The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
Open accessAbstract
Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed exome sequencing and copy number analysis to define genomic aberrations in a prospectively accrued clinical cohort (n = 142) of early (stage I and II) sporadic pancreatic ductal adenocarcinoma. Detailed analysis of 99 informative tumours identified substantial heterogeneity with 2,016 non-silent mutations and 1,628 copy-number variations. We define 16 significantly mutated genes, reaffirming known mutations (KRAS, TP53, CDKN2A, SMAD4, MLL3, TGFBR2, ARID1A and SF3B1), and uncover novel mutated genes including additional genes involved in chromatin modification (EPC1 and ARID2), DNA damage repair (ATM) and other mechanisms (ZIM2, MAP2K4, NALCN, SLC16A4 and MAGEA6). Integrative analysis with in vitro functional data and animal models provided supportive evidence for potential roles for these genetic aberrations in carcinogenesis. Pathway-based analysis of recurrently mutated genes recapitulated clustering in core signalling pathways in pancreatic ductal adenocarcinoma, and identified new mutated genes in each pathway. We also identified frequent and diverse somatic aberrations in genes described traditionally as embryonic regulators of axon guidance, particularly SLIT/ROBO signalling, which was also evident in murine Sleeping Beauty transposon-mediated somatic mutagenesis models of pancreatic cancer, providing further supportive evidence for the potential involvement of axon guidance genes in pancreatic carcinogenesis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Among the identified genomic alterations (GAs) in PDAC, oncogenic KRAS mutations are the most common, occurring in close to 90% of patients, followed by TP53, CDKN2A, and SMAD47,8.”
From Impact of KRAS mutations and co-mutations on clinical outcomes in pancreatic ductal adenocarcinoma (2024) · cites this paper as [7]
In the citing paper
“Amongst these are four canonical mutations – KRAS (~85%), TP53 (60–70%), CDKN2A (>50%), and SMAD4 (~50%).”
From KRAS mutation in pancreatic cancer (2021) · cites this paper as [50]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
Jemal, A., Siegel, R., Xu, J., & Ward, E. (2010) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20073 · Cited by 12,596
Trastuzumab-Induced Hepatotoxicity: A Case Report
Vucicevic, D., Carey, E. J., & Karlin, N. J. (2013) · Breast Care · doi:10.1159/000346844 · Cited by 4,432
Brocken, P., van der Heijden, E. H. F. M., Dekhuijzen, P. N. R., Peters-Bax, L., & de Geus‐Oei, L. (2013) · Respiration · doi:10.1159/000347096 · Cited by 4,011
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969
Self-citationMermel, C. H., Schumacher, S. E., Hill, B., Meyerson, M. M., Beroukhim, R., & Getz, G. A. (2011) · Genome biology · doi:10.1186/gb-2011-12-4-r41 · Cited by 3,520
International network of cancer genome projects
The International Cancer Genome Consortium (2010) · Nature · doi:10.1038/nature08987 · Cited by 2,299
Self-citationNeoptolemos, J. P., Stocken, D. D., Bassi, C., Ghaneh, P., Cunningham, D., Goldstein, D., Padbury, R., Moore, M. J., Gallinger, S., Mariette, C., et al. (2010) · JAMA · doi:10.1001/jama.2010.1275 · Cited by 1,395
Self-citationThe patterns and dynamics of genomic instability in metastatic pancreatic cancer
Campbell, P. J., Yachida, S., Mudie, L. J., Stephens, P. J., Pleasance, E. D., Stebbings, L. A., Morsberger, L. A., Latimer, C., McLaren, S., Lin, M.-L., et al. (2010) · Nature · doi:10.1038/nature09460 · Cited by 1,317
Self-citationExome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
Varela, I., Tarpey, P. S., Raine, K. M., Huang, D., Ong, C. K., Stephens, P., Davies, H. R., Jones, D., Lin, M., Teague, J. W., et al. (2011) · Nature · doi:10.1038/nature09639 · Cited by 1,302
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 901–1,000 of 1,002
Fan, W. Q., Shi, W., Zhang, W., Jia, Y., Zhou, Z., Brusnahan, S. K., & Garrison, J. C. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.05.036 · Cited by 29
Shimada, Y., Kohno, T., Ueno, H., Ino, Y., Hayashi, H., Nakaoku, T., Sakamoto, Y., Kondo, S., Morizane, C., Shimada, K., et al. (2017) · The Oncologist · doi:10.1634/theoncologist.2016-0194 · Cited by 28
Cozzitorto, C., & Spagnoli, F. M. (2019) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2018.12.005 · Cited by 29
Sieow, J. L., Penny, H. L., Gun, S. Y., Tan, L. Q., Duan, K., Yeong, J. P. S., Pang, A., Lim, D., Toh, H. C., Lim, T. K. H., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24010753 · Cited by 27
Genomic alterations in pancreatic cancer and their relevance to therapy
Takai, E., & Yachida, S. (2015) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v7.i10.250 · Cited by 27
SIBLINGs and SPARC families: Their emerging roles in pancreatic cancer
Kaleağasıoğlu, F. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i40.14747 · Cited by 27
Low RASSF6 expression in pancreatic ductal adenocarcinoma is associated with poor survival
Ye, H. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i21.6621 · Cited by 27
Quattrochi, B., Gulvady, A., Driscoll, D. R., Sano, M., Klimstra, D., Turner, C., & Lewis, B. (2017) · OncoTarget · doi:10.18632/oncotarget.16277 · Cited by 32
Saxena, S., Hayashi, Y., Wu, L., Awaji, M. I., Atri, P., Varney, M. L., Purohit, A., Rachagani, S., Batra, S. K., & Singh, R. K. (2017) · Oncotarget · doi:10.18632/oncotarget.23644 · Cited by 27
Takeuchi, M., Tanikawa, M., Nagasaka, K., Oda, K., Kawata, Y., Oki, S., Chuwa, A. H., Sone, K., Miyagawa, Y., Hiraike, H., et al. (2019) · Cancers · doi:10.3390/cancers11121913 · Cited by 30
A CRISPR-Cas9 repressor for epigenetic silencing of KRAS
Liu, J., Sun, M., Cho, K. B., Gao, X., & Guo, B. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105304 · Cited by 28
Hoyer, K., Hablesreiter, R., Inoue, Y., Yoshida, K., Briest, F., Christen, F., Kakiuchi, N., Yoshizato, T., Shiozawa, Y., Shiraishi, Y., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103327 · Cited by 26
Molecular alterations in pancreatic tumors
Visani, M., Acquaviva, G., Leo, A. D., Sanza, V., Merlo, L., Maloberti, T., Brandes, A. A., Franceschi, E., Battista, M. D., Masetti, M., et al. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i21.2710 · Cited by 29
Identifying Critical States of Complex Diseases by Single-Sample Jensen-Shannon Divergence
Yan, J., Li, P., Gao, R. B., Li, Y., & Chen, L. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.684781 · Cited by 27
van der Sijde, F., Homs, M. Y. V., van Bekkum, M. L., van den Bosch, T. P. P., Bosscha, K. P., Besselink, M. G., Bonsing, B. A., de Groot, J. W. B., Karsten, T. M., Koerkamp, B. G., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222010902 · Cited by 27
Impact of alternative splicing on mechanisms of resistance to anticancer drugs
Reviejo, M., Soto, M., Lozano, E., Asensio, M., Martínez‐Augustin, O., de Medina, F. S., & Marı́n, J. J. G. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114810 · Cited by 28
Bansod, S., Dodhiawala, P. B., & Lim, K. (2021) · Cancers · doi:10.3390/cancers13215481 · Cited by 28
Huang, X., Huang, K., Johnson, T. S., Radovich, M., Zhang, J., Ma, J., & Wang, Y. (2021) · NAR Genomics and Bioinformatics · doi:10.1093/nargab/lqab097 · Cited by 26
The role of alternative pre-mRNA splicing in cancer progression
Choi, S., Cho, N., Kim, E.-M., & Kim, K. K. (2023) · Cancer Cell International · doi:10.1186/s12935-023-03094-3 · Cited by 32
Xu, W., Liu, J., Zhang, J., Lu, J., & Guo, J. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.189032 · Cited by 27
Cortesi, A., Gandolfi, F., Arco, F., Chiaro, P. D., Valli, E., Polletti, S., Noberini, R., Gualdrini, F., Attanasio, S., Citron, F., et al. (2024) · Science Advances · doi:10.1126/sciadv.adk5386 · Cited by 29
Rhabdoid Tumors: An Initial Clue to the Role of Chromatin Remodeling in Cancer
Lee, R. S., & Roberts, C. W. M. (2013) · Brain Pathology · doi:10.1111/bpa.12021 · Cited by 27
Simpson, H. M., Khan, R. Z., Song, C. H., Sharma, D., Sadashivaiah, K., Furusawa, A., Liu, X., Nagaraj, S., Sengamalay, N. A., Sadzewicz, L., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141906 · Cited by 27
Incorporation of Biological Knowledge Into the Study of Gene-Environment Interactions
Ritchie, M. D., Davis, J. R., Aschard, H., Battle, A. J., Conti, D. V., Du, M., Eskin, E., Fallin, M. D., Hsu, L., Kraft, P. L., et al. (2017) · American Journal of Epidemiology · doi:10.1093/aje/kwx229 · Cited by 28
Prognostic Role of KRAS mRNA Expression in Breast Cancer
Hwang, K., Kim, B. H., Oh, S., Park, S. Y., Jung, J., Kim, J.-J., Choi, I. S., Jeon, S. Y., & Kim, W. (2019) · Journal of Breast Cancer · doi:10.4048/jbc.2019.22.e55 · Cited by 27
Hussung, S., Follo, M., Klar, R. F. U., Michalczyk, S., Fritsch, K., Nollmann, F. I., Hipp, J., Duyster, J., Scherer, F., von Bubnoff, N. C. C., et al. (2020) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2020.04.206 · Cited by 28
New and emerging treatment options for biliary tract cancer
Hezel, A. F., & Noel, M. S. (2013) · OncoTargets and Therapy · doi:10.2147/ott.s32545 · Cited by 26
Andrei, A.-Z., Hall, A., Smith, A. L., Bascuñana, C., Malina, A., Connor, A. A., Altinel-Omeroglu, G., Huang, S., Pelletier, J., Huntsman, D. D., et al. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.04.003 · Cited by 26
Self-citationAdvances in Molecular Pathology and Treatment of Periampullary Cancers
Chandrasegaram, M. D., Chen, J. W., Price, T. J., Zalcberg, J. R., Sjoquist, K. M., & Merrett, N. D. (2015) · Pancreas · doi:10.1097/mpa.0000000000000385 · Cited by 26
Self-citationInhibiting the RAS–PI3K Pathway in Cancer Therapy
Sheridan, C., & Downward, J. (2013) · The Enzymes · doi:10.1016/b978-0-12-420146-0.00005-6 · Cited by 25
Lu, S., Ahmed, T., Du, P., & Wang, Y. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061201 · Cited by 27
Lin, J., Wu, Y., Liang, X., Ji, M., Ying, H., Wang, X., Sun, X., Shao, C., Zhan, L., & Zhang, Y. (2018) · Molecular Carcinogenesis · doi:10.1002/mc.22920 · Cited by 26
Maji, D., Grossfield, A. M., & Kielkopf, C. L. (2019) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2019.194440 · Cited by 27
Updated risk factors to inform early pancreatic cancer screening and identify high risk patients
Principe, D. R., & Rana, A. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.04.022 · Cited by 27
Xiao, Z., Wu, W. Y.-Y., Wu, C., Li, M., Sun, F.-M., Zheng, L., Liu, G.-J., Li, X., Yun, Z., Tang, J., et al. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12833 · Cited by 26
Yang, J., Huo, Y., Yang, M., Shen, Y., Liu, D., Fu, X., Tao, L., He, R., Zhang, J., Hua, R., et al. (2021) · Molecular Oncology · doi:10.1002/1878-0261.12970 · Cited by 26
Hafezi, S., Saber-Ayad, M. M., & Abdel‐Rahman, W. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910219 · Cited by 28
Current and emerging therapeutic strategies in pancreatic cancer: Challenges and opportunities
Manrai, M., Tilak, T., Dawra, S., Srivastava, S., & Singh, A. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i39.6572 · Cited by 25
Ultrasounds in cancer therapy: A summary of their use and unexplored potential
Dıáz-Alejo, J. F., González, I., & Earl, J. (2022) · Oncology Reviews · doi:10.4081/oncol.2022.531 · Cited by 26
Jo, J. H., Jung, D., Lee, H. S., Park, S. B., Chung, M. J., Park, J. Y., Bang, S., Park, S. W., Cho, S., & Song, S. Y. (2022) · International Journal of Cancer · doi:10.1002/ijc.34144 · Cited by 26
Self-citationApplication of high-throughput single-nucleus DNA sequencing in pancreatic cancer
Zhang, H., Karnoub, E.-R. R., Umeda, S., Chaligné, R., Masilionis, I., McIntyre, C. A., Sashittal, P., Hayashi, A., Zucker, A., Mullen, K. M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36344-z · Cited by 24
Self-citationComplex metastatic niches: already a target for therapy?
Ordóñez‐Morán, P., & Huelsken, J. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.06.012 · Cited by 26
Sorber, R. A., Teper, Y., Abisoye-Ogunniyan, A., Waterfall, J. J., Davis, S. R., Killian, J. K., Pineda, M. A., Ray, S., McCord, M., Pflicke, H., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149833 · Cited by 26
Role of RHOT1 on migration and proliferation of pancreatic cancer.
Li, Q., Yao, L., Wei, Y., Geng, S., He, C., & Jiang, H. (2015) · Europe PMC (PubMed Central) · Cited by 26
Woo, W., Carey, E. T., & Choi, M. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s167590 · Cited by 26
Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells
Bakke, J., Wright, W. C., Zamora, A. E., Oladimeji, P. O., Crawford, J. C., Brewer, C., Autry, R. J., Evans, W. E., Thomas, P. G., & Chen, T. (2019) · BMC Cancer · doi:10.1186/s12885-019-5455-1 · Cited by 26
Li, Z., Shao, C., Liu, X., Lu, X., Jia, X., Zheng, X., Wang, S., Zhu, L., Li, K., Pang, Y., et al. (2019) · Carcinogenesis · doi:10.1093/carcin/bgz086 · Cited by 26
Medullary Pancreatic Carcinoma Due to Somatic POLE Mutation
Kryklyva, V., ter Linden, E., Kroeze, L. I., de Voer, R. M., Kolk, B., Stommel, M. W. J., Hermans, J. J., Luchini, C., Wood, L. D., Hruban, R. H., et al. (2020) · Pancreas · doi:10.1097/mpa.0000000000001588 · Cited by 26
Self-citationAn open access pilot freely sharing cancer genomic data from participants in Texas
Becnel, L. B., Pereira, S., Drummond, J., Gingras, M., Covington, K. R., Kovar, C., Doddapaneni, H., Hu, J., Muzny, D. M., McGuire, A. L., et al. (2016) · Scientific Data · doi:10.1038/sdata.2016.10 · Cited by 26
Self-citationRodríguez, C., Furlan, C. L. A., Tosello, J., Bossio, S. N., Boccardo, S., Fozzatti, L., Canale, F. P., Beccaría, C. G., Núñez, N. G., Ceschin, D. G., et al. (2023) · OncoImmunology · doi:10.1080/2162402x.2023.2261326 · Cited by 26
Optimizing drug design by merging generative AI with a physics-based active learning framework
Filella-Mercè, I., Molina, A., Díaz, L., Orzechowski, M., Berchiche, Y. A., Zhu, Y. M., Vilalta-Mor, J., Malo, L., Yekkirala, A. S., Ray, S. S., et al. (2025) · Communications Chemistry · doi:10.1038/s42004-025-01635-7 · Cited by 46
Molecular imaging in pancreatic cancer – A roadmap for therapeutic decisions
Krämer-Marek, G., Gore, J., & Korc, M. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.08.008 · Cited by 25
A historical perspective of pancreatic cancer mouse models
Colvin, E. K., & Scarlett, C. J. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.03.025 · Cited by 26
Self-citationPhotosensitizers Binding to Nucleic Acids as Anticancer Agents
Xodo, L. E., Cogoi, S., & Rapozzi, V. (2016) · Future Medicinal Chemistry · doi:10.4155/fmc.15.180 · Cited by 26
Mutations of RNA splicing factors in hematological malignancies
Shukla, G. C., & Singh, J. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.08.042 · Cited by 25
Characterization of genetic subclonal evolution in pancreatic cancer mouse models
Niknafs, N., Zhong, Y., Moral, J. A., Zhang, L., Shao, M. X., Lo, A., Makohon-Moore, A. P., Iacobuzio–Donahue, C. A., & Karchin, R. (2019) · Nature Communications · doi:10.1038/s41467-019-13100-w · Cited by 26
Self-citationUpcoming Revolutionary Paths in Preclinical Modeling of Pancreatic Adenocarcinoma
Swayden, M., Soubeyran, P., & Iovanna, J. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2019.01443 · Cited by 27
Harbhajanka, A., Michael, C. W., Janaki, N., Gokozan, H. N., Wasman, J. K., Bomeisl, P., Yoest, J. M., & Sadri, N. (2020) · Modern Pathology · doi:10.1038/s41379-020-0577-1 · Cited by 25
Ou, K., Liu, X., Li, W., Yang, Y., Ying, J., & Yang, L. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.724815 · Cited by 25
Li, H., Qi, W.-L., Wang, Y., & Meng, L. (2021) · Genes & Diseases · doi:10.1016/j.gendis.2021.08.011 · Cited by 28
Sekita‐Hatakeyama, Y., Fujii, T., Nishikawa, T., Mitoro, A., Sawai, M., Itami, H., Morita, K., Uchiyama, T., Takeda, M., Sho, M., et al. (2021) · Cancer Cytopathology · doi:10.1002/cncy.22525 · Cited by 24
Zhan, Q., Wen, C., Zhao, Y., Fang, L., Jin, Y., Zhang, Z., Zou, S., Li, F., Yang, Y., Wu, L., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103716 · Cited by 25
van Roey, R., Brabletz, T., Stemmler, M. P., & Armstark, I. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.753456 · Cited by 26
Dalmasso, B., Puccini, A., Catalano, F., Borea, R., Iaia, M. L., Bruno, W., Fornarini, G., Sciallero, S., Rebuzzi, S. E., & Ghiorzo, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094709 · Cited by 25
Integrative genomic and functional profiling of the pancreatic cancer genome
Shain, A. H., Salari, K., Giacomini, C. P., & Pollack, J. R. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-624 · Cited by 25
Clonal Evolution and Therapeutic Resistance in Solid Tumors
Barrett, M. T., Lenkiewicz, E., Evers, L., Holley, T., Ruiz, C. F., Bubendorf, L., Sekulic, A., Ramanathan, R. K., & Hoff, D. D. V. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00002 · Cited by 25
Variant Profiling of Candidate Genes in Pancreatic Ductal Adenocarcinoma
Huang, J., Löhr, M. J., NILSSON, M. H. L., Segersvärd, R., Matsson, H., Verbeke, C. S., Heuchel, R. L., Kere, J., Iafrate, A. J., Zheng, Z., et al. (2015) · Clinical Chemistry · doi:10.1373/clinchem.2015.238543 · Cited by 27
Martínez‐Useros, J., & García‐Foncillas, J. (2016) · BioMed Research International · doi:10.1155/2016/1869304 · Cited by 25
Reviewing the Utility of EUS FNA to Advance Precision Medicine in Pancreatic Cancer
Berry, W., Lundy, J., Croagh, D. G., & Jenkins, B. J. (2018) · Cancers · doi:10.3390/cancers10020035 · Cited by 27
Yoon, K., Woo, S. M., Kim, Y., Kong, S., Lee, M. K., Han, S., Kim, T. H., Lee, W. J., & Park, S. (2019) · Gut and Liver · doi:10.5009/gnl18355 · Cited by 25
Deciphering The Potential Role of Hox Genes in Pancreatic Cancer
Kuo, T., Cheng, K., Chen, L., & Hung, W. (2019) · Cancers · doi:10.3390/cancers11050734 · Cited by 25
Andriamanantena, M., Danthu, P., Cardon, D., Razafimbelo, F. F., Ramaroson‐Raonizafinimanana, B., Razafintsalama, V. E., Rakotonandrasana, S. R., Ethève, A., Petit, T., & Caro, Y. (2019) · Chemistry & Biodiversity · doi:10.1002/cbdv.201900442 · Cited by 25
PDAC as an immune evasive disease: can 3D model systems aid to tackle this clinical problem?
Narayanan, S., Vicent, S., & Ponz-Sarvisé, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.787249 · Cited by 24
Lost in translation: returning germline genetic results in genome-scale cancer research
Initiative, A. P. C. G., Johns, A. L., McKay, S. H., Humphris, J. L., Pinese, M., Chantrill, L. A., Mead, R. S., Tucker, K., Andrews, L., Goodwin, A., et al. (2017) · Genome Medicine · doi:10.1186/s13073-017-0430-4 · Cited by 79
Self-citationYavas, A., Özcan, K., Adsay, V. N., Balcı, S., Tarcan, Z. C., Hechtman, J. F., Luchini, C., Scarpa, A., Lawlor, R. T., Mafficini, A., et al. (2024) · Modern Pathology · doi:10.1016/j.modpat.2024.100585 · Cited by 24
Self-citationGenome variation and personalized cancer medicine
Hudson, T. J. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12097 · Cited by 25
Self-citationChanging the course of pancreatic cancer – Focus on recent translational advances
Javle, M. M., Golan, T., & Maitra, A. (2016) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2016.01.004 · Cited by 24
Self-citationEnhanced expression of semaphorin 3E is involved in the gastric cancer development
Maejima, R., Tamai, K., Shiroki, T., Yokoyama, M., Shibuya, R., Nakamura, M., Yamaguchi, K., Abue, M., Oikawa, T., Noguchi, T., et al. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3593 · Cited by 24
Jing, W., Song, N., Liu, Y., Qu, X., Qi, Y., Li, C., Hou, K., Che, X., & Yang, X.-H. (2019) · Cancer Management and Research · doi:10.2147/cmar.s201610 · Cited by 24
Is there a CDKN2A-centric network in pancreatic ductal adenocarcinoma?
Wu, C. L., Yang, P., Liu, B., & Tang, Y. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s232464 · Cited by 29
Liu, S., Yu, J., Creeden, J. F., Sutton, J. M., Markowiak, S. F., Sanchez, R., Nemunaitis, J. J., Nestor‐Kalinoski, A. L., Zhang, J., Damoiseaux, R. D., et al. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.08.002 · Cited by 24
Animal Models of Cancer-Related Pain: Current Perspectives in Translation
Pineda-Farías, J. B., Saloman, J. L., & Scheff, N. N. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.610894 · Cited by 24
Roles of the nervous system in pancreatic cancer
Wakiya, T., Ishido, K., Yoshizawa, T., Kanda, T., & Hakamada, K. (2021) · Annals of Gastroenterological Surgery · doi:10.1002/ags3.12459 · Cited by 22
Bianchi, G., Czarnecki, P. G., Ho, M., Roccaro, A. M., Sacco, A., Kawano, Y., Gullà, A., Samur, A. A., Chen, T., Wen, K., et al. (2021) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-20-0164 · Cited by 24
Ghareyazi, A., Mohseni, A., Dashti, H., Beheshti, A., Dehzangi, A., Rabiee, H. R., & Alinejad‐Rokny, H. (2021) · Cancers · doi:10.3390/cancers13174376 · Cited by 24
KRAS G12C fragment screening renders new binding pockets
Mathieu, M., Steier, V., Fassy, F., Delorme, C., Papin, D., Genêt, B., Duffieux, F., Bertrand, T., Delarbre, L., Le-Borgne, H., et al. (2021) · Small GTPases · doi:10.1080/21541248.2021.1979360 · Cited by 24
Kuznetsova, A. V., Попова, О. П., Panchenkov, D. N., Dyuzheva, Т. G., & Aa, I. (2022) · Clinical and Experimental Medicine · doi:10.1007/s10238-022-00886-1 · Cited by 24
Emerging roles of hnRNP A2B1 in cancer and inflammation
Xu, H., Li, P., Wang, X., Zhuang, H., & Hua, Z. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.09.104 · Cited by 27
Identification and affinity enhancement of T-cell receptor targeting a KRASG12V cancer neoantigen
Zhang, M., Xu, W. L., Luo, L., Guan, F., Wang, X., Zhu, P., Zhang, J., Zhou, X., Wang, F., & Ye, S. (2024) · Communications Biology · doi:10.1038/s42003-024-06209-2 · Cited by 24
Pircher, A., Fiegl, M., Untergasser, G., Heidegger, I. M., Medinger, M., Kern, J., & Hilbe, W. (2013) · Lung Cancer · doi:10.1016/j.lungcan.2013.04.014 · Cited by 24
Frequency and distribution of Notch mutations in tumor cell lines
Mutvei, A. P., Fredlund, E., & Lendahl, U. (2015) · BMC Cancer · doi:10.1186/s12885-015-1278-x · Cited by 24
SWI/SNF Chromatin Remodeling Enzymes in Melanocyte Differentiation and Melanoma
Mehrotra, A., Mehta, G., Aras, S., Trivedi, A. R., & de la Serna, I. L. (2014) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukaryotgeneexpr.2014007882 · Cited by 25
Pancreatic cancer genomics: insights and opportunities for clinical translation
Makohon-Moore, A. P., Brosnan‐Cashman, J. A., & Iacobuzio–Donahue, C. A. (2013) · Genome Medicine · doi:10.1186/gm430 · Cited by 25
Self-citationSawai, Y., Kodama, Y., Shimizu, T., Ota, Y., Maruno, T., Eso, Y., Kurita, A., Shiokawa, M., Tsuji, Y., Uza, N., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3028 · Cited by 24
Brunet, L. R., Hagemann, T., Gaya, A. M., Mudan, S., & Marabelle, A. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1112942 · Cited by 25
Genomic alterations and molecular subtypes of gastric cancers in Asians
Ye, X. S., Yu, C., Aggarwal, A., & Reinhard, C. (2016) · 癌症：英文版 · doi:10.1186/s40880-016-0106-2 · Cited by 24
Inflammation, Biomarkers and Immuno-Oncology Pathways in Pancreatic Cancer
Lee, B., & Gibbs, P. (2019) · Journal of Personalized Medicine · doi:10.3390/jpm9020020 · Cited by 24
Saha, G., Singh, R., Mandal, A., Das, S. K., Chattopadhyay, E., Panja, P., Roy, P., Sarkar, N. D., Gulati, S., Ghatak, S., et al. (2020) · Molecular Medicine · doi:10.1186/s10020-020-00183-1 · Cited by 23
Personalising pancreas cancer treatment: When tissue is the issue
Sjoquist, K. M. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i24.7849 · Cited by 24
Pan, T., Zhang, Y., Zhou, N., He, X., Chen, C., Liang, L., Duan, X., Lin, Y., Wu, K., & Zhang, H. (2016) · Oncotarget · doi:10.18632/oncotarget.9996 · Cited by 21
Metadata
- Authors
- Initiative, A. P. C. G., Biankin, A. V., Waddell, N., Kassahn, K. S., Gingras, M.-C., Muthuswamy, L. B., Johns, A. L., Miller, D. K., Wilson, P. J., Patch, A.-M., Wu, J., Chang, D. K., Cowley, M. J., Gardiner, B. B., Song, S., Harliwong, I., Idrisoglu, S., Nourse, C., Nourbakhsh, E., Manning, S., Wani, S., Gongora, M., Pajic, M., Scarlett, C. J., Gill, A. J., Pinho, A. V., Rooman, I., Anderson, M., Holmes, O., Leonard, C., Taylor, D., Wood, S., Xu, Q., Nones, K., Lynn Fink, J., Christ, A., Bruxner, T., Cloonan, N., Kolle, G., Newell, F., Pinese, M., Scott Mead, R., Humphris, J. L., Kaplan, W., Jones, M. D., Colvin, E. K., Nagrial, A. M., Humphrey, E. S., Chou, A., Chin, V. T., Chantrill, L. A., Mawson, A., Samra, J. S., Kench, J. G., Lovell, J. A., Daly, R. J., Merrett, N. D., Toon, C., Epari, K., Nguyen, N. Q., Barbour, A., Zeps, N., Kakkar, N., Zhao, F., Qing Wu, Y., Wang, M., Muzny, D. M., Fisher, W. E., Charles Brunicardi, F., Hodges, S. E., Reid, J. G., Drummond, J., Chang, K., Han, Y., Lewis, L. R., Dinh, H., Buhay, C. J., Beck, T., Timms, L., Sam, M., Begley, K., Brown, A., Pai, D., Panchal, A., Buchner, N., De Borja, R., Denroche, R. E., Yung, C. K., Serra, S., Onetto, N., Mukhopadhyay, D., Tsao, M.-S., Shaw, P. A., Petersen, G. M., Gallinger, S., Hruban, R. H., Maitra, A., Iacobuzio-Donahue, C. A., Schulick, R. D., Wolfgang, C. L., Morgan, R. A., Lawlor, R. T., Capelli, P., Corbo, V., Scardoni, M., Tortora, G., Tempero, M. A., Mann, K. M., Jenkins, N. A., Perez-Mancera, P. A., Adams, D. J., Largaespada, D. A., Wessels, L. F. A., Rust, A. G., Stein, L. D., Tuveson, D. A., Copeland, N. G., Musgrove, E. A., Scarpa, A., Eshleman, J. R., Hudson, T. J., Sutherland, R. L., Wheeler, D. A., Pearson, J. V., McPherson, J. D., Gibbs, R. A., & Grimmond, S. M.
- Affiliations
- Garvan Institute of Medical Research (AU)
- The University of Queensland (AU)
- Ontario Institute for Cancer Research (CA)
- The University of Sydney (AU)
- Royal Adelaide Hospital (AU)
- St John of God Subiaco Hospital (AU)
- Baylor College of Medicine (US)
- University of California, Los Angeles (US)
- University Health Network (CA)
- Johns Hopkins University (US)
- University of Verona (IT)
- Houston Methodist (US)
- University of Minnesota (US)
- Wellcome Sanger Institute (GB)
- Corresponding author
- Grimmond, Sean M.
- ORCID
- Biankin, Andrew V.
- Waddell, Nicola
- Kassahn, Karin S.
- Gingras, Marie-Claude
- Muthuswamy, Lakshmi B.
- Johns, Amber L.
- Wilson, Peter J.
- Patch, Ann-Marie
- Wu, Jianmin
- Chang, David K.
- Cowley, Mark J.
- Gardiner, Brooke B.
- Song, Sarah
- Harliwong, Ivon
- Nourbakhsh, Ehsan
- Manning, Suzanne
- Wani, Shivangi
- Pajic, Marina
- Scarlett, Christopher J.
- Gill, Anthony J.
- Pinho, Andreia V.
- Rooman, Ilse
- Anderson, Matthew
- Holmes, Oliver
- Leonard, Conrad
- Wood, Scott
- Christ, Angelika
- Cloonan, Nicole
- Newell, Felicity
- Pinese, Mark
- Kaplan, Warren
- Jones, Marc D.
- Colvin, Emily K.
- Nagrial, Adnan M.
- Chou, Angela
- Chin, Venessa T.
- Chantrill, Lorraine A.
- Mawson, Amanda
- Samra, Jaswinder S.
- Kench, James G.
- Daly, Roger J.
- Merrett, Neil D.
- Toon, Christopher
- Nguyen, Nam Q.
- Barbour, Andrew
- Zeps, Nikolajs
- Zhao, Fengmei
- Muzny, Donna M.
- Drummond, Jennifer
- Chang, Kyle
- Han, Yi
- Dinh, Huyen
- Beck, Timothy
- Begley, Kimberly
- Brown, Andrew
- Denroche, Robert E.
- Yung, Christina K.
- Serra, Stefano
- Mukhopadhyay, Debabrata
- Tsao, Ming-Sound
- Petersen, Gloria M.
- Hruban, Ralph H.
- Maitra, Anirban
- Schulick, Richard D.
- Wolfgang, Christopher L.
- Lawlor, Rita T.
- Corbo, Vincenzo
- Tortora, Giampaolo
- Tempero, Margaret A.
- Mann, Karen M.
- Jenkins, Nancy A.
- Adams, David J.
- Wessels, Lodewyk F. A.
- Rust, Alistair G.
- Stein, Lincoln D.
- Tuveson, David A.
- Scarpa, Aldo
- Eshleman, James R.
- Hudson, Thomas J.
- Wheeler, David A.
- Pearson, John V.
- McPherson, John D.
- Gibbs, Richard A.
- Grimmond, Sean M.
- Venue
- Nature
- Published
- 2012-10-24
- Volume
- 491
- Issue
- 7424
- Pages
- 399-405
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3530898
- OpenAlex
- W2161884651
- Cited by
- 2,058
- References
- 41
- Citations by year
- 2026: 62 · 2025: 98 · 2024: 90 · 2023: 128 · 2022: 173 · 2021: 190 · 2020: 168 · 2019: 163 · 2018: 159 · 2017: 187 · 2016: 191 · 2015: 176 · 2014: 157 · 2013: 113 · 2012: 1
- FWCI
- 70.75
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- eSpace (Curtin University) (submittedVersion)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- NOVA (University of Newcastle Australia) (submittedVersion)
- Funders
- American Association for Cancer Research
- Cancer Prevention and Research Institute of Texas (RP101353-P7, RP101353)
- Johns Hopkins University (P50CA062924)
- Royal College of Pathologists of Australasia
- Wellcome Trust
- Australian Government
- Cancer Research UK (13031)
- Australian Cancer Research Foundation
- Cancer Institute NSW
- Gastroenterological Society of Australia
- Royal Australasian College of Physicians
- Agency for Science, Technology and Research
- Petre Foundation
- Queensland Government
- R.T. Hall Trust
- Associazione Italiana per la Ricerca sul Cancro (12182, 5 x mille)
- Università degli Studi di Verona
- Ministero dello Sviluppo Economico
- National Institutes of Health (CA102701)
- Medical Research Council
- National Health and Medical Research Council (535914, 631701, 535903, 427601)
- Cancer Council NSW (SRP06-01)
- National Human Genome Research Institute (HG003273, U54HG003273)
- National Cancer Institute (CA102701, R01CA-97075, P01CA134292, P50CA101955, P50CA102701, R01CA113636, R01CA097075, P50CA062924)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- pancreatic ductal adenocarcinoma, axon guidance genes, somatic mutations, copy number variation, chromatin modification, DNA repair, ATM, carcinogenesis, pathway analysis, patient survival, Sleeping Beauty transposon mutagenesis, early-stage pancreatic cancer
- MeSH terms
- Animals, Axons, Humans, Mutation, Pancreatic Neoplasms, Proteins, Signal Transduction, Gene Expression Regulation, Neoplastic, Genome, Gene Dosage, Carcinoma, Pancreatic Ductal, Mice, Kaplan-Meier Estimate
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
