Picazo, O., Zugaza, J. L., Izquierdo, M., Ruilope, L. M., & Lucia, A. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0065-1 · Cited by 803 · see citing works
Mailing, L. J., Allen, J. M., Buford, T. W., Fields, C. J., & Woods, J. A. (2019) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000183 · Cited by 521 · see citing works
Gut Microbiota, Muscle Mass and Function in Aging: A Focus on Physical Frailty and Sarcopenia
Ticinesi, A., Nouvenne, A., Cerundolo, N., Catania, P., Prati, B., Tana, C., & Meschi, T. (2019) · Nutrients · doi:10.3390/nu11071633 · Cited by 418 · see citing works
Ticinesi, A., Lauretani, F., Milani, C., Nouvenne, A., Tana, C., Del Rio, D., Maggio, M., Ventura, M., & Meschi, T. (2017) · Nutrients · doi:10.3390/nu9121303 · Cited by 401 · see citing works
Mohr, A. E., Jäger, R., Carpenter, K. C., Kerksick, C. M., Purpura, M., Townsend, J. R., West, N. P., Black, K., Gleeson, M., Pyne, D. B., et al. (2020) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-00353-w · Cited by 378 · see citing works
“, 2017, Finland [94] Premenopausal females with low, moderate and highcardiorespiratory fitness (VO2max), n = 71, Low VO2max: 40.”
BackgroundInfluentialWolters, M., Ahrens, J., Romaní-Pérez, M., Watkins, C., Sanz, Y., Benítez-Páez, A., Stanton, C., & Günther, K. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.12.024 · Cited by 299 · see citing works
Martinez, J. E., Kahana, D. D., Ghuman, S., Wilson, H. P., Wilson, J. B., Kim, S. C. J., Lagishetty, V., Jacobs, J. P., Sinha‐Hikim, A. P., & Friedman, T. C. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.667066 · Cited by 233 · see citing works
Morita, E., Yokoyama, H., Imai, D., Takeda, R., Ota, A., Kawai, E., Hisada, T., Emoto, M., Suzuki, Y., & Okazaki, K. (2019) · Nutrients · doi:10.3390/nu11040868 · Cited by 169 · see citing works
Strasser, B., Wolters, M., Weyh, C., Krüger, K., & Ticinesi, A. (2021) · Nutrients · doi:10.3390/nu13062045 · Cited by 181 · see citing works
How Diet and Physical Activity Modulate Gut Microbiota: Evidence, and Perspectives
Campaniello, D., Corbo, M. R., Sinigaglia, M., Speranza, B., Racioppo, A., Altieri, C., & Bevilacqua, A. (2022) · Nutrients · doi:10.3390/nu14122456 · Cited by 173 · see citing works
Codella, R., Luzi, L., & Terruzzi, I. (2018) · Digestive and Liver Disease · doi:10.1016/j.dld.2017.11.016 · Cited by 158 · see citing works
Aya, V., Flórez, A., Perez, L., & Ramírez, J. D. (2021) · PLoS ONE · doi:10.1371/journal.pone.0247039 · Cited by 158 · see citing works
Varghese, S., Rao, S., Khattak, A., Zamir, F., & Chaari, A. (2024) · Nutrients · doi:10.3390/nu16213663 · Cited by 152 · see citing works
Exercise immunology: Future directions
Nieman, D. C., & Pence, B. D. (2019) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2019.12.003 · Cited by 148 · see citing works
Physical activity induced alterations of gut microbiota in humans: a systematic review
Dziewiecka, H., Buttar, H. S., Kasperska, A., Ostapiuk–Karolczuk, J., Domagalska, M., Cichoń-Woźniak, J., & Skarpańska-Stejnborn, A. (2022) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-022-00513-2 · Cited by 149 · see citing works
Influence of Exercise on the Human Gut Microbiota of Healthy Adults: A Systematic Review
Ortiz-Alvarez, L., Xu, H., & Martínez‐Téllez, B. (2020) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000126 · Cited by 146 · see citing works
A Review of the Role of the Gut Microbiome in Personalized Sports Nutrition
Hughes, R. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00191 · Cited by 141 · see citing works
Distinct microbiome composition and metabolome exists across subgroups of elite Irish athletes
O’Donovan, C. M., Madigan, S. M., Garcia-Perez, I., Rankin, A., O’ Sullivan, O., & Cotter, P. D. (2020) · Journal of Science and Medicine in Sport · doi:10.1016/j.jsams.2019.08.290 · Cited by 133 · see citing works
Mutual Interactions among Exercise, Sport Supplements and Microbiota
Zeppa, S. D., Agostini, D., Gervasi, M., Annibalini, G., Amatori, S., Ferrini, F., Sisti, D., Piccoli, G., Barbieri, E., Sestili, P., et al. (2019) · Nutrients · doi:10.3390/nu12010017 · Cited by 122 · see citing works
Exercise effects on cardiovascular disease: from basic aspects to clinical evidence
Sanchis‐Gomar, F., Lavie, C. J., Marín-Puyalto, J., Pérez-Quilis, C., Eijsvogels, T. M. H., O’Keefe, J. H., Perez, M. V., & Blair, S. N. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab272 · Cited by 99 · see citing works
Impact of Exercise on Gut Microbiota in Obesity
Aragón‐Vela, J., Solis‐Urra, P., Ruiz‐Ojeda, F. J., Álvarez‐Mercado, A. I., Arancibia, J. E. O., & Plaza‐Díaz, J. (2021) · Nutrients · doi:10.3390/nu13113999 · Cited by 84 · see citing works
Huang, W.-C., Chen, Y., Chuang, H.-L., Chiu, C.-C., & Huang, C. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01906 · Cited by 73 · see citing works
Cataldi, S., Bonavolontà, V., Poli, L., Clemente, F. M., De Candia, M., Carvutto, R., Silva, A. F., Badicu, G., Greco, G., & Fischetti, F. (2022) · Biology · doi:10.3390/biology11030479 · Cited by 68 · see citing works
An exercise intervention alters stool microbiota and metabolites among older, sedentary adults
Erlandson, K. M., Liu, J., Johnson, R. L., Dillon, S. M., Jankowski, C. M., Kroehl, M., Robertson, C. E., Frank, D. N., Tunçil, Y. E., HIGGINS, J. A., et al. (2021) · Therapeutic Advances in Infectious Disease · doi:10.1177/20499361211027067 · Cited by 50 · see citing works
Cataldi, S., Poli, L., Şahin, F. N., Patti, A., Santacroce, L., Bianco, A., Greco, G., Ghinassi, B., Baldassarre, A. D., & Fischetti, F. (2022) · Nutrients · doi:10.3390/nu14163293 · Cited by 55 · see citing works
Cella, V., Bimonte, V. M., Sabato, C., Paoli, A., Baldari, C., Campanella, M., Lenzi, A., Ferretti, E., & Migliaccio, S. (2021) · Foods · doi:10.3390/foods10123075 · Cited by 48 · see citing works
Morales, D., Shetty, S. A., Plaza, B. L., Gómez‐Candela, C., Smidt, H., Marín, F. R., & Soler‐Rivas, C. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02504-4 · Cited by 47 · see citing works
Resende, A. D. S., Leite, G. S., & Lancha, A. H. (2021) · Nutrients · doi:10.3390/nu13082839 · Cited by 44 · see citing works
Maillard, F., Vazeille, E., Sauvanet, P., Sirvent, P., Combaret, L., Sourdrille, A., Chavanelle, V., Bonnet, R., Otero, Y. F., Delcros, G., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214660 · Cited by 41 · see citing works
Schlegel, P., Novotný, M., Klímová, B., & Vališ, M. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190460 · Cited by 38 · see citing works
Šoltýs, K., Lendvorský, L., Hric, I., Baranovičová, E., Penesová, A., Mikula, I., Böhmer, M., Budiš, J., Vávrová, S., Grones, J., et al. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.670989 · Cited by 36 · see citing works
Zeppa, S. D., Amatori, S., Sisti, D., Gervasi, M., Agostini, D., Piccoli, G., Pazienza, V., Gobbi, P., Rocchi, M., Sestili, P., et al. (2021) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-021-00471-z · Cited by 35 · see citing works
Mach, N., Midoux, C., Leclercq, S., Pennarun, S., Moyec, L. L., Rué, O., Robert, C., Sallé, G., & Barrey, É. (2022) · Communications Biology · doi:10.1038/s42003-022-03977-7 · Cited by 36 · see citing works
The Effect of Athletes’ Probiotic Intake May Depend on Protein and Dietary Fiber Intake
Son, J., Jang, L.-G., Kim, B., Lee, S., & Park, H. (2020) · Nutrients · doi:10.3390/nu12102947 · Cited by 33 · see citing works
Komodromou, I., Andreou, E. P., Vlahoyiannis, A., Christofidou, M., Felekkis, K. N., Pieri, M., & Giannaki, C. D. (2024) · Nutrients · doi:10.3390/nu16050660 · Cited by 33 · see citing works
Gut Microbiota, Microbial Metabolites and Human Physical Performance
Lensu, S., & Pekkala, S. (2021) · Metabolites · doi:10.3390/metabo11110716 · Cited by 30 · see citing works
Forteza, F., Bourdeau‐Julien, I., Nguyen, G. Q. H., Agudelo, F. A. G., Rochefort, G., Parent, L., Rakotoarivelo, V., Feutry, P., Martin, C., Perron, J., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-10757-0 · Cited by 30 · see citing works
Ribeiro, F. M., Ribeiro, C. F. A., Garcia, A. C., de Castro, A. P., de Almeida, J. A., Franco, O. L., & Petriz, B. A. (2019) · Nutrients · doi:10.3390/nu11010149 · Cited by 29 · see citing works
Ghaffar, T., Ubaldi, F., Volpini, V., Valeriani, F., & Spica, V. R. (2024) · Sports · doi:10.3390/sports12080221 · Cited by 31 · see citing works
Carter, S. J., Hunter, G. R., Blackston, J. W., Liu, N., Lefkowitz, E. J., Pol, W. J. V. D., Morrow, C. D., Paulsen, J. A., & Rogers, L. Q. (2019) · Experimental Physiology · doi:10.1113/ep087404 · Cited by 27 · see citing works
Papageorgiou, M., & Biver, E. (2021) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x211009018 · Cited by 22 · see citing works
Optimizing the Gut Microbiota for Individualized Performance Development in Elite Athletes
Nolte, S., Krüger, K., Lenz, C., & Zentgraf, K. (2023) · Biology · doi:10.3390/biology12121491 · Cited by 24 · see citing works
Yasueda, A., Sekido, Y., Takeda, T., Ogino, T., Miyoshi, N., Takahashi, H., Uemura, M., Doki, Y., Eguchi, H., & Mizushima, T. (2021) · Nutrition · doi:10.1016/j.nut.2021.111526 · Cited by 20 · see citing works
The Role of G Protein-Coupled Receptors in the Regulation of Orthopaedic Diseases by Gut Microbiota
Sun, P., Liu, J., Chen, G., & Guo, Y. (2025) · Nutrients · doi:10.3390/nu17101702 · Cited by 18 · see citing works
Williams, C. J., Torquati, L., Li, Z., Lea, R. A., Croci, I., Keating, E., Little, J. P., Eynon, N., & Coombes, J. S. (2021) · Journal of Nutrition · doi:10.1093/jn/nxab426 · Cited by 18 · see citing works
An insight into gut microbiota and metabolites in the mice with adenomyosis
Chen, P., Wang, K., Zhuang, M., Fu, X., Liu, S., Chen, M., & Lei, Y. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1075387 · Cited by 17 · see citing works
Modulation of oral microbiota: A new frontier in exercise supplementation
Bescós, R., Brookes, Z. L. S., Belfield, L., Fernández‐Sanjurjo, M., & Casas‐Agustench, P. (2020) · PharmaNutrition · doi:10.1016/j.phanu.2020.100230 · Cited by 15 · see citing works
A Bibliometric Analysis on the Research Trend of Exercise and the Gut Microbiome
Deng, R., Wang, M., Song, Y., & Shi, Y. (2023) · Microorganisms · doi:10.3390/microorganisms11040903 · Cited by 19 · see citing works
Self-citationThe impact of preterm adversity on cardiorespiratory function
McDonald, F. B., Dempsey, E. M., & O’Halloran, K. D. (2019) · Experimental Physiology · doi:10.1113/ep087490 · Cited by 14 · see citing works
Uchida, M., Park, J., Fujie, S. J., Hosomi, K., Horii, N., Watanabe, K., Sanada, K., Shinohara, Y., Mizuguchi, K., Kunisawa, J., et al. (2024) · Physiological Reports · doi:10.14814/phy2.16100 · Cited by 11 · see citing works
Effects of Dietary Protein Levels on Bamei Pig Intestinal Colony Compositional Traits
Wang, D., Chen, G., Song, L., Chai, M., Wang, Y., Shui, S., Zhang, H., Sha, Y., & Yao, Y. (2020) · BioMed Research International · doi:10.1155/2020/2610431 · Cited by 11 · see citing works
Anhê, F. F., Zlitni, S., Barra, N. G., Foley, K. P., Nilsson, M. I., Nederveen, J. P., Koch, L. G., Britton, S. L., Tarnopolsky, M. A., & Schertzer, J. D. (2022) · Physiological Reports · doi:10.14814/phy2.15215 · Cited by 10 · see citing works
Leptin in the Respiratory Tract: Is There a Role in SARS-CoV-2 Infection?
Bruno, A., Ferrante, G., Vincenzo, S. D., Pace, E., & Grutta, S. L. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.776963 · Cited by 10 · see citing works
Martínez‐Téllez, B., Xu, H., Ortiz-Alvarez, L., Rodríguez‐García, C., Schönke, M., Jurado‐Fasoli, L., Osuna‐Prieto, F. J., Alcántara, J. M. A., Acosta, F. M., Amaro‐Gahete, F. J., et al. (2025) · Clinical Nutrition · doi:10.1016/j.clnu.2025.04.008 · Cited by 9 · see citing works
Álvarez‐Herms, J. (2024) · Microorganisms · doi:10.3390/microorganisms12061138 · Cited by 9 · see citing works
Sanborn, V. E., & Gunstad, J. (2020) · Geriatrics · doi:10.3390/geriatrics5040063 · Cited by 8 · see citing works
The athlete gut microbiota: state of the art and practical guidance
Pérez-Castillo, Í. M., Sabag-Daigle, A., Chicharro, J. L., Mihic, N., Rueda, R., & Bouzamondo, H. (2024) · Beneficial Microbes · doi:10.1163/18762891-bja00007 · Cited by 7 · see citing works
Sugimura, Y., Yang, Y., Kanda, A., Mawatari, A., Tamada, Y., Mikami, T., Nakaji, S., & Ihara, K. (2024) · Microorganisms · doi:10.3390/microorganisms12030622 · Cited by 7 · see citing works
Self-citationLittle, R. B., Carter, S. J., Motl, R. W., Hunter, G. R., Cook, A., Liu, N., Krontiras, H., Lefkowitz, E. J., Turan, B., Schleicher, E. A., et al. (2024) · BMJ Open · doi:10.1136/bmjopen-2023-081660 · Cited by 6 · see citing works
Morgado-Cáceres, P., Huerta, H., Bergman, C., Figueroa, R., Farías, P., Quiroz, G., Woehlbier, U., Mella, K., Díaz-Rivera, O., Linsambarth, S., et al. (2025) · Aging and Disease · doi:10.14336/ad.2025.0188 · Cited by 5 · see citing works
Advancements of physical exercise and intestinal microbiota and their potential mechanisms
Li, R., Zhang, T., Cheng, Z. L., Yao, C., Meng, X., & Ma, T. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1595118 · Cited by 4 · see citing works
Lietzén, M. S., Guzzardi, M. A., Ojala, R., Hentilä, J., Heiskanen, M. A., Honkala, S. M., Läutamaki, R., Löyttyniemi, E., Kirjavainen, A. K., Rajander, J., et al. (2024) · Nutrients · doi:10.3390/nu16203554 · Cited by 4 · see citing works
Relationship between Gut-Microbiota and Sport Activity
Mokarrami, A., Capacci, A., Trio, B., Merra, G., & Canosci, D. D. M. (2024) · Central European Journal of Sport Sciences and Medicine · doi:10.18276/cej.2024.1-03 · Cited by 4 · see citing works
Cho, J. M., Park, S.-K., Babu, A. K. S., Mookherjee, S., Hansen, M., Petersen, C., Zhong, Y., Jalili, T., Robeson, M. S., Wankhade, U. D., et al. (2026) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00354.2025 · Cited by 2 · see citing works
Precision Nutrition in Exercise and Sports Performance
Cooper, C., & Heber, D. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15315-0.00004-3 · Cited by 2 · see citing works
Exercise in Metabolic Syndrome and Diabetes: A Central Role for Insulin Sensitivity
Schauer, I. E., Regensteiner, J. G., & Reusch, J. E. B. (2019) · Contemporary Endocrinology · doi:10.1007/978-3-030-25057-7_18 · Cited by 2 · see citing works
Wood, A., Glynn, T. K., & Cahalin, L. P. (2022) · Journal of Womenʼs Health Physical Therapy · doi:10.1097/jwh.0000000000000249 · Cited by 2 · see citing works
Meng, D., He, S., Wei, M., Lv, Z., Yang, G., & Wang, Z. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.115190 · Cited by 1 · see citing works
Physical Activity Induced Alterations of Gut Microbiota in Humans: A Systematic ReviewPreprint
Dziewiecka, H., Buttar, H. S., Kasperska, A., Ostapiuk–Karolczuk, J., Domagalska, M., Cichoń-Woźniak, J., & Skarpańska-Stejnborn, A. (2022) · Research Square · doi:10.21203/rs.3.rs-1533424/v1 · Cited by 1 · see citing works
Villanueva, E. M. G. D. P. (2018) · doi:10.4995/thesis/10251/114770
Liu, D.-Q., Yang, C.-X., Guo, T.-Y., Guo, Y., Xiong, J.-J., Chen, R., & Deng, S. (2025) · Healthcare · doi:10.3390/healthcare13091018
Relationship between gut microbiota and exercise
Morita, H. (2025) · Japanese Journal of Lactic Acid Bacteria · doi:10.4109/jslab.36.51
- Authors
- Yang, Y., Shi, Y., Wiklund, P., Tan, X., Wu, N., Zhang, X., Tikkanen, O., Zhang, C., Munukka, E., & Cheng, S.
- Affiliations
- Shanghai Jiao Tong University (CN)
- University of Turku (FI)
- Corresponding author
- Shi, Yi
- Cheng, Sulin
- ORCID
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2017-07-25
- Volume
- 9
- Issue
- 8
- Pages
- 792
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC5579588
- OpenAlex
- W2739180281
- Cited by
- 72
- References
- 49
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 10 · 2023: 4 · 2022: 9 · 2021: 16 · 2020: 7 · 2019: 13 · 2018: 3 · 2017: 2
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Jyväskylä University Digital Archive (University of Jyväskylä) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- China State Sport General Administration (2015B039)
- Academy of Finland (Grant 24302031)
- National Natural Science Foundation of China (31571219)
- Shanghai Jiao Tong University Zhiyuan Foundation (CP2014013)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- cardiorespiratory fitness, gut microbiota, premenopausal women, VO2max, Bacteroides, adiposity, leptin, triglycerides, dietary fat intake, carbohydrate intake, HDL cholesterol
- MeSH terms
- Gastrointestinal Microbiome, Cardiorespiratory Fitness, Adult, Bacteroides, Body Composition, Cholesterol, Clostridium, Cross-Sectional Studies, Dietary Carbohydrates, Dietary Fats, Dietary Proteins, DNA, Bacterial, Eubacterium, Feces, Female, Finland, Humans, Middle Aged, Oxygen Consumption, Physical Fitness, RNA, Ribosomal, 16S, Triglycerides, Exercise, Sequence Analysis, DNA, Premenopause, Leptin, White People, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
